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pocos estudios han evaluado los estilos de vida de la poblaci&#243;n que realiza pr&#225;cticas de detecci&#243;n precoz de c&#225;ncer&#44; especialmente del colorrectal y del de pr&#243;stata&#44; y existe escasa informaci&#243;n sobre la relaci&#243;n entre diferentes pruebas&#46; Esta informaci&#243;n puede ser muy &#250;til en el contexto actual de despliegue y evaluaci&#243;n de los programas de cribado&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">El objetivo de este estudio es estimar la prevalencia de pr&#225;cticas de cribado&#44; la relaci&#243;n entre ellas y evaluar su asociaci&#243;n con los estilos de vida en una muestra de controles poblacionales del estudio multi-caso control &#40;MCC-Spain&#41;&#44; un estudio multic&#233;ntrico sobre factores ambientales y c&#225;ncer&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">M&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Poblaci&#243;n de estudio</span><p id="par0040" class="elsevierStylePara elsevierViewall">El estudio MCC-Spain recoge casos incidentes de c&#225;ncer de mama&#44; colon-recto&#44; est&#243;mago-es&#243;fago&#44; pr&#243;stata y leucemia linfoc&#237;tica cr&#243;nica&#44; y controles poblacionales en las &#225;reas de influencia de 22 hospitales de 11 provincias espa&#241;olas&#46; Para el presente an&#225;lisis se ha obtenido informaci&#243;n de los 1505 controles poblacionales de las regiones disponibles&#44; reclutados desde el comienzo del estudio en 2008 hasta febrero de 2010&#46; Estos controles fueron seleccionados de forma aleatoria simple a partir de las listas de poblaci&#243;n asignada a los m&#233;dicos de familia de los centros de atenci&#243;n primaria escogidos del &#225;rea de referencia de los hospitales participantes&#44; seg&#250;n la distribuci&#243;n esperada de los casos en funci&#243;n del sexo y la edad&#44; considerando las tasas de incidencia de los tumores del estudio&#46; Todos los controles ten&#237;an entre 20 y 85 a&#241;os de edad&#44; resid&#237;an en el &#225;rea de influencia del hospital como m&#237;nimo desde 6 meses antes de la selecci&#243;n&#44; no ten&#237;an impedimentos para la comunicaci&#243;n y firmaron el consentimiento informado&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Se reclutaron controles poblacionales para el 91&#37; de los casos&#46; Este porcentaje no contempla las personas contactadas por cada control &#40;promedio&#58; 2&#41;&#46; Si se consideran todas las personas con las que se estableci&#243; comunicaci&#243;n&#44; la tasa de participaci&#243;n de los controles de nuestra poblaci&#243;n de estudio fue del 53&#37;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Variables de estudio</span><p id="par0050" class="elsevierStylePara elsevierViewall">Los datos recogidos por MCC-Spain&#44; de los que se seleccionaron las variables de inter&#233;s&#44; se obtuvieron mediante un cuestionario estructurado e informatizado&#44; administrado por entrevistadores entrenados mediante una entrevista personal de unos 90 minutos&#46; &#201;ste reuni&#243; informaci&#243;n sobre factores sociodemogr&#225;ficos&#44; estilos de vida&#44; dieta&#44; historia personal&#44; familiar y m&#233;dica&#46; El cuestionario inclu&#237;a preguntas sobre las pr&#225;cticas de cribado en los &#250;ltimos 5 a&#241;os&#44; especificando haberlas realizado sin estar enfermo ni tener s&#237;ntomas&#44; y concretamente sobre mamograf&#237;a &#40;mujeres&#41;&#44; citolog&#237;a cervicovaginal &#40;mujeres&#41;&#44; prueba de SOH&#44; colonoscopia&#47;sigmoidoscopia y PSA &#40;hombres&#41;&#46; Si la respuesta era positiva&#44; se recog&#237;a tambi&#233;n la fecha aproximada de la &#250;ltima prueba e informaci&#243;n relativa a &#233;sta&#46; Dicho cuestionario recogi&#243; tambi&#233;n informaci&#243;n sobre edad&#44; nivel de estudios&#44; ocupaci&#243;n&#44; estado civil&#44; peso y altura autonotificados &#40;obteniendo el &#237;ndice de masa corporal&#41;&#44; consumo de tabaco &#40;fumador&#44; ex fumador&#44; no fumador&#41;&#44; actividad f&#237;sica &#40;autonotificada&#44; especificando el tipo de actividad y la frecuencia semanal&#44; recodificada seg&#250;n recomendaciones semanales de las gu&#237;as de prevenci&#243;n de c&#225;ncer<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>&#41;&#44; comorbilidad &#40;enfermedades diferentes del c&#225;ncer&#41;&#44; antecedentes personales de c&#225;ncer &#40;tumores anteriores de diferente localizaci&#243;n&#41; y familiares &#40;al menos un familiar de cualquier grado&#41;&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Los participantes rellenaron adem&#225;s un cuestionario de frecuencia alimentaria autoadministrado&#44; adaptado de un cuestionario validado<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a>&#46; De &#233;ste se calcul&#243; la frecuencia del consumo de fruta y verdura &#40;recodificadas en una variable conjunta dicot&#243;mica&#41; y de alcohol&#44; por categor&#237;as de bebidas &#40;convertido a gramos de etanol&#47;d&#237;a&#44; recategorizado siguiendo las recomendaciones de consumo por sexo<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">An&#225;lisis estad&#237;stico</span><p id="par0060" class="elsevierStylePara elsevierViewall">C&#225;lculo de las frecuencias notificadas de pr&#225;cticas de cribado &#40;mamograf&#237;a&#44; citolog&#237;a&#44; pruebas de SOH y de PSA&#41; por tipo de prueba&#44; en funci&#243;n de estilos de vida y otras caracter&#237;sticas personales&#44; evaluando las diferencias con los que no realizan pruebas de cribado mediante la prueba de ji al cuadrado&#46; Las variables relevantes seg&#250;n la literatura o estad&#237;sticamente significativas &#40;p &#60; 0&#44;05&#41; se han incluido en modelos de regresi&#243;n log&#237;stica multivariada no condicional para obtener las <span class="elsevierStyleItalic">odds ratio</span> ajustadas &#40;OR<span class="elsevierStyleInf">a</span>&#41; de las variables de estudio y sus correspondientes intervalos de confianza del 95&#37; &#40;IC95&#37;&#41; en la realizaci&#243;n de la pr&#225;ctica de cribado espec&#237;fica&#44; ajustadas por edad&#44; nivel de estudios y regi&#243;n geogr&#225;fica del estudio&#46; Se ha utilizado el paquete estad&#237;stico SPSS v&#46;17&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Resultados</span><p id="par0065" class="elsevierStylePara elsevierViewall">Un 58&#37; de la poblaci&#243;n de estudio eran mujeres &#40;n &#61; 866&#41;&#44; la mediana de edad fue de 65 a&#241;os&#44; mayor en los hombres &#40;68 a&#241;os&#41; que en las mujeres &#40;62 a&#241;os&#41;&#46; &#201;stas y otras caracter&#237;sticas sociodemogr&#225;ficas&#44; de estilos de vida y pr&#225;ctica de cribado de la poblaci&#243;n analizada se muestran en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46; Un 85&#37; de los sujetos se hab&#237;a realizado alguna prueba de cribado &#40;mamograf&#237;a&#44; citolog&#237;a&#44; SOH&#44; colonoscopia&#47;sigmoidoscopia o PSA&#41; en los &#250;ltimos 5 a&#241;os&#44; porcentaje que fue de un 75&#37; en los hombres y un 93&#37; en las mujeres&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">La <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a> muestra los porcentajes de la poblaci&#243;n de estudio que declaran haber realizado pruebas de cribado en los &#250;ltimos 5 a&#241;os&#44; considerando la edad diana de cada prueba&#46; La mamograf&#237;a present&#243; una elevada prevalencia en mujeres &#40;98&#44;2&#37; en mujeres de 50-69 a&#241;os&#41;&#44; as&#237; como la citolog&#237;a &#40;94&#44;5&#37; en mujeres de 25-65 a&#241;os&#41;&#46; Aproximadamente la mitad de las mamograf&#237;as y citolog&#237;as se hab&#237;an realizado en el &#250;ltimo a&#241;o &#40;53&#44;2&#37; y 44&#44;1&#37;&#44; respectivamente&#41;&#46; La frecuencia de la prueba de SOH fue del 16&#44;2&#37; y el 11&#44;2&#37; en hombres y mujeres de 50-74 a&#241;os de edad&#44; respectivamente&#46; En las regiones en que hab&#237;an comenzado los programas de cribado poblacional la prevalencia fue superior&#46; El mayor porcentaje de estas pruebas se hab&#237;a realizado hac&#237;a m&#225;s de 3 a&#241;os&#46; Aunque no se muestran los datos por no ser la prueba de cribado de c&#225;ncer colorrectal poblacional recomendada&#44; la frecuencia declarada de colonoscopia o sigmoidoscopia en los &#250;ltimos 5 a&#241;os fue del 24&#44;9&#37; en los hombres y del 18&#44;7&#37; en las mujeres de 50 a&#241;os o m&#225;s de edad&#46; El PSA fue la prueba m&#225;s frecuente en los hombres &#40;71&#44;5&#37; en los de 50 a&#241;os o m&#225;s&#41;&#44; realizada principalmente en el &#250;ltimo a&#241;o &#40;70&#37;&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">La <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a> describe las prevalencias por tipo de prueba&#44; en funci&#243;n de los estilos de vida y otros factores&#46; En los hombres con sobrepeso se observ&#243; una mayor prevalencia del PSA frente a aquellos con normopeso o bajo peso &#40;72&#44;1&#37; y 60&#44;1&#37;&#41;&#44; y en sentido inverso en las mujeres que se hac&#237;an citolog&#237;as &#40;82&#44;3&#37; en las que ten&#237;an sobrepeso y 90&#44;8&#37; en las que no&#41;&#44; diferencias estad&#237;sticamente significativas &#40;p &#60; 0&#44;05&#41;&#46; El consumo de tabaco y la actividad f&#237;sica s&#243;lo presentaron relaci&#243;n estad&#237;sticamente significativa con la participaci&#243;n en citolog&#237;a&#59; el alcohol s&#243;lo lo hizo con la prueba de SOH en los hombres&#46; Las mamograf&#237;as y citolog&#237;as eran m&#225;s frecuentes en las mujeres que consum&#237;an tres o m&#225;s piezas de fruta y verdura al d&#237;a &#40;94&#44;6&#37; y 86&#44;1&#37;&#44; respectivamente&#41; que en las que no &#40;80&#44;8&#37; y 79&#44;6&#37;&#44; respectivamente&#44; p &#60; 0&#44;05&#41;&#46; La participaci&#243;n en las pruebas de cribado siempre fue superior entre los que presentaban comorbilidad&#44; excepto para la citolog&#237;a&#44; de forma estad&#237;sticamente significativa&#46; La prevalencia de la prueba del PSA fue mayor en los hombres con antecedentes personales de c&#225;ncer&#46; Ninguna pr&#225;ctica de cribado se asoci&#243; con los antecedentes familiares de c&#225;ncer&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">La <a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a> describe la distribuci&#243;n de la participaci&#243;n en diferentes pruebas de cribado de c&#225;ncer&#46; Se observ&#243; un porcentaje elevado de mamograf&#237;as en las mujeres que hab&#237;an realizado alguna de las otras pruebas de cribado &#40;89&#44;3&#37;&#59; IC95&#37;&#58; 87&#44;1-91&#44;5&#41;&#44; espec&#237;ficamente en las que se hab&#237;an hecho citolog&#237;as &#40;90&#44;4&#37;&#59; IC95&#37;&#58; 88&#44;3-92&#44;6&#41; y la prueba de SOH &#40;94&#44;3&#37;&#59; IC95&#37;&#58; 89&#44;4-99&#44;1&#41;&#46; La participaci&#243;n en citolog&#237;a s&#243;lo se asoci&#243; significativamente con mamograf&#237;a&#46; Entre los hombres con la prueba de SOH&#44; tambi&#233;n hab&#237;a una mayor realizaci&#243;n de la del PSA&#46; Entre los que se hab&#237;an hecho alguna colonoscopia&#47;sigmoidoscopia hab&#237;a mayores porcentajes de realizaci&#243;n de SOH que en los que no&#44; con diferencias significativas en las mujeres &#40;29&#44;5&#37; y 6&#44;2&#37;&#44; respectivamente&#41; y los hombres &#40;27&#44;8&#37; y 11&#44;2&#37;&#44; respectivamente&#41;&#46; De igual modo&#44; la proporci&#243;n de participaci&#243;n en la prueba del PSA en los &#250;ltimos 5 a&#241;os en los hombres que declararon haberse realizado otras pruebas de cribado de c&#225;ncer diferentes fue mayor que en los que no&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">La <a class="elsevierStyleCrossRef" href="#tbl0025">tabla 5</a> muestra las OR<span class="elsevierStyleInf">a</span> de realizar pruebas de cribado en funci&#243;n de los estilos de vida y la pr&#225;ctica de cribado&#46; El sobrepeso-obesidad se asoci&#243; &#250;nicamente a la realizaci&#243;n de la prueba del PSA &#40;OR<span class="elsevierStyleInf">a</span>&#58; 1&#44;88&#59; IC95&#37;&#58; 1&#44;15-3&#44;08&#41;&#46; Consumir al menos tres piezas de fruta y verdura al d&#237;a se asocia a la participaci&#243;n en mamograf&#237;as &#40;OR<span class="elsevierStyleInf">a</span>&#58; 5&#44;24&#59; IC95&#37;&#58; 1&#44;96-14&#44;07&#41;&#46; La presencia de comorbilidad present&#243; asociaci&#243;n estad&#237;sticamente significativa con la realizaci&#243;n de mamograf&#237;as en mujeres y la prueba de SOH en hombres&#46; Los antecedentes personales y familiares de c&#225;ncer no se asociaron de forma estad&#237;sticamente significativa con ninguna prueba de cribado&#46; En cuanto a la relaci&#243;n entre pruebas de cribado&#44; s&#243;lo se observa una asociaci&#243;n positiva y estad&#237;sticamente significativa entre la prueba de SOH y la colonoscopia en ambos