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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La contaminaci&#243;n por compuestos t&#243;xicos persistentes &#40;CTP&#41; de la poblaci&#243;n general es un hecho relevante desde una perspectiva de salud p&#250;blica&#46; Es&#44; asimismo&#44; importante para el sistema sanitario asistencial y para las pol&#237;ticas ambientales&#44; alimentarias&#44; industriales y econ&#243;micas&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Aunque en Espa&#241;a los conocimientos sobre la contaminaci&#243;n de los alimentos por CTP presentan grandes vac&#237;os temporales y geogr&#225;ficos&#44; a&#250;n es menor la informaci&#243;n sobre sus concentraciones en las personas&#58; no existe ning&#250;n estudio representativo de una poblaci&#243;n general sana efectuado en una zona geogr&#225;fica amplia&#46; Los estudios disponibles indican que un 80-100&#37; de la poblaci&#243;n tiene concentraciones detectables de DDE&#44; policlorobifenilos&#44; hexaclorobenceno o lindano&#46; En Espa&#241;a el n&#250;mero de estudios sobre los efectos que los CTP tienen en las personas es todav&#237;a m&#225;s exiguo&#46; Los estudios internacionales sugieren que dosis de algunos CTP por debajo de las que normalmente se consideran &#171;seguras&#187; pueden causar efectos biol&#243;gicos y cl&#237;nicos relevantes&#46; Los mecanismos de acci&#243;n no comprenden s&#243;lo la disrupci&#243;n endocrina&#46; La valoraci&#243;n de la significaci&#243;n cl&#237;nica y social del espectro de efectos m&#225;s sutiles y con per&#237;odos de latencia mayores de los CTP presenta interesantes retos y oportunidades&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Espa&#241;a y otros pa&#237;ses europeos sufren un d&#233;ficit de indicadores poblacionales sobre el impacto que los procesos ambientales tienen en la salud humana&#46; Los distintos &#225;mbitos de la Administraci&#243;n deben monitorizar los valores biol&#243;gicos de los CTPs y valorar sus posibles riesgos para la salud&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Junto con m&#225;s de cien otros pa&#237;ses&#44; pr&#243;ximamente Espa&#241;a intentar&#225; implementar el Tratado sobre los Contaminantes Org&#225;nicos Persistentes &#40;Convenio de Estocolmo&#41;&#46; Ello constituye un nuevo motivo para desarrollar programas m&#225;s eficientes de vigilancia y control de los residuos de los CTP en alimentos&#44; humanos y medio ambiente&#46; Como parte de la aplicaci&#243;n del Convenio&#44; es necesario iniciar un informe pe-dom&#233;stiri&#243;dico sobre los factores que condicionan las concentraciones internas de CTP en la poblaci&#243;n general espa&#241;ola&#46;</p>"
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        "resumen" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The contamination by persistent toxic compounds &#40;PTCs&#41; of the general population is a fact of relevance from a public health perspective&#46; It is also relevant to health care professionals&#44; as well as for environmental&#44; food&#44; industrial and economic policies&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Though in Spain information on food contamination by PTCs shows large time and geographic gaps&#44; the scarcity of data is even moren severe on the concentrations that PTCs have in people&#58; a representative study of a general healthy population living in a wide geographic area has never been conducted in the country&#46; However&#44; the available studies indicate that around 80-100&#37; of the population has detectable concentrations of DDE&#44; PCBs&#44; hexachlorbenzene or lindane&#46; Studies on the effects that PTCs have upon humans are extremely infrequent in Spain&#46; Yet&#44; the international literature suggests that some PTCs may induce significant biological and clinical effects at doses below those tradicionally deemed &#8220;safe&#8221;&#46; The mechanism of action of PTCs are not restricted to endocrine disruption&#46; Assessing the clinical and social relevance of the more subtle and long-term effects of PTCs presents interesting challenges and opportunities&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Spain and other European countries lack population indicators on the impact that environmental processes have on human health&#46; Several government levels have a role to fulfill in the monitoring of biological levels of PTCs among persons in order to assess the risks of adverse health effects&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Along with over a hundred other countries&#46; Spain will soon try to implement the Stockholm treaty on persistent organic pollutants &#40;POPs&#41;&#46; This constitutes a new opportunity to develop more efficient policies to control PTC residues in food&#44; humans and the enviroment&#46; As part of the treaty implementation it is necessary to launch a Report on factors that influence body concentrations of PTCs in the Spain general population&#46;</p>"
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Concentraciones de compuestos tóxicos persistentes en la población española: el rompecabezas sin piezas y la protección de la salud pública
Concentrations of persistent toxic compounds in the Spanish population: a puzzle without pieces and the protection of public health
M. Portaa,b,
Autor para correspondencia
mporta@imim.es

Correspondencia: Prof. M. Porta. Instituto Municipal de Investigación Médica. Universidad Autónoma de Barcelona. Dr. Aiguader, 80. 08003 Barcelona.
