array:24 [
  "pii" => "S0213911105713996"
  "issn" => "02139111"
  "doi" => "10.1157/13082794"
  "estado" => "S300"
  "fechaPublicacion" => "2005-11-01"
  "aid" => "71399"
  "copyright" => "Sociedad Española de Salud Pública y Administración Sanitaria"
  "copyrightAnyo" => "2005"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "sco"
  "cita" => "Gac Sanit. 2005;19:471-4"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2764
    "formatos" => array:3 [
      "EPUB" => 129
      "HTML" => 2009
      "PDF" => 626
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S021391110571400X"
    "issn" => "02139111"
    "doi" => "10.1157/13082795"
    "estado" => "S300"
    "fechaPublicacion" => "2005-11-01"
    "aid" => "71400"
    "copyright" => "Sociedad Española de Salud Pública y Administración Sanitaria"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "sco"
    "cita" => "Gac Sanit. 2005;19:475-80"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2615
      "formatos" => array:3 [
        "EPUB" => 132
        "HTML" => 2038
        "PDF" => 445
      ]
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Opini&#243;n</span>"
      "titulo" => "El Acuerdo General sobre el Comercio de Servicios y sus implicaciones para la salud p&#250;blica"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "475"
          "paginaFinal" => "480"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "General Agreement on Trade in Services and its implications for public health"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Rom&#225;n Uma&#241;a-Pe&#241;a, Carlos &#193;lvarez-Dardet"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "Rom&#225;n"
              "apellidos" => "Uma&#241;a-Pe&#241;a"
            ]
            1 => array:2 [
              "nombre" => "Carlos"
              "apellidos" => "&#193;lvarez-Dardet"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021391110571400X?idApp=WGSE"
    "url" => "/02139111/0000001900000006/v2_201302051753/S021391110571400X/v2_201302051753/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0213911105713984"
    "issn" => "02139111"
    "doi" => "10.1157/13082793"
    "estado" => "S300"
    "fechaPublicacion" => "2005-11-01"
    "aid" => "71398"
    "copyright" => "Sociedad Espa&#241;ola de Salud P&#250;blica y Administraci&#243;n Sanitaria"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "mis"
    "cita" => "Gac Sanit. 2005;19:470"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3233
      "formatos" => array:3 [
        "EPUB" => 110
        "HTML" => 2439
        "PDF" => 684
      ]
    ]
    "es" => array:9 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>"
      "titulo" => "Comentario&#58; el s&#237;ndrome de desgaste profesional como problema de salud p&#250;blica"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "470"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Comentary&#58; the professional burnout syndrome as a public health problem"
        ]
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Jordi Cebri&#224;-Andreu"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Jordi"
              "apellidos" => "Cebri&#224;-Andreu"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911105713984?idApp=WGSE"
    "url" => "/02139111/0000001900000006/v2_201302051753/S0213911105713984/v2_201302051753/es/main.assets"
  ]
  "es" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original breve</span>"
    "titulo" => "Tendencias en la prescripci&#243;n de f&#225;rmacos preventivos en el distrito de atenci&#243;n primaria de Sevilla &#40;2000-2003&#41;"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "471"
        "paginaFinal" => "474"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Ana Monroy-Morcillo, Soledad M&#225;rquez-Calder&#243;n, Teresa Molina-L&#243;pez, Juan C&#46; Dom&#237;nguez-Camacho, Clara Berm&#250;dez-Tamayo, Antonio Escolar-Pujolar"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "Ana"
            "apellidos" => "Monroy-Morcillo"
            "email" => array:1 [
              0 => "anamonroy&#64;andaluciajunta&#46;es"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Soledad"
            "apellidos" => "M&#225;rquez-Calder&#243;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Teresa"
            "apellidos" => "Molina-L&#243;pez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Juan C&#46;"
            "apellidos" => "Dom&#237;nguez-Camacho"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Clara"
            "apellidos" => "Berm&#250;dez-Tamayo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Antonio"
            "apellidos" => "Escolar-Pujolar"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Escuela Andaluza de Salud P&#250;blica&#46; Granada&#46; Espa&#241;a"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Hospital Universitario Puerta del Mar&#46; C&#225;diz&#46; Espa&#241;a"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
          2 => array:3 [
            "entidad" => "Distrito Sanitario de Atenci&#243;n Primaria Sevilla&#46; Servicio Andaluz de Salud&#46; Sevilla&#46; Espa&#241;a"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff3"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspondencia&#58; Ana Monroy-Morcillo&#46; Hospital Universitario Puerta del Mar&#46; Servicio de Medicina Preventiva y Salud p&#250;blica&#46; Avda&#46; Ana de Viya&#44; 21&#46; 11009 C&#225;diz&#46; Espa&#241;a&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Trends in preventive drug prescription in the Primary Care District of Seville &#91;2000-2003&#93;"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2004-12-02"
    "fechaAceptado" => "2005-07-04"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec16863"
          "palabras" => array:6 [
            0 => "Farmacoepidemiolog&#237;a"
            1 => "Tendencias"
            2 => "Prevenci&#243;n primaria"
            3 => "Hipercolesterolemia"
