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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Pharmaceuticals are used for many beneficial purposes in modern society&#44; but commonly constitute pollutants when encountered in the environment<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46; Sometimes&#44; these compounds are not managed properly and are discharged directly into drains&#44; while at other times they are not completely metabolized by the human body and are excreted via urine and feces in sewage treatment plants &#40;STPs&#41;&#46; Pharmaceuticals are not completely removed in STPs and may end up in the environment&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Pollution by pharmaceuticals is recognized as an environmental concern in many countries and has led to an extensive area of research&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Several therapeutic groups such as anti-inflammatory and cardiovascular drugs&#44; analgesics&#44; antibiotics&#44; steroids and related hormones have been detected in the aquatic environment&#46; In Spain&#44; one of the most widely consumed drug groups are psychoactive pharmaceuticals&#46; The prevalence of the total consumption of tranquilizers and relaxants was 17&#46;4&#37; &#40;10&#46;2&#37; men and 17&#46;5&#37; women&#41; in 2006&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Several studies have shown the occurrence of this group in the river and tap waters of the Ebro Basin&#44; Llobregat river&#44; Region of Madrid and northwest of Spain&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;8</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The occurrence of pharmaceuticals in the environment leads to various unanswered questions with regard to their biological potency in flora&#44; fauna&#44; and humans&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Very few data are available on the presence of pharmaceuticals in point-of-use drinking waters&#44; partly due to the belief that modern treatment processes will remove pharmaceuticals from potable supplies&#46; Although the risks associated with exposure to drugs are probably most significant with regard to the natural environment&#44; the public&#39;s concern is understandably more focused on human exposure&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The aim of this study was to monitor the presence of 14 psychoactive pharmaceutical residues belonging to three therapeutic groups in Galicia&#39;s watersheds&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Method</span><p id="par0025" class="elsevierStylePara elsevierViewall">The autonomous region of Galicia has a total area of 29&#44;574&#46;38 km<span class="elsevierStyleSup">2</span> and an estimated population of 2&#44;796&#44;089 inhabitants &#91;5&#46;98&#37; of the population of Spain&#44; database of the National Institute of Statistics &#40;INEbase&#41; 2009&#93;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Five STPs were selected&#44; one for each of the five main cities in Galicia&#58; A Coru&#241;a&#44; Ourense&#44; Pontevedra&#44; Santiago de Compostela and Vigo&#46; For confidentiality reasons&#44; the citation order of the cities does not reflect the numeration of the STPs &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">STP1 and STP5 discharge into surface waters of the basins of Galicia-Coast and Mi&#241;o-Sil respectively&#44; and the remainder &#40;STP2&#44; STP3 and STP4&#41; discharge directly into the sea&#46; The sampling stations were carefully selected in order to produce consistent and representative results for the final interpretation of data&#46; Pharmaceuticals were analyzed in the influent and effluent water from all STPs and also 50 meters downstream of the emission points of STP1 &#40;DSSTP1&#41; and STP5 &#40;DSSTP5&#41;&#46; Thirty-six grab samples were collected in three campaigns&#58; August 2008&#44; January 2009 and June 2009&#46; One sample for each campaign was taken from each sample point&#46; Seventy-five tap water samples were also taken from public places and private residences of the cities selected in the same campaigns as the wastewater and river water samples&#46; Five samples for each campaign were taken in each city&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Thirteen pharmaceuticals and one metabolite were chosen because of their potential toxicity and persistence in the environment&#46; The pharmaceuticals analyzed are used as medications for the central nervous system and belong to three of the most frequently prescribed therapeutic groups&#58; antidepressants&#44; anxiolytics and antiepileptics&#46; The method described in the literature and used by Gros et al&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> was chosen for sample extraction and instrumental analysis&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results</span><p id="par0045" class="elsevierStylePara elsevierViewall">Of the 14 psychoactive pharmaceuticals analyzed&#44; 12 were detected in the wastewater samples of the STPs studied&#46; However&#44; in some STP samples the concentrations were below the limit of quantification&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The percentage of samples and average values of detectable concentrations in the influent and effluent samples are shown in <a class="elsevierStyleCrossRef" href="#tbl0010">table 2</a>&#46; Among 15 influent samples&#44; venlafaxine was detected in 43&#37;&#44; with an average concentration of 401<span class="elsevierStyleHsp" style=""></span>ng&#47;L&#46; Lorazepam was found in 87&#37; of influent samples with concentrations of 10&#44;598<span class="elsevierStyleHsp" style=""></span>ng&#47;L&#46; Among 15 effluent samples&#44; venlafaxine and lorazepam were detected in 67&#37;&#46; The average concentrations detected of venlafaxine and lorazepam were 317<span class="elsevierStyleHsp" style=""></span>ng&#47;L and 689<span class="elsevierStyleHsp" style=""></span>ng&#47;L&#44; respectively&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">Most of the pharmaceuticals studied showed elevated concentrations in effluents and in some samples the concentrations found in the effluents were higher than those detected in the influents&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The percentage of samples with detectable concentrations of DSSTP1 and DSSTP5 reached 50&#37; for venlafaxine and lorazepam &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">table 2</a>&#41;&#46; The average concentration of lorazepam was 168<span class="elsevierStyleHsp" style=""></span>ng&#47;L while that of venlafaxine was 67<span class="elsevierStyleHsp" style=""></span>ng&#47;L&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Among 75 tap water samples&#44; lorazepam was found in 3&#37;&#44; with an average concentration of 562<span class="elsevierStyleHsp" style=""></span>ng&#47;L &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">table 2</a>&#41;&#46; Venlafaxine was found in 1&#37; of samples at concentrations of 44<span