La acumulación de alteraciones genéticas y epigenéticas: un proceso causal clave entre el medio ambiente y las enfermedades de etiología compleja

Porta, Miquel; Crous, Marta

doi:10.1157/13078023

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"referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Morange M. La part des gènes. Paris: Odile Jacob; 1998. [Traducción al inglés: The misunderstood gene. Cambridge, Mass.: Harvard University Press; 2001]." ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B. Lewin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "edicion" => "7.a edición" "fecha" => "2000" "editorial" => "Oxford University Press" "editorialLocalizacion" => "Nueva York" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Individual susceptibility to carcinogens" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P. Vineis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.onc.1207897" "Revista" => array:6 [ "tituloSerie" => "Oncogene" "fecha" => "2004" "volumen" => "23" "paginaInicial" => "6477" "paginaFinal" => "6483" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15322518" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:1 [ "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:2 [ "titulo" => "Genetics and public health in the 21st century - using genetic information to improve health and prevent disease" "serieFecha" => "2000" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Análisis estadístico de polimorfismos genéticos en estudios epidemiológicos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Iniesta" 1 => "E. Guinó" 2 => "V. Moreno" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Gac Sanit" "fecha" => "2005" "volumen" => "19" "paginaInicial" => "334" "paginaFinal" => "342" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Riesgos competitivos de muerte y equilibrio de Hardy-Weinberg en estudios de casos y controles sobre asociación entre genes y enfermedades" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Llorca" 1 => "D. Prieto-Salceda" 2 => "O. Combarros" 3 => "T. Dierssen-Sotos" 4 => "J. Berciano" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Gac Sanit" "fecha" => "2005" "volumen" => "19" "paginaInicial" => "322" "paginaFinal" => "325" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chemical-induced DNA damage and human cancer risk" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.C. Poirier" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nrc1410" "Revista" => array:6 [ "tituloSerie" => "Nat Rev Cancer" "fecha" => "2004" "volumen" => "4" "paginaInicial" => "630" "paginaFinal" => "637" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15286742" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nature and nurture - lessons from chemical carcinogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Luch" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nrc1546" "Revista" => array:6 [ "tituloSerie" => "Nat Rev Cancer" "fecha" => "2005" "volumen" => "5" "paginaInicial" => "113" "paginaFinal" => "125" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15660110" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Concentraciones de compuestos tóxicos persistentes en la población española: el rompecabezas sin piezas y la protección de la salud pública" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Porta" 1 => "M. Kogevinas" 2 => "E. Zumeta" 3 => "J. Sunyer" 4 => "N. Ribas-Fitó" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gac Sanit" "fecha" => "2002" "volumen" => "16" "paginaInicial" => "257" "paginaFinal" => "266" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12057183" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cell cycle control, checkpoint mechanisms, and genotoxic stress" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.E. Shackelford" 1 => "W.K. Kaufmann" 2 => "R.S. Paules" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Environ Health Perspect" "fecha" => "1999" "volumen" => "107" "numero" => "Supl 1" "paginaInicial" => "5" "paginaFinal" => "24" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10229703" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exploring environmental causes of altered ras effects: fragmentation plus integration?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Porta" 1 => "D. Ayude" 2 => "J. Alguacil" 3 => "M. Jariod" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Molec Carcinogenesis" "fecha" => "2003" "volumen" => "36" "paginaInicial" => "45" "paginaFinal" => "52" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiologic methods: beyond clinical medicine, beyond epidemiology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F. Bolúmar" 1 => "M. Porta" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Epidemiol" "fecha" => "2004" "volumen" => "19" "paginaInicial" => "733" "paginaFinal" => "735" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15469027" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The hedgehog, the fox and the magister's pox: mending the gap between science and the humanities" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S.J. Gould" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2004" "editorial" => "Vintage" "editorialLocalizacion" => "London" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic variation and cancer: improving the environment for publication of association studies [editorial]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T.R. Rebbeck" 1 => "M.E. Martínez" 2 => "T.A. Sellers" 3 => "P.G. Shields" 4 => "C.P. Wild" 5 => "J.D. Potter" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Epidemiol Biomarkers Prev" "fecha" => "2004" "volumen" => "13" "paginaInicial" => "1985" "paginaFinal" => "1986" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15598750" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The social life of genes: privacy, property and the new genetics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Everett" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Soc Sci Med" "fecha" => "2003" "volumen" => "56" "paginaInicial" => "53" "paginaFinal" => "65" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12435551" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Porta M. La influencia del medio ambiente en la salud pública. Eidon - Revista de la Fundación de Ciencias de la Salud. 