            4 => "Osteoporosis"
            5 => "Terapia hormonal sustitutiva"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec16862"
          "palabras" => array:6 [
            0 => "Pharmacoepidemiology"
            1 => "Trends"
            2 => "Primary prevention"
            3 => "Hypercholesterolemia"
            4 => "Osteoporosis"
            5 => "Hormone replacement therapy"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Describir las tendencias en las tasas de prescripci&#243;n de bisfosfonatos&#44; raloxifeno&#44; calcitonina&#44; estatinas y terapia hormonal sustitutiva &#40;THS&#41; entre 2000 y 2003&#44; y medir el impacto de la difusi&#243;n en los medios de la interrupci&#243;n del ensayo Women&#39;s Health Initiative&#44; sobre la prescripci&#243;n de terapia hormonal&#46;</p> <span class="elsevierStyleSectionTitle">Metodolog&#237;a</span><p class="elsevierStyleSimplePara elsevierViewall">Estudio ecol&#243;gico descriptivo&#44; con el tiempo &#40;mes&#41; como unidad de observaci&#243;n&#46; Se midieron las tasas de prescripci&#243;n mensuales de bisfosfonatos&#44; calcitonina&#44; raloxifeno&#44; estatinas y THS&#44; en dosis diarias definidas por 1&#46;000 personas en la poblaci&#243;n adscrita a 249 m&#233;dicos de familia de 27 centros de salud del distrito de Sevilla&#46; Se realizaron gr&#225;ficas de tendencias y an&#225;lisis de series temporales&#46;</p> <span class="elsevierStyleSectionTitle">Resultados y discusi&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">Hay una tendencia al aumento en la prescripci&#243;n de f&#225;rmacos preventivos &#40;salvo calcitonina&#41;&#44; entre 2000 y 2003&#46; La tasa de prescripci&#243;n de THS sufri&#243; un descenso a partir de la suspensi&#243;n del ensayo Women&#39;s Health Initiative&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">To describe trends in prescription rates for biphosphonates&#44; raloxifene&#44; calcitonin&#44; statins and hormone replacement therapy &#40;HRT&#41; between 2000 and 2003 and to assess the impact of mass media information on the interruption of the Women&#39;s Health Initiative trial on HRT prescription rates&#46;</p> <span class="elsevierStyleSectionTitle">Methodology</span><p class="elsevierStyleSimplePara elsevierViewall">We performed a descriptive&#44; ecological study&#44; with time &#40;month&#41; as the observation unit&#46; Monthly rates of bisphosphonate&#44; calcitonin&#44; raloxifene&#44; statins and HRT prescription&#44; in defined daily doses per 1000 persons&#44; were measured in the population assigned to 249 family physicians in 27 health centers in Seville&#46; Trend graphs and time series analysis were carried out&#46;</p> <span class="elsevierStyleSectionTitle">Results and discussion</span><p class="elsevierStyleSimplePara elsevierViewall">The prescription of preventive drugs has tended to increase between 2000 and 2003&#46; The HRT prescription rate has decreased since the interruption of the Women&#39;s Health Initiative trial&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:12 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "La medicalizaci&#243;n de la vida y sus protagonistas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; M&#225;rquez"
                            1 => "R&#46; Meneu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Gesti&#243;n Cl&#237;nica y Sanitaria"
                        "fecha" => "2003"
                        "volumen" => "5"
                        "paginaInicial" => "47"
                        "paginaFinal" => "53"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risks and benefits of estrogen plus progestin in healthy postmenopausal women&#58; principal results from the Women&#39;s Health Initiative randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;E&#46; Rossouw"
                            1 => "G&#46;L&#46; Anderson"
                            2 => "R&#46;L&#46; Prentice"
                            3 => "A&#46; LaCroix"
                            4 => "C&#46; Kooperberg"
                            5 => "M&#46;I&#46; Stefanick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2002"
                        "volumen" => "288"
                        "paginaInicial" => "321"
                        "paginaFinal" => "333"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12117397"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "M&#233;todos estad&#237;sticos de series temporales"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "C&#46; Murillo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "1994"
                        "editorial" => "SG Editores"
                        "editorialLocalizacion" => "Barcelona"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Consumo de hipolipemiantes en Espa&#241;a&#44; 1987-2000"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46;M&#46; Siles"
                            1 => "T&#46;M&#46; Goldaracena"
                            2 => "M&#46;L&#46; &#193;vila"
                            3 => "S&#46;E&#46; Crespo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Esp Salud P&#250;blica"
                        "fecha" => "2001"
                        "volumen" => "75"
                        "paginaInicial" => "129"
                        "paginaFinal" => "142"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11400423"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Utilizaci&#243;n de medicamentos para la osteoporosis en Espa&#241;a"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Garc&#237;a"
                            1 => "V&#46; Garc&#237;a"
                            2 => "M&#46; S&#225;inz"
                            3 => "A&#46; Carvajal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Aten Primaria"
                        "fecha" => "2004"
                        "volumen" => "33"