class="elsevierStyleHsp" style=""></span>ng&#47;L&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0070" class="elsevierStylePara elsevierViewall">In all the water samples analyzed&#44; the highest concentrations corresponded to the group of anxiolytics&#46; In particular&#44; lorazepam was found in high concentrations in the river and tap water samples&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">The average concentration of venlafaxine detected in effluent samples was similar to that reported in other works&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;11</span></a> However&#44; lorazepam was found in higher concentrations than in other studies&#46; Coetsier et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> reported lorazepam levels of up to 200<span class="elsevierStyleHsp" style=""></span>ng&#47;L in treated sewage&#46; In river waters&#44; the concentration of lorazepam was higher than that reported in the literature &#40;40<span class="elsevierStyleHsp" style=""></span>ng&#47;L&#41;&#46; An important aspect to highlight is the deconjugation phenomenon that may occur in STPs&#46; In some samples&#44; the increase in pharmaceuticals in effluents was demonstrated to occur due to conversion of glucuronides and other conjugated metabolites to the parent compound by enzymatic processes taking place in the treatment plant&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">The presence of lorazepam in drinking and tap waters has not been studied in other works&#46; The high concentrations detected in some tap water samples probably indicate that lorazepam is not eliminated by advanced drinking water treatments&#46; In some cases&#44; anxiolytics are subject to illicit use by the population because of their properties<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> and are also common in veterinary treatments&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> Benzodiazepines are also used in stockbreeding&#44; an important sector of the Galician economy&#44; and therefore this source should also be considered&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Several studies have shown that the likelihood of acute effects of such low pharmaceutical concentrations in drinking water is very low&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;9</span></a> However&#44; little is known about the possible long-term effects of continuous exposure to low concentrations of these pharmaceuticals&#46; Some authors suggest that although the consequences in healthy adults would be negligible&#44; in the young or elderly these effects might be more pronounced due to reduced ability to remove toxic compounds from their bodies&#46; In addition&#44; in particular conditions such as allergies to certain compounds or vulnerable life stages such as pregnancy the possible effects could be more important&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;14&#44;15</span></a> However&#44; these affirmations do not constitute proof because there are insufficient studies in tap water exposure&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">The results obtained in this study are representative of the watersheds of the autonomous region of Galicia but may not be extrapolable to river and tap water from other areas&#46; Another limitation are the point measurements&#46; A continuous monitoring system would have been desirable to detect these compounds in higher concentrations&#46; Finally&#44; the design of this investigation did not allow assessment of potential risks to public health&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">To conclude&#44; this study demonstrates the presence of psychoactive pharmaceuticals in the watersheds of the autonomous region of Galicia and shows conversion of metabolites to parent compounds&#46; This work also highlights the need to increase environmental monitoring of watersheds and to improve sewage and drinking water treatment processes to remove these pharmaceuticals&#46;<elsevierMultimedia ident="tb0005"></elsevierMultimedia></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Authors&#8217; contributions</span><p id="par0110" class="elsevierStylePara elsevierViewall">This research was co-directed by Y&#46; Valc&#225;rcel and M&#46; Catal&#225; and was performed by S&#46; Esteban&#46; The sampling design&#44; sampling and analysis of the pharmaceuticals were performed by the Laboratory of Analysis and Environmental Quality &#40;CIS&#41; under the direction of M&#46; Gonz&#225;lez Castromil&#46; All the authors contributed to drafting the manuscript and have approved the final document&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Funding</span><p id="par0115" class="elsevierStylePara elsevierViewall">None&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of interest</span><p id="par0120" class="elsevierStylePara elsevierViewall">None&#46;</p></span></span>"
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            0 => "Antidepresivos"
            1 => "Ansiol&#237;ticos"
            2 => "Antiepil&#233;pticos"
            3 => "Contaminaci&#243;n del agua"
            4 => "Agua del grifo"
            5 => "Espa&#241;a"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To monitor the presence of pharmaceutical residues of 14 psychoactive drugs belonging to three therapeutic groups in the watersheds of Galicia &#40;Spain&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Five sewage treatment plants were selected in the main cities of Galicia&#46; Thirteen psychoactive pharmaceutical compounds and one metabolite were chosen&#46; In addition&#44; tap water samples were taken from public places and private residences in the selected cities&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">In all the water samples analyzed&#44; the highest concentrations corresponded to the group of anxiolytics&#46; In particular&#44; high concentrations of lorazepam were found in river and tap water samples&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">This investigation demonstrates the presence of psychoactive pharmaceuticals in the watersheds of the autonomous region of Galicia and the conversion of metabolites to parent compounds&#46; This work also shows the need to increase environmental monitoring of watersheds and to improve sewage and drinking water treatment processes to remove these pharmaceuticals&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Monitorizar la presencia de 14 f&#225;rmacos psicoactivos pertenecientes a tres grupos terap&#233;uticos en la cuenca de Galicia&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se seleccionaron cinco estaciones depuradoras de aguas residuales en las principales ciudades de Galicia&#46; Se escogieron trece compuestos farmac&#233;uticos psicoactivos y un metabolito&#46; Asimismo&#44; se tomaron muestras de aguas del grifo de espacios p&#250;blicos y privados en las ciudades seleccionadas&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">En todas las muestras de agua analizadas&#44; las mayores concentraciones han correspondido al grupo de los ansiol&#237;ticos&#44; y especialmente el