array:24 [
  "pii" => "S0213911106715825"
  "issn" => "02139111"
  "doi" => "10.1157/13086042"
  "estado" => "S300"
  "fechaPublicacion" => "2006-03-01"
  "aid" => "71582"
  "copyright" => "Sociedad Española de Salud Pública y Administración Sanitaria"
  "copyrightAnyo" => "2006"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Gac Sanit. 2006;20 Supl 1:182-91"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3460
    "formatos" => array:3 [
      "EPUB" => 155
      "HTML" => 2741
      "PDF" => 564
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0213911106715837"
    "issn" => "02139111"
    "doi" => "10.1157/13086043"
    "estado" => "S300"
    "fechaPublicacion" => "2006-03-01"
    "aid" => "71583"
    "copyright" => "Sociedad Española de Salud Pública y Administración Sanitaria"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Gac Sanit. 2006;20 Supl 1:192-202"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4388
      "formatos" => array:3 [
        "EPUB" => 148
        "HTML" => 3634
        "PDF" => 606
      ]
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Parte IV&#46; Ecosalud y participaci&#243;n social</span>"
      "titulo" => "Participaci&#243;n social y orientaci&#243;n comunitaria en los servicios de salud"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "192"
          "paginaFinal" => "202"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Social participation and community orientation in health services"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Manuel Mart&#237;n-Garc&#237;a, Carlos Ponte-Mittelbrun, Marciano S&#225;nchez-Bayle"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Manuel"
              "apellidos" => "Mart&#237;n-Garc&#237;a"
            ]
            1 => array:2 [
              "nombre" => "Carlos"
              "apellidos" => "Ponte-Mittelbrun"
            ]
            2 => array:2 [
              "nombre" => "Marciano"
              "apellidos" => "S&#225;nchez-Bayle"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911106715837?idApp=WGSE"
    "url" => "/02139111/00000020000000S1/v1_201301241552/S0213911106715837/v1_201301241552/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0213911106715813"
    "issn" => "02139111"
    "doi" => "10.1157/13086041"
    "estado" => "S300"
    "fechaPublicacion" => "2006-03-01"
    "aid" => "71581"
    "copyright" => "Sociedad Espa&#241;ola de Salud P&#250;blica y Administraci&#243;n Sanitaria"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Gac Sanit. 2006;20 Supl 1:175-81"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4193
      "formatos" => array:3 [
        "EPUB" => 166
        "HTML" => 3418
        "PDF" => 609
      ]
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Parte IV&#46; Ecosalud y participaci&#243;n social</span>"
      "titulo" => "Alteraciones del nicho ecol&#243;gico&#58; resistencias bacterianas a los antibi&#243;ticos"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "175"
          "paginaFinal" => "181"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Ecological niche altering&#58; bacteria resistance to antibiotics"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Raimundo Pastor-S&#225;nchez"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Raimundo"
              "apellidos" => "Pastor-S&#225;nchez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911106715813?idApp=WGSE"
    "url" => "/02139111/00000020000000S1/v1_201301241552/S0213911106715813/v1_201301241552/es/main.assets"
  ]
  "es" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Parte IV&#46; Ecosalud y participaci&#243;n social</span>"
    "titulo" => "La comorbilidad en atenci&#243;n primaria"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "182"
        "paginaFinal" => "191"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Luis Palomo, Carlos Rubio, Juan G&#233;rvas"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "Luis"
            "apellidos" => "Palomo"
            "email" => array:1 [
              0 => "luispalomo&#64;wanadoo&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Carlos"
            "apellidos" => "Rubio"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Juan"
            "apellidos" => "G&#233;rvas"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Centro de Salud de Coria&#46; Red Espa&#241;ola de Atenci&#243;n Primaria&#46; C&#225;ceres&#46; Espa&#241;a"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Centro de Salud Plaza de Argel&#46; Red Espa&#241;ola de Atenci&#243;n Primaria&#46; C&#225;ceres&#46; Espa&#241;a"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
          2 => array:3 [
            "entidad" => "Red Espa&#241;ola de Atenci&#243;n Primaria&#46; Madrid&#46; Espa&#241;a"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff3"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspondencia&#58; Luis Palomo&#46; Centro de Salud de Coria&#46; C&#47; Cervantes&#44; s&#47;n&#46; 10800 Coria&#46; C&#225;ceres&#46; Espa&#241;a&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "The comorbidity in primary care"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec13935"
          "palabras" => array:3 [
            0 => "Comorbilidad"
            1 => "Atenci&#243;n primaria"
            2 => "Calidad de vida"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec13936"
          "palabras" => array:3 [
            0 => "Comorbidity"
            1 => "Primary care"
            2 => "Quality of life"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La cronificaci&#243;n de un n&#250;mero cada vez mayor de enfermedades en poblaciones que viven cada vez m&#225;s a&#241;os acarrea un incremento de la comorbilidad&#46; Su frecuencia se comprueba en los registros de morbilidad atendida y su importancia se manifiesta en el uso de los servicios&#44; en los tratamientos&#44; en la supervivencia&#44; y en la calidad de vida de los pacientes afectados&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">Una asociaci&#243;n frecuente&#44; como diabetes y depresi&#243;n&#44; ocasiona m&#225;s gastos en atenci&#243;n primaria&#44; m&#225;s atenci&#243;n urgente&#44; m&#225;s ingresos&#44; m&#225;s probabilidad de tener riesgo vascular&#44; menor adherencia al tratamiento y a la dieta&#44; peor percepci&#243;n del estado f&#237;sico y mental y&#44; en general&#44; m&#225;s gastos totales&#46; La tasa anual de mortalidad se multiplica en presencia de anemia o de insuficiencia card&#237;aca o renal&#46; La percepci&#243;n de la calidad de vida se relaciona m&#225;s con la comorbilidad mental que con la f&#237;sica&#46; La comorbilidad incrementa los ingresos evitables y las complicaciones prevenibles asociadas a ingreso hospitalario&#46; La ideaci&#243;n suicida es mayor con enfermedad pulmonary obstructiva cr&#243;nica &#40;EPOC&#41; que con otras enfermedades cr&#243;nicas org&#225;nicas&#46; El riesgo de crisis coronaria aguda se incrementa con la edad en pacientes con fibrilaci&#243;n auricular y la comorbilidad incrementa el uso de inhibidores de la enzima de conversi&#243;n de la angiotensina &#40;IECA&#41;&#44; la toma de antidepresivos y las visitas al psiquiatra&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">As patients live longer&#44; and more illnesses become chronic&#44; comorbidity rates increase&#46; This increase shows in attended morbidity registers&#44; and its importance is revealed by the use of services&#44; treatments&#44; the survival rates and the patients&#8217; life quality&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">A frequent coexistence of illnesses&#44; such as diabetes and depression&#44; increases the cost of primary care and emergency treatments and the number of hospital admissions&#59; increases the probability of cardiovascular risk and non-adherence to treatment and diet&#59; causes a perception of poor physical and mental health and&#44; on the whole&#44; increases global costs&#46; The annual mortality rate shoots up when anemia and cardiovascular or kidney failure occur&#46; Mental comorbidity has a greater effect on the patients&#8217; perception of their life quality than physical comorbidity&#46; Comorbidity increases the number of hospital admissions which could have been prevented&#44; as well as the avoidable complications related to them&#46; Suicidal thoughts occur more frequently in patients suffering from chronic obstructive pulmonary disease &#40;COPD&#41; than in those suffering from other chronic organic illnesses&#46; In patients suffering from atrial fibrillation&#44; the risk of acute coronary crisis increases as they age and the comorbidity increases the use of angiotensin-converting enzymes &#40;ICAE&#41;&#44; antidepressant drugs and the visits to the psychiatrist&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">En este trabajo se emplea el t&#233;rmino comorbilidad como sin&#243;nimo de multimorbilidad&#44; sin que este t&#233;rmino implique una jerarqu&#237;as entre enfermedades&#44; a no ser que se haga menci&#243;n expresa a una enfermedad &#237;ndice&#46; Por otra parte&#44; el t&#233;rmino comorbilidad es el com&#250;nmente utilizado en la literatura m&#233;dica internacional&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:49 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "How to measure comorbidity&#58; a critical review of available methods"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "V&#46; Groot"
