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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">PMS symptoms could be indicated feeling excessive&#44; irritable&#44; late in the breasts&#44; increased appetite&#44; or vomiting&#44; acne breakouts&#44; back pain&#44; and fainting&#46; With some of these symptoms&#44; it can be ascertained that PMS tends to reduce the productivity of adolescents in general&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">1</span></a> The impact of PMS includes reduced performance in the workplace&#46; Depression can be subject to feelings of suicidal thoughts&#44; even the desire to commit violence on oneself or others&#46; Hence&#44; there is also a condition where a person wakes up feeling angry&#44; anxious&#44; and&#47;or sad in the morning&#46; It is not uncommon for depression&#44; anger&#44; aggressive or excessive nature and has consequences for the person or the surrounding environment&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In America&#44; the incidence reaches 70&#8211;90&#37;&#44; Sweden around 61&#8211;85&#37;&#44; Morocco 51&#46;2&#37;&#44; Australia 85&#44; Japan reaches 95&#37;&#44; and Taiwan 73&#37; who experience PMS&#46; Knight&#44; in 2004 announced that research at least 50&#37; of women experience PMS&#46; Likewise&#44; symptoms of PMS have been reported to affect as many as 90&#37; of women of reproductive age in the United States&#46; The determination of a survey of 242 students at Jimma University&#44; Ethiopia&#44; with an average age of 20 years of respondents who found 99&#46;6&#37; of participants experiencing PMS&#46; It was reported that 27&#37; of the participants experienced <span class="elsevierStyleItalic">premenstrual dysphoric disorder</span>&#44; 14&#37; often missed classes&#44; and 15&#37; could not take exams because of their PMS&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">In Iran&#44; it was found that around 98&#46;2&#37; of students experienced PMS with mild or moderate degrees&#59; the overall evidence suggests that PMS is a common form of disorder experienced by teenagers in Asia&#46; In Sri Lanka&#44; PMS affects about 65&#46;7&#37; of young women &#40;<span class="elsevierStyleItalic">American College of Obstetricians and Gynecologists</span>&#41;<span class="elsevierStyleItalic">&#46;</span> In Indonesia&#44; the incidence rate is around 70&#8211;90&#37; &#40;Ernawati&#44; 2012&#41;&#46; One of the causes of PMS is the factor of women&#39;s nutritional status&#46; Other causes are due to hormonal imbalance&#44; psychological factors&#44; social problems&#44; and serotonin dysfunction&#46; The nutritional status of adolescent girls greatly affects the occurrence of menarche &#40;first menstruation&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">PMS that occurs in adolescents can reduce productivity in carrying out daily activities&#46; PMS symptoms in adolescents can affect their performance at A study conducted in 2011 with hsCRP levels &#60;1&#46;70&#37; of women&#44; as many as seven respondents experienced mild PMS&#46; Meanwhile&#44; for those with hs-CRP levels &#62;1&#44; 70&#37; of respondents with severe PMS had a body mass index of eight waist circumference&#44; 70&#37; had severe PMS&#46; The hs-CRP level is five times &#40;IK&#58; 2&#44;155&#8211;204&#44;614&#41; is at risk for PMS&#46; While the waist circumference is five times &#40;CI&#58; 1&#44;039&#8211;28&#44;533&#41;&#44; there is a risk of STDs&#46; Based on the previous&#44; this study aims to respondents who had a normal BMI of 30&#37; had severe PMS&#46; Meanwhile&#44; of the 15 respondents with obese BMI&#44; 70&#37; had severe PMS&#46; Based on the waist circumference size of 6 respondents who had normal waist circumference&#44; 30&#37; had severe PMS&#46; Meanwhile&#44; of the 14 respondents with obesity&#44; determine the effect of the hormone estrogen on adolescent girls who experience <span class="elsevierStyleItalic">premenstrual syndrome&#46;</span><a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">5</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">This study used a cross-sectional where the Researcher demand to see the effect of estrogen levels on adolescent girls who experience premenstrual syndrome&#46; The research location was carried out at the Ummul Mukminin Islamic Boarding School in Makassar&#46; The research period was accomplished in March&#8211;May 2018&#46; The population was all students at Darul Arqam Islamic Boarding School who experienced PMS&#46; Therefore&#44; the sample was part of the population to be studied or a part of the characteristics possessed by the population&#44; namely young girls who experienced PMS at Darul Arqam Islamic Boarding School Makassar&#46; The sample used is the formula of Stephen Issac and William B&#46; Michael&#46; The number of samples is determined based on Isaac and Michael&#39;s table with a significance level of 95&#37; and based on the error rate of 1&#37;&#44; 5&#37;&#44; and 10&#37;&#46; The samples obtained with PMS were 25 people&#44; and 25 people did not experience PMS&#44; considering the inclusion and exclusion criteria&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Data collection was carried out with research preparation&#59; &#40;1&#41; Preparation of menstrual cycle daily notes &#40;LCH&#41; &#40;2&#41; Arrangement of research permits for the principal of Madrasah Aliyah Pesantren Darul Arqam&#44; research permit from the health research ethics committee&#44; Hasanuddin University&#44; RSPTN UH&#44; RSP dr&#46; Wahidin Sudirohusoda &#40;Number&#58; 72&#47;H4-8&#46;4&#46;5&#46;3&#46;1&#47;PP 36-KOMETIK&#47;2018&#41;&#46; Initial data collection was conducted to determine the population size and minimum sample size required in the study&#46; This study&#44; began with sample grouping according to inclusion and exclusion criteria&#46; Then