lorazepam ha aparecido en altas concentraciones en las muestras de aguas de r&#237;o y del grifo&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Esta investigaci&#243;n demuestra la presencia de f&#225;rmacos psicoactivos en las cuencas de Galicia y la reversi&#243;n de los metabolitos a sus compuestos parentales&#46; Asimismo&#44; muestra la necesidad de incrementar la monitorizaci&#243;n ambiental de las cuencas y de mejorar los procesos de tratamiento de las aguas residuales y potables para eliminar estos f&#225;rmacos&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">STP&#58; sewage treatment plants&#59; BAS&#58; biologic-activated sludge&#59; bf&#58; belt filter-drying&#59; d&#58; anaerobic digestion&#59; PQ&#58; physical-chemical processes&#59; s&#58; spin-drying&#59; td&#58; thermal drying&#59; TT&#58; tertiary treatment &#40;UV&#58; UV disinfection&#59; NP&#58; nitrogen and phosphorus removal&#59; N&#58; nitrogen removal&#59; C&#58; chlorination&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">STP code&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Basin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Population equivalent&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Receiving water&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Treatment</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Water&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Slugde&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">STP1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Galicia-Coast&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;407&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BAS<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>TT &#40;NP<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>C&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">s&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">STP2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Galicia-Coast&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">358&#46;257&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Coast of A Coru&#241;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BAS<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>TT &#40;UV&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">d<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>s&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">STP3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Galicia-Coast&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">111&#46;240&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">R&#237;a de Pontevedra&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PQ<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>BAS<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>TT &#40;UV&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">bf&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">STP4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Galicia-Coast&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;234&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">R&#237;a de Vigo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BAS<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>TT &#40;UV&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">s&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">STP5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mi&#241;o-Sil&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">295&#46;790&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mi&#241;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BAS<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>TT &#40;NP&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">d<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>dt&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab10576.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Characteristics of the sewage treatment plants selected in the watersheds of Galicia in 2008-2009&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">I&#58; percentage of samples with detectable concentrations in influent wastewater&#59; E&#58; percentage of samples with detectable concentrations in effluent wastewater&#59; DSSTP&#58; percentage of samples with detectable concentrations 50 meters downstream of sewage treatment plants&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">I &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Average &#40;ng&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">E &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Average &#40;ng&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">DSSTP &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Average &#40;ng&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Tap water &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Average &#40;ng&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Amitriptiline&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Citalopram&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Clomipramine&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fluoxetine&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Nortriptiline&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Percentage &#40;&#37;&#41; of samples and average concentrations &#40;ng&#47;L&#41; with detectable concentrations in the influent &#40;I&#41; and effluent &#40;E&#41; wastewater of sewage treatment plants&#44; downstream rivers &#40;DSSTP&#41; and tap water in the watersheds of Galicia in 2008-2009&#46;</p>"
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          "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">What is known on this topic</span><p id="par0100" class="elsevierStylePara elsevierViewall">Previous studies have focused on the detection of some pharmaceutical groups in the environment&#46; However there are few studies on the presence of these compounds in tap water and their possible effects on public health&#46; Therefore&#44; studies are required not only to determine the presence of pharmaceutical residues in tap water&#44; but also to identify their possible effects on human health&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">What does this study add to the literature&#63;</span><p id="par0105" class="elsevierStylePara elsevierViewall">This study demonstrates the presence of psychoactive pharmaceuticals in natural and tap waters of the autonomous region of Galicia and shows conversion of metabolites to parent compounds&#46; This work also highlights the need to increase environmental monitoring of watersheds and to improve of sewage and drinking water treatment processes to remove these pharmaceuticals&#46;</p></span></span>"
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Vol. 26. Núm. 5.
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Vol. 26. Núm. 5.
Páginas 457-459 (septiembre - octubre 2012)
Brief article
Open Access
Psychoactive pharmaceutical residues in the watersheds of Galicia (Spain)
Fármacos psicoactivos en las cuencas de Galicia
Visitas
1106
Sara Estebana,
Autor para correspondencia
saraestgn@telefonica.net