sexos&#44; y entre la mamograf&#237;a y la citolog&#237;a&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Analizando estas asociaciones en los grupos de edad diana de cada prueba&#44; se observan resultados en la misma direcci&#243;n en general&#44; aunque ciertas asociaciones perd&#237;an significaci&#243;n estad&#237;stica &#40;resultados no mostrados&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discusi&#243;n</span><p id="par0095" class="elsevierStylePara elsevierViewall">Los resultados del presente estudio muestran una elevada prevalencia de pr&#225;cticas de cribado de c&#225;ncer de mama&#44; cuello uterino y pr&#243;stata&#44; y baja del c&#225;ncer colorrectal&#46; Indican que mientras la pr&#225;ctica de la mamograf&#237;a y la citolog&#237;a est&#225; relativamente bien establecida en la poblaci&#243;n diana&#44; la realizaci&#243;n de la prueba de SOH a&#250;n no est&#225; consolidada&#44; y la del PSA&#44; sin evidencia concluyente de beneficio&#44; est&#225; muy extendida&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Los datos de la EESE-2009 mostraron que un 83&#44;27&#37; de las mujeres de 45 a 55 a&#241;os de edad y un 93&#44;29&#37; de las de 55 a 65 a&#241;os declaran haberse realizado alguna mamograf&#237;a a lo largo de su vida<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#44; resultados coherentes con el presente estudio&#44; aunque nuestro marco temporal son los &#250;ltimos 5 a&#241;os&#46; Destaca la elevada prevalencia de esta prueba en las menores de 50 a&#241;os&#44; del 65&#44;8&#37; en nuestro estudio y del 43&#44;9&#37; en las mujeres de 35 a 45 a&#241;os de edad en la EESE-2009&#44; a pesar de no haber evidencia concluyente del beneficio del cribado de c&#225;ncer de mama en las menores de 50 a&#241;os<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>&#46; Sin embargo&#44; algunas comunidades aut&#243;nomas como Navarra&#44; incluida en el estudio&#44; inician el cribado poblacional a los 45 a&#241;os<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46; Tambi&#233;n es alta la realizaci&#243;n de citolog&#237;as&#44; coincidiendo con distintas encuestas de salud&#46; En la EESE-2009&#44; un 81&#44;2&#37; de las mujeres de 35 a 54 a&#241;os de edad se hab&#237;a hecho alguna en los &#250;ltimos 5 a&#241;os&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Muy poco evaluada hasta la fecha ha sido la pr&#225;ctica del cribado de c&#225;ncer colorrectal&#46; Los primeros resultados de prevalencia de la prueba de SOH son los de la EESE-2009&#44; inferiores a los nuestros&#44; aunque los datos de programas piloto de esta prueba muestran una participaci&#243;n del 17&#37; al 38&#37; entre los 50 y los 69 a&#241;os de edad<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>&#44; resultados coherentes con los de nuestro estudio en zonas donde han comenzado estos programas&#46; No obstante&#44; existe un intenso debate cient&#237;fico sobre si la sigmoidoscopia o colonoscopia podr&#237;an incrementar su e&#64257;ciencia&#46; Algunos autores recomiendan la colonoscopia&#44; que adem&#225;s es la prueba de cribado en la poblaci&#243;n de alto riesgo<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a>&#44; y seg&#250;n sugieren los datos hallados podr&#237;a ser relativamente habitual como prueba oportunista&#46; Como en otros estudios&#44; los hombres declaran mayor participaci&#243;n en pruebas de cribado de c&#225;ncer colorrectal<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">No hay datos de &#225;mbito nacional de pr&#225;cticas de cribado de c&#225;ncer de pr&#243;stata mediante la prueba del PSA&#46; Un estudio realizado en centros de atenci&#243;n primaria en Gij&#243;n<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> present&#243; una prevalencia de determinaciones de hasta un 45&#44;8&#37; anual&#44; seg&#250;n el centro&#44; en hombres mayores de 50 a&#241;os&#46; Contrasta&#44; pues&#44; la elevada frecuencia de cribado mediante esta prueba&#44; dado que no existe evidencia concluyente sobre su beneficio y s&#237; del sobrediagn&#243;stico que puede suponer<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a>&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">En relaci&#243;n con los estilos de vida&#44; no se observa un patr&#243;n com&#250;n para todas las pruebas de cribado&#44; sino que existen diferencias por sexo y tipo de prueba&#46; A pesar de la falta de poder estad&#237;stico para confirmar algunas asociaciones&#44; la relaci&#243;n entre el consumo de fruta y verdura y la participaci&#243;n en mamograf&#237;as concuerda con la literatura publicada<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> y se atribuye a un mayor autocuidado&#46; En el mismo sentido&#44; se observa una relaci&#243;n entre la presencia de comorbilidad y la realizaci&#243;n de mamografia y la prueba de SOH en los hombres&#44; que coincide con otros estudios<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;23</span></a>&#46; La hip&#243;tesis que se plantea es que la presencia de enfermedades&#44; en su mayor&#237;a cr&#243;nicas&#44; implica un mayor contacto con el m&#233;dico&#44; lo que predispone a la participaci&#243;n en el cribado&#46; No obstante&#44; en Espa&#241;a&#44; Jim&#233;nez-Garc&#237;a et al&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> presentaron resultados en sentido contrario en mujeres con diabetes&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Sin embargo&#44; la utilizaci&#243;n de la prueba del PSA no se asocia a la presencia de comorbilidad ni a otras variables de estilos de vida&#44; excepto sobrepeso-obesidad&#44; resultado que coincide con otros estudios<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> y parece indicar que no hay una mayor predisposici&#243;n al cuidado de la salud en los hombres que se realizan dicha prueba&#46; Esto puede verse afectado en parte porque&#44; a diferencia de las otras pruebas&#44; &#233;sta no requiere una participaci&#243;n activa por parte del paciente&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Predictores de participaci&#243;n en el cribado establecidos en otros estudios&#44; como el consumo de alcohol&#44; la actividad f&#237;sica<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> o los antecedentes familiares de c&#225;ncer&#44; no han presentado un patr&#243;n claro en el actual&#46; Esto puede atender a caracter&#237;sticas espec&#237;ficas del grupo de edad&#44; como la menor prevalencia de ejercicio f&#237;sico