                            1 => "H&#46; Beckerman"
                            2 => "G&#46;J&#46; Lankhorst"
                            3 => "L&#46;M&#46; Bouter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Epidemiol"
                        "fecha" => "2003"
                        "volumen" => "56"
                        "paginaInicial" => "221"
                        "paginaFinal" => "229"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12725876"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multimorbidity in general practice&#58; Prevalence&#44; incidence and determinants of co-ocurring chronic and recurrent diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Van den Akker"
                            1 => "K&#46; Buntinks"
                            2 => "J&#46;F&#46; Met semakers"
                            3 => "S&#46; Roos"
                            4 => "A&#46; Knottnerus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Epidemiol"
                        "fecha" => "1998"
                        "volumen" => "51"
                        "paginaInicial" => "367"
                        "paginaFinal" => "375"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9619963"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic diseases in general practice&#58; the longitudinal dimension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "C&#46; Van Weel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur J General Practice"
                        "fecha" => "1996"
                        "volumen" => "2"
                        "paginaInicial" => "17"
                        "paginaFinal" => "21"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Which chronic conditions are associated with better or poorer quality of life&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;A&#46;G&#46; Sprangers"
                            1 => "E&#46;B&#46; Regt"
                            2 => "F&#46; Andries"
                            3 => "H&#46;M&#46;E&#46; Van Agt"
                            4 => "R&#46;V&#46; Bijl"
                            5 => "J&#46;B&#46; De Boer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Epidemiol"
                        "fecha" => "2000"
                        "volumen" => "53"
                        "paginaInicial" => "895"
                        "paginaFinal" => "907"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11004416"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comorbidity&#58; Implications for the importance of primary care in &#171;Case&#187; Management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46; Starfield"
                            1 => "K&#46;W&#46; Lemke"
                            2 => "T&#46; Bernhardt"
                            3 => "S&#46;S&#46; Foldes"
                            4 => "C&#46;B&#46; Forrest"
                            5 => "J&#46;P&#46; Weiner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Annals of Family Medicine"
                        "fecha" => "2003"
                        "volumen" => "1"
                        "paginaInicial" => "8"
                        "paginaFinal" => "14"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15043174"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comorbidities and the willingness to pay for reducing the risk of a targeted disease&#58; introducing endogenous effort for risk"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L&#46; Liu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/hec.865"
                      "Revista" => array:6 [
                        "tituloSerie" => "Health Econ"
                        "fecha" => "2004"
                        "volumen" => "13"
                        "paginaInicial" => "493"
                        "paginaFinal" => "498"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15127428"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Episodios de enfermedad atendidos en medicina general&#47;de familia&#44; seg&#250;n medio demogr&#225;fico &#40;I&#41;&#58; morbilidad"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46; Palomo"
                            1 => "L&#46; Garc&#237;a"
                            2 => "J&#46; G&#233;rvas"
                            3 => "A&#46; Garc&#237;a"
                            4 => "A&#46; L&#243;pez"
                            5 => "F&#46; S&#225;nchez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Aten Primaria"
                        "fecha" => "1997"
                        "volumen" => "19"
                        "paginaInicial" => "469"
                        "paginaFinal" => "476"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9264682"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Palomo L&#46; Morbilidad atendida y utilizaci&#243;n de las consultas de medicina general&#47;de familia por pacientes con enfermedades endocrinas&#44; nutricionales y del metabolismo&#46; Tesis Doctoral&#46; Universidad de Extremadura&#59; 1999&#46;"
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac risk factors in patients with diabetes mellitus and major depression"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "W&#46;J&#46; Katon"
                            1 => "E&#46;H&#46; Lin"
                            2 => "J&#46; Russo"
                            3 => "M&#46; Von Korff"
                            4 => "P&#46; Ciechanowski"
                            5 => "G&#46; Simon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1525-1497.2004.30405.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Gen Intern Med"
                        "fecha" => "2004"
                        "volumen" => "19"
                        "paginaInicial" => "1192"
                        "paginaFinal" => "1199"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15610329"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical features of depressed outpatients with and without co-occurring general medical conditions in STAR&#42;D"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "W&#46;R&#46; Yates"
                            1 => "J&#46; Mitchell"
                            2 => "A&#46;J&#46; Rush"
                            3 => "M&#46;H&#46; Trivedi"
                            4 => "S&#46;R&#46; Wisniewski"
                            5 => "D&#46; Warden"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.genhosppsych.2004.06.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "Gen Hosp Psychiatry"
                        "fecha" => "2004"
                        "volumen" => "26"
                        "paginaInicial" => "421"
                        "paginaFinal" => "429"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15567207"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High prevalence of peripheral arterial disease and co-morbidity in 6880 primary care patients&#58; cross-sectional study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Diehm"
                            1 => "A&#46; Schuster"
                            2 => "J&#46;R&#46; Allenberg"
                            3 => "H&#46; Darius"
                            4 => "R&#46; Haberl"
                            5 => "S&#46; Lange"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Atherosclerosis"
                        "fecha" => "2004"
                        "volumen" => "172"
                        "paginaInicial" => "95"
                        "paginaFinal" => "105"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14709362"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A descriptive and comparative study of the prevalence of depressive and anxiety disorders in low-income adults with type 2 diabetes and other chronic illnesses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Thomas"
                            1 => "G&#46; Jones"
                            2 => "I&#46; Scarinci"
                            3 => "P&#46; Brantley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes Care"
                        "fecha" => "2003"
                        "volumen" => "26"
                        "paginaInicial" => "2311"
                        "paginaFinal" => "2317"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12882854"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Major depression&#44; physical illness&#44; and suicidal ideation in primary care"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;D&#46; Goodwin"
                            1 => "K&#46; Kroenke"
                            2 => "C&#46;W&#46; Hoven"
                            3 => "R&#46;L&#46; Spitzer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Psychosom Med"
                        "fecha" => "2003"
                        "volumen" => "65"
                        "paginaInicial" => "501"