take blood samples&#44; then was collected&#44; processed&#44; and analyzed&#46; Furthermore&#44; the conclusion is drawn according to the research results&#46; After the data was collected&#44; the data was managed with the help of Excel and SPSS version 21 computer programs&#46; Analysis of the effect of the estrogen hormone using the ELISA kit on adolescent girls who experienced PMS was then performed data management using univariable&#44; and bivariable analyzed using the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Result</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Univariate analysis</span><p id="par0035" class="elsevierStylePara elsevierViewall">From <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#44; it clearly shows that the 25 respondents with PMS the most age group was 17 years&#44; namely 19 people &#40;76&#37;&#41;&#44; the lowest was 15 years &#40;4&#37;&#41;&#44; while of the 25 respondents who are not PMS the most age group was 23 people &#40;92&#37;&#41;&#46; at 15 and 16 years&#44; namely 1 person &#40;4&#37;&#41;&#44; the most menarche age was 11 years old as many as 15 people &#40;60&#37;&#41; and the lowest was 13 years old as many as 2 people &#40;8&#37;&#41;&#44; while respondents who were not PMS had the most menarche age&#44; namely 13 14 people &#40;56&#37;&#41; and the lowest at 12 and 15 years were 2 people &#40;8&#37;&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">On the body mass index of respondents who have the most PMS in overweight BMI&#44; namely 14 people &#40;56&#37;&#41; and the lowest is 1 person &#40;4&#37;&#41; while those who were not PMS mostly normal&#44; 14 people &#40;56&#37;&#41; and none are obese&#44; 0 people &#40;0&#37;&#41;&#46; For respondents whose length cycle was carried out on PMS&#44; respondents were 28 days as many as 8 people &#40;32&#37;&#41; and the day cycle was 2 people &#40;8&#37;&#41;&#46; The respondent who were not PMS with a cycle of 29 days were 7 people &#40;28&#37;&#41; while in the 31-day cycle there were 2 people &#40;8&#37;&#41;&#46; For volunteers who came from STD respondents&#44; there were at most 3&#8211;7 days as many as 14 people &#40;56&#37;&#41; and &#62;7 days as many as 11 people &#40;44&#37;&#41;&#44; for those who did not have PMS consisting of menstruation &#62;7 days as many as 15 people &#40;60&#37;&#41; and 10 respondents with a menstrual duration of 3&#8211;7 days &#40;40&#37;&#41;&#46; For PMS respondents with a blood count of 3&#8211;5 sanitary napkins per day&#44; 23 people &#40;92&#37;&#41; and 0 blood counts &#60; 3 sanitary napkins or none had a blood count &#60; 3 days&#44; while 23 people without PMS &#40;92&#37;&#41; who have a blood count of 3&#8211;5 pads per day and 0 &#40;0&#37;&#41; people who have a menstrual blood count &#60;3 sanitary napkins&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">From <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#44; it was illustrated that 25 respondents based on the symptom group the most experienced affective symptoms were 17 people &#40;68&#37;&#41; difficult to concentrate&#44; while the most experienced somatic symptoms were the waist pain as many as 14 people &#40;56&#46;0&#37;&#41; and from affective symptoms&#44; namely decreased appetite&#44; none of the respondents experienced these symptoms and for somatic symptoms 1 respondent &#40;4&#46;0&#37;&#41; experienced symptoms of weight gain&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Bivariate analysis</span><p id="par0050" class="elsevierStylePara elsevierViewall">From <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#44; it is found that of the 50 respondents&#44; 25 who are PMS and 25 who are not PMS&#44; the average value of respondents who have estrogen levels is that the respondents with PMS the average estrogen value is 148&#46;32<span class="elsevierStyleHsp" style=""></span>pg&#47;ml higher than those who are not PMS amounting to 98&#46;00<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#46; After checking the concentration of estrogen and the data processed using Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span>&#44; it was found that Ha was accepted and Ho was rejected&#44; where the mean value of PMS adolescents was higher than those without PMS with <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;000<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#945;</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46; This means that there is a significant difference in the increase in estrogen for people with PMS and those who do not have PMS&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">From <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#44; it is established that the average value of estrogen with mild PMS is 130&#46;72<span class="elsevierStyleHsp" style=""></span>pg&#47;ml and those who experience severe PMS&#44; the average value of estrogen is 162&#46;14<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;000<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#945;</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#44; this means that there is a significant difference in the mean value between no PMS&#44; mild PMS&#44; and severe PMS&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Discussion</span><p id="par0060" class="elsevierStylePara elsevierViewall">The results of this study illustrate that there are differences in age levels&#46; The PMS group who became respondents were from the age of 15&#44; 16 years and 17 years&#44; as well as the group that was not PMS&#46; In the 17 year age group the most experienced PMS was 19 people &#40;76&#46;0&#37;&#41;&#46; Adolescence is a period of transitional development between childhood and adulthood which includes changes in the biological&#44; cognitive&#44; socio-emotional&#44; adolescent age range 12&#8211;21 years&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Referring