moderado&#44; as&#237; como a la codificaci&#243;n de la informaci&#243;n o la extensi&#243;n de ciertos cribados&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">En cuanto a la asociaci&#243;n entre distintas pr&#225;cticas de cribado&#44; se hall&#243; una estrecha relaci&#243;n entre mamograf&#237;a y citolog&#237;a&#44; coincidiendo con la literatura publicada<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a>&#46; En cambio&#44; la asociaci&#243;n entre mamograf&#237;a y el cribado de c&#225;ncer colorrectal desaparece al ajustar por el resto de variables en el an&#225;lisis multivariado&#44; aunque s&#237; se ha encontrado en otros estudios<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a>&#46; Una posible asociaci&#243;n entre estas pruebas&#44; ya sea positiva o negativa&#44; puede tener importantes implicaciones en el despliegue de este cribado y deber&#237;a evaluarse en un futuro&#46; La correlaci&#243;n entre la prueba de SOH y la colonoscopia&#47;sigmoidoscopia encontrada probablemente se debe a la realizaci&#243;n de colonoscopias de confirmaci&#243;n en SOH positivas y a la posible confusi&#243;n entre colonoscopia de cribado y diagn&#243;stica&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Aunque es necesaria mayor investigaci&#243;n&#44; estas asociaciones podr&#237;an no relacionarse con la edad de recomendaci&#243;n de las pruebas&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Al interpretar estos resultados es necesario tener en cuenta ciertas limitaciones&#44; ya que el estudio MCC-Spain no fue dise&#241;ado para evaluar la participaci&#243;n en pruebas de cribado&#46; Los controles poblacionales de este estudio podr&#237;an no ser representativos de la poblaci&#243;n general&#44; y esto llevar&#237;a a una sobreestimaci&#243;n de las pr&#225;cticas&#44; por estar m&#225;s representada la poblaci&#243;n en edad diana de algunas pruebas o haberse dado una cierta autoselecci&#243;n de la poblaci&#243;n participante&#46; Para minimizar estos sesgos&#44; se ha ajustado por edad y nivel de estudios&#46; Por otro lado&#44; la obtenci&#243;n de informaci&#243;n autonotificada sobre el uso de las pruebas de cribado&#44; utilizando adem&#225;s un cuestionario con preguntas no validadas&#44; puede conllevar cierta sobreestimaci&#243;n<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a>&#44; en parte debido a la confusi&#243;n entre las pruebas de cribado y las diagn&#243;sticas&#44; o las realizadas para el control de otras enfermedades&#46; En cualquier caso&#44; con el fin de reducir los sesgos&#44; las entrevistas se hicieron por personal especialmente entrenado&#44; con indicaciones para explicar que las pruebas de cribado son aquellas realizadas en ausencia de s&#237;ntomas&#44; aunque sin diferenciar entre cribado poblacional u oportunista<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a>&#46; Finalmente&#44; el car&#225;cter transversal del estudio no permite inferir una relaci&#243;n temporal o causal entre la participaci&#243;n en el cribado y ciertos estilos de vida&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">A pesar de dichas limitaciones&#44; el presente estudio aporta informaci&#243;n sobre la utilizaci&#243;n de las pruebas de cribado en la poblaci&#243;n espa&#241;ola de diferentes provincias&#44; con informaci&#243;n hasta ahora poco disponible&#44; principalmente en el cribado de c&#225;ncer colorrectal y de pr&#243;stata&#46; Los resultados apuntan ciertas discrepancias entre la pr&#225;ctica de cribado y lo recomendado seg&#250;n la evidencia&#44; as&#237; como su relaci&#243;n con los estilos de vida y la realizaci&#243;n de otras pruebas&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Esta informaci&#243;n puede ser &#250;til para orientar nuevos estudios sobre las pr&#225;cticas de cribado que puedan servir para mejorar la participaci&#243;n y revisar posibles ineficiencias del sistema&#44; considerando el momento actual de consolidaci&#243;n del cribado de c&#225;ncer de mama&#44; implantaci&#243;n del de c&#225;ncer colorrectal mediante la prueba de SOH y la pr&#225;ctica extendida del cribado oportunista no recomendado de c&#225;ncer de pr&#243;stata&#46; Por otro lado&#44; tambi&#233;n ser&#225; &#250;til para generar hip&#243;tesis sobre la posible relaci&#243;n entre ciertos estilos de vida&#44; algunos a su vez factores de riesgo de c&#225;ncer&#44; y la utilizaci&#243;n de la detecci&#243;n precoz de esta enfermedad&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Responsabilidades &#233;ticas</span><p id="par0155" class="elsevierStylePara elsevierViewall">El estudio fue aprobado por el Comit&#233; de &#201;tica de todos los centros participantes&#46; En la realizaci&#243;n del estudio se cumpli&#243; con las normas &#233;ticas de la Declaraci&#243;n de Helsinki y con la normativa legal sobre confidencialidad de datos &#40;Ley Org&#225;nica 15&#47;1999 del 13 de diciembre de Protecci&#243;n de Datos de Car&#225;cter Personal &#91;LOPD&#93;&#41;&#46;<elsevierMultimedia ident="tb0005"></elsevierMultimedia></p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Contribuciones de autor&#237;a</span><p id="par0190" class="elsevierStylePara elsevierViewall">M&#46;D&#46; Perea ha realizado la revisi&#243;n bibliogr&#225;fica del tema&#44; ha efectuado el an&#225;lisis y ha escrito las sucesivas versiones del manuscrito&#46; M&#46; Sala ha participado en la concepci&#243;n del estudio sobre pr&#225;cticas de cribado y supervisado&#44; junto con G&#46; Casta&#241;o-Vinyals&#44; todo el proceso de an&#225;lisis y redacci&#243;n del manuscrito&#46; M&#46; Poll&#225;n es coinvestigadora principal del estudio MCC-Spain&#58; junto con J&#46;M&#46; Altzibar&#44; N&#46; Ascunce&#44; V&#46; Moreno y A&#46; Tard&#243;n son investigadores del proyecto en Madrid&#44; Gipuzkoa&#44; Navarra&#44; Barcelona y Oviedo&#46; Todos ellos han participado en la concepci&#243;n del estudio y han supervisado el trabajo de campo de MCC-Spain&#46; Todos los autores han participado en la revisi&#243;n del art&#237;culo y han aceptado la versi&#243;n final&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Financiaci&#243;n</span><p id="par0175" class="elsevierStylePara elsevierViewall">El estudio ha sido parcialmente financiado por la Acci&#243;n Transversal del C&#225;ncer del Consejo de Ministros del 11&#47;10&#47;2007&#44; por el Instituto de Salud Carlos III-FEDER &#40;PI08&#47;1770&#41; y por el CIBER de Epidemiolog&#237;a y Salud P&#250;blica &#40;FIS multic&#233;ntrico&#58; PS09&#47;00773&#44; Cantabria&#59; PS09&#47;01286&#44; Le&#243;n&#59; PS09&#47;01903&#44; Valencia&#59; PS09&#47;02078&#59; PS09&#47;01662&#41;&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflictos de intereses</span><p id="par0180" class="elsevierStylePara elsevierViewall">Ninguno&#46;</p></span></span>"