                        "paginaFinal" => "505"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12883095"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characteristics of comorbidity in adult asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L&#46; Ben-Noun"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Public Health Rev"
                        "fecha" => "2001"
                        "volumen" => "29"
                        "paginaInicial" => "49"
                        "paginaFinal" => "61"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11780716"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comorbidity associated with atrial fibrillation&#58;a general practice-based study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46; Carroll"
                            1 => "A&#46; Majeed"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Gen Pract"
                        "fecha" => "2001"
                        "volumen" => "51"
                        "paginaInicial" => "884"
                        "paginaFinal" => "886"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11761201"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Depression and diabetes&#58; impact of depressive symptoms on adherence&#44; function&#44; and costs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;S&#46; Ciechanowski"
                            1 => "W&#46;J&#46; Katon"
                            2 => "J&#46;E&#46; Russo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "2000"
                        "volumen" => "160"
                        "paginaInicial" => "3278"
                        "paginaFinal" => "3285"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11088090"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comorbidity of chronic diseases and psychiatric disorders among patients attending public primary care"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Fullerton"
                            1 => "R&#46; Florenzano"
                            2 => "J&#46; Acuna"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Med Chil"
                        "fecha" => "2000"
                        "volumen" => "128"
                        "paginaInicial" => "729"
                        "paginaFinal" => "734"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11050833"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Marginal impact of psychosocial factors on multimorbidity&#58; results of an explorative nested case-control study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Van den Akker"
                            1 => "F&#46; Buntinx"
                            2 => "J&#46;F&#46; Metsemakers"
                            3 => "J&#46;A&#46; Knottnerus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Soc Sci Med"
                        "fecha" => "2000"
                        "volumen" => "50"
                        "paginaInicial" => "1679"
                        "paginaFinal" => "1693"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10795973"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cancer and comorbidity&#58;redefining chronic diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46;S&#46; Ogle"
                            1 => "G&#46;M&#46; Swanson"
                            2 => "N&#46; Woods"
                            3 => "F&#46; Azzouz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "2000"
                        "volumen" => "88"
                        "paginaInicial" => "653"
                        "paginaFinal" => "663"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10649261"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patient-reported measures of health&#58; The Veterans Health Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;E&#46; Kazis"
                            1 => "D&#46;R&#46; Miller"
                            2 => "K&#46;M&#46; Skinner"
                            3 => "A&#46; Lee"
                            4 => "X&#46;S&#46; Ren"
                            5 => "J&#46;A&#46; Clark"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Ambul Care Manage"
                        "fecha" => "2004"
                        "volumen" => "27"
                        "paginaInicial" => "70"
                        "paginaFinal" => "83"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14717468"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Health related quality of life in pregeriatric patients with chronic diseases at urban&#44; public supported clinics"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46; Cheng"
                            1 => "S&#46; Cumber"
                            2 => "C&#46; Dumas"
                            3 => "R&#46; Winter"
                            4 => "K&#46;M&#46; Nguyen"
                            5 => "L&#46;Z&#46; Nieman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1477-7525-1-63"
                      "Revista" => array:6 [
                        "tituloSerie" => "Health Qual Life Outcomes"
                        "fecha" => "2003"
                        "volumen" => "1"
                        "paginaInicial" => "63"
                        "paginaFinal" => "66"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14613559"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predicting declines in physical function in persons with multiple chronic medical conditions&#58; what we can learn from the medical problem list"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46;A&#46; Bayliss"
                            1 => "M&#46;S&#46; Bayliss"
                            2 => "J&#46;E&#46; Ware Jr"
                            3 => "J&#46;F&#46; Steiner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1477-7525-2-47"
                      "Revista" => array:6 [
                        "tituloSerie" => "Health Qual Life Outcomes"
                        "fecha" => "2004"
                        "volumen" => "2"
                        "paginaInicial" => "47"
                        "paginaFinal" => "51"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15353000"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The influence of co-morbidity on health-related quality of life in asthma and COPD patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46;A&#46; Wijnhoven"
                            1 => "D&#46;M&#46; Kriegsman"
                            2 => "A&#46;E&#46; Hesselink"
                            3 => "M&#46; De Haan"
                            4 => "F&#46;G&#46; Schellevis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Respir Med"
                        "fecha" => "2003"
                        "volumen" => "97"
                        "paginaInicial" => "468"
                        "paginaFinal" => "475"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12735662"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiple chronic health problems are negatively associated with health related quality of life &#40;HRQoL&#41; irrespective of age"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Michelson"
                            1 => "C&#46; Bolund"
                            2 => "Y&#46; Brandberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Qual Life Res"
                        "fecha" => "2001"
                        "volumen" => "9"
                        "paginaInicial" => "1093"
                        "paginaFinal" => "1104"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11401042"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Functional status&#44; health problems&#44; age and comorbidity in primary care patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Wensing"
                            1 => "E&#46; Vingerhoets"
                            2 => "R&#46; Grol"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Qual Life Res"
                        "fecha" => "2001"
                        "volumen" => "10"
                        "paginaInicial" => "141"
                        "paginaFinal" => "148"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11642684"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Percepci&#243;n del estado de salud en varones y mujeres en las &#250;ltimas etapas de la vida"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E&#46; S&#233;culi"
                            1 => "J&#46; Fust&#233;"
                            2 => "P&#46; Brugulat"
                            3 => "S&#46; Junc&#225;"
                            4 => "M&#46; Ru&#233;"
                            5 => "M&#46; Guillen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gac Sanit"
                        "fecha" => "2001"
                        "volumen" => "15"
                        "paginaInicial" => "217"
                        "paginaFinal" => "223"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11423025"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of congestive heart failure&#44; chronic kidney disease&#44; and anemia on survival in the Medicare population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46;A&#46; Herzog"
                            1 => "H&#46;A&#46; Muster"
                            2 => "S&#46; Li"
