Originales
Evaluación económica del tratamiento con ácido acetilsalicílico más esomeprazol comparado con clopidogrel en la prevención de la hemorragia gastrointestinal
Economic evaluation of the treatment of aspirin plus esomeprazole compared to clopidogrel in gastrointestinal bleeding prevention
Carme Piñol
Autor para correspondencia
carmen.pinol.cp@bayer.es
Correspondencia: Carme Piñol. Unidad de Farmacoeconomía y Relaciones Institucionales. Departamento de Investigación y Desarrollo. Química Farmacéutica Bayer, S.A. Pau Claris, 196. 08037 Barcelona. España.
Correspondencia: Carme Piñol. Unidad de Farmacoeconomía y Relaciones Institucionales. Departamento de Investigación y Desarrollo. Química Farmacéutica Bayer, S.A. Pau Claris, 196. 08037 Barcelona. España.
Unidad de Farmacoeconomía y Relaciones Institucionales, Química Farmacéutica Bayer, S.A., Barcelona, España
Leído
1005
Vecesse ha leído el artículo
429
Total PDF
576
Total HTML
Compartir estadísticas
array:24 [ "pii" => "S0213911106714522" "issn" => "02139111" "doi" => "10.1157/13084128" "estado" => "S300" "fechaPublicacion" => "2006-01-01" "aid" => "71452" "copyright" => "Sociedad Española de Salud Pública y Administración Sanitaria" "copyrightAnyo" => "2006" "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Gac Sanit. 2006;20:54-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3315 "formatos" => array:3 [ "EPUB" => 140 "HTML" => 2705 "PDF" => 470 ] ] "itemSiguiente" => array:19 [ "pii" => "S0213911106714534" "issn" => "02139111" "doi" => "10.1157/13084129" "estado" => "S300" "fechaPublicacion" => "2006-01-01" "aid" => "71453" "copyright" => "Sociedad Española de Salud Pública y Administración Sanitaria" "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Gac Sanit. 2006;20:58" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2637 "formatos" => array:3 [ "EPUB" => 112 "HTML" => 2026 "PDF" => 499 ] ] "es" => array:9 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Comentario. Mayor seguridad para los pacientes y menor coste para la sociedad" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "58" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Comment. Higher safety for patients and lower costs for society" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Anna García-Altés" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Anna" "apellidos" => "García-Altés" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911106714534?idApp=WGSE" "url" => "/02139111/0000002000000001/v2_201301241556/S0213911106714534/v2_201301241556/es/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0213911106714510" "issn" => "02139111" "doi" => "10.1157/13084127" "estado" => "S300" "fechaPublicacion" => "2006-01-01" "aid" => "71451" "copyright" => "Sociedad Española de Salud Pública y Administración Sanitaria" "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Gac Sanit. 2006;20:47-53" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4160 "formatos" => array:3 [ "EPUB" => 115 "HTML" => 3022 "PDF" => 1023 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Análisis coste-efectividad de tipo probabilístico del tratamiento de la apnea del sueño" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "47" "paginaFinal" => "53" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Probabilistic cost-effectiveness analysis of the treatment of sleep apnea" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Javier Mar, Santiago Gutiérrez-Moreno, Jim Chilcott" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Javier" "apellidos" => "Mar" ] 1 => array:2 [ "nombre" => "Santiago" "apellidos" => "Gutiérrez-Moreno" ] 2 => array:2 [ "nombre" => "Jim" "apellidos" => "Chilcott" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911106714510?idApp=WGSE" "url" => "/02139111/0000002000000001/v2_201301241556/S0213911106714510/v2_201301241556/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Evaluación económica del tratamiento con ácido acetilsalicílico más esomeprazol comparado con clopidogrel en la prevención de la hemorragia gastrointestinal" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "54" "paginaFinal" => "57" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Carme Piñol" "autores" => array:1 [ 0 => array:4 [ "nombre" => "Carme" "apellidos" => "Piñol" "email" => array:1 [ 0 => "carmen.pinol.cp@bayer.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Unidad de Farmacoeconomía y Relaciones Institucionales, Química Farmacéutica Bayer, S.A., Barcelona, España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondencia: Carme Piñol. Unidad de Farmacoeconomía y Relaciones Institucionales. Departamento de Investigación y Desarrollo. Química Farmacéutica Bayer, S.A. Pau Claris, 196. 