Corresponding author.
, Yolanda Valcárcela, Myriam Cataláb, Miguel González Castromilc
a Department of Preventive Medicine and Public Health, Medical Immunology and Microbiology, Faculty of Health Sciences, Universidad Rey Juan Carlos, Alcorcón (Madrid), Spain
b Department of Biology and Geology, Faculty of Experimental Sciences and Technology, Universidad Rey Juan Carlos, Móstoles (Madrid), Spain
c CIS Laboratory of Analysis and Envionmental Quality, Santiago de Compostela (La Coruña), Spain
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Tablas (2)
Table 1. Characteristics of the sewage treatment plants selected in the watersheds of Galicia in 2008-2009.
Table 2. Percentage (%) of samples and average concentrations (ng/L) with detectable concentrations in the influent (I) and effluent (E) wastewater of sewage treatment plants, downstream rivers (DSSTP) and tap water in the watersheds of Galicia in 2008-2009.
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Abstract
Objective

To monitor the presence of pharmaceutical residues of 14 psychoactive drugs belonging to three therapeutic groups in the watersheds of Galicia (Spain).

Method

Five sewage treatment plants were selected in the main cities of Galicia. Thirteen psychoactive pharmaceutical compounds and one metabolite were chosen. In addition, tap water samples were taken from public places and private residences in the selected cities.