                            3 => "A&#46;J&#46; Collins"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Card Fail"
                        "fecha" => "2004"
                        "volumen" => "10"
                        "paginaInicial" => "467"
                        "paginaFinal" => "472"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15599836"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An adaptation of Charlson comorbidity index predicted subsequent mortality in a health survey"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Rius"
                            1 => "G&#46; Perez"
                            2 => "J&#46;M&#46; Martinez"
                            3 => "M&#46; Bares"
                            4 => "A&#46; Schiaffino"
                            5 => "R&#46; Gispert"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jclinepi.2003.09.016"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Epidemiol"
                        "fecha" => "2004"
                        "volumen" => "57"
                        "paginaInicial" => "403"
                        "paginaFinal" => "408"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15135843"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of Charlson&#39;s comorbidity index in elderly living in nursing homes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46; Buntinx"
                            1 => "L&#46; Niclaes"
                            2 => "C&#46; Suetens"
                            3 => "B&#46; Jans"
                            4 => "R&#46; Mertens"
                            5 => "M&#46; Van den Akker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin Epidemiol"
                        "fecha" => "2002"
                        "volumen" => "5"
                        "paginaInicial" => "1144"
                        "paginaFinal" => "1147"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Physical inactivity and short-term all-cause mortality in adults with chronic disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46;C&#46; Martinson"
                            1 => "P&#46;J&#46; O&#8217;Connor"
                            2 => "N&#46;P&#46; Pronk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "2001"
                        "volumen" => "161"
                        "paginaInicial" => "1173"
                        "paginaFinal" => "1180"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11343440"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comorbid mental disorders account for the role impairment of commonly occurring chronic physical disorders&#58; results from the National Comorbidity Survey"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;C&#46; Kessler"
                            1 => "J&#46; Ormel"
                            2 => "O&#46; Demler"
                            3 => "P&#46;E&#46; Stang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.jom.0000100000.70011.bb"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Occup Environ Med"
                        "fecha" => "2003"
                        "volumen" => "45"
                        "paginaInicial" => "1257"
                        "paginaFinal" => "1266"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14665811"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Depression status&#44; medical comorbidity and resource costs&#46; Evidence from an international study of major depression in primary care &#40;LIDO&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Chisholm"
                            1 => "P&#46; Diehr"
                            2 => "M&#46; Knapp"
                            3 => "D&#46; Patrick"
                            4 => "M&#46; Treglia"
                            5 => "G&#46; Simon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Psychiatry"
                        "fecha" => "2003"
                        "volumen" => "183"
                        "paginaInicial" => "121"
                        "paginaFinal" => "131"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12893665"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence&#44; expenditures&#44; and complications of multiple chronic conditions in the elderly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;L&#46; Wolff"
                            1 => "B&#46; Starfield"
                            2 => "G&#46; Anderson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "2002"
                        "volumen" => "162"
                        "paginaInicial" => "2269"
                        "paginaFinal" => "2276"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12418941"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Health care utilization and costs of Alzheimer&#39;s disease&#58; the role of co-morbid conditions&#44; disease stage&#44; and pharmacotherapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Fillit"
                            1 => "J&#46;W&#46; Hill"
                            2 => "R&#46; Futterman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Fam Med"
                        "fecha" => "2002"
                        "volumen" => "34"
                        "paginaInicial" => "528"
                        "paginaFinal" => "535"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12144008"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib35"
              "etiqueta" => "35&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Does comorbidity explain trends in prescribing of newer antihypertensive agents&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;P&#46; Greving"
                            1 => "P&#46; Denig"
                            2 => "W&#46;J&#46; Van der Veen"
                            3 => "F&#46;W&#46; Beltman"
                            4 => "M&#46;C&#46; Sturkenboom"
                            5 => "De Zeeuw"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hypertens"
                        "fecha" => "2004"
                        "volumen" => "22"
                        "paginaInicial" => "2209"
                        "paginaFinal" => "2215"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15480107"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib36"
              "etiqueta" => "36&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Improving the care for depression in patients with comorbid medical illness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;K&#46; Koike"
                            1 => "J&#46; Unutzer"
                            2 => "K&#46;B&#46; Wells"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1176/appi.ajp.159.10.1738"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Psychiatry"
                        "fecha" => "2002"
                        "volumen" => "159"
                        "paginaInicial" => "1738"
                        "paginaFinal" => "1745"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12359681"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Competing demands from physical problems&#58; effect on initiating and completing depression care over 6 months"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46;A&#46; Nutting"
                            1 => "K&#46; Rost"
                            2 => "J&#46; Smith"
                            3 => "J&#46;J&#46; Werner"
                            4 => "C&#46; Elliot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Fam Med"
                        "fecha" => "2000"
                        "volumen" => "9"
                        "paginaInicial" => "1059"
                        "paginaFinal" => "1064"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11115208"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib38"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Depression and associated organic pathologies&#44; a still underestimated comorbidity&#46; Results of the DIALOGUE study"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Depression and Organic Diseases Study"
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46;M&#46; Consoli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Presse Med"
                        "fecha" => "2003"
                        "volumen" => "32"
                        "paginaInicial" => "10"
                        "paginaFinal" => "21"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12610390"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib39"
              "etiqueta" => "39&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comorbidity of chronic diseases in general practice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "F&#46;G&#46; Schellevis"
                            1 => "J&#46; Van der Velden"
                            2 => "E&#46; Van de Lisdonk"
                            3 => "J&#46; Van Eijk"
                            4 => "C&#46; Van Weel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Epidemiol"
                        "fecha" => "1993"
                        "volumen" => "46"
                        "paginaInicial" => "469"
                        "paginaFinal" => "473"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8501473"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib40"
