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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La contaminaci&#243;n por compuestos t&#243;xicos persistentes &#40;CTP&#41; de la poblaci&#243;n general es un hecho relevante desde una perspectiva de salud p&#250;blica&#46; Es&#44; asimismo&#44; importante para el sistema sanitario asistencial y para las pol&#237;ticas ambientales&#44; alimentarias&#44; industriales y econ&#243;micas&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Aunque en Espa&#241;a los conocimientos sobre la contaminaci&#243;n de los alimentos por CTP presentan grandes vac&#237;os temporales y geogr&#225;ficos&#44; a&#250;n es menor la informaci&#243;n sobre sus concentraciones en las personas&#58; no existe ning&#250;n estudio representativo de una poblaci&#243;n general sana efectuado en una zona geogr&#225;fica amplia&#46; Los estudios disponibles indican que un 80-100&#37; de la poblaci&#243;n tiene concentraciones detectables de DDE&#44; policlorobifenilos&#44; hexaclorobenceno o lindano&#46; En Espa&#241;a el n&#250;mero de estudios sobre los efectos que los CTP tienen en las personas es todav&#237;a m&#225;s exiguo&#46; Los estudios internacionales sugieren que dosis de algunos CTP por debajo de las que normalmente se consideran &#171;seguras&#187; pueden causar efectos biol&#243;gicos y cl&#237;nicos relevantes&#46; Los mecanismos de acci&#243;n no comprenden s&#243;lo la disrupci&#243;n endocrina&#46; La valoraci&#243;n de la significaci&#243;n cl&#237;nica y social del espectro de efectos m&#225;s sutiles y con per&#237;odos de latencia mayores de los CTP presenta interesantes retos y oportunidades&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Espa&#241;a y otros pa&#237;ses europeos sufren un d&#233;ficit de indicadores poblacionales sobre el impacto que los procesos ambientales tienen en la salud humana&#46; Los distintos &#225;mbitos de la Administraci&#243;n deben monitorizar los valores biol&#243;gicos de los CTPs y valorar sus posibles riesgos para la salud&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Junto con m&#225;s de cien otros pa&#237;ses&#44; pr&#243;ximamente Espa&#241;a intentar&#225; implementar el Tratado sobre los Contaminantes Org&#225;nicos Persistentes &#40;Convenio de Estocolmo&#41;&#46; Ello constituye un nuevo motivo para desarrollar programas m&#225;s eficientes de vigilancia y control de los residuos de los CTP en alimentos&#44; humanos y medio ambiente&#46; Como parte de la aplicaci&#243;n del Convenio&#44; es necesario iniciar un informe pe-dom&#233;stiri&#243;dico sobre los factores que condicionan las concentraciones internas de CTP en la poblaci&#243;n general espa&#241;ola&#46;</p>"
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        "resumen" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The contamination by persistent toxic compounds &#40;PTCs&#41; of the general population is a fact of relevance from a public health perspective&#46; It is also relevant to health care professionals&#44; as well as for environmental&#44; food&#44; industrial and economic policies&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Though in Spain information on food contamination by PTCs shows large time and geographic gaps&#44; the scarcity of data is even moren severe on the concentrations that PTCs have in people&#58; a representative study of a general healthy population living in a wide geographic area has never been conducted in the country&#46; However&#44; the available studies indicate that around 80-100&#37; of the population has detectable concentrations of DDE&#44; PCBs&#44; hexachlorbenzene or lindane&#46; Studies on the effects that PTCs have upon humans are extremely infrequent in Spain&#46; Yet&#44; the international literature suggests that some PTCs may induce significant biological and clinical effects at doses below those tradicionally deemed &#8220;safe&#8221;&#46; The mechanism of action of PTCs are not restricted to endocrine disruption&#46; Assessing the clinical and social relevance of the more subtle and long-term effects of PTCs presents interesting challenges and opportunities&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Spain and other European countries lack population indicators on the impact that environmental processes have on human health&#46; Several government levels have a role to fulfill in the monitoring of biological levels of PTCs among persons in order to assess the risks of adverse health effects&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Along with over a hundred other countries&#46; Spain will soon try to implement the Stockholm treaty on persistent organic pollutants &#40;POPs&#41;&#46; This constitutes a new opportunity to develop more efficient policies to control PTC residues in food&#44; humans and the enviroment&#46; As part of the treaty implementation it is necessary to launch a Report on factors that influence body concentrations of PTCs in the Spain general population&#46;</p>"
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                  "referenciaCompleta" => "Physicians for Social Responsibility&#46; Environmental endocrine disruptors&#46; What health care providers should know &#91;consultado 04&#47;02&#47;2002&#93;&#46; Disponible en&#58; <a class="elsevierStyleInterRef" href="http://www.psrus.org/enddisprimer.pdf">http&#58;&#47;&#47;www&#46;psrus&#46;org&#47;enddisprimer&#46;pdf</span>&#46; Frequently asked questions about endocrine disruptors &#91;consultado 04&#47;02&#47;2002&#93;&#46; Disponible en&#58; <span class="elsevierStyleInterRef" href="http://www.psrus.org/endofs.htm">http&#58;&#47;&#47;www&#46;psrus&#46;org&#47;endofs&#46;htm</span>&#46; International effort would phase out 12 toxins &#91;consultado 04&#47;02&#47;2002&#93;&#46; Disponible en&#58; <span class="elsevierStyleInterRef" href="http://www.psrus.org/popsmonitor.pdf">http&#58;&#47;&#47;www&#46;psrus&#46;org&#47;popsmonitor&#46;pdf</a>"
                ]
              ]
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            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Organochlorine residues in human adipose tissue in Spain&#58; study of an agrarian area"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Camps"
                            1 => "J&#46; Planas"
                            2 => "J&#46; G&#243;mez-Catal&#225;n"
                            3 => "M&#46; Sabroso"
                            4 => "J&#46; To-Figueras"
                            5 => "J&#46; Corbella"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Bull Environ Contam Toxicol"
                        "fecha" => "1989"
                        "volumen" => "42"
                        "paginaInicial" => "195"
                        "paginaFinal" => "201"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2920226"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Organochlorine insecticide and polychlorinated biphenyl residues in human breast milk in Madrid &#40;Spain&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46;M&#46; Hern&#225;ndez"
                            1 => "M&#46;A&#46; Fern&#225;ndez"
                            2 => "E&#46; Hoyas"
                            3 => "M&#46;J&#46; Gonz&#225;lez"
                            4 => "J&#46;F&#46; Garc&#237;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Bull Environ Contam Toxicol"
                        "fecha" => "1993"
                        "volumen" => "50"
                        "paginaInicial" => "308"
                        "paginaFinal" => "315"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8422534"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Surprising findings following a Belgian food contamination with polychlorobiphenyls and dioxins"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46;J&#46; Schepens"
                            1 => "A&#46; Covaci"
                            2 => "P&#46;G&#46; Jorens"
                            3 => "L&#46; Hens"
                            4 => "S&#46; Scharpe"
                            5 => "N&#46; Van Larebeke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Environ Health Perspect"
                        "fecha" => "2001"
                        "volumen" => "109"
                        "paginaInicial" => "101"
                        "paginaFinal" => "103"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11266317"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The global distribution of PCBs and organochlorine pesticides in butter"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "O&#46;I&#46; Kalantzi"
                            1 => "G&#46;O&#46; Thomas"
                            2 => "R&#46;E&#46; Alcock"
                            3 => "A&#46; Stephenson"