2003;13:20-5 [citado 15 marzo 2005]. Disponible en: <a class="elsevierStyleInterRef" href="http://www.fcs.es/fcs/esp/eidon/Introesp/eidon13/inicio.jsp">http://www.fcs.es/fcs/esp/eidon/Introesp/eidon13/inicio.jsp</a>" ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Davey Smith G. Cochrane lecture. Randomised by (your) god: Robust inference from an observational study design [en prensa]. J Epidemiol Community Health. 2005." ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Abre los ojos, sin miedo. Por una pedagogía científica culturalmente sostenible" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Porta" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "WorldWatch" "fecha" => "2004" "volumen" => "22" "paginaInicial" => "12" "paginaFinal" => "13" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lessons from metabolic engineering for functional genomics and drug discovery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.E. Bailey" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Nature Biotechnol" "fecha" => "1999" "volumen" => "17" "paginaInicial" => "616" "paginaFinal" => "618" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic biomarkers and occupational epidemiology–recollections, reflections and reconsiderations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "H. Vainio" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scand J Work Environ Health" "fecha" => "2004" "volumen" => "30" "paginaInicial" => "1" "paginaFinal" => "3" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15255560" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Why have we failed to find the low penetrance genetic constituents of common cancers?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "N.E. Caporaso" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Epidemiol Biomarkers Prev" "fecha" => "2002" "volumen" => "11" "paginaInicial" => "1544" "paginaFinal" => "1549" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12496041" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinogens leave fingerprints" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. Vogelstein" 1 => "K.W. Kinzler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/355209a0" "Revista" => array:6 [ "tituloSerie" => "Nature" "fecha" => "1992" "volumen" => "355" "paginaInicial" => "209" "paginaFinal" => "210" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1309937" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human cancer, carcinogenic exposures and mutational spectra" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Vineis" 1 => "N. Malats" 2 => "M. Porta" 3 => "F.X. Real" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mutation Research" "fecha" => "1999" "volumen" => "436" "paginaInicial" => "185" "paginaFinal" => "194" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10095140" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Occupational exposure to organic solvents and K-ras mutations in exocrine pancreatic cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Alguacil" 1 => "M. Porta" 2 => "N. Malats" 3 => "T. Kauppinen" 4 => "M. Kogevinas" 5 => "F.G. Benavides" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Carcinogenesis" "fecha" => "2002" "volumen" => "23" "paginaInicial" => "101" "paginaFinal" => "106" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11756230" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genomic interrogation of mechanism(s) underlying cellular responses to toxicants" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R.P. Amin" 1 => "H.K. Hamadeh" 2 => "P.R. Bushel" 3 => "L. Bennett" 4 => "C.A. Afshari" 5 => "R.S. Paules" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Toxicology" "fecha" => "2002" "volumen" => "181-2" "paginaInicial" => "555" "paginaFinal" => "563" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The history of cancer epigenetics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.P. Feinberg" 1 => "B. Tycko" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nrc1279" "Revista" => array:6 [ "tituloSerie" => "Nat Rev Cancer" "fecha" => "2004" "volumen" => "4" "paginaInicial" => "143" "paginaFinal" => "153" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14732866" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Jaenisch" 1 => "A. Bird" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ng1089" "Revista" => array:7 [ "tituloSerie" => "Nat Genet" "fecha" => "2003" "volumen" => "33" "numero" => "Supl" "paginaInicial" => "245" "paginaFinal" => "254" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12610534" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gene silencing in cancer in association with promoter hypermethylation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.G. Herman" 1 => "S.B. Baylin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMra023075" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2003" "volumen" => "349" "paginaInicial" => "2042" "paginaFinal" => "2054" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14627790" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proteomic analysis of plasma proteins of workers exposed to benzene" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "W.A. Joo" 1 => "D. Sul" 2 => "D.Y. Lee" 3 => "E. Lee" 4 => "C.W. Kim" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.mrgentox.2003.10.015" "Revista" => array:6 [ "tituloSerie" => "Mutat Res" "fecha" => "2004" "volumen" => "558" "paginaInicial" => "35" "paginaFinal" => "44" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15036117" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/02139111/0000001900000004/v2_201302051757/S0213911105747804/v2_201302051757/es/main.assets" "Apartado" => array:4 [ "identificador" => "668" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Editorial" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02139111/0000001900000004/v2_201302051757/S0213911105747804/v2_201302051757/es/main.pdf?idApp=WGSE&text.app=https://gacetasanitaria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911105747804?idApp=WGSE"]

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Bibliografía

[1.]