              "etiqueta" => "40&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Consultation rates and incidente of intercurrent morbidity among patients with chronic disease in general practice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46;G&#46; Schellevis"
                            1 => "E&#46;H&#46; Van de Lisdonk"
                            2 => "J&#46; Van der Velden"
                            3 => "S&#46;H&#46; Hoogbergen"
                            4 => "J&#46;T&#46; Van Eijk"
                            5 => "C&#46; Van Wel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "British J General Practice"
                        "fecha" => "1994"
                        "volumen" => "44"
                        "paginaInicial" => "259"
                        "paginaFinal" => "262"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib41"
              "etiqueta" => "41&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Capacidad funcional y problemas socioasistenciales de los ancianos del &#225;rea de salud de C&#225;ceres"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Corrales"
                            1 => "L&#46; Palomo"
                            2 => "M&#46;J&#46; Magari&#241;o"
                            3 => "G&#46; Alonso"
                            4 => "P&#46; Torrico"
                            5 => "A&#46; Barroso"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Aten Primaria"
                        "fecha" => "2004"
                        "volumen" => "33"
                        "paginaInicial" => "426"
                        "paginaFinal" => "433"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15151789"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib42"
              "etiqueta" => "42&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "El impacto del envejecimiento sobre la casu&#237;stica del hospital"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Varela"
                            1 => "X&#46; Castells"
                            2 => "M&#46; Riu"
                            3 => "A&#46;M&#46; Cervera"
                            4 => "T&#46; Vernhes"
                            5 => "A&#46; D&#237;ez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gac Sanit"
                        "fecha" => "2000"
                        "volumen" => "14"
                        "paginaInicial" => "203"
                        "paginaFinal" => "209"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10984984"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib43"
              "etiqueta" => "43&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognostic importance of comorbidity in a hospital-based cancer registry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;F&#46; Piccirillo"
                            1 => "R&#46;M&#46; Tierney"
                            2 => "R&#46; Costas"
                            3 => "L&#46; Grove"
                            4 => "E&#46;L&#46; Spitznagel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.291.20.2441"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2004"
                        "volumen" => "291"
                        "paginaInicial" => "2441"
                        "paginaFinal" => "2447"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15161894"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib44"
              "etiqueta" => "44&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Morbimortalidad de los pacientes ingresados por insuficiencia card&#237;aca&#46; Factores predictores de reingreso"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "N&#46; Galofr&#233;"
                            1 => "L&#46; San Vicente"
                            2 => "J&#46; Ant&#243;n"
                            3 => "F&#46; Planas"
                            4 => "J&#46; Vila"
                            5 => "J&#46; Grau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2005"
                        "volumen" => "124"
                        "paginaInicial" => "285"
                        "paginaFinal" => "290"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib45"
              "etiqueta" => "45&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The obesity paradox&#58; body mass index and outcomes in patients with hearth failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;P&#46; Curtis"
                            1 => "J&#46;G&#46; Selter"
                            2 => "Y&#46; Wang"
                            3 => "S&#46;S&#46; Rathore"
                            4 => "I&#46;S&#46; Joven"
                            5 => "F&#46; Jadbabaie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archinte.165.1.55"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "2005"
                        "volumen" => "165"
                        "paginaInicial" => "55"
                        "paginaFinal" => "61"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15642875"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib46"
              "etiqueta" => "46&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of specialist follow-up in outpatients with congestive hearth failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;A&#46; Ezekowitz"
                            1 => "C&#46; Van Walraben"
                            2 => "F&#46;A&#46; McAlister"
                            3 => "P&#46;W&#46; Armstrong"
                            4 => "P&#46; Kaul"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1503/cmaj.1032017"
                      "Revista" => array:6 [
                        "tituloSerie" => "CMAJ"
                        "fecha" => "2005"
                        "volumen" => "172"
                        "paginaInicial" => "189"
                        "paginaFinal" => "194"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15655239"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib47"
              "etiqueta" => "47&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comorbidity as a predictor of stage of illness for patients with breast cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46;T&#46; Fleming"
                            1 => "H&#46;G&#46; Pursley"
                            2 => "B&#46; Newman"
                            3 => "D&#46; Pavlov"
                            4 => "K&#46; Chen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Care"
                        "fecha" => "2005"
                        "volumen" => "43"
                        "paginaInicial" => "132"
                        "paginaFinal" => "140"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15655426"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib48"
              "etiqueta" => "48&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Women with disabilities&#58; general practitioners and breast cancer screening"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Verger"
                            1 => "M&#46; Aulagrnier"
                            2 => "M&#46; Souville"
                            3 => "J&#46;F&#46; Ravaud"
                            4 => "P&#46;Y&#46; Lussault"
                            5 => "J&#46;P&#46; Garnier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amepre.2004.10.010"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Prev Med"
                        "fecha" => "2005"
                        "volumen" => "28"
                        "paginaInicial" => "215"
                        "paginaFinal" => "220"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15710278"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib49"
              "etiqueta" => "49&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The association of ambulatory care with breast cancer stage at diagnosis among Medicare beneficiaries"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46;L&#46; Keating"
                            1 => "M&#46;B&#46; Landrum"
                            2 => "J&#46;Z&#46; Ayanian"
                            3 => "E&#46;P&#46; Winer"
                            4 => "E&#46; Guadagnoli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1525-1497.2004.40079.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Gen Intern Med"
                        "fecha" => "2005"
                        "volumen" => "20"
                        "paginaInicial" => "38"
                        "paginaFinal" => "44"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15693926"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/02139111/00000020000000S1/v1_201301241552/S0213911106715825/v1_201301241552/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "747"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Parte IV&#46; Ecosalud y participaci&#243;n social"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02139111/00000020000000S1/v1_201301241552/S0213911106715825/v1_201301241552/es/main.pdf?idApp=WGSE&text.app=https://gacetasanitaria.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911106715825?idApp=WGSE"
]
Compartir
Publique en esta revista
Información de la revista
Vol. 20. Núm. S1.