                        "paginaInicial" => "114"
                        "paginaFinal" => "115"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Meta-analysis of raloxifene for the prevention and treatment of postmenopausal osteoporosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Cranney"
                            1 => "P&#46; Tugwell"
                            2 => "N&#46; Zytaruk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Endocrine Rev"
                        "fecha" => "2002"
                        "volumen" => "23"
                        "paginaInicial" => "524"
                        "paginaFinal" => "528"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Variations and increase in use of statins across Europe&#58; data from administrative database"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46; Walley"
                            1 => "P&#46; Folino Gallo"
                            2 => "U&#46; Schwabe"
                            3 => "E&#46; Van Ganse"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bmj.328.7436.385"
                      "Revista" => array:6 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "2004"
                        "volumen" => "328"
                        "paginaInicial" => "385"
                        "paginaFinal" => "386"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14962875"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hormone replacement therapy&#58; changes in frequency and type of prescription by Dutch GPs during the last decade of the millennium"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "G&#46;A&#46; Donker"
                            1 => "P&#46; Spreeuwenberg"
                            2 => "A&#46;I&#46; Bartelds"
                            3 => "K&#46; Van der Velden"
                            4 => "M&#46; Foets"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Farm Pract"
                        "fecha" => "2000"
                        "volumen" => "17"
                        "paginaInicial" => "508"
                        "paginaFinal" => "513"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "National use of postmenopausal hormone therapy&#58; annual trends and response to recent evidence"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;L&#46; Hersh"
                            1 => "M&#46;L&#46; Stefanick"
                            2 => "R&#46;S&#46; Stafford"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.291.1.47"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2004"
                        "volumen" => "291"
                        "paginaInicial" => "47"
                        "paginaFinal" => "53"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14709575"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Changes in the use of postmenopausal hormone therapy after the publication of clinical trials results"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;S&#46; Haas"
                            1 => "C&#46;P&#46; Kaplan"
                            2 => "E&#46;P&#46; Gerstenberger"
                            3 => "K&#46; Kerlikowske"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "2004"
                        "volumen" => "140"
                        "paginaInicial" => "184"
                        "paginaFinal" => "188"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14757616"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The cost of inadequate prescriptions for hypolipidaemic drugs&#46; VICAF Group"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46;C&#46; Ballesteros"
                            1 => "M&#46;I&#46; Fern&#225;ndez"
                            2 => "T&#46; Sanz"
                            3 => "E&#46; Escortell"
                            4 => "C&#46; L&#243;pez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pharmacoeconomics"
                        "fecha" => "2001"
                        "volumen" => "19"
                        "paginaInicial" => "513"
                        "paginaFinal" => "522"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11465310"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Abordaje de la osteoporosis en un centro de atenci&#243;n primaria"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Zwart"
                            1 => "M&#46; Fradera"
                            2 => "P&#46; Solanas"
                            3 => "C&#46; Gonz&#225;lez"
                            4 => "C&#46; Adalid"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Aten Primaria"
                        "fecha" => "2004"
                        "volumen" => "33"
                        "paginaInicial" => "183"
                        "paginaFinal" => "187"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15023320"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/02139111/0000001900000006/v2_201302051753/S0213911105713996/v2_201302051753/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "691"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Estado de Salud"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02139111/0000001900000006/v2_201302051753/S0213911105713996/v2_201302051753/es/main.pdf?idApp=WGSE&text.app=https://gacetasanitaria.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911105713996?idApp=WGSE"
]
Compartir
Publique en esta revista
Información de la revista
Vol. 19. Núm. 6.
Páginas 471-474 (noviembre - diciembre 2005)
Respuestas rápidas
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 19. Núm. 6.
Páginas 471-474 (noviembre - diciembre 2005)
Original breve
Open Access
Tendencias en la prescripción de fármacos preventivos en el distrito de atención primaria de Sevilla (2000-2003)
Trends in preventive drug prescription in the Primary Care District of Seville [2000-2003]
Visitas
1012
Ana Monroy-Morcilloa,b,
Autor para correspondencia
anamonroy@andaluciajunta.es