Results

In all the water samples analyzed, the highest concentrations corresponded to the group of anxiolytics. In particular, high concentrations of lorazepam were found in river and tap water samples.

Conclusions

This investigation demonstrates the presence of psychoactive pharmaceuticals in the watersheds of the autonomous region of Galicia and the conversion of metabolites to parent compounds. This work also shows the need to increase environmental monitoring of watersheds and to improve sewage and drinking water treatment processes to remove these pharmaceuticals.

Keywords:
Antidepressants
Anxiolytics
Antiepileptics
Water pollution
Tap water
Spain
Resumen
Objetivo

Monitorizar la presencia de 14 fármacos psicoactivos pertenecientes a tres grupos terapéuticos en la cuenca de Galicia.

Método

Se seleccionaron cinco estaciones depuradoras de aguas residuales en las principales ciudades de Galicia. Se escogieron trece compuestos farmacéuticos psicoactivos y un metabolito. Asimismo, se tomaron muestras de aguas del grifo de espacios públicos y privados en las ciudades seleccionadas.

Resultados

En todas las muestras de agua analizadas, las mayores concentraciones han correspondido al grupo de los ansiolíticos, y especialmente el lorazepam ha aparecido en altas concentraciones en las muestras de aguas de río y del grifo.

Conclusiones

Esta investigación demuestra la presencia de fármacos psicoactivos en las cuencas de Galicia y la reversión de los metabolitos a sus compuestos parentales. Asimismo, muestra la necesidad de incrementar la monitorización ambiental de las cuencas y de mejorar los procesos de tratamiento de las aguas residuales y potables para eliminar estos fármacos.

Palabras clave:
Antidepresivos
Ansiolíticos
Antiepilépticos
Contaminación del agua
Agua del grifo
España
Texto completo
Introduction

Pharmaceuticals are used for many beneficial purposes in modern society, but commonly constitute pollutants when encountered in the environment1. Sometimes, these compounds are not managed properly and are discharged directly into drains, while at other times they are not completely metabolized by the human body and are excreted via urine and feces in sewage treatment plants (STPs). Pharmaceuticals are not completely removed in STPs and may end up in the environment.

Pollution by pharmaceuticals is recognized as an environmental concern in many countries and has led to an extensive area of research.2 Several therapeutic groups such as anti-inflammatory and cardiovascular drugs, analgesics, antibiotics, steroids and related hormones have been detected in the aquatic environment. In Spain, one of the most widely consumed drug groups are psychoactive pharmaceuticals. The prevalence of the total consumption of tranquilizers and relaxants was 17.4% (10.2% men and 17.5% women) in 2006.3 Several studies have shown the occurrence of this group in the river and tap waters of the Ebro Basin, Llobregat river, Region of Madrid and northwest of Spain.4–8

The occurrence of pharmaceuticals in the environment leads to various unanswered questions with regard to their biological potency in flora, fauna, and humans.2 Very few data are available on the presence of pharmaceuticals in point-of-use drinking waters, partly due to the belief that modern treatment processes will remove pharmaceuticals from potable supplies. Although the risks associated with exposure to drugs are probably most significant with regard to the natural environment, the public's concern is understandably more focused on human exposure.9

The aim of this study was to monitor the presence of 14 psychoactive pharmaceutical residues belonging to three therapeutic groups in Galicia's watersheds.

Method

The autonomous region of Galicia has a total area of 29,574.38 km2 and an estimated population of 2,796,089 inhabitants [5.98% of the population of Spain, database of the National Institute of Statistics (INEbase) 2009].