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          "titulo" => "Introducci&#243;n"
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          "titulo" => "M&#233;todos"
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              "titulo" => "An&#225;lisis estad&#237;stico"
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    "fechaRecibido" => "2011-04-22"
    "fechaAceptado" => "2012-01-09"
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          "palabras" => array:7 [
            0 => "Detecci&#243;n precoz del c&#225;ncer"
            1 => "Cribado poblacional"
            2 => "Estilo de vida"
            3 => "Comorbilidad"
            4 => "Factores de riesgo"
            5 => "Mamograf&#237;a"
            6 => "Ant&#237;geno espec&#237;fico de pr&#243;stata"
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        0 => array:4 [
          "clase" => "keyword"
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          "identificador" => "xpalclavsec12824"
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            0 => "Early detection of cancer"
            1 => "Mass screening"
            2 => "Lifestyle"
            3 => "Comorbidity"
            4 => "Risk factors"
            5 => "Mammography"
            6 => "Prostate-specific antigen"
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        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estimar la prevalencia de pr&#225;cticas de cribado de c&#225;ncer en los controles del estudio multi-caso control &#40;MCC-Spain&#41; y evaluar su asociaci&#243;n con los estilos de vida&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">An&#225;lisis transversal de 1505 controles poblacionales del estudio MCC-Spain&#44; de 20-85 a&#241;os&#44; recogidos entre 2008-2010 en cinco &#225;reas de Espa&#241;a&#46; Se ha calculado la prevalencia de pruebas de cribado en los &#250;ltimos 5 a&#241;os&#44; evaluando la relaci&#243;n con los estilos de vida y analizando su asociaci&#243;n mediante modelos de regresi&#243;n log&#237;stica&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Las pruebas m&#225;s prevalentes en las mujeres fueron mamograf&#237;a &#40;98&#44;2&#37;&#44; en mujeres de 50-69 a&#241;os&#41; y citolog&#237;a &#40;94&#44;5&#37;&#44; en las de 25-65 a&#241;os&#41;&#44; y ant&#237;geno espec&#237;fico de pr&#243;stata en los hombres &#40;71&#44;5&#37;&#44; 50 a&#241;os o m&#225;s&#41;&#46; La realizaci&#243;n de la prueba de sangre oculta en heces fue muy inferior &#40;11&#44;2&#37; y 16&#44;2&#37;&#44; en mujeres y hombres de 50-74 a&#241;os&#44; respectivamente&#41;&#46; Consumir al menos tres raciones de fruta y verdura al d&#237;a se asocia con una mayor participaci&#243;n en mamograf&#237;as &#40;<span class="elsevierStyleItalic">odds ratio</span> ajustadas &#91;OR<span class="elsevierStyleInf">a</span>&#93;&#58; 5&#44;24&#59; intervalo de confianza del 95&#37; &#91;IC95&#37;&#93;&#58; 1&#44;96-14&#44;07&#41;&#46; En los hombres&#44; el sobrepeso-obesidad se relaciona con la mayor realizaci&#243;n de la prueba del ant&#237;geno espec&#237;fico de pr&#243;stata &#40;OR<span class="elsevierStyleInf">a</span>&#58; 1&#44;88&#59; IC95&#37;&#58; 1&#44;15-3&#44;08&#41;&#46; En general&#44; destaca la presencia de comorbilidad asociada con la realizaci&#243;n de pruebas de cribado&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Este estudio muestra una elevada prevalencia de pr&#225;cticas de cribado de c&#225;ncer de mama&#44; cuello uterino y pr&#243;stata&#44; y baja del c&#225;ncer colorrectal&#46; No se observa un patr&#243;n com&#250;n de estilos de vida asociado al cribado&#44; sino que hay diferencias por sexo y tipo de prueba&#46; Estos resultados pueden ser &#250;tiles para orientar nuevos estudios sobre las pr&#225;cticas de cribado y revisar posibles ineficiencias&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To estimate the prevalence of screening practices in the population controls of the multi-case control study &#40;MCC-Spain&#41; study and to evaluate its association with lifestyles&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We carried out a cross-sectional analysis of 1505 population controls of the MCC-Spain study&#44; aged 20-85&#44; enrolled from 2008-2010 in five areas of Spain&#46; The prevalence of screening tests in the last 5 years was estimated and its association with lifestyles was assessed using logistic regression models&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The most prevalent tests were mammography &#40;98&#46;2&#37;&#44; age 50-69 years&#41; and cytology &#40;94&#46;5&#37;&#44; age 25-65 years&#41; in women and prostate-specific antigen in men &#40;71&#46;5&#37;&#44; age 50 or over&#41;&#46; Participation in fecal occult blood testing was lower &#40;11&#46;2&#37; and 16&#46;2&#37; in women and men aged 50-74&#44; respectively&#41;&#46; Eating at least three pieces of fruit and vegetables per day was associated with higher participation in mammography &#40;ORa&#58; 5&#46;24&#44; 95&#37; CI&#58; 1&#46;96-14&#46;07&#41;&#46; In men&#44; overweight-obesity was linked to higher participation in prostate-specific antigen testing &#40;ORa&#58; 1&#46;88&#59; 95&#37; CI&#58; 1&#46;15-3&#46;08&#41;&#46; In general&#44; the presence of comorbidities was associated with utilization of cancer screening tests&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The prevalence of screening practices was high for breast&#44; cervical and prostate cancer and was low for colorectal cancer&#46; No common lifestyle patterns were associated with participation&#44; although differences were found by sex and type of screening test&#46; These results may be useful to guide further studies on screening practices and review possible inefficiencies&#46;</p>"