08037 Barcelona. España." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Economic evaluation of the treatment of aspirin plus esomeprazole compared to clopidogrel in gastrointestinal bleeding prevention" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-05-18" "fechaAceptado" => "2005-09-29" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec14015" "palabras" => array:7 [ 0 => "Ácido acetilsalicílico" 1 => "Esomeprazol" 2 => "Clopidogrel" 3 => "Análisis coste-efectividad" 4 => "Hemorragia gastrointestinal" 5 => "Prevención de eventos cardiovasculares" 6 => "Omeprazol" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec14016" "palabras" => array:7 [ 0 => "Aspirin" 1 => "Esomeprazole" 2 => "Clopidogrel" 3 => "Cost-effectiveness analysis" 4 => "Gastrointestinal bleeding" 5 => "Cardiovascular events prevention" 6 => "Omeprazole" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Evaluar la eficiencia del ácido acetilsalicílico (AAS) más esomeprazol frente a clopidogrel en la prevención de la hemorragia gastrointestinal.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Análisis coste-efectividad (árbol de decisión de 2 ramas: AAS más esomeprazol y clopidogrel) respecto a la evitación de casos de hemorragia gastrointestinal en 2 años, y análisis de sensibilidad.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El coste total del tratamiento con AAS más esomeprazol (2.865 S por paciente libre de hemorragia) fue inferior al clopidogrel (2.965 S). El tratamiento con AAS resultó dominante. En todos los análisis de sensibilidad la combinación siguió siendo dominante. Al sustituir esomeprazol 40<span class="elsevierStyleHsp" style=""></span>mg por omeprazol 40<span class="elsevierStyleHsp" style=""></span>mg, el coste del tratamiento combinado descendió hasta 1.934S/por episodio evitado.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La asociación de esomeprazol y AAS es más coste-efectiva que clopidogrel en la prevención de la hemorragia gastrointestinal. La combinación con omeprazol resulta aún más coste-efectiva.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To evaluate the use of aspirin plus esomeprazole vs. clopidogrel in the prevention of gastrointestinal bleeding.</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We performed a cost-effectiveness analysis (two-branch decision tree: aspirin plus esomeprazole or clopidogrel) of prevention of gastrointestinal bleeding over a 2-year period, as well as sensitivity analyses.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The total cost of aspirin plus esomeprazole treatment (2,865S/patient free of hemorrhage) was lower than that of clopidogrel (2,965S). Aspirin treatment was dominant. The combination continued to be dominant in all sensitivity analyses. When esomeprazole 40<span class="elsevierStyleHsp" style=""></span>mg was substituted by omeprazole 40<span class="elsevierStyleHsp" style=""></span>mg, the cost of combination therapy decreased to 1,934 €/prevented hemorrhage.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The association of esomeprazole and aspirin is more cost-effective than clopidogrel in preventing gastrointestinal bleeding. Aspirin plus omeprazole was even more cost-effective.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "¿Deben administrarse protectores gástricos a los pacientes coronarios que toman dosis bajas de Aspirina<span class="elsevierStyleSup">®</span> de forma crónica?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Lanas" 1 => "A. Fernández" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Esp Cardiol" "fecha" => "2001" "volumen" => "54" "paginaInicial" => "1361" "paginaFinal" => "1364" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11754803" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between aspirin and upper gastrointestinal complications: systemic review of epidemiologic studies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.A. García Rodríguez" 1 => "S. Hernández-Díaz" 2 => "F.J. De Abajo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Clin Pharmacol" "fecha" => "2001" "volumen" => "52" "paginaInicial" => "563" "paginaFinal" => "571" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11736865" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "CAPRIE Steering Commitee" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1996" "volumen" => "348" "paginaInicial" => "1329" "paginaFinal" => "1339" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8918275" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "New recommendations from the 1999 American College of Cardiology/American Heart Association. Acute Myocardial