                            4 => "K&#46;C&#46; Jones"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Environ Sci Technol"
                        "fecha" => "2001"
                        "volumen" => "35"
                        "paginaInicial" => "1013"
                        "paginaFinal" => "1018"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11347908"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dioxinas y salud"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Kogevinas"
                            1 => "G&#46; Janer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Cl&#237;n &#40;Barc&#41;"
                        "fecha" => "2000"
                        "volumen" => "115"
                        "paginaInicial" => "740"
                        "paginaFinal" => "748"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Organochlorine pesticide residues in total diet samples from Arag&#243;n &#40;Northeastern Spain&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; L&#225;zaro"
                            1 => "A&#46; Herrera"
                            2 => "A&#46; Ari&#241;o"
                            3 => "M&#46;P&#46; Conchello"
                            4 => "S&#46; Bayarri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Agric Food Chem"
                        "fecha" => "1996"
                        "volumen" => "44"
                        "paginaInicial" => "2742"
                        "paginaFinal" => "2747"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Organochlorine pollutants in meats and cows milk from Madrid &#40;Spain&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;M&#46; Hern&#225;ndez"
                            1 => "M&#46;A&#46; Fern&#225;ndez"
                            2 => "B&#46; Jim&#233;nez"
                            3 => "M&#46;J&#46; Gonz&#225;lez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Bull Environ Contam Toxicol"
                        "fecha" => "1994"
                        "volumen" => "52"
                        "paginaInicial" => "246"
                        "paginaFinal" => "253"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8123985"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Organochlorine compound concentration in the serum of inhabitants living near an electrochemical factory"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Sala"
                            1 => "J&#46; Sunyer"
                            2 => "R&#46; Otero"
                            3 => "M&#46; Santiago-Silva"
                            4 => "C&#46; Camps"
                            5 => "J&#46;O&#46; Grimalt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Occup Environ Medicine"
                        "fecha" => "1999"
                        "volumen" => "56"
                        "paginaInicial" => "152"
                        "paginaFinal" => "158"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of hexachlorobenzene serum levels with gammaglutamyl transpeptidase and other biomarkers of early effects in humans"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Sala"
                            1 => "J&#46; Sunyer"
                            2 => "C&#46; Herrero"
                            3 => "D&#46; Ozalla"
                            4 => "J&#46; To-Figueras"
                            5 => "J&#46; Grimalt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Occup Environ Med"
                        "fecha" => "2001"
                        "volumen" => "58"
                        "paginaInicial" => "172"
                        "paginaFinal" => "177"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11171930"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Worldwide trends in DDT levels in human breast milk"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46; Smith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Epidemiol"
                        "fecha" => "1999"
                        "volumen" => "28"
                        "paginaInicial" => "179"
                        "paginaFinal" => "188"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10342677"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Estudio de plaguicidas organoclorados en suero de aplicadores&#46; Primeras Jornadas Nacionales sobre Hexaclorobenceno&#59; 1988&#44; mayo 23-24 Libro de actas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;A&#46; P&#233;rez de Ciriza"
                            1 => "A&#46; Samanes"
                            2 => "E&#46; Gil"
                            3 => "P&#46; Fraile"
                            4 => "V&#46; Garisoain"
                            5 => "C&#46; Mart&#237;nez"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:3 [
                        "paginaInicial" => "123"
                        "paginaFinal" => "130"
                        "serieFecha" => "1990"
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                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estudio de plaguicidas organoclorados en leche materna en Navarra&#46; Primeras Jornadas Nacionales sobre Hexaclorobenceno&#59; 1988&#44; mayo 23-24&#46; Libro de actas"
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                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;A&#46; P&#233;rez de Ciriza"
                            1 => "A&#46; Samanes"
                            2 => "J&#46;E&#46; Olivera"
                            3 => "C&#46; Garc&#237;a"
                            4 => "R&#46; Elcarte"
                            5 => "D&#46; Conde"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:3 [
                        "paginaInicial" => "95"
                        "paginaFinal" => "106"
                        "serieFecha" => "1990"
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                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Contaminaci&#243;n por organoclorados en tejido adiposo humano&#46; Primeras Jornadas Nacionales sobre Hexaclorobenceno&#59; 1988&#44; mayo 23-24&#46; Libro de actas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;B&#46; Mart&#237; Lloret"
                            1 => "D&#46; Prats Rico"
                            2 => "M&#46;E&#46; Mas Selles"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:3 [
                        "paginaInicial" => "141"
                        "paginaFinal" => "147"
                        "serieFecha" => "1990"
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                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Organochlorine residues in the population of Catalonia &#40;Spain&#41;"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; G&#243;mez-Catal&#225;n"
                            1 => "J&#46; Planas"
                            2 => "J&#46; To-Figueras"
                            3 => "M&#46; Camps"
                            4 => "J&#46; Corbella"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Bull Environ Contam Toxicol"
                        "fecha" => "1993"
                        "volumen" => "51"
                        "paginaInicial" => "160"
                        "paginaFinal" => "164"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8318767"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Organochlorine residues in the adipose tissue of the population of Navarra &#40;Spain&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; G&#243;mez-Catal&#225;n"
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                            2 => "J&#46; To-Figueras"
                            3 => "J&#46; Corbella"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Bull Environ Contam Toxicol"
                        "fecha" => "1995"
                        "volumen" => "54"
                        "paginaInicial" => "534"
                        "paginaFinal" => "540"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7767031"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An&#225;lisis de la acumulaci&#243;n de residuos organoclorados en tejido adiposo humano en muestras procedentes del partido judicial de Lleida &#91;tesis doctoral&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "C&#46; Barrotx"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:1 [
                        "serieFecha" => "1995"
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                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Compuestos organoclorados&#58; relaci&#243;n de niveles sangu&#237;neos en madres y reci&#233;n nacidos y en leche materna con par&#225;metros maternos y de lactantes&#46; Estudio en la provincia de Huelva"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Mart&#237;nez"
                            1 => "A&#46; Romanos"
                            2 => "M&#46; Praena"