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            "apendice" => "<p id="par0185" class="elsevierStylePara elsevierViewall">Los investigadores del MCC-Spain en este art&#237;culo son&#58; M&#46; Dolores Perea &#40;Servei d&#8217;Epidemiologia i Avaluaci&#243;&#44; Hospital del Mar&#44; Parc de Salut Mar&#44; Barcelona&#41;&#44; Gemma Casta&#241;o-Vinyals &#40;Centre for Research in Environmental Epidemiology&#44; CREAL&#44; Hospital del Mar Research Institute&#44; IMIM&#44; Barcelona&#59; CIBER de Epidemolog&#237;a y Salud P&#250;blica&#44; CIBERESP&#41;&#44; Nuria Aragon&#233;s &#40;Centro Nacional de Epidemiolog&#237;a&#44; Instituto de Salud Carlos III&#44; Madrid&#59; CIBER de Epidemolog&#237;a y Salud P&#250;blica&#44; CIBERESP&#41;&#44; Beatriz P&#233;rez-G&#243;mez &#40;Centro Nacional de Epidemiolog&#237;a&#44; Instituto de Salud Carlos III&#44; Madrid&#59; CIBER de Epidemolog&#237;a y Salud P&#250;blica&#44; CIBERESP&#41;&#44; Jone M&#46; Altzibar &#40;Subdirecci&#243;n de Salud P&#250;blica de Gipuzkoa&#59; CIBER de Epidemolog&#237;a y Salud P&#250;blica&#44; CIBERESP&#41;&#44; Victor Moreno &#40;Institut Catal&#224; d&#8217;Oncologia&#44; Barcelona&#59; CIBER de Epidemolog&#237;a y Salud P&#250;blica&#44; CIBERESP&#41;&#44; Nieves Ascunce &#40;Instituto de Salud P&#250;blica de Navarra&#59; CIBER de Epidemiolog&#237;a y Salud P&#250;blica&#44; CIBERESP&#41;&#44; Adonina Tard&#243;n &#40;Instituto Universitario de Oncolog&#237;a&#44; Universidad de Oviedo&#44; Asturias&#59; CIBER de Epidemolog&#237;a y Salud P&#250;blica&#44; CIBERESP&#41;&#44; Antoni Castells &#40;Hospital Cl&#237;nic de Barcelona&#59; CIBER de Enfermedades Hep&#225;ticas y Digestivas&#44; CIBEREHD&#41;&#44; Xavier Castells &#40;Servei d&#8217;Epidemiologia i Avaluaci&#243;&#44; Hospital del Mar&#44; Parc de Salut Mar&#44; Barcelona&#59; CIBER de Epidemolog&#237;a y Salud P&#250;blica&#44; CIBERESP&#41;&#44; Marina Poll&#225;n &#40;Centro Nacional de Epidemiolog&#237;a&#44; Instituto de Salud Carlos III&#44; Madrid&#59; CIBER de Epidemolog&#237;a y Salud P&#250;blica&#44; CIBERESP&#41;&#44; Manolis Kogevinas &#40;Centre for Research in Environmental Epidemiology&#44; CREAL&#59; Hospital del Mar Research Institute&#44; IMIM&#44; Barcelona&#59; CIBER de Epidemolog&#237;a y Salud P&#250;blica&#44; CIBERESP&#59; National School of Public Health&#44; Athens&#41; y Mar&#237;a Sala &#40;Servei d&#8217;Epidemiologia i Avaluaci&#243;&#44; Hospital del Mar&#44; Parc de Salut Mar&#44; Barcelona&#59; CIBER de Epidemolog&#237;a y Salud P&#250;blica&#46; CIBERESP&#41;&#46;</p>"
            "etiqueta" => "Anexo"
            "identificador" => "sec0065"
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="7" align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Soltero&#47;a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">95&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">125&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Casado&#47;a-viviendo con compa&#241;ero&#47;a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">558&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1130&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;75&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Separado&#47;a o divorciado&#47;a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">21&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">84&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Viudo&#47;a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">135&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">27&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="7" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">&#205;ndice de masa corporal</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Normopeso-bajo peso&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;41&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sobrepeso-obesidad&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Consumo de tabaco</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No fumador&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ex fumador&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">185&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;21&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">347&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;54&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">532&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;35&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fumador actual&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">150&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;17&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">122&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&#40;19&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">272&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;18&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Consumo de alcohol</span><a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bajo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;81&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t">&#40;63&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;36&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;26&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Actividad f&#237;sica</span><a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">d</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Baja&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;65&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;52&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">907&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;60&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Alta&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&#40;34&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;47&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">598&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;39&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Consumo de frutas y verduras</span><a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">e</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bajo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">480&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;70&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t">&#40;79&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;74&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Alto&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;20&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;25&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Comorbilidad</span><a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">f</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;14&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;16&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;85&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Familiares