to the results of the study&#44; 15 girls who experienced PMS experienced menarche at the age of 13 years &#40;15&#37;&#41; where menarche was a sign of sexual organ maturity which was marked by the arrival of their first menstruation&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">6</span></a> From the results of research on the number of adolescent girls who experience PMS with overweight BMI as many as 14 people &#40;56&#46;0&#37;&#41; the more distribution of fat in the body causes fat levels which are a source of estrogen production which is the cause of PMS&#46; The length of the menstrual cycle was 28 days in young women who experienced PMS as many as 8 people &#40;32&#37;&#41;&#44; the length of menstruation was 3&#8211;7 days for 14 people with PMS while the characteristics of the number of menstrual blood 3&#8211;5 pads&#47;day were 23 people &#40;92&#37;&#41; and the length of menstruation for 8&#8211;10 days among young women with PMS was 15 people &#40;60&#37;&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Based on the results of research conducted on young women experiencing PMS as many as 17 people &#40;68&#37;&#41; apperceived difficulty concentrating&#44; this was an effective symptom&#44; while the most somatic symptoms were a pain in the waist as many as 14 people &#40;56&#37;&#41;&#46; <span class="elsevierStyleItalic">Premenstrual syndrome</span> &#40;PMS&#41; is a complaint that usually starts one week to several days before the onset of menstruation&#44; and disappears after menstruation comes&#44; although sometimes it continues until menstruation stops&#46; Premenstrual syndrome &#40;PMS&#41; is a complaint that feels like&#59; anxiety&#44; depression&#44; unstable mood&#44; fatigue&#44; weight gain&#44; swelling&#44; breast pain&#44; spasms&#44; and back pain that can occur about 7&#8211;10 days before the onset of menstruation and peaks at the time menstruation occurs&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">3</span></a> PMS is a collection of physical&#44; psychological&#44; and emotional symptoms associated with a woman&#39;s menstrual cycle&#46; About 80&#8211;95&#37; of women at childbirth experience premenstrual symptoms that can interfere with several aspects of their lives&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">7</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">The results of the study of 50 respondents&#44; where 25 people with an average value of 148&#46;32<span class="elsevierStyleHsp" style=""></span>pg&#47;ml who experienced PMS and 25 people with an average value of 98&#46;00<span class="elsevierStyleHsp" style=""></span>pg&#47;ml who did not experience PMS&#44; after examining their estrogen hormone levels and the data processed by Mann-Whitney U&#44; it is found that the mean value of PMS adolescents is greater than those who are not PMS with a value of <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;000<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#945;</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46; This means that there is a significant difference in the average level of estrogen in adolescent girls who experience PMS and do not experience PMS&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">In women who experience premenstrual syndrome&#44; there is an imbalance of the hormones estrogen and progesterone&#44; where estrogen levels increase&#44; resulting in a decrease<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">8</span></a> serotonin synthesis which affects mood and behavior changes&#46; This decrease in serotonin synthesis is emotional symptoms that affect his appetite&#46; The influence of appetite will have an impact on their eating behavior&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">2</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Excess estrogen can increase prolactin&#44; which can cause breast pain and increase aldosterone which contributes to increased sodium levels and water retention which results in breast tension&#46; In one study 63&#37; of women had a 25&#37; increase in the number of inflammatory or acne lesions associated with the premenstrual disease&#46; Hormonal changes can cause the sebaceous glands to produce more sebum&#46; This oily substance can clog pores and cause acne lesions&#46; Women who experience PMS have high levels of leptin during the menstrual cycle&#46; They tend to eat foods that are high in fat&#44; high in sugar&#44; and low in protein&#46; Changes in neurotransmitters and their interactions with hormones can lead to overweight and obesity&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">9</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Changes in levels of the hormone estrogen affect the centrally acting neurotransmitter&#44; serotonin&#46; Lack of serotonergic neurotransmission results in depressed mood&#44; irritability&#44; aggression&#44; poor implant control&#46; An increase in the ratio of estrogen and progesterone is associated with a decrease in endorphins in the brain&#44; causing changes in mood&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">8</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">The corpus luteum will regress if pregnancy does not occur&#46; This will result in a decrease in progesterone levels and result in lysosomal membrane labilization so that it is easily split and releases the enzyme A2 phospholipase&#46; Phospholipase A2 will hydrolyze the phospholipid compounds present in the endometrial cell membrane and produce arachidonic acid&#46; Arachidonic acid together with endometrial damage will stimulate the arachidonic acid cascade and produce prostaglandins PGE2 and PGF2 alpha&#46; Women with primary <span class="elsevierStyleItalic">dysmenorrhoea</span> have elevated blood levels of PGE and PGF2 alpha&#44; which stimulate the myometrium&#46; As a result&#44; there