                            3 => "M&#46; Repetto"
                            4 => "D&#46; Mart&#237;nez"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "An Esp Pediatr"
                        "fecha" => "1993"
                        "volumen" => "38"
                        "paginaInicial" => "493"
                        "paginaFinal" => "498"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8368676"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Porta"
                            1 => "N&#46; Malats"
                            2 => "M&#46; Jariod"
                            3 => "J&#46;O&#46; Grimalt"
                            4 => "J&#46; Rif&#224;"
                            5 => "A&#46; Carrato"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1999"
                        "volumen" => "354"
                        "paginaInicial" => "2125"
                        "paginaFinal" => "2129"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10609819"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "DDT &#40;dicophane&#41; and postmenopausal breast cancer in Europe&#58; case-control study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Van&#39;t Veer"
                            1 => "I&#46;E&#46; Lobbezoo"
                            2 => "J&#46;M&#46; Mart&#237;n-Moreno"
                            3 => "E&#46; Guallar"
                            4 => "J&#46; G&#243;mez-Aracena"
                            5 => "A&#46;F&#46; Kardinaal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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                        "tituloSerie" => "Br Med J"
                        "fecha" => "1997"
                        "volumen" => "315"
                        "paginaInicial" => "81"
                        "paginaFinal" => "85"
                      ]
                    ]
                  ]
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                      "titulo" => "Levels of hexachlorobenzene and other organochlorine compounds in cord blood&#58; exposure across placenta"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Sala"
                            1 => "N&#46; Ribas-Fit&#243;"
                            2 => "E&#46; Cardo"
                            3 => "M&#46;E&#46; De Muga"
                            4 => "E&#46; Marco"
                            5 => "C&#46; Maz&#243;n"
                          ]
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                        "tituloSerie" => "Chemosphere"
                        "fecha" => "2001"
                        "volumen" => "43"
                        "paginaInicial" => "895"
                        "paginaFinal" => "901"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11372882"
                            "web" => "Medline"
                          ]
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                ]
              ]
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            26 => array:3 [
              "identificador" => "bib0135"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inadvertent exposure to xenoestrogens in children"
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                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46; Olea"
                            1 => "A&#46; Barba"
                            2 => "P&#46; Lardelli"
                            3 => "A&#46; Rivas"
                            4 => "M&#46;F&#46; Olea-Serrano"
                          ]
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                    0 => array:1 [
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                        "tituloSerie" => "Toxicol Industrial Health"
                        "fecha" => "1999"
                        "volumen" => "15"
                        "paginaInicial" => "151"
                        "paginaFinal" => "158"
                      ]
                    ]
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            27 => array:3 [
              "identificador" => "bib0140"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Monitoritzaci&#243; biol&#242;gica dels residents de Matar&#243; que viuen prop de la incineradora de residus s&#242;lids urbans del Maresme&#46; Resultats de la tercera fase de l&#39;estudi"
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;A&#46; Gonz&#225;lez"
                            1 => "M&#46; Kogevinas"
                            2 => "E&#46; Gadea"
                            3 => "O&#46; P&#228;pke"
                            4 => "A&#46; Bosch"
                            5 => "A&#46; Qu&#237;lez"
                          ]
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                    0 => array:1 [
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            28 => array:3 [
              "identificador" => "bib0145"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increase of dioxin blood levels over the last 4 years in the general population in Spain"
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                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;A&#46; Gonz&#225;lez"
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                            2 => "E&#46; Gadea"
                            3 => "G&#46; Pera"
                            4 => "O&#46; Papke"
                          ]
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                    0 => array:1 [
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                        "tituloSerie" => "Epidemiology"
                        "fecha" => "2001"
                        "volumen" => "12"
                        "paginaInicial" => "365"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11338318"
                            "web" => "Medline"
                          ]
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                ]
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            29 => array:3 [
              "identificador" => "bib0150"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "El medio ambiente saludable"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46; Ballester"
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                        "titulo" => "La salud p&#250;blica ante los desaf&#237;osde un nuevo siglo&#46; Informe SESPAS&#46; 2000"
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                        "serieFecha" => "2000"
                      ]
                    ]
                  ]
                ]
              ]
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            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Desarrollar e implantar pol&#237;ticas sobre medio ambiente y salud"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Daponte"
                            1 => "P&#46; L&#243;pez del Amo"
                            2 => "J&#46; Sunyer"
                          ]
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                      ]
                    ]
                  ]
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                    0 => array:1 [
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                        "titulo" => "La salud p&#250;blica ante los desaf&#237;os de un nuevo siglo&#46; Informe SESPAS 2000"
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                        "paginaFinal" => "258"
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              ]
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            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Las estructuras de salud p&#250;blica en Espa&#241;a&#58; un panorama cambiante"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Segura"
                            1 => "J&#46;R&#46; Villalb&#237;"
                            2 => "E&#46; Mata"
                            3 => "M&#46;L&#46; De la Puente"
                            4 => "O&#46; Ramis"
                            5 => "R&#46; Tresseras"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gac Sanit"
                        "fecha" => "1999"
                        "volumen" => "13"
                        "paginaInicial" => "218"
                        "paginaFinal" => "225"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10477865"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33&#46;"
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                0 => array:1 [