con c&#225;ncer</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;26&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;30&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Alguna prueba de cribado</span><a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">g</span></a></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Fecha de la prueba</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#8805; 75 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="5" align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Fecha de la prueba</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#60; 1 a&#241;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>1-3 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#62; 3 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;44&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;51&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Regi&#243;n cribado de c&#225;ncer colorrectal</span><a class="elsevierStyleCrossRef" href="#tblfn0045"><span class="elsevierStyleSup">b</span></a></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Prueba del ant&#237;geno espec&#237;fico de pr&#243;stata</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#8805; 50 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">294&#47;420&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>1-3 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#62; 3 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;11&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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              "nota" => "<p class="elsevierStyleNotepara">Residentes en regiones donde han comenzado programas de cribado de c&#225;ncer colorrectal mediante prueba de SOH&#58; No &#40;Madrid&#44; Navarra y Asturias&#41;&#44; S&#237; &#40;Barcelona y Gipuzkoa&#41;&#46; Diferencias significativas &#40;ji al cuadrado&#44; p &#60; 0&#44;05&#41; para controles de ambos sexos&#46;</p>"
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                  \t\t\t\t">Caracter&#237;sticas de estilos de vida y otros<a class="elsevierStyleCrossRef" href="#tblfn0050"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Mamograf&#237;a &#40;727&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Citolog&#237;a &#40;712&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="8" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Prueba de sangre oculta en heces</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Prueba del ant&#237;geno espec&#237;fico de pr&#243;stata &#40;426&#41;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Mujeres &#40;87&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Hombres &#40;96&#41;</td><td class="td" title="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&#40;IC95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&#40;IC95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&#40;IC95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&#40;IC95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&#40;IC95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="21" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">&#205;ndice de masa corporal</span><a class="elsevierStyleCrossRef" href="#tblfn0055"><span class="elsevierStyleSup">b</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Normopeso-bajo peso&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">33 5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">354&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">101&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">60&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&#40;52&#44;7-67&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">0&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sobrepeso-obesidad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">312&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&#40;83&#44;3-90&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">292&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t">&#40;8&#44;9-15&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;10&#44;6-17&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">72&#44;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;67&#44;9-76&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="21" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Consumo de tabaco</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No fumador&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;81&#44;1-87&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">77&#44;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&#40;9&#44;0-19&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">69&#44;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;62&#44;0-76&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ex fumador&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">87&#44;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;82&#44;8-92&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;88&#44;0-95&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#40;12&#44;9-20&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">236&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;65&#44;1-74&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fumador actual&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;73&#44;3-86&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">91&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#40;86&#44;7-95&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">6&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">76&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Citolog&#237;a &#40;712&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Mujeres &#40;87&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Hombres &#40;96&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Otras pruebas de cribado</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&#40;87&#44;1-91&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&#40;85&#44;2-90&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;8&#44;7-13&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  <table border="0" frame="\n
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caracter&#237;sticas de estilos de vida y otros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Mamograf&#237;a</td><td class="td" title="\n