, M. Kogevinasa,b, E. Zumetaa, J. Sunyera,c, N. Ribas-Fitóa, Grupo de Trabajo sobre Compuestos Tóxicos Persistentes y Salud del IMIM *
a Instituto Municipal de Investigación Médica (IMIM)
b Universidad Autónoma de Barcelona
c Universidad Pompeu Fabra
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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La contaminaci&#243;n por compuestos t&#243;xicos persistentes &#40;CTP&#41; de la poblaci&#243;n general es un hecho relevante desde una perspectiva de salud p&#250;blica&#46; Es&#44; asimismo&#44; importante para el sistema sanitario asistencial y para las pol&#237;ticas ambientales&#44; alimentarias&#44; industriales y econ&#243;micas&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Aunque en Espa&#241;a los conocimientos sobre la contaminaci&#243;n de los alimentos por CTP presentan grandes vac&#237;os temporales y geogr&#225;ficos&#44; a&#250;n es menor la informaci&#243;n sobre sus concentraciones en las personas&#58; no existe ning&#250;n estudio representativo de una poblaci&#243;n general sana efectuado en una zona geogr&#225;fica amplia&#46; Los estudios disponibles indican que un 80-100&#37; de la poblaci&#243;n tiene concentraciones detectables de DDE&#44; policlorobifenilos&#44; hexaclorobenceno o lindano&#46; En Espa&#241;a el n&#250;mero de estudios sobre los efectos que los CTP tienen en las personas es todav&#237;a m&#225;s exiguo&#46; Los estudios internacionales sugieren que dosis de algunos CTP por debajo de las que normalmente se consideran &#171;seguras&#187; pueden causar efectos biol&#243;gicos y cl&#237;nicos relevantes&#46; Los mecanismos de acci&#243;n no comprenden s&#243;lo la disrupci&#243;n endocrina&#46; La valoraci&#243;n de la significaci&#243;n cl&#237;nica y social del espectro de efectos m&#225;s sutiles y con per&#237;odos de latencia mayores de los CTP presenta interesantes retos y oportunidades&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Espa&#241;a y otros pa&#237;ses europeos sufren un d&#233;ficit de indicadores poblacionales sobre el impacto que los procesos ambientales tienen en la salud humana&#46; Los distintos &#225;mbitos de la Administraci&#243;n deben monitorizar los valores biol&#243;gicos de los CTPs y valorar sus posibles riesgos para la salud&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Junto con m&#225;s de cien otros pa&#237;ses&#44; pr&#243;ximamente Espa&#241;a intentar&#225; implementar el Tratado sobre los Contaminantes Org&#225;nicos Persistentes &#40;Convenio de Estocolmo&#41;&#46; Ello constituye un nuevo motivo para desarrollar programas m&#225;s eficientes de vigilancia y control de los residuos de los CTP en alimentos&#44; humanos y medio ambiente&#46; Como parte de la aplicaci&#243;n del Convenio&#44; es necesario iniciar un informe pe-dom&#233;stiri&#243;dico sobre los factores que condicionan las concentraciones internas de CTP en la poblaci&#243;n general espa&#241;ola&#46;</p>"
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        "resumen" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The contamination by persistent toxic compounds &#40;PTCs&#41; of the general population is a fact of relevance from a public health perspective&#46; It is also relevant to health care professionals&#44; as well as for environmental&#44; food&#44; industrial and economic policies&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Though in Spain information on food contamination by PTCs shows large time and geographic gaps&#44; the scarcity of data is even moren severe on the concentrations that PTCs have in people&#58; a representative study of a general healthy population living in a wide geographic area has never been conducted in the country&#46; However&#44; the available studies indicate that around 80-100&#37; of the population has detectable concentrations of DDE&#44; PCBs&#44; hexachlorbenzene or lindane&#46; Studies on the effects that PTCs have upon humans are extremely infrequent in Spain&#46; Yet&#44; the international literature suggests that some PTCs may induce significant biological and clinical effects at doses below those tradicionally deemed &#8220;safe&#8221;&#46; The mechanism of action of PTCs are not restricted to endocrine disruption&#46; Assessing the clinical and social relevance of the more subtle and long-term effects of PTCs presents interesting challenges and opportunities&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Spain and other European countries lack population indicators on the impact that environmental processes have on human health&#46; Several government levels have a role to fulfill in the monitoring of biological levels of PTCs among persons in order to assess the risks of adverse health effects&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Along with over a hundred other countries&#46; Spain will soon try to implement the Stockholm treaty on persistent organic pollutants &#40;POPs&#41;&#46; This constitutes a new opportunity to develop more efficient policies to control PTC residues in food&#44; humans and the enviroment&#46; As part of the treaty implementation it is necessary to launch a Report on factors that influence body concentrations of PTCs in the Spain general population&#46;</p>"
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