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        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">To describe trends in prescription rates for biphosphonates&#44; raloxifene&#44; calcitonin&#44; statins and hormone replacement therapy &#40;HRT&#41; between 2000 and 2003 and to assess the impact of mass media information on the interruption of the Women&#39;s Health Initiative trial on HRT prescription rates&#46;</p> <span class="elsevierStyleSectionTitle">Methodology</span><p class="elsevierStyleSimplePara elsevierViewall">We performed a descriptive&#44; ecological study&#44; with time &#40;month&#41; as the observation unit&#46; Monthly rates of bisphosphonate&#44; calcitonin&#44; raloxifene&#44; statins and HRT prescription&#44; in defined daily doses per 1000 persons&#44; were measured in the population assigned to 249 family physicians in 27 health centers in Seville&#46; Trend graphs and time series analysis were carried out&#46;</p> <span class="elsevierStyleSectionTitle">Results and discussion</span><p class="elsevierStyleSimplePara elsevierViewall">The prescription of preventive drugs has tended to increase between 2000 and 2003&#46; The HRT prescription rate has decreased since the interruption of the Women&#39;s Health Initiative trial&#46;</p>"
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Vol. 19. Núm. 6.
Páginas 471-474 (noviembre - diciembre 2005)
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Vol. 19. Núm. 6.
Páginas 471-474 (noviembre - diciembre 2005)
Original breve
Open Access
Tendencias en la prescripción de fármacos preventivos en el distrito de atención primaria de Sevilla (2000-2003)
Trends in preventive drug prescription in the Primary Care District of Seville [2000-2003]
Visitas
1011
Ana Monroy-Morcilloa,b,
Autor para correspondencia
anamonroy@andaluciajunta.es

Correspondencia: Ana Monroy-Morcillo. Hospital Universitario Puerta del Mar. Servicio de Medicina Preventiva y Salud pública. Avda. Ana de Viya, 21. 11009 Cádiz. España.
, Soledad Márquez-Calderóna, Teresa Molina-Lópezc, Juan C. Domínguez-Camachoc, Clara Bermúdez-Tamayoa, Antonio Escolar-Pujolarb
a Escuela Andaluza de Salud Pública. Granada. España
b Hospital Universitario Puerta del Mar. Cádiz. España
c Distrito Sanitario de Atención Primaria Sevilla. Servicio Andaluz de Salud. Sevilla. España
Este artículo ha recibido

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Información del artículo
Resumen
Objetivos

Describir las tendencias en las tasas de prescripción de bisfosfonatos, raloxifeno, calcitonina, estatinas y terapia hormonal sustitutiva (THS) entre 2000 y 2003, y medir el impacto de la difusión en los medios de la interrupción del ensayo Women's Health Initiative, sobre la prescripción de terapia hormonal.

Metodología

Estudio ecológico descriptivo, con el tiempo (mes) como unidad de observación. Se midieron las tasas de prescripción mensuales de bisfosfonatos, calcitonina, raloxifeno, estatinas y THS, en dosis diarias definidas por 1.000 personas en la población adscrita a 249 médicos de familia de 27 centros de salud del distrito de Sevilla. Se realizaron gráficas de tendencias y análisis de series temporales.

Resultados y discusión

Hay una tendencia al aumento en la prescripción de fármacos preventivos (salvo calcitonina), entre 2000 y 2003. La tasa de prescripción de THS sufrió un descenso a partir de la suspensión del ensayo Women's Health Initiative.

Palabras clave:
Farmacoepidemiología
Tendencias
Prevención primaria
Hipercolesterolemia
Osteoporosis
Terapia hormonal sustitutiva
Abstract
Objectives

To describe trends in prescription rates for biphosphonates, raloxifene, calcitonin, statins and hormone replacement therapy (HRT) between 2000 and 2003 and to assess the impact of mass media information on the interruption of the Women's Health Initiative trial on HRT prescription rates.

Methodology

We performed a descriptive, ecological study, with time (month) as the observation unit. Monthly rates of bisphosphonate, calcitonin, raloxifene, statins and HRT prescription, in defined daily doses per 1000 persons, were measured in the population assigned to 249 family physicians in 27 health centers in Seville. Trend graphs and time series analysis were carried out.

Results and discussion

The prescription of preventive drugs has tended to increase between 2000 and 2003. The HRT prescription rate has decreased since the interruption of the Women's Health Initiative trial.

Key words:
Pharmacoepidemiology
Trends
Primary prevention
Hypercholesterolemia
Osteoporosis
Hormone replacement therapy
El Texto completo está disponible en PDF
Bibliografía
[1.]
S. Márquez, R. Meneu.
La medicalización de la vida y sus protagonistas.
Gestión Clínica y Sanitaria, 5 (2003), pp. 47-53
[2.]
J.E. Rossouw, G.L. Anderson, R.L. Prentice, A. LaCroix, C. Kooperberg, M.I. Stefanick.
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial.
JAMA, 288 (2002), pp. 321-333
[3.]
C. Murillo.
Métodos estadísticos de series temporales.
SG Editores, (1994),
[4.]
G.M. Siles, T.M. Goldaracena, M.L. Ávila, S.E. Crespo.
Consumo de hipolipemiantes en España, 1987-2000.
Rev Esp Salud Pública, 75 (2001), pp. 129-142
[5.]
J. García, V. García, M. Sáinz, A. Carvajal.
Utilización de medicamentos para la osteoporosis en España.
Aten Primaria, 33 (2004), pp. 114-115
[6.]
A. Cranney, P. Tugwell, N. Zytaruk, et al.
Meta-analysis of raloxifene for the prevention and treatment of postmenopausal osteoporosis.
Endocrine Rev, 23 (2002), pp. 524-528
[7.]
T. Walley, P. Folino Gallo, U. Schwabe, E. Van Ganse.
Variations and increase in use of statins across Europe: data from administrative database.
[8.]
G.A. Donker, P. Spreeuwenberg, A.I. Bartelds, K. Van der Velden, M. Foets.
Hormone replacement therapy: changes in frequency and type of prescription by Dutch GPs during the last decade of the millennium.
Farm Pract, 17 (2000), pp. 508-513
[9.]
A.L. Hersh, M.L. Stefanick, R.S. Stafford.
National use of postmenopausal hormone therapy: annual trends and response to recent evidence.
JAMA, 291 (2004), pp. 47-53
[10.]
J.S. Haas, C.P. Kaplan, E.P. Gerstenberger, K. Kerlikowske.
Changes in the use of postmenopausal hormone therapy after the publication of clinical trials results.
Ann Intern Med, 140 (2004), pp. 184-188
[11.]
L.C. Ballesteros, M.I. Fernández, T. Sanz, E. Escortell, C. López.
The cost of inadequate prescriptions for hypolipidaemic drugs. VICAF Group.
Pharmacoeconomics, 19 (2001), pp. 513-522
[12.]
M. Zwart, M. Fradera, P. Solanas, C. González, C. Adalid.
Abordaje de la osteoporosis en un centro de atención primaria.
Aten Primaria, 33 (2004), pp. 183-187
Copyright © 2005. Sociedad Española de Salud Pública y Administración Sanitaria
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