Correspondencia: Ana Monroy-Morcillo. Hospital Universitario Puerta del Mar. Servicio de Medicina Preventiva y Salud pública. Avda. Ana de Viya, 21. 11009 Cádiz. España.
, Soledad Márquez-Calderóna, Teresa Molina-Lópezc, Juan C. Domínguez-Camachoc, Clara Bermúdez-Tamayoa, Antonio Escolar-Pujolarb
a Escuela Andaluza de Salud Pública. Granada. España
b Hospital Universitario Puerta del Mar. Cádiz. España
c Distrito Sanitario de Atención Primaria Sevilla. Servicio Andaluz de Salud. Sevilla. España
Este artículo ha recibido

Under a Creative Commons license
Información del artículo
Resumen
Bibliografía
Descargar PDF
Estadísticas
Resumen
Objetivos

Describir las tendencias en las tasas de prescripción de bisfosfonatos, raloxifeno, calcitonina, estatinas y terapia hormonal sustitutiva (THS) entre 2000 y 2003, y medir el impacto de la difusión en los medios de la interrupción del ensayo Women's Health Initiative, sobre la prescripción de terapia hormonal.

Metodología

Estudio ecológico descriptivo, con el tiempo (mes) como unidad de observación. Se midieron las tasas de prescripción mensuales de bisfosfonatos, calcitonina, raloxifeno, estatinas y THS, en dosis diarias definidas por 1.000 personas en la población adscrita a 249 médicos de familia de 27 centros de salud del distrito de Sevilla. Se realizaron gráficas de tendencias y análisis de series temporales.

Resultados y discusión

Hay una tendencia al aumento en la prescripción de fármacos preventivos (salvo calcitonina), entre 2000 y 2003. La tasa de prescripción de THS sufrió un descenso a partir de la suspensión del ensayo Women's Health Initiative.

Palabras clave:
Farmacoepidemiología
Tendencias
Prevención primaria
Hipercolesterolemia
Osteoporosis
Terapia hormonal sustitutiva
Abstract
Objectives

To describe trends in prescription rates for biphosphonates, raloxifene, calcitonin, statins and hormone replacement therapy (HRT) between 2000 and 2003 and to assess the impact of mass media information on the interruption of the Women's Health Initiative trial on HRT prescription rates.

Methodology

We performed a descriptive, ecological study, with time (month) as the observation unit. Monthly rates of bisphosphonate, calcitonin, raloxifene, statins and HRT prescription, in defined daily doses per 1000 persons, were measured in the population assigned to 249 family physicians in 27 health centers in Seville. Trend graphs and time series analysis were carried out.

Results and discussion

The prescription of preventive drugs has tended to increase between 2000 and 2003. The HRT prescription rate has decreased since the interruption of the Women's Health Initiative trial.

Key words:
Pharmacoepidemiology
Trends
Primary prevention
Hypercholesterolemia
Osteoporosis
Hormone replacement therapy
El Texto completo está disponible en PDF
Bibliografía
[1.]
S. Márquez, R. Meneu.
La medicalización de la vida y sus protagonistas.
Gestión Clínica y Sanitaria, 5 (2003), pp. 47-53
[2.]
J.E. Rossouw, G.L. Anderson, R.L. Prentice, A. LaCroix, C. Kooperberg, M.I. Stefanick.
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial.
JAMA, 288 (2002), pp. 321-333
[3.]
C. Murillo.
Métodos estadísticos de series temporales.
SG Editores, (1994),
[4.]
G.M. Siles, T.M. Goldaracena, M.L. Ávila, S.E. Crespo.
Consumo de hipolipemiantes en España, 1987-2000.
Rev Esp Salud Pública, 75 (2001), pp. 129-142
[5.]
J. García, V. García, M. Sáinz, A. Carvajal.
Utilización de medicamentos para la osteoporosis en España.
Aten Primaria, 33 (2004), pp. 114-115
[6.]
A. Cranney, P. Tugwell, N. Zytaruk, et al.
Meta-analysis of raloxifene for the prevention and treatment of postmenopausal osteoporosis.
Endocrine Rev, 23 (2002), pp. 524-528
[7.]
T. Walley, P. Folino Gallo, U. Schwabe, E. Van Ganse.
Variations and increase in use of statins across Europe: data from administrative database.
[8.]
G.A. Donker, P. Spreeuwenberg, A.I. Bartelds, K. Van der Velden, M. Foets.
Hormone replacement therapy: changes in frequency and type of prescription by Dutch GPs during the last decade of the millennium.
Farm Pract, 17 (2000), pp. 508-513
[9.]
A.L. Hersh, M.L. Stefanick, R.S. Stafford.
National use of postmenopausal hormone therapy: annual trends and response to recent evidence.
JAMA, 291 (2004), pp. 47-53
[10.]
J.S. Haas, C.P. Kaplan, E.P. Gerstenberger, K. Kerlikowske.
Changes in the use of postmenopausal hormone therapy after the publication of clinical trials results.
Ann Intern Med, 140 (2004), pp. 184-188
[11.]
L.C. Ballesteros, M.I. Fernández, T. Sanz, E. Escortell, C. López.
The cost of inadequate prescriptions for hypolipidaemic drugs. VICAF Group.
Pharmacoeconomics, 19 (2001), pp. 513-522
[12.]
M. Zwart, M. Fradera, P. Solanas, C. González, C. Adalid.
Abordaje de la osteoporosis en un centro de atención primaria.
Aten Primaria, 33 (2004), pp. 183-187
Copyright © 2005. Sociedad Española de Salud Pública y Administración Sanitaria
Descargar PDF
Idiomas
Gaceta Sanitaria
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?