Morange M. La part des gènes. Paris: Odile Jacob; 1998. [Traducción al inglés: The misunderstood gene. Cambridge, Mass.: Harvard University Press; 2001].

[2.]

B. Lewin.

Genes.

7.a edición, Oxford University Press, (2000),

[3.]

P. Vineis.

Individual susceptibility to carcinogens.

Oncogene, 23 (2004), pp. 6477-6483

http://dx.doi.org/10.1038/sj.onc.1207897 | Medline

[4.]

Genetics and public health in the 21st century - using genetic information to improve health and prevent disease,

[5.]

R. Iniesta, E. Guinó, V. Moreno.

Análisis estadístico de polimorfismos genéticos en estudios epidemiológicos.

Gac Sanit, 19 (2005), pp. 334-342

[6.]

J. Llorca, D. Prieto-Salceda, O. Combarros, T. Dierssen-Sotos, J. Berciano.

Riesgos competitivos de muerte y equilibrio de Hardy-Weinberg en estudios de casos y controles sobre asociación entre genes y enfermedades.

Gac Sanit, 19 (2005), pp. 322-325

[7.]

M.C. Poirier.

Chemical-induced DNA damage and human cancer risk.

Nat Rev Cancer, 4 (2004), pp. 630-637

http://dx.doi.org/10.1038/nrc1410 | Medline

[8.]

A. Luch.

Nature and nurture - lessons from chemical carcinogenesis.

Nat Rev Cancer, 5 (2005), pp. 113-125

http://dx.doi.org/10.1038/nrc1546 | Medline

[9.]

M. Porta, M. Kogevinas, E. Zumeta, J. Sunyer, N. Ribas-Fitó.

Concentraciones de compuestos tóxicos persistentes en la población española: el rompecabezas sin piezas y la protección de la salud pública.

Gac Sanit, 16 (2002), pp. 257-266

Medline

[10.]

R.E. Shackelford, W.K. Kaufmann, R.S. Paules.

Cell cycle control, checkpoint mechanisms, and genotoxic stress.

Environ Health Perspect, 107 (1999), pp. 5-24

Medline

[11.]

M. Porta, D. Ayude, J. Alguacil, M. Jariod.

Exploring environmental causes of altered ras effects: fragmentation plus integration?.

Molec Carcinogenesis, 36 (2003), pp. 45-52

[12.]

F. Bolúmar, M. Porta.

Epidemiologic methods: beyond clinical medicine, beyond epidemiology.

Eur J Epidemiol, 19 (2004), pp. 733-735

Medline

[13.]

S.J. Gould.

The hedgehog, the fox and the magister's pox: mending the gap between science and the humanities.

Vintage, (2004),

[14.]

T.R. Rebbeck, M.E. Martínez, T.A. Sellers, P.G. Shields, C.P. Wild, J.D. Potter.

Genetic variation and cancer: improving the environment for publication of association studies [editorial].

Cancer Epidemiol Biomarkers Prev, 13 (2004), pp. 1985-1986

Medline

[15.]

M. Everett.

The social life of genes: privacy, property and the new genetics.

Soc Sci Med, 56 (2003), pp. 53-65

Medline

[16.]

Porta M. La influencia del medio ambiente en la salud pública. Eidon - Revista de la Fundación de Ciencias de la Salud. 2003;13:20-5 [citado 15 marzo 2005]. Disponible en: http://www.fcs.es/fcs/esp/eidon/Introesp/eidon13/inicio.jsp

[17.]

Davey Smith G. Cochrane lecture. Randomised by (your) god: Robust inference from an observational study design [en prensa]. J Epidemiol Community Health. 2005.

[18.]

M. Porta.

Abre los ojos, sin miedo. Por una pedagogía científica culturalmente sostenible.

WorldWatch, 22 (2004), pp. 12-13

[19.]

J.E. Bailey.

Lessons from metabolic engineering for functional genomics and drug discovery.

Nature Biotechnol, 17 (1999), pp. 616-618

[20.]

H. Vainio.

Genetic biomarkers and occupational epidemiology–recollections, reflections and reconsiderations.

Scand J Work Environ Health, 30 (2004), pp. 1-3