                  "referenciaCompleta" => "Buckley-Golder D&#44; Coleman P&#44; Davies M&#44; King K&#44; Petersen A&#44; Watterson J&#44; et al&#46; Compilation of EU dioxin exposure and health data&#46; Summary report&#46; Report no&#46; AEAT&#47;EEQC&#47;0016&#46; Bruels&#58; European Commission&#44; DG Environment&#44; 1999 &#91;consultado 04&#47;02&#47;2002&#93;&#46; Disponible en&#58; <a class="elsevierStyleInterRef" href="http://europa.eu.int/comm/-environment/dioxin/summary.pdf">http&#58;&#47;&#47;europa&#46;eu&#46;int&#47;comm&#47;-environment&#47;dioxin&#47;summary&#46;pdf</a>"
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            33 => array:3 [
              "identificador" => "bib0170"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Belgian PCB and dioxin incident of January-June 1999&#58; exposure data and potential impact on health"
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                          "etal" => true
                          "autores" => array:6 [
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                            1 => "L&#46; Hens"
                            2 => "P&#46; Schepens"
                            3 => "A&#46; Covaci"
                            4 => "J&#46; Baeyens"
                            5 => "K&#46; Everaert"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Environ Health Perspect"
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                        "volumen" => "109"
                        "paginaInicial" => "265"
                        "paginaFinal" => "273"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11333188"
                            "web" => "Medline"
                          ]
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                ]
              ]
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            34 => array:3 [
              "identificador" => "bib0175"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lead&#44; mercury&#44; and organochlorine compound levels in cord blood in Quebec&#44; Canada"
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                          "etal" => false
                          "autores" => array:4 [
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                            2 => "E&#46; Dewailly"
                            3 => "P&#46; Ayotte"
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                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "Arch Environ Health"
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                        "volumen" => "54"
                        "paginaInicial" => "40"
                        "paginaFinal" => "47"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10025415"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0180"
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                  "referenciaCompleta" => "Centers for Disease Control and Prevention&#44; National Center for Environmental Health&#46; National Report on Human Exposure to Environmental Chemicals &#91;consultado 4&#47;02&#47;2002&#93;&#46; Disponible en&#58; <a class="elsevierStyleInterRef" href="http://www.cdc.gov/nceh/dls/report/overview.htm">http&#58;&#47;&#47;www&#46;cdc&#46;gov&#47;nceh&#47;dls&#47;report&#47;overview&#46;htm</a>"
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                    0 => array:2 [
                      "titulo" => "PCDD&#47;PCDF&#58; human background data for Germany&#44; a 10-year experience"
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                          "etal" => false
                          "autores" => array:1 [
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                        "tituloSerie" => "Environ Health Perspect"
                        "fecha" => "1998"
                        "volumen" => "106"
                        "numero" => "Suppl 2"
                        "paginaInicial" => "723"
                        "paginaFinal" => "731"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9599723"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exposure of populations to dioxins and related compounds"
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                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;K&#46; Liem"
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                            2 => "C&#46; Rappe"
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                        "tituloSerie" => "Food Addit Contam"
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                        "volumen" => "17"
                        "paginaInicial" => "241"
                        "paginaFinal" => "259"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10912239"
                            "web" => "Medline"
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              "identificador" => "bib0195"
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                            4 => "P&#46;J&#46; Landrigan"
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                        "volumen" => "85"
                        "paginaInicial" => "59"
                        "paginaFinal" => "68"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11161655"
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                      "titulo" => "Association of hexachlorobenzene and other organochlorine compounds with anthropometric measures at birth &#91;en prensa&#93;"
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                          "etal" => true
                          "autores" => array:6 [
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                            5 => "A&#46; Verd&#250;"
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                        "tituloSerie" => "Pediatr Res"
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                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20010379"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0210"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of urinary porphyrin excretion in neonates born to mothers exposed to airborne hexachlorobenzene"
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                          "etal" => true
                          "autores" => array:6 [
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                        "paginaInicial" => "205"
                        "paginaFinal" => "209"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11836151"
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                      "titulo" => "Exposure to pesticides and cryptorchidism&#58; geographical evidence of a posible association"
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                        "tituloSerie" => "Environ Health Perspect"
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                        "paginaInicial" => "1090"
                        "paginaFinal" => "1095"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8930551"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0220"
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                0 => array:2 [
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                      "titulo" => "Society of Toxicology meeting&#46; Hazards of particles&#44; PCBs focus of Philadelphia meeting"
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                          "etal" => false
                          "autores" => array:1 [
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                        "link" => array:1 [
                          0 => array:2 [
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                          "autores" => array:1 [
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                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11184192"
                            "web" => "Medline"
                          ]
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              ]
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              "identificador" => "bib0230"
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              "identificador" => "bib0235"
              "etiqueta" => "47&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Polycyclic aromatic hydrocarbons in carcinogenesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46; Warshawsky"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Environ Health Perspect"
                        "fecha" => "1999"
                        "volumen" => "107"
                        "paginaInicial" => "317"
                        "paginaFinal" => "319"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10090712"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "48&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Modulation of proto-oncogene expression by polychlorinated biphenyls in 3T3-L1 cell line"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Gribaldo"
                            1 => "M&#46;G&#46; Sacco"
                            2 => "S&#46; Casati"