Five STPs were selected, one for each of the five main cities in Galicia: A Coruña, Ourense, Pontevedra, Santiago de Compostela and Vigo. For confidentiality reasons, the citation order of the cities does not reflect the numeration of the STPs (table 1).

Table 1.

Characteristics of the sewage treatment plants selected in the watersheds of Galicia in 2008-2009.

STP code  Basin  Population equivalent  Receiving water  Treatment
        Water  Slugde 
STP1  Galicia-Coast  9.407  Sar  BAS+TT (NP+C) 
STP2  Galicia-Coast  358.257  Coast of A Coruña  BAS+TT (UV)  d+
STP3  Galicia-Coast  111.240  Ría de Pontevedra  PQ+BAS+TT (UV)  bf 
STP4  Galicia-Coast  8.234  Ría de Vigo  BAS+TT (UV) 
STP5  Miño-Sil  295.790  Miño  BAS+TT (NP)  d+dt 

STP: sewage treatment plants; BAS: biologic-activated sludge; bf: belt filter-drying; d: anaerobic digestion; PQ: physical-chemical processes; s: spin-drying; td: thermal drying; TT: tertiary treatment (UV: UV disinfection; NP: nitrogen and phosphorus removal; N: nitrogen removal; C: chlorination).

STP1 and STP5 discharge into surface waters of the basins of Galicia-Coast and Miño-Sil respectively, and the remainder (STP2, STP3 and STP4) discharge directly into the sea. The sampling stations were carefully selected in order to produce consistent and representative results for the final interpretation of data. Pharmaceuticals were analyzed in the influent and effluent water from all STPs and also 50 meters downstream of the emission points of STP1 (DSSTP1) and STP5 (DSSTP5). Thirty-six grab samples were collected in three campaigns: August 2008, January 2009 and June 2009. One sample for each campaign was taken from each sample point. Seventy-five tap water samples were also taken from public places and private residences of the cities selected in the same campaigns as the wastewater and river water samples. Five samples for each campaign were taken in each city.

Thirteen pharmaceuticals and one metabolite were chosen because of their potential toxicity and persistence in the environment. The pharmaceuticals analyzed are used as medications for the central nervous system and belong to three of the most frequently prescribed therapeutic groups: antidepressants, anxiolytics and antiepileptics. The method described in the literature and used by Gros et al.5 was chosen for sample extraction and instrumental analysis.

Results

Of the 14 psychoactive pharmaceuticals analyzed, 12 were detected in the wastewater samples of the STPs studied. However, in some STP samples the concentrations were below the limit of quantification.

The percentage of samples and average values of detectable concentrations in the influent and effluent samples are shown in table 2. Among 15 influent samples, venlafaxine was detected in 43%, with an average concentration of 401ng/L. Lorazepam was found in 87% of influent samples with concentrations of 10,598ng/L. Among 15 effluent samples, venlafaxine and lorazepam were detected in 67%. The average concentrations detected of venlafaxine and lorazepam were 317ng/L and 689ng/L, respectively.

Table 2.

Percentage (%) of samples and average concentrations (ng/L) with detectable concentrations in the influent (I) and effluent (E) wastewater of sewage treatment plants, downstream rivers (DSSTP) and tap water in the watersheds of Galicia in 2008-2009.

  I (%)  Average (ng/L)  E (%)  Average (ng/L)  DSSTP (%)  Average (ng/L)  Tap water (%)  Average (ng/L) 
Antidepressants
Amitriptiline  15  20  24  15  27  22  75 
Citalopram  15  33  114  15  73  149  33  10  75 
Clomipramine  15  15  75  27 
Fluoxetine  15  16  15  60  28  75 
Nortriptiline  15  15  13  11  75 
Sertraline  15  13  113  15  27  33  75 
Venlafaxine  15  47  401  15  67  317  50  67  75  44 
Antiepileptics
Carbamazepine  15  30  73  15  40  181  33  63  75 
Anxiolytics
α-Alprazolam  15  13  20  15  75 
Alprazolam  15  20  27  15  20  17  17  17  75  11 
Lorazepam  15  87  10598  15  67  689  50  167  75  562 
Nordiazepam  15  13  16  15  40  17  75 
Oxazepam  15  47  83  15  67  84  75 
Tetrazepam  15  40  92  15  53  64  75 

I: percentage of samples with detectable concentrations in influent wastewater; E: percentage of samples with detectable concentrations in effluent wastewater; DSSTP: percentage of samples with detectable concentrations 50 meters downstream of sewage treatment plants.