is an increase in uterine contractions and dysrhythmias&#44; resulting in decreased blood flow to the uterus and resulting in ischemia&#46; Prostaglandins cause sensitization&#44; further decreasing the pain threshold at the <span class="elsevierStyleItalic">pelvic afferent</span> nerve endings against physical and chemical stimuli&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">10</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">The theory suggests that the cause of PMS is the result of excess estrogen&#44; pyridoxine deficiency&#44; and changes in glucose metabolism and electrolyte imbalance&#46; However&#44; recent research suggests that PMS is greatly affected by sex hormones&#44; including metabolites and their interactions with the neurotransmitter and neurohormonal systems such as serotonin&#44; GABA&#44; cholecystokinin&#44; and aldosterone renin-angiotensin&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">11</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">According to the ACOG&#44; at least 85&#37; of women experience PMS&#46; They experience PMS symptoms ranging from mild&#44; which does not require treatment to more severe than PMS called PMDD &#40;<span class="elsevierStyleItalic">Premenstrual Dysphoric Disorder</span>&#41;&#46; PMDD is a condition accompanied by severe emotional and physical problems related to the sexual cycle&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">12</span></a> PMDD is a severe form of PMS and affects about 5&#37; of menstruating women&#46; PMDD is a form of the disorder that is more severe than PMS which affects about 3&#8211;8&#37; of reproductive women&#46; PMDD symptoms may differ from cloud to cloud&#46; In the measurement of estrogen and progesterone&#44; there was no difference between PMDD and PMS&#46; The fluctuation of circulating estrogens and progesterone can cause effects on neurotransmitters in the brain&#44; especially the serotonergic&#44; noradrenergic&#44; and dopaminergic pathways&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">8</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">These premenstrual symptoms cause them to feel exactly sad&#44; <span class="elsevierStyleItalic">irritable</span>&#44; or depressed&#46; The women even feel <span class="elsevierStyleItalic">out of control</span>&#44; and this affects their relationships with partners&#44; colleagues&#44; children&#44; and friends&#46; This is what is called <span class="elsevierStyleItalic">Premenstrual Dysphoric Disorder &#40;PMDD&#41;&#46;</span> PMDD is a condition accompanied by serious emotional and physical problems related to the menstrual cycle&#46; The syndrome occurs after the middle of the menstrual cycle and ends when menstruation begins&#46; PMDD and PMS both have the same symptoms including depression&#44; anxiety&#44; tension&#44; irritability&#44; and irritability&#44; which differ in the degree of severity&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">13</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conclusion</span><p id="par0115" class="elsevierStylePara elsevierViewall">Adolescence is a period of transition from childhood to adulthood&#46; In this transition period&#44; there are so many changes&#44; both physically and psychologically for children&#46; Menstruation is one of the signs that a girl has gone through puberty&#46; Menstruation is a regular discharge of blood that comes from the uterine wall out into the vagina&#46; This indicates that the female reproductive organs have worked&#46; Menstruation is influenced by the interaction of hormones released by the hypothalamus&#44; anterior pituitary&#44; and ovaries&#46; Cycles in women have different cycle variations&#46; During menstruation&#44; women have various kinds of symptoms and menstruation during menstruation&#46; Discomfort or symptoms that can occur can be felt physically and psychologically&#46; Starting from complaints of abdominal pain&#44; breast pain&#44; dizziness&#44; nausea&#44; insomnia&#44; irritability&#47;irritability&#46; This symptom is called premenstrual syndrome &#40;PMS&#41;&#44; where these symptoms are mild to severe and require medical treatment&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">PMS has a huge impact on student activities and achievement&#46; From research conducted at the Darul Arqam Islamic Boarding School&#44; high-fat levels in the body of young women are a source of estrogen production which causes PMS to be more common in overweight women&#46; During adolescent girls experiencing PMS on average the most symptoms&#44; they will feel are difficulty concentrating&#44; and the most frequent somatic symptom is a pain in the hip area&#46; Estrogen levels in young women who experience PMS are 148&#46;32 and not PMS 98&#46;00<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#46; PMS occurs due to a hormonal imbalance between estrogen and progesterone&#44; where levels of the hormone estrogen increase&#44; resulting in a decrease in serotonin synthesis which affects mood and behavior&#46; Excess estrogen can increase prolactin which can cause breast pain and increase aldosterone which plays a role in increasing sodium levels and air retention which causes tension in the breasts&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conflicts of interest</span><p id="par0125" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">PMS symptoms can include anxiety&#44; quick temper&#44; excessive strain on the breasts&#44; increased or decreased appetite&#44; nausea&#44; vomiting&#44; acne&#44; low back pain&#44; to faint&#46; This study aimed to determine the effect of estrogen hormone in Adolescent Girls who experienced premenstrual syndrome at Darul Arqam&#44; Makassar&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The research design used the cross-sectional approach using the purposive sampling technique