                            3 => "I&#46; Zucchi"
                            4 => "M&#46;K&#46; Dosanjh"
                            5 => "P&#46; Catalani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Toxicol Env Health"
                        "fecha" => "1998"
                        "volumen" => "55"
                        "paginaInicial" => "121"
                        "paginaFinal" => "131"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "49&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Polychlorinated biphenyls modulate protooncogene expression in Chang liver cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Hornhardt"
                            1 => "H&#46;S&#46; Jenke"
                            2 => "G&#46; Michel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "FEBS Lett"
                        "fecha" => "1994"
                        "volumen" => "339"
                        "paginaInicial" => "185"
                        "paginaFinal" => "188"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7508867"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "50&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessing the cancer risk from environmental PCBs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "V&#46;J&#46; Cogliano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Environ Health Perspect"
                        "fecha" => "1998"
                        "volumen" => "106"
                        "paginaInicial" => "317"
                        "paginaFinal" => "323"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9618347"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "51&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oxidative DNA damage induced by activation of polychlorinated biphenyls &#40;PCBs&#41;&#58; implications for PCB-induced oxidative stress in breast cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46;G&#46; Oakley"
                            1 => "U&#46; Devanaboyina"
                            2 => "L&#46;W&#46; Robertson"
                            3 => "R&#46;C&#46; Gupta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1021/tx960103o"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chem Res Toxicol"
                        "fecha" => "1996"
                        "volumen" => "9"
                        "paginaInicial" => "1285"
                        "paginaFinal" => "1292"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8951230"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "52&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The DDT question"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "W&#46;J&#46; Rogan"
                            1 => "R&#46;A&#46; Liroff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(05)72884-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2000"
                        "volumen" => "356"
                        "paginaInicial" => "1189"
                        "paginaFinal" => "1191"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11030317"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "53&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Global &#43; local &#61; glocal public health"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "I&#46; Kickbusch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Epidemiol Community Health"
                        "fecha" => "1999"
                        "volumen" => "53"
                        "paginaInicial" => "451"
                        "paginaFinal" => "452"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10562861"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "54&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of organochlorine compounds in the etiology of pancreatic cancer&#58; A proposal to develop methodological standards"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Porta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Epidemiology"
                        "fecha" => "2001"
                        "volumen" => "12"
                        "paginaInicial" => "272"
                        "paginaFinal" => "276"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11246593"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "55&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Utopies assequibles"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Porta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "El Temps Ambiental"
                        "fecha" => "2001"
                        "volumen" => "58"
                        "paginaInicial" => "11"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "56&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiolog&#237;a&#44; ecolog&#237;a y epistemolog&#237;a&#58; nuevas pr&#225;cticas y paradigmas para la salud p&#250;blica en la aldea global"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Porta"
                            1 => "C&#46; &#193;lvarez-Dardet"
                            2 => "E&#46; Fern&#225;ndez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Revisiones Salud P&#250;blica"
                        "fecha" => "1997"
                        "volumen" => "5"
                        "paginaInicial" => "13"
                        "paginaFinal" => "21"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "57&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The elaboration of the &#8220;Stockholm Convention&#8221; on Persistent Organic Pollutants &#40;POPs&#41;&#58; a negotiation process fraught with obstacles and opportunities"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46; Karlaganis"
                            1 => "R&#46; Marioni"
                            2 => "I&#46; Sieber"
                            3 => "A&#46; Weber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Environ Sci Poll Res Int"
                        "fecha" => "2001"
                        "volumen" => "8"
                        "paginaInicial" => "216"
                        "paginaFinal" => "221"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "58&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Introducci&#243;n al Convenio de Estocolmo&#46; Un instrumento internacional para un problema global&#46; Congreso sobre Implementaci&#243;n del Convenio sobre COPs &#91;monograf&#237;a en CD-ROM&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "E&#46; Blount"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:1 [
                        "serieFecha" => "2001"
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                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "59&#46;"
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                0 => array:1 [
                  "referenciaCompleta" => "United Nations Environment Programme&#46; Persistent Organic Pollutants &#91;consultado 04&#47;02&#47;2002&#93;&#46; Disponible en&#58; <a class="elsevierStyleInterRef" href="http://irptc.unep.ch/pops">http&#58;&#47;&#47;irptc&#46;unep&#46;ch&#47;pops</span>&#44; y en&#58; <span class="elsevierStyleInterRef" href="http://www.chem.unep.ch/sc/">http&#58;&#47;&#47;www&#46;chem&#46;unep&#46;ch&#47;sc&#47;</a>"
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "60&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "The International POPs Elimination Network&#46; IPEN&#39;s Stockholm Declaration &#91;consultado 04&#47;02&#47;2002&#93;&#46; Disponible en&#58; <a class="elsevierStyleInterRef" href="http://www.ipen.org">http&#58;&#47;&#47;www&#46;ipen&#46;org</a>"
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "61&#46;"
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                0 => array:1 [
                  "referenciaCompleta" => "World Wildlife Fund &#40;WWF&#41;&#46; Toxic chemicals&#46; Persistent Organic Pollutants &#40;POPs&#41; &#91;consultado 04&#47;02&#47;2002&#93;&#46; Disponible en&#58; <a class="elsevierStyleInterRef" href="http://www.worldwildlife.org/toxics">http&#58;&#47;&#47;www&#46;worldwildlife&#46;org&#47;toxics</a>"
                ]
              ]
            ]
          ]
        ]
      ]
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Vol. 16. Núm. 3.
Páginas 257-266 (mayo - junio 2002)
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Vol. 16. Núm. 3.
Páginas 257-266 (mayo - junio 2002)
Open Access
Concentraciones de compuestos tóxicos persistentes en la población española: el rompecabezas sin piezas y la protección de la salud pública
Concentrations of persistent toxic compounds in the Spanish population: a puzzle without pieces and the protection of public health
Visitas
8432
M. Portaa,b,
Autor para correspondencia
mporta@imim.es

Correspondencia: Prof. M. Porta. Instituto Municipal de Investigación Médica. Universidad Autónoma de Barcelona. Dr. Aiguader, 80. 08003 Barcelona.