Most of the pharmaceuticals studied showed elevated concentrations in effluents and in some samples the concentrations found in the effluents were higher than those detected in the influents.

The percentage of samples with detectable concentrations of DSSTP1 and DSSTP5 reached 50% for venlafaxine and lorazepam (table 2). The average concentration of lorazepam was 168ng/L while that of venlafaxine was 67ng/L.

Among 75 tap water samples, lorazepam was found in 3%, with an average concentration of 562ng/L (table 2). Venlafaxine was found in 1% of samples at concentrations of 44ng/L.

Discussion

In all the water samples analyzed, the highest concentrations corresponded to the group of anxiolytics. In particular, lorazepam was found in high concentrations in the river and tap water samples.

The average concentration of venlafaxine detected in effluent samples was similar to that reported in other works.7,11 However, lorazepam was found in higher concentrations than in other studies. Coetsier et al.12 reported lorazepam levels of up to 200ng/L in treated sewage. In river waters, the concentration of lorazepam was higher than that reported in the literature (40ng/L). An important aspect to highlight is the deconjugation phenomenon that may occur in STPs. In some samples, the increase in pharmaceuticals in effluents was demonstrated to occur due to conversion of glucuronides and other conjugated metabolites to the parent compound by enzymatic processes taking place in the treatment plant.10

The presence of lorazepam in drinking and tap waters has not been studied in other works. The high concentrations detected in some tap water samples probably indicate that lorazepam is not eliminated by advanced drinking water treatments. In some cases, anxiolytics are subject to illicit use by the population because of their properties13 and are also common in veterinary treatments.10 Benzodiazepines are also used in stockbreeding, an important sector of the Galician economy, and therefore this source should also be considered.

Several studies have shown that the likelihood of acute effects of such low pharmaceutical concentrations in drinking water is very low.7,9 However, little is known about the possible long-term effects of continuous exposure to low concentrations of these pharmaceuticals. Some authors suggest that although the consequences in healthy adults would be negligible, in the young or elderly these effects might be more pronounced due to reduced ability to remove toxic compounds from their bodies. In addition, in particular conditions such as allergies to certain compounds or vulnerable life stages such as pregnancy the possible effects could be more important.9,14,15 However, these affirmations do not constitute proof because there are insufficient studies in tap water exposure.

The results obtained in this study are representative of the watersheds of the autonomous region of Galicia but may not be extrapolable to river and tap water from other areas. Another limitation are the point measurements. A continuous monitoring system would have been desirable to detect these compounds in higher concentrations. Finally, the design of this investigation did not allow assessment of potential risks to public health.

To conclude, this study demonstrates the presence of psychoactive pharmaceuticals in the watersheds of the autonomous region of Galicia and shows conversion of metabolites to parent compounds. This work also highlights the need to increase environmental monitoring of watersheds and to improve sewage and drinking water treatment processes to remove these pharmaceuticals.

What is known on this topic

Previous studies have focused on the detection of some pharmaceutical groups in the environment. However there are few studies on the presence of these compounds in tap water and their possible effects on public health. Therefore, studies are required not only to determine the presence of pharmaceutical residues in tap water, but also to identify their possible effects on human health.

What does this study add to the literature?

This study demonstrates the presence of psychoactive pharmaceuticals in natural and tap waters of the autonomous region of Galicia and shows conversion of metabolites to parent compounds. This work also highlights the need to increase environmental monitoring of watersheds and to improve of sewage and drinking water treatment processes to remove these pharmaceuticals.