Informe SESPAS 2006: Los desajustes en la salud en el mundo desarrollado
Páginas 182-191 (marzo 2006)
Respuestas rápidas
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 20. Núm. S1.
Informe SESPAS 2006: Los desajustes en la salud en el mundo desarrollado
Páginas 182-191 (marzo 2006)
Parte IV. Ecosalud y participación social
Open Access
La comorbilidad en atención primaria
The comorbidity in primary care
Visitas
1168
Luis Palomoa,
Autor para correspondencia
luispalomo@wanadoo.es

Correspondencia: Luis Palomo. Centro de Salud de Coria. C/ Cervantes, s/n. 10800 Coria. Cáceres. España.
, Carlos Rubiob, Juan Gérvasc
a Centro de Salud de Coria. Red Española de Atención Primaria. Cáceres. España
b Centro de Salud Plaza de Argel. Red Española de Atención Primaria. Cáceres. España
c Red Española de Atención Primaria. Madrid. España
Este artículo ha recibido

Under a Creative Commons license
Información del artículo
Resumen
Bibliografía
Descargar PDF
Estadísticas
Resumen

La cronificación de un número cada vez mayor de enfermedades en poblaciones que viven cada vez más años acarrea un incremento de la comorbilidad. Su frecuencia se comprueba en los registros de morbilidad atendida y su importancia se manifiesta en el uso de los servicios, en los tratamientos, en la supervivencia, y en la calidad de vida de los pacientes afectados.

Una asociación frecuente, como diabetes y depresión, ocasiona más gastos en atención primaria, más atención urgente, más ingresos, más probabilidad de tener riesgo vascular, menor adherencia al tratamiento y a la dieta, peor percepción del estado físico y mental y, en general, más gastos totales. La tasa anual de mortalidad se multiplica en presencia de anemia o de insuficiencia cardíaca o renal. La percepción de la calidad de vida se relaciona más con la comorbilidad mental que con la física. La comorbilidad incrementa los ingresos evitables y las complicaciones prevenibles asociadas a ingreso hospitalario. La ideación suicida es mayor con enfermedad pulmonary obstructiva crónica (EPOC) que con otras enfermedades crónicas orgánicas. El riesgo de crisis coronaria aguda se incrementa con la edad en pacientes con fibrilación auricular y la comorbilidad incrementa el uso de inhibidores de la enzima de conversión de la angiotensina (IECA), la toma de antidepresivos y las visitas al psiquiatra.

Palabras clave:
Comorbilidad
Atención primaria
Calidad de vida
Abstract

As patients live longer, and more illnesses become chronic, comorbidity rates increase. This increase shows in attended morbidity registers, and its importance is revealed by the use of services, treatments, the survival rates and the patients’ life quality.

A frequent coexistence of illnesses, such as diabetes and depression, increases the cost of primary care and emergency treatments and the number of hospital admissions; increases the probability of cardiovascular risk and non-adherence to treatment and diet; causes a perception of poor physical and mental health and, on the whole, increases global costs. The annual mortality rate shoots up when anemia and cardiovascular or kidney failure occur. Mental comorbidity has a greater effect on the patients’ perception of their life quality than physical comorbidity. Comorbidity increases the number of hospital admissions which could have been prevented, as well as the avoidable complications related to them. Suicidal thoughts occur more frequently in patients suffering from chronic obstructive pulmonary disease (COPD) than in those suffering from other chronic organic illnesses. In patients suffering from atrial fibrillation, the risk of acute coronary crisis increases as they age and the comorbidity increases the use of angiotensin-converting enzymes (ICAE), antidepressant drugs and the visits to the psychiatrist.

Key words:
Comorbidity
Primary care
Quality of life
El Texto completo está disponible en PDF
Bibliografía
[1.]
V. Groot, H. Beckerman, G.J. Lankhorst, L.M. Bouter.
How to measure comorbidity: a critical review of available methods.
J Clin Epidemiol, 56 (2003), pp. 221-229
[2.]
M. Van den Akker, K. Buntinks, J.F. Met semakers, S. Roos, A. Knottnerus.
Multimorbidity in general practice: Prevalence, incidence and determinants of co-ocurring chronic and recurrent diseases.
J Clin Epidemiol, 51 (1998), pp. 367-375
[3.]
C. Van Weel.
Chronic diseases in general practice: the longitudinal dimension.