Infarction Guidelines" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.A. Spinler" 1 => "D.E. Hilleman" 2 => "J.WM. Cheng" 3 => "P.A. Howard" 4 => "V.F. Mauro" 5 => "L.M. López" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Pharmacother" "fecha" => "2001" "volumen" => "35" "paginaInicial" => "589" "paginaFinal" => "617" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11346067" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expert consensus document on the use of antiplatelet agents" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Patrono" 1 => "F. Bachmann" 2 => "C. Baigent" 3 => "C. Bode" 4 => "R. De Caterina" 5 => "B. Chambonnier" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Heart J" "fecha" => "2004" "volumen" => "25" "paginaInicial" => "166" "paginaFinal" => "181" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14720534" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CYP2C19 polymorphism and proton pump inhibitors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "U. Klotz" 1 => "M. Schwab" 2 => "G. Treiber" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1600-0773.2004.pto950102.x" "Revista" => array:6 [ "tituloSerie" => "Basic Clin Pharmacol Toxicol" "fecha" => "2004" "volumen" => "95" "paginaInicial" => "2" "paginaFinal" => "8" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15245569" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F.KL. Chan" 1 => "J.YL. Ching" 2 => "L.CT. Hung" 3 => "V.WS. Wong" 4 => "V.KS. Leung" 5 => "N.NS. Kung" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa042087" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2005" "volumen" => "352" "paginaInicial" => "238" "paginaFinal" => "244" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15659723" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "SOIKOS. Base de datos de costes sanitarios. Versión 2.2. Barcelona: SOIKOS; 2005." ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The comparative medical costs of atherothrombotic disease in European countries" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Levy" 1 => "S. Gabriel" 2 => "J. Dinel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pharmacoeconomics" "fecha" => "2003" "volumen" => "21" "paginaInicial" => "651" "paginaFinal" => "659" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12807366" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Meta-analysis: comparative efficacy of different proton-pump inhibitors in triple therapy for Helicobacter pylori eradication" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Vergara" 1 => "M. Vallve" 2 => "J.P. Gisbert" 3 => "X. Calvet" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Aliment Pharmacol Ther" "fecha" => "2003" "volumen" => "18" "paginaInicial" => "647" "paginaFinal" => "654" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12969092" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clopidogrel plus omeprazole compared with aspirin plus omeprazole for aspirin-induced symptomatic peptic ulcers/erosions with low to moderate bleeding/re-bleeding risk: a single-blind, randomised controlled study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "F.H. Ng" 1 => "B.C.Y. Wong" 2 => "S.Y. Wong" 3 => "W.H. Chen" 4 => "C.M. Chang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Aliment Pharmacol Ther" "fecha" => "2004" "volumen" => "19" "paginaInicial" => "359" "paginaFinal" => "365" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14984383" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/02139111/0000002000000001/v2_201301241556/S0213911106714522/v2_201301241556/es/main.assets" "Apartado" => array:4 [ "identificador" => "764" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02139111/0000002000000001/v2_201301241556/S0213911106714522/v2_201301241556/es/main.pdf?idApp=WGSE&text.app=https://gacetasanitaria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911106714522?idApp=WGSE" ]
Información del artículo
ISSN: 02139111Idioma original: Español
DOI:10.1157/13084128
Datos actualizados diariamente
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 5 | 5 | 10 |
| 2024 Octubre | 56 | 35 | 91 |
| 2024 Septiembre | 41 | 36 | 77 |
| 2024 Agosto | 43 | 29 | 72 |
| 2024 Julio | 36 | 22 | 58 |
| 2024 Junio | 35 | 12 | 47 |
| 2024 Mayo | 32 | 30 | 62 |
| 2024 Abril | 39 | 10 | 49 |
| 2024 Marzo | 49 | 32 | 81 |
| 2024 Febrero | 22 | 45 | 67 |
| 2024 Enero | 21 | 20 | 41 |
| 2023 Diciembre | 23 | 19 | 42 |
| 2023 Noviembre | 19 | 24 | 43 |
| 2023 Octubre | 30 | 21 | 51 |
| 2023 Septiembre | 30 | 16 | 46 |
| 2023 Agosto | 25 | 15 | 40 |
| 2023 Julio | 33 | 30 | 63 |
| 2023 Junio | 24 | 18 | 42 |
| 2023 Mayo | 13 | 10 | 23 |
Mostrar todo