, M. Kogevinasa,b, E. Zumetaa, J. Sunyera,c, N. Ribas-Fitóa, Grupo de Trabajo sobre Compuestos Tóxicos Persistentes y Salud del IMIM *
a Instituto Municipal de Investigación Médica (IMIM)
b Universidad Autónoma de Barcelona
c Universidad Pompeu Fabra
Este artículo ha recibido

Under a Creative Commons license
Información del artículo
Resumen

La contaminación por compuestos tóxicos persistentes (CTP) de la población general es un hecho relevante desde una perspectiva de salud pública. Es, asimismo, importante para el sistema sanitario asistencial y para las políticas ambientales, alimentarias, industriales y económicas.

Aunque en España los conocimientos sobre la contaminación de los alimentos por CTP presentan grandes vacíos temporales y geográficos, aún es menor la información sobre sus concentraciones en las personas: no existe ningún estudio representativo de una población general sana efectuado en una zona geográfica amplia. Los estudios disponibles indican que un 80-100% de la población tiene concentraciones detectables de DDE, policlorobifenilos, hexaclorobenceno o lindano. En España el número de estudios sobre los efectos que los CTP tienen en las personas es todavía más exiguo. Los estudios internacionales sugieren que dosis de algunos CTP por debajo de las que normalmente se consideran «seguras» pueden causar efectos biológicos y clínicos relevantes. Los mecanismos de acción no comprenden sólo la disrupción endocrina. La valoración de la significación clínica y social del espectro de efectos más sutiles y con períodos de latencia mayores de los CTP presenta interesantes retos y oportunidades.

España y otros países europeos sufren un déficit de indicadores poblacionales sobre el impacto que los procesos ambientales tienen en la salud humana. Los distintos ámbitos de la Administración deben monitorizar los valores biológicos de los CTPs y valorar sus posibles riesgos para la salud.

Junto con más de cien otros países, próximamente España intentará implementar el Tratado sobre los Contaminantes Orgánicos Persistentes (Convenio de Estocolmo). Ello constituye un nuevo motivo para desarrollar programas más eficientes de vigilancia y control de los residuos de los CTP en alimentos, humanos y medio ambiente. Como parte de la aplicación del Convenio, es necesario iniciar un informe pe-doméstiriódico sobre los factores que condicionan las concentraciones internas de CTP en la población general española.

Palabras clave:
Compuestos tóxicos persistentes
Agentes químicos ambientales
Compuestos organoclorados
DDT
DDE
Policlorobifenilos
Dioxinas
Hexaclorobenceno
Lindano
Convenio de Estocolmo
Summary

The contamination by persistent toxic compounds (PTCs) of the general population is a fact of relevance from a public health perspective. It is also relevant to health care professionals, as well as for environmental, food, industrial and economic policies.

Though in Spain information on food contamination by PTCs shows large time and geographic gaps, the scarcity of data is even moren severe on the concentrations that PTCs have in people: a representative study of a general healthy population living in a wide geographic area has never been conducted in the country. However, the available studies indicate that around 80-100% of the population has detectable concentrations of DDE, PCBs, hexachlorbenzene or lindane. Studies on the effects that PTCs have upon humans are extremely infrequent in Spain. Yet, the international literature suggests that some PTCs may induce significant biological and clinical effects at doses below those tradicionally deemed “safe”. The mechanism of action of PTCs are not restricted to endocrine disruption. Assessing the clinical and social relevance of the more subtle and long-term effects of PTCs presents interesting challenges and opportunities.

Spain and other European countries lack population indicators on the impact that environmental processes have on human health. Several government levels have a role to fulfill in the monitoring of biological levels of PTCs among persons in order to assess the risks of adverse health effects.

Along with over a hundred other countries. Spain will soon try to implement the Stockholm treaty on persistent organic pollutants (POPs). This constitutes a new opportunity to develop more efficient policies to control PTC residues in food, humans and the enviroment. As part of the treaty implementation it is necessary to launch a Report on factors that influence body concentrations of PTCs in the Spain general population.

key words:
Persistent toxic compounds
Persistent organicpollutants (POPs)
Organochlorine compounds
Environment/ chemistry
DDT
DDE
Polychlorinated biphenyls
Dioxins
Hexachlorobenzene
Lindane
Stockholm treaty
El Texto completo está disponible en PDF
Bibliografía
[1.]
N. Olea, M.F. Fernández, P. Areque, F. Olea Serrano.
Perspectivas en disrupción endocrina.
Gac Sanit, 16 (2002), pp. 261-267
[2.]
V. Turusov, V. Rakitsky, L. Tomatis.
Dichlorodiphenyltrichloroethane (DDT): ubiquity, persistence, and risks.
Environ Health Perspect, 110 (2002), pp. 125-128
[3.]
J. Martí, J.M. Antó, J. Santamaría, J.O. Grimalt, N. Olea, M. Porta, et al.
Documentos de la IV Conferencia sobre Disruptores Endocrinos (Barcelona, 26-2711.1999).
Quadern CAPS, 29 (2000), pp. 5-67
[4.]
L.G. Hansen.
Stepping backward to improve assessment of PCB congener toxicities.
Environ Health Perspect, 106 (1998), pp. 171-189
[5.]
United States Environmental Protection Agency, Environment Canada. Background information on PCB sources and regulations [consultado 04/02/2002]. Disponible en: http://www.epa.gov/grtlakes/bnsdocs/pcbsrce/index.html
[7.]
M. Camps, J. Planas, J. Gómez-Catalán, M. Sabroso, J. To-Figueras, J. Corbella.
Organochlorine residues in human adipose tissue in Spain: study of an agrarian area.
Bull Environ Contam Toxicol, 42 (1989), pp. 195-201
[8.]
L.M. Hernández, M.A. Fernández, E. Hoyas, M.J. González, J.F. García.
Organochlorine insecticide and polychlorinated biphenyl residues in human breast milk in Madrid (Spain).
Bull Environ Contam Toxicol, 50 (1993), pp. 308-315
[9.]
P.J. Schepens, A. Covaci, P.G. Jorens, L. Hens, S. Scharpe, N. Van Larebeke.
Surprising findings following a Belgian food contamination with polychlorobiphenyls and dioxins.
Environ Health Perspect, 109 (2001), pp. 101-103
[10.]
O.I. Kalantzi, G.O. Thomas, R.E. Alcock, A. Stephenson, K.C. Jones.
