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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Evaluar la eficiencia del &#225;cido acetilsalic&#237;lico &#40;AAS&#41; m&#225;s esomeprazol frente a clopidogrel en la prevenci&#243;n de la hemorragia gastrointestinal&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">An&#225;lisis coste-efectividad &#40;&#225;rbol de decisi&#243;n de 2 ramas&#58; AAS m&#225;s esomeprazol y clopidogrel&#41; respecto a la evitaci&#243;n de casos de hemorragia gastrointestinal en 2 a&#241;os&#44; y an&#225;lisis de sensibilidad&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El coste total del tratamiento con AAS m&#225;s esomeprazol &#40;2&#46;865 S por paciente libre de hemorragia&#41; fue inferior al clopidogrel &#40;2&#46;965 S&#41;&#46; El tratamiento con AAS result&#243; dominante&#46; En todos los an&#225;lisis de sensibilidad la combinaci&#243;n sigui&#243; siendo dominante&#46; Al sustituir esomeprazol 40<span class="elsevierStyleHsp" style=""></span>mg por omeprazol 40<span class="elsevierStyleHsp" style=""></span>mg&#44; el coste del tratamiento combinado descendi&#243; hasta 1&#46;934S&#47;por episodio evitado&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La asociaci&#243;n de esomeprazol y AAS es m&#225;s coste-efectiva que clopidogrel en la prevenci&#243;n de la hemorragia gastrointestinal&#46; La combinaci&#243;n con omeprazol resulta a&#250;n m&#225;s coste-efectiva&#46;</p>"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To evaluate the use of aspirin plus esomeprazole vs&#46; clopidogrel in the prevention of gastrointestinal bleeding&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We performed a cost-effectiveness analysis &#40;two-branch decision tree&#58; aspirin plus esomeprazole or clopidogrel&#41; of prevention of gastrointestinal bleeding over a 2-year period&#44; as well as sensitivity analyses&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The total cost of aspirin plus esomeprazole treatment &#40;2&#44;865S&#47;patient free of hemorrhage&#41; was lower than that of clopidogrel &#40;2&#44;965S&#41;&#46; Aspirin treatment was dominant&#46; The combination continued to be dominant in all sensitivity analyses&#46; When esomeprazole 40<span class="elsevierStyleHsp" style=""></span>mg was substituted by omeprazole 40<span class="elsevierStyleHsp" style=""></span>mg&#44; the cost of combination therapy decreased to 1&#44;934 &#8364;&#47;prevented hemorrhage&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The association of esomeprazole and aspirin is more cost-effective than clopidogrel in preventing gastrointestinal bleeding&#46; Aspirin plus omeprazole was even more cost-effective&#46;</p>"
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Vol. 20. Núm. 1.
Páginas 54-57 (enero - febrero 2006)
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Vol. 20. Núm. 1.
Páginas 54-57 (enero - febrero 2006)
Originales
Open Access
Evaluación económica del tratamiento con ácido acetilsalicílico más esomeprazol comparado con clopidogrel en la prevención de la hemorragia gastrointestinal
Economic evaluation of the treatment of aspirin plus esomeprazole compared to clopidogrel in gastrointestinal bleeding prevention
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Carme Piñol
Autor para correspondencia
carmen.pinol.cp@bayer.es

Correspondencia: Carme Piñol. Unidad de Farmacoeconomía y Relaciones Institucionales. Departamento de Investigación y Desarrollo. Química Farmacéutica Bayer, S.A. Pau Claris, 196. 08037 Barcelona. España.
Unidad de Farmacoeconomía y Relaciones Institucionales, Química Farmacéutica Bayer, S.A., Barcelona, España
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Información del artículo
Resumen
Objetivo

Evaluar la eficiencia del ácido acetilsalicílico (AAS) más esomeprazol frente a clopidogrel en la prevención de la hemorragia gastrointestinal.

Métodos

Análisis coste-efectividad (árbol de decisión de 2 ramas: AAS más esomeprazol y clopidogrel) respecto a la evitación de casos de hemorragia gastrointestinal en 2 años, y análisis de sensibilidad.

Resultados

El coste total del tratamiento con AAS más esomeprazol (2.865 S por paciente libre de hemorragia) fue inferior al clopidogrel (2.965 S). El tratamiento con AAS resultó dominante. En todos los análisis de sensibilidad la combinación siguió siendo dominante. Al sustituir esomeprazol 40mg por omeprazol 40mg, el coste del tratamiento combinado descendió hasta 1.934S/por episodio evitado.

Conclusiones

La asociación de esomeprazol y AAS es más coste-efectiva que clopidogrel en la prevención de la hemorragia gastrointestinal. La combinación con omeprazol resulta aún más coste-efectiva.

Palabras clave:
Ácido acetilsalicílico
Esomeprazol
Clopidogrel
Análisis coste-efectividad
Hemorragia gastrointestinal
Prevención de eventos cardiovasculares
Omeprazol
Abstract
Objective

To evaluate the use of aspirin plus esomeprazole vs. clopidogrel in the prevention of gastrointestinal bleeding.

Methods

We performed a cost-effectiveness analysis (two-branch decision tree: aspirin plus esomeprazole or clopidogrel) of prevention of gastrointestinal bleeding over a 2-year period, as well as sensitivity analyses.

Results

The total cost of aspirin plus esomeprazole treatment (2,865S/patient free of hemorrhage) was lower than that of clopidogrel (2,965S). Aspirin treatment was dominant. The combination continued to be dominant in all sensitivity analyses. When esomeprazole 40mg was substituted by omeprazole 40mg, the cost of combination therapy decreased to 1,934 €/prevented hemorrhage.

Conclusions

The association of esomeprazole and aspirin is more cost-effective than clopidogrel in preventing gastrointestinal bleeding. Aspirin plus omeprazole was even more cost-effective.

Key words:
Aspirin
Esomeprazole
Clopidogrel
Cost-effectiveness analysis
Gastrointestinal bleeding
Cardiovascular events prevention
Omeprazole
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Copyright © 2006. Sociedad Española de Salud Pública y Administración Sanitaria
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