Eur J General Practice, 2 (1996), pp. 17-21
[4.]
M.A.G. Sprangers, E.B. Regt, F. Andries, H.M.E. Van Agt, R.V. Bijl, J.B. De Boer, et al.
Which chronic conditions are associated with better or poorer quality of life?.
J Clin Epidemiol, 53 (2000), pp. 895-907
[5.]
B. Starfield, K.W. Lemke, T. Bernhardt, S.S. Foldes, C.B. Forrest, J.P. Weiner.
Comorbidity: Implications for the importance of primary care in «Case» Management.
Annals of Family Medicine, 1 (2003), pp. 8-14
[6.]
L. Liu.
Comorbidities and the willingness to pay for reducing the risk of a targeted disease: introducing endogenous effort for risk.
Health Econ, 13 (2004), pp. 493-498
[7.]
L. Palomo, L. García, J. Gérvas, A. García, A. López, F. Sánchez.
Episodios de enfermedad atendidos en medicina general/de familia, según medio demográfico (I): morbilidad.
Aten Primaria, 19 (1997), pp. 469-476
[8.]
Palomo L. Morbilidad atendida y utilización de las consultas de medicina general/de familia por pacientes con enfermedades endocrinas, nutricionales y del metabolismo. Tesis Doctoral. Universidad de Extremadura; 1999.
[9.]
W.J. Katon, E.H. Lin, J. Russo, M. Von Korff, P. Ciechanowski, G. Simon, et al.
Cardiac risk factors in patients with diabetes mellitus and major depression.
J Gen Intern Med, 19 (2004), pp. 1192-1199
[10.]
W.R. Yates, J. Mitchell, A.J. Rush, M.H. Trivedi, S.R. Wisniewski, D. Warden, et al.
Clinical features of depressed outpatients with and without co-occurring general medical conditions in STAR*D.
Gen Hosp Psychiatry, 26 (2004), pp. 421-429
[11.]
C. Diehm, A. Schuster, J.R. Allenberg, H. Darius, R. Haberl, S. Lange, et al.
High prevalence of peripheral arterial disease and co-morbidity in 6880 primary care patients: cross-sectional study.
Atherosclerosis, 172 (2004), pp. 95-105
[12.]
J. Thomas, G. Jones, I. Scarinci, P. Brantley.
A descriptive and comparative study of the prevalence of depressive and anxiety disorders in low-income adults with type 2 diabetes and other chronic illnesses.
Diabetes Care, 26 (2003), pp. 2311-2317
[13.]
R.D. Goodwin, K. Kroenke, C.W. Hoven, R.L. Spitzer.
Major depression, physical illness, and suicidal ideation in primary care.
Psychosom Med, 65 (2003), pp. 501-505
[14.]
L. Ben-Noun.
Characteristics of comorbidity in adult asthma.
Public Health Rev, 29 (2001), pp. 49-61
[15.]
K. Carroll, A. Majeed.
Comorbidity associated with atrial fibrillation:a general practice-based study.
Br J Gen Pract, 51 (2001), pp. 884-886
[16.]
P.S. Ciechanowski, W.J. Katon, J.E. Russo.
Depression and diabetes: impact of depressive symptoms on adherence, function, and costs.
Arch Intern Med, 160 (2000), pp. 3278-3285
[17.]
C. Fullerton, R. Florenzano, J. Acuna.
Comorbidity of chronic diseases and psychiatric disorders among patients attending public primary care.
Rev Med Chil, 128 (2000), pp. 729-734
[18.]
M. Van den Akker, F. Buntinx, J.F. Metsemakers, J.A. Knottnerus.
Marginal impact of psychosocial factors on multimorbidity: results of an explorative nested case-control study.
Soc Sci Med, 50 (2000), pp. 1679-1693
[19.]
K.S. Ogle, G.M. Swanson, N. Woods, F. Azzouz.
Cancer and comorbidity:redefining chronic diseases.
Cancer, 88 (2000), pp. 653-663
[20.]
L.E. Kazis, D.R. Miller, K.M. Skinner, A. Lee, X.S. Ren, J.A. Clark, et al.
Patient-reported measures of health: The Veterans Health Study.
J Ambul Care Manage, 27 (2004), pp. 70-83
[21.]
L. Cheng, S. Cumber, C. Dumas, R. Winter, K.M. Nguyen, L.Z. Nieman.
Health related quality of life in pregeriatric patients with chronic diseases at urban, public supported clinics.
Health Qual Life Outcomes, 1 (2003), pp. 63-66
[22.]
E.A. Bayliss, M.S. Bayliss, J.E. Ware Jr, J.F. Steiner.
Predicting declines in physical function in persons with multiple chronic medical conditions: what we can learn from the medical problem list.
Health Qual Life Outcomes, 2 (2004), pp. 47-51
[23.]
H.A. Wijnhoven, D.M. Kriegsman, A.E. Hesselink, M. De Haan, F.G. Schellevis.
The influence of co-morbidity on health-related quality of life in asthma and COPD patients.
Respir Med, 97 (2003), pp. 468-475
[24.]
H. Michelson, C. Bolund, Y. Brandberg.
Multiple chronic health problems are negatively associated with health related quality of life (HRQoL) irrespective of age.
Qual Life Res, 9 (2001), pp. 1093-1104
[25.]
M. Wensing, E. Vingerhoets, R. Grol.
Functional status, health problems, age and comorbidity in primary care patients.
Qual Life Res, 10 (2001), pp. 141-148
[26.]
E. Séculi, J. Fusté, P. Brugulat, S. Juncá, M. Rué, M. Guillen.
Percepción del estado de salud en varones y mujeres en las últimas etapas de la vida.
Gac Sanit, 15 (2001), pp. 217-223
[27.]
C.A. Herzog, H.A. Muster, S. Li, A.J. Collins.
Impact of congestive heart failure, chronic kidney disease, and anemia on survival in the Medicare population.
J Card Fail, 10 (2004), pp. 467-472
[28.]