The global distribution of PCBs and organochlorine pesticides in butter.
Environ Sci Technol, 35 (2001), pp. 1013-1018
[11.]
M. Kogevinas, G. Janer.
Dioxinas y salud.
Med Clín (Barc), 115 (2000), pp. 740-748
[12.]
R. Lázaro, A. Herrera, A. Ariño, M.P. Conchello, S. Bayarri.
Organochlorine pesticide residues in total diet samples from Aragón (Northeastern Spain).
J Agric Food Chem, 44 (1996), pp. 2742-2747
[13.]
L.M. Hernández, M.A. Fernández, B. Jiménez, M.J. González.
Organochlorine pollutants in meats and cows milk from Madrid (Spain).
Bull Environ Contam Toxicol, 52 (1994), pp. 246-253
[14.]
M. Sala, J. Sunyer, R. Otero, M. Santiago-Silva, C. Camps, J.O. Grimalt.
Organochlorine compound concentration in the serum of inhabitants living near an electrochemical factory.
Occup Environ Medicine, 56 (1999), pp. 152-158
[15.]
M. Sala, J. Sunyer, C. Herrero, D. Ozalla, J. To-Figueras, J. Grimalt.
Association of hexachlorobenzene serum levels with gammaglutamyl transpeptidase and other biomarkers of early effects in humans.
Occup Environ Med, 58 (2001), pp. 172-177
[16.]
D. Smith.
Worldwide trends in DDT levels in human breast milk.
Int J Epidemiol, 28 (1999), pp. 179-188
[17.]
J.A. Pérez de Ciriza, A. Samanes, E. Gil, P. Fraile, V. Garisoain, C. Martínez.
Estudio de plaguicidas organoclorados en suero de aplicadores. Primeras Jornadas Nacionales sobre Hexaclorobenceno; 1988, mayo 23-24 Libro de actas.
pp. 123-130
[18.]
J.A. Pérez de Ciriza, A. Samanes, J.E. Olivera, C. García, R. Elcarte, D. Conde.
Estudio de plaguicidas organoclorados en leche materna en Navarra. Primeras Jornadas Nacionales sobre Hexaclorobenceno; 1988, mayo 23-24. Libro de actas.
pp. 95-106
[19.]
J.B. Martí Lloret, D. Prats Rico, M.E. Mas Selles.
Contaminación por organoclorados en tejido adiposo humano. Primeras Jornadas Nacionales sobre Hexaclorobenceno; 1988, mayo 23-24. Libro de actas.
pp. 141-147
[20.]
J. Gómez-Catalán, J. Planas, J. To-Figueras, M. Camps, J. Corbella.
Organochlorine residues in the population of Catalonia (Spain).
Bull Environ Contam Toxicol, 51 (1993), pp. 160-164
[21.]
J. Gómez-Catalán, M. Lezaun, J. To-Figueras, J. Corbella.
Organochlorine residues in the adipose tissue of the population of Navarra (Spain).
Bull Environ Contam Toxicol, 54 (1995), pp. 534-540
[22.]
C. Barrotx.
Análisis de la acumulación de residuos organoclorados en tejido adiposo humano en muestras procedentes del partido judicial de Lleida [tesis doctoral].
[23.]
E. Martínez, A. Romanos, M. Praena, M. Repetto, D. Martínez.
Compuestos organoclorados: relación de niveles sanguíneos en madres y recién nacidos y en leche materna con parámetros maternos y de lactantes. Estudio en la provincia de Huelva.
An Esp Pediatr, 38 (1993), pp. 493-498
[24.]
M. Porta, N. Malats, M. Jariod, J.O. Grimalt, J. Rifà, A. Carrato, et al.
Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer.
Lancet, 354 (1999), pp. 2125-2129
[25.]
P. Van't Veer, I.E. Lobbezoo, J.M. Martín-Moreno, E. Guallar, J. Gómez-Aracena, A.F. Kardinaal, et al.
DDT (dicophane) and postmenopausal breast cancer in Europe: case-control study.
Br Med J, 315 (1997), pp. 81-85
[26.]
M. Sala, N. Ribas-Fitó, E. Cardo, M.E. De Muga, E. Marco, C. Mazón, et al.
Levels of hexachlorobenzene and other organochlorine compounds in cord blood: exposure across placenta.
Chemosphere, 43 (2001), pp. 895-901
[27.]
N. Olea, A. Barba, P. Lardelli, A. Rivas, M.F. Olea-Serrano.
Inadvertent exposure to xenoestrogens in children.
Toxicol Industrial Health, 15 (1999), pp. 151-158
[28.]
C.A. González, M. Kogevinas, E. Gadea, O. Päpke, A. Bosch, A. Quílez, et al.
Monitorització biològica dels residents de Mataró que viuen prop de la incineradora de residus sòlids urbans del Maresme. Resultats de la tercera fase de l'estudi.
[29.]
C.A. González, M. Kogevinas, E. Gadea, G. Pera, O. Papke.
Increase of dioxin blood levels over the last 4 years in the general population in Spain.
Epidemiology, 12 (2001), pp. 365
[30.]
F. Ballester.
El medio ambiente saludable.
La salud pública ante los desafíosde un nuevo siglo. Informe SESPAS. 2000, pp. 241-250
[31.]
A. Daponte, P. López del Amo, J. Sunyer.
Desarrollar e implantar políticas sobre medio ambiente y salud.
La salud pública ante los desafíos de un nuevo siglo. Informe SESPAS 2000, pp. 251-258
[32.]
A. Segura, J.R. Villalbí, E. Mata, M.L. De la Puente, O. Ramis, R. Tresseras.
Las estructuras de salud pública en España: un panorama cambiante.
Gac Sanit, 13 (1999), pp. 218-225
[33.]
Buckley-Golder D, Coleman P, Davies M, King K, Petersen A, Watterson J, et al. Compilation of EU dioxin exposure and health data. Summary report. Report no. AEAT/EEQC/0016. Bruels: European Commission, DG Environment, 1999 [consultado 04/02/2002]. Disponible en: http://europa.eu.int/comm/-environment/dioxin/summary.pdf
[34.]