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                  \t\t\t\t  " colspan="2" align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Citolog&#237;a</td><td class="td" title="\n
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                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Prueba de sangre oculta en heces</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Prueba del ant&#237;geno espec&#237;fico de pr&#243;stata</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " colspan="2" align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Mujeres</td><td class="td" title="\n
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                  \t\t\t\t  " colspan="2" align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Hombres</td><td class="td" title="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">OR<span class="elsevierStyleInf">a</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&#40;IC95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&#40;IC95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&#40;IC95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&#40;IC95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">OR<span class="elsevierStyleInf">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&#40;IC95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Sobrepeso-obesidad</span><a class="elsevierStyleCrossRef" href="#tblfn0090"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#44;97&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;0&#44;45-2&#44;11&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;1&#44;15-3&#44;08&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="11" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="11" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Consumo de tabaco</span><a class="elsevierStyleCrossRef" href="#tblfn0095"><span class="elsevierStyleSup">b</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fumador&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ex fumador&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Alcohol</span><a class="elsevierStyleCrossRef" href="#tblfn0100"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;0&#44;27-1&#44;01&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;96&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;60-1&#44;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Actividad f&#237;sica</span><a class="elsevierStyleCrossRef" href="#tblfn0100"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#40;0&#44;29-1&#44;22&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;50&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#40;0&#44;76-2&#44;98&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;33-1&#44;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;49&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;81-2&#44;74&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;07&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;66-1&#44;72&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Consumo de fruta y verdura</span><a class="elsevierStyleCrossRef" href="#tblfn0100"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;24&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#40;1&#44;96-14&#44;07&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">0&#44;80&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;40-1&#44;61&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;52&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;26-1&#44;06&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;25-1&#44;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;85&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#40;0&#44;49-1&#44;48&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Comorbilidad</span><a class="elsevierStyleCrossRef" href="#tblfn0105"><span class="elsevierStyleSup">d</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">2&#44;76&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#40;1&#44;17-6&#44;49&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;80&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#40;0&#44;31-2&#44;07&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#40;0&#44;61-5&#44;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#40;1&#44;44-31&#44;22&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;37-1&#44;46&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Familiar con c&#225;ncer</span><a class="elsevierStyleCrossRef" href="#tblfn0105"><span class="elsevierStyleSup">d</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;31&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;62-2&#44;79&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;53&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#40;0&#44;26-1&#44;09&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;85-3&#44;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;08&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#40;0&#44;59-1&#44;98&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;71-1&#44;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Otro c&#225;ncer anterior</span><a class="elsevierStyleCrossRef" href="#tblfn0105"><span class="elsevierStyleSup">d</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;98&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;57-6&#44;92&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;49&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;19-1&#44;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;37-2&#44;66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;30-1&#44;80&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&#44;20&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#40;0&#44;95-5&#44;08&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Mamografia</span><a class="elsevierStyleCrossRef" href="#tblfn0110"><span class="elsevierStyleSup">e</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">37&#44;34&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;12&#44;41-112&#44;41&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;45&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#40;0&#44;66-9&#44;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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Original
Prácticas de cribado de cáncer y estilos de vida asociados en la población de controles del estudio español multi-caso control (MCC-Spain)
Cancer screening practices and associated lifestyles in population controls of the Spanish multi-case control study
M. Dolores Pereaa, Gemma Castaño-Vinyalsb,c,d, Jone M. Altzibare,d, Nieves Ascuncef,d, Víctor Morenog,d, