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    "titulo" => "Serosubtipos de meningococo B causantes de enfermedad invasiva en Cantabria y concordancia con la cepa de la vacuna cubana"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Conocer los serosubtipos de meningococo B causantes de enfermedad invasiva en Cantabria y el porcentaje de concordancia con la cepa de la vacuna cubana VA-Mengoc-BC&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Revisi&#243;n retrospectiva de todos los casos de enfermedad invasiva por meningococo B declarados a trav&#233;s del sistema de Enfermedades de Declaraci&#243;n Obligatoria &#40;EDO&#41; entre el 1 de enero de 1998 y el 28 de febrero de 2003&#44; los aislamientos bacteriol&#243;gicos del Hospital Universitario Marqu&#233;s de Valdecilla y la serosubtipificaci&#243;n hecha en el laboratorio de referencia de Majadahonda&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">De los 117 casos declarados&#44; se identific&#243; el serosubtipo de 79 &#40;67&#44;5&#37;&#41;&#46; La coincidencia con la cepa vacunal cubana fue del 67&#44; el 71 y el 76&#37; en los grupos de edad de 0 a 19 a&#241;os&#44; 18 meses a 19 a&#241;os&#44; y de 4 a 19 a&#241;os&#44; respectivamente&#46; Incluyendo las cepas con protecci&#243;n cruzada&#44; estos porcentajes se elevan al 83&#44; el 83 y el 84&#37;&#44; respectivamente&#44; en los mismos grupos de edad&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El porcentaje de coincidencia con la cepa vacunal cubana y con las cepas heter&#243;logas con protecci&#243;n cruzada es alto&#44; por lo que esta vacuna podr&#237;a ser de utilidad para la situaci&#243;n epidemiol&#243;gica de Cantabria&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To determine the serosubtypes of meningococcus B causing invasive disease in Cantabria and the percentage of agreement with the Cuban vaccine strain&#44; VA-MENGOC-BC&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We performed a retrospective review of all cases of invasive disease due to meningococcus B declared through the Diseases of Mandatory Reporting System between 1st January 1998 and 28th February 2003&#46; The bacteriological isolates of the &#171;Marqu&#233;s de Valdecilla&#187; University Hospital&#44; and the serosubtyping performed in the Majadahonda reference laboratory &#40;Madrid&#44; Spain&#41; were also analyzed&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Of the 117 declared cases&#44; serosubtype was identified in 79 &#40;67&#46;5&#37;&#41;&#46; The agreement with the Cuban vaccine strain was 67&#37;&#44; 71&#37; and 76&#37; in the age groups of newborn to 19 years&#44; 18 months to 19 years&#44; and 4 to 19 years&#44; respectively&#46; When strains with cross-protection were included&#44; these percentages increased to 83&#37;&#44; 83&#37; and 84&#37;&#44; respectively&#44; in the same age groups&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The percentage of agreement between the Cuban vaccine strain and heterologous strains with cross-protection was high&#46; Therefore&#44; this vaccine could be useful in Cantabria&#46;</p>"
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Vol. 18. Núm. 1.
Páginas 45-49 (enero - febrero 2004)
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Vol. 18. Núm. 1.
Páginas 45-49 (enero - febrero 2004)
Open Access
Serosubtipos de meningococo B causantes de enfermedad invasiva en Cantabria y concordancia con la cepa de la vacuna cubana
Meningococcus B serosubtypes causing invasive disease in Cantabria [Spain] and agreement with the Cuban vaccine strain
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Álvaro González de Aledoa,
Autor para correspondencia
gonzalezdealedo_a@gobcantabria.es

Correspondencia: A. González de Aledo Linos. Valdenoja, 46, 7.° I. 39012 Santander (Cantabria). España.
, Luis Viloriab
a Especialista en Pediatría y en Medicina Preventiva y Salud Pública. Jefe de Sección de Promoción y Educación para la Salud
b Especialista en Medicina Preventiva y Salud Pública. Sección de Vigilancia Epidemiológica
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Resumen
Objetivo

Conocer los serosubtipos de meningococo B causantes de enfermedad invasiva en Cantabria y el porcentaje de concordancia con la cepa de la vacuna cubana VA-Mengoc-BC.

Métodos

Revisión retrospectiva de todos los casos de enfermedad invasiva por meningococo B declarados a través del sistema de Enfermedades de Declaración Obligatoria (EDO) entre el 1 de enero de 1998 y el 28 de febrero de 2003, los aislamientos bacteriológicos del Hospital Universitario Marqués de Valdecilla y la serosubtipificación hecha en el laboratorio de referencia de Majadahonda.

Resultados

De los 117 casos declarados, se identificó el serosubtipo de 79 (67,5%). La coincidencia con la cepa vacunal cubana fue del 67, el 71 y el 76% en los grupos de edad de 0 a 19 años, 18 meses a 19 años, y de 4 a 19 años, respectivamente. Incluyendo las cepas con protección cruzada, estos porcentajes se elevan al 83, el 83 y el 84%, respectivamente, en los mismos grupos de edad.

Conclusiones

El porcentaje de coincidencia con la cepa vacunal cubana y con las cepas heterólogas con protección cruzada es alto, por lo que esta vacuna podría ser de utilidad para la situación epidemiológica de Cantabria.

Palabras clave:
Vacunas meningocócicas
Infecciones meningocócicas
Abstract
Objective

To determine the serosubtypes of meningococcus B causing invasive disease in Cantabria and the percentage of agreement with the Cuban vaccine strain, VA-MENGOC-BC.

Methods

We performed a retrospective review of all cases of invasive disease due to meningococcus B declared through the Diseases of Mandatory Reporting System between 1st January 1998 and 28th February 2003. The bacteriological isolates of the «Marqués de Valdecilla» University Hospital, and the serosubtyping performed in the Majadahonda reference laboratory (Madrid, Spain) were also analyzed.

Results

Of the 117 declared cases, serosubtype was identified in 79 (67.5%). The agreement with the Cuban vaccine strain was 67%, 71% and 76% in the age groups of newborn to 19 years, 18 months to 19 years, and 4 to 19 years, respectively. When strains with cross-protection were included, these percentages increased to 83%, 83% and 84%, respectively, in the same age groups.

Conclusions

The percentage of agreement between the Cuban vaccine strain and heterologous strains with cross-protection was high. Therefore, this vaccine could be useful in Cantabria.

Key words:
Meningococcal vaccines
Meningococcal infections
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Copyright © 2004. Sociedad Española de Salud Pública y Administración Sanitaria
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