N. Van Labereke, L. Hens, P. Schepens, A. Covaci, J. Baeyens, K. Everaert, et al.
The Belgian PCB and dioxin incident of January-June 1999: exposure data and potential impact on health.
Environ Health Perspect, 109 (2001), pp. 265-273
[35.]
M. Rhainds, P. Levallois, E. Dewailly, P. Ayotte.
Lead, mercury, and organochlorine compound levels in cord blood in Quebec, Canada.
Arch Environ Health, 54 (1999), pp. 40-47
[36.]
Centers for Disease Control and Prevention, National Center for Environmental Health. National Report on Human Exposure to Environmental Chemicals [consultado 4/02/2002]. Disponible en: http://www.cdc.gov/nceh/dls/report/overview.htm
[37.]
O. Papke.
PCDD/PCDF: human background data for Germany, a 10-year experience.
Environ Health Perspect, 106 (1998), pp. 723-731
[38.]
A.K. Liem, P. Furst, C. Rappe.
Exposure of populations to dioxins and related compounds.
Food Addit Contam, 17 (2000), pp. 241-259
[39.]
Dioxines dans l'environnement. Quels risques pour la santé? Vol 1, pp. 359-367
[40.]
G.S. Berkowitz, M.S. Wolff, T. Matte, E. Susser, P.J. Landrigan.
The rationale for a national prospective cohort study of environmental exposure and childhood development.
Environ Res, 85 (2001), pp. 59-68
[41.]
N. Ribas-Fitó, M. Sala, E. Cardo, C. Mazón, M.E. De Muga, A. Verdú, et al.
Association of hexachlorobenzene and other organochlorine compounds with anthropometric measures at birth [en prensa].
[42.]
D. Ozalla, C. Herrero, N. Ribas-Fitó, J. To-Figueras, A. Toll, M. Sala, et al.
Evaluation of urinary porphyrin excretion in neonates born to mothers exposed to airborne hexachlorobenzene.
Environ Health Perspect, 110 (2002), pp. 205-209
[43.]
J. García, M. García, M. Nogueras, C.J. De Dios, M. Espigares, N. Olea, et al.
Exposure to pesticides and cryptorchidism: geographical evidence of a posible association.
Environ Health Perspect, 104 (1996), pp. 1090-1095
[44.]
J. Kaiser.
Society of Toxicology meeting. Hazards of particles, PCBs focus of Philadelphia meeting.
Science, 288 (2000), pp. 424-425
[45.]
J. Kaiser.
Endocrine disrupters. Panel cautiously confirms lowdose effects.
Science, 290 (2000), pp. 695-697
[46.]
United States Environmental Protection Agency, Office of Pesticide programs. Potential of chemicals to affect the endocrine system [consultado 04/02/2002]. Disponible en: http://www.epa.gov/opp00001/citizens/3file.htm#1
[47.]
D. Warshawsky.
Polycyclic aromatic hydrocarbons in carcinogenesis.
Environ Health Perspect, 107 (1999), pp. 317-319
[48.]
L. Gribaldo, M.G. Sacco, S. Casati, I. Zucchi, M.K. Dosanjh, P. Catalani, et al.
Modulation of proto-oncogene expression by polychlorinated biphenyls in 3T3-L1 cell line.
J Toxicol Env Health, 55 (1998), pp. 121-131
[49.]
S. Hornhardt, H.S. Jenke, G. Michel.
Polychlorinated biphenyls modulate protooncogene expression in Chang liver cells.
FEBS Lett, 339 (1994), pp. 185-188
[50.]
V.J. Cogliano.
Assessing the cancer risk from environmental PCBs.
Environ Health Perspect, 106 (1998), pp. 317-323
[51.]
G.G. Oakley, U. Devanaboyina, L.W. Robertson, R.C. Gupta.
Oxidative DNA damage induced by activation of polychlorinated biphenyls (PCBs): implications for PCB-induced oxidative stress in breast cancer.
Chem Res Toxicol, 9 (1996), pp. 1285-1292
[52.]
W.J. Rogan, R.A. Liroff.
The DDT question.
Lancet, 356 (2000), pp. 1189-1191
[53.]
I. Kickbusch.
Global + local = glocal public health.
J Epidemiol Community Health, 53 (1999), pp. 451-452
[54.]
M. Porta.
Role of organochlorine compounds in the etiology of pancreatic cancer: A proposal to develop methodological standards.
Epidemiology, 12 (2001), pp. 272-276
[55.]
M. Porta.
Utopies assequibles.
El Temps Ambiental, 58 (2001), pp. 11
[56.]
M. Porta, C. Álvarez-Dardet, E. Fernández.
Epidemiología, ecología y epistemología: nuevas prácticas y paradigmas para la salud pública en la aldea global.
Revisiones Salud Pública, 5 (1997), pp. 13-21
[57.]
G. Karlaganis, R. Marioni, I. Sieber, A. Weber.
The elaboration of the “Stockholm Convention” on Persistent Organic Pollutants (POPs): a negotiation process fraught with obstacles and opportunities.
Environ Sci Poll Res Int, 8 (2001), pp. 216-221
[58.]
E. Blount.
Introducción al Convenio de Estocolmo. Un instrumento internacional para un problema global. Congreso sobre Implementación del Convenio sobre COPs [monografía en CD-ROM].
[59.]
United Nations Environment Programme. Persistent Organic Pollutants [consultado 04/02/2002]. Disponible en: http://irptc.unep.ch/pops, y en: http://www.chem.unep.ch/sc/
[60.]
The International POPs Elimination Network. IPEN's Stockholm Declaration [consultado 04/02/2002]. Disponible en: http://www.ipen.org
[61.]
World Wildlife Fund (WWF). Toxic chemicals. Persistent Organic Pollutants (POPs) [consultado 04/02/2002]. Disponible en: http://www.worldwildlife.org/toxics

Formado asimismo por Laura Ruiz, Manuel Jariod, Jesús Vioque, Juan Alguacil, Piedad Martín, Núria Malats y Daniel Ayude.

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