C. Rius, G. Perez, J.M. Martinez, M. Bares, A. Schiaffino, R. Gispert, et al.
An adaptation of Charlson comorbidity index predicted subsequent mortality in a health survey.
J Clin Epidemiol, 57 (2004), pp. 403-408
[29.]
F. Buntinx, L. Niclaes, C. Suetens, B. Jans, R. Mertens, M. Van den Akker.
Evaluation of Charlson's comorbidity index in elderly living in nursing homes.
J Clin Epidemiol, 5 (2002), pp. 1144-1147
[30.]
B.C. Martinson, P.J. O’Connor, N.P. Pronk.
Physical inactivity and short-term all-cause mortality in adults with chronic disease.
Arch Intern Med, 161 (2001), pp. 1173-1180
[31.]
R.C. Kessler, J. Ormel, O. Demler, P.E. Stang.
Comorbid mental disorders account for the role impairment of commonly occurring chronic physical disorders: results from the National Comorbidity Survey.
J Occup Environ Med, 45 (2003), pp. 1257-1266
[32.]
D. Chisholm, P. Diehr, M. Knapp, D. Patrick, M. Treglia, G. Simon, et al.
Depression status, medical comorbidity and resource costs. Evidence from an international study of major depression in primary care (LIDO).
Br J Psychiatry, 183 (2003), pp. 121-131
[33.]
J.L. Wolff, B. Starfield, G. Anderson.
Prevalence, expenditures, and complications of multiple chronic conditions in the elderly.
Arch Intern Med, 162 (2002), pp. 2269-2276
[34.]
H. Fillit, J.W. Hill, R. Futterman.
Health care utilization and costs of Alzheimer's disease: the role of co-morbid conditions, disease stage, and pharmacotherapy.
Fam Med, 34 (2002), pp. 528-535
[35.]
J.P. Greving, P. Denig, W.J. Van der Veen, F.W. Beltman, M.C. Sturkenboom, De Zeeuw, et al.
Does comorbidity explain trends in prescribing of newer antihypertensive agents?.
J Hypertens, 22 (2004), pp. 2209-2215
[36.]
A.K. Koike, J. Unutzer, K.B. Wells.
Improving the care for depression in patients with comorbid medical illness.
Am J Psychiatry, 159 (2002), pp. 1738-1745
[37.]
P.A. Nutting, K. Rost, J. Smith, J.J. Werner, C. Elliot.
Competing demands from physical problems: effect on initiating and completing depression care over 6 months.
Arch Fam Med, 9 (2000), pp. 1059-1064
[38.]
S.M. Consoli, Depression and Organic Diseases Study.
Depression and associated organic pathologies, a still underestimated comorbidity. Results of the DIALOGUE study.
Presse Med, 32 (2003), pp. 10-21
[39.]
F.G. Schellevis, J. Van der Velden, E. Van de Lisdonk, J. Van Eijk, C. Van Weel.
Comorbidity of chronic diseases in general practice.
J Clin Epidemiol, 46 (1993), pp. 469-473
[40.]
F.G. Schellevis, E.H. Van de Lisdonk, J. Van der Velden, S.H. Hoogbergen, J.T. Van Eijk, C. Van Wel.
Consultation rates and incidente of intercurrent morbidity among patients with chronic disease in general practice.
British J General Practice, 44 (1994), pp. 259-262
[41.]
D. Corrales, L. Palomo, M.J. Magariño, G. Alonso, P. Torrico, A. Barroso, et al.
Capacidad funcional y problemas socioasistenciales de los ancianos del área de salud de Cáceres.
Aten Primaria, 33 (2004), pp. 426-433
[42.]
J. Varela, X. Castells, M. Riu, A.M. Cervera, T. Vernhes, A. Díez, et al.
El impacto del envejecimiento sobre la casuística del hospital.
Gac Sanit, 14 (2000), pp. 203-209
[43.]
J.F. Piccirillo, R.M. Tierney, R. Costas, L. Grove, E.L. Spitznagel.
Prognostic importance of comorbidity in a hospital-based cancer registry.
JAMA, 291 (2004), pp. 2441-2447
[44.]
N. Galofré, L. San Vicente, J. Antón, F. Planas, J. Vila, J. Grau.
Morbimortalidad de los pacientes ingresados por insuficiencia cardíaca. Factores predictores de reingreso.
Med Clin (Barc), 124 (2005), pp. 285-290
[45.]
J.P. Curtis, J.G. Selter, Y. Wang, S.S. Rathore, I.S. Joven, F. Jadbabaie, et al.
The obesity paradox: body mass index and outcomes in patients with hearth failure.
Arch Intern Med, 165 (2005), pp. 55-61
[46.]
J.A. Ezekowitz, C. Van Walraben, F.A. McAlister, P.W. Armstrong, P. Kaul.
Impact of specialist follow-up in outpatients with congestive hearth failure.
CMAJ, 172 (2005), pp. 189-194
[47.]
S.T. Fleming, H.G. Pursley, B. Newman, D. Pavlov, K. Chen.
Comorbidity as a predictor of stage of illness for patients with breast cancer.
Med Care, 43 (2005), pp. 132-140
[48.]
P. Verger, M. Aulagrnier, M. Souville, J.F. Ravaud, P.Y. Lussault, J.P. Garnier, et al.
Women with disabilities: general practitioners and breast cancer screening.
Am J Prev Med, 28 (2005), pp. 215-220
[49.]
N.L. Keating, M.B. Landrum, J.Z. Ayanian, E.P. Winer, E. Guadagnoli.
The association of ambulatory care with breast cancer stage at diagnosis among Medicare beneficiaries.
J Gen Intern Med, 20 (2005), pp. 38-44

En este trabajo se emplea el término comorbilidad como sinónimo de multimorbilidad, sin que este término implique una jerarquías entre enfermedades, a no ser que se haga mención expresa a una enfermedad índice. Por otra parte, el término comorbilidad es el comúnmente utilizado en la literatura médica internacional.

Copyright © 2006. Sociedad Española de Salud Pública y Administración Sanitaria
Descargar PDF
Idiomas
Gaceta Sanitaria
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?