to get the samples of female teenagers who had PMS and another 25 samples of female teenagers who did not have PMS&#46; The respondent who had experienced PMS filled in the daily diary sheets&#44; did the blood taking of five ccs and underwent the examination of estrogen level using ELISA method&#46; The study was conducted for three months&#44; and the data were analyzed using the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Result</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The research result indicated that the mean value of estrogen hormone in adolescent girls who experienced PMS was 148&#46;32<span class="elsevierStyleHsp" style=""></span>pg&#47;ml higher than the female teenagers who did not experience PMS of 98&#46;00<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#46; The analysis result indicated that Ha was accepted&#44; and H0 was rejected since the mean value in PMS teenagers was higher compared to the non-PMS teenagers with the value of <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;000<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#945;</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46; This result showed a significant effect of estrogen hormone in adolescent girls who experienced PMS compared to those who did not experience PMS&#46; The adolescent girls who experience mild PMS with the mean value of estrogen hormone were 130&#46;73<span class="elsevierStyleHsp" style=""></span>pg&#47;dl&#44; while those who experienced severe PMS of 162&#46;14<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">It was found that the value of <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;000<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#945;</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#44; which indicated that there was a significant effect of the levels of estrogen hormone between the non-PMS&#44; mild PMS&#44; and severe PMS<span class="elsevierStyleItalic">&#46;</span></p></span>"
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                  \t\t\t\t" scope="col">The characteristics of respondents&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="4" align="center" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>15 year&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>12 year&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Obesity&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Menstrual cycle length</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>28 days&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">24&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>29 days&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">24&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>30 days&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">22&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>31 days&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>32 days&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3&#8211;7 days&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">The amount of menstrual blood loss</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62;5&#215;&#47;day&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8&#46;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  """
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Weight gain&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Frequently want to eat something &#40;food&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Decreased appetite&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Feeling useless&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sad and desperate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anxious and uptight&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Feeling uneasy and restless&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">84&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sad and crying&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Easily offended&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>A lot of anger and annoyance&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lazy to do something&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Difficult to concentrate&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Easily tired&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Get plenty of sleep&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>I feel like shouting&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Being annoyed I wanted to slam things around me&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">100&#46;0&nbsp;\t\t\t\t\t\t\n
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                  """
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                  <table border="0" frame="\n
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                  \t\t\t\t" scope="col">PMS youth group&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mean&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Std&#46; deviation&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">PMS&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">148&#46;32&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">19&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Non-PMS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">7&#46;39&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t" scope="col">Adolescent group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Std&#46; deviation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mild PMS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">130&#46;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Heavy PMS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">162&#46;14&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">12&#46;41&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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