Authors’ contributions

This research was co-directed by Y. Valcárcel and M. Catalá and was performed by S. Esteban. The sampling design, sampling and analysis of the pharmaceuticals were performed by the Laboratory of Analysis and Environmental Quality (CIS) under the direction of M. González Castromil. All the authors contributed to drafting the manuscript and have approved the final document.

Funding

None.

Conflict of interest

None.

References
[1]
B. Halling-Sorensen, N.S. Nors, P.F. Lanzky, et al.
Occurrence, fate and effects of pharmaceutical substances in the environment: a review.
Chemosphere, 36 (1998), pp. 357-393
[2]
D. Fatta-Kassinos, S. Meric, A. Nikolaou.
Pharmaceutical residues in environmental waters and wastewater: current state of knowledge and future research.
Anal Bioanal Chem, 399 (2011), pp. 251-275
[3]
P. Carrasco, P. Astasio, P. Ortega, et al.
Factors related to psychotropic drugs consumption among the Spanish adult population. Data from the Spanish National Health Surveys for 1993, 1995 and 1997.
Med Clin (Barc), 116 (2001), pp. 324-329
[4]
M. Carballa, F. Omil, J.M. Lema.
Comparison of predicted and measured concentrations of selected pharmaceuticals, fragrances and hormones in Spanish sewage.
Chemosphere, 72 (2008), pp. 1118-1123
[5]
M. Gros, M. Petrovic, D. Barcelo.
Wastewater treatment plants as a pathway for aquatic contamination by pharmaceuticals in the Ebro river basin (northeast Spain).
Environ Toxicol Chem, 26 (2007), pp. 1553-1562
[6]
M. Huerta-Fontela, M.T. Galcerán, J. Martín-Alonso, et al.
Occurrence of psychoactive stimulatory drugs in wastewaters in north-eastern Spain.
Sci Total Environ, 397 (2008), pp. 31-40
[7]
Y. Valcárcel, S.G. Alonso, J.L. Rodríguez-Gil, et al.
Analysis of the presence of cardiovascular and analgesic/anti-inflammatory/antipyretic pharmaceuticals in river- and drinking-water of the Madrid Region in Spain.
Chemosphere, 82 (2011), pp. 1062-1071
[8]
Y. Valcárcel, S. González-Alonso, J. Rodríguez Gil, et al.
Detection of pharmaceutically active compounds in the rivers and tap water of the Madrid Region (Spain) and potential ecotoxicological risk.
Chemosphere, 8 (2011), pp. 1336-1348
[9]
O.A. Jones, J.N. Lester, N. Voulvoulis.
Pharmaceuticals: a threat to drinking water.
Trends Biotechnol, 23 (2005), pp. 163-167
[10]
V. Calisto, V.I. Esteves.
Psychiatric pharmaceuticals in the environment.
Chemosphere, 77 (2009), pp. 1257-1274
[11]
M. Martínez-Bueno, M. Dolores Hernando, S. Herrera, et al.
Pilot survey of chemical contaminants from industrial and human activities in river waters of Spain.
Intern J Environ Anal Chem, 90 (2010), pp. 321-343
[12]
C.M. Coetsier, S. Spinelli, L. Lin, et al.
Discharge of pharmaceutical products (PPs) through a conventional biological sewage treatment plant: MECs vs PECs.
Environ Int, 35 (2009), pp. 787-792
[13]
C.G. Daughton.
Illicit drugs: contaminants in the environment and utility in forensic epidemiology.
Rev Environ Contam Toxicol, 210 (2011), pp. 59-110
[14]
A.C. Collier.
Pharmaceutical contaminants in potable water: potential concerns for pregnant women and children.
EcoHealth, 4 (2007), pp. 164-171
[15]
González AS, Valcárcel Y, Montero JC, et al. Nicotine occurrence in bottled mineral water: analysis of 10 brands of water in Spain. Sci Total Environ. 2011;416:527-31.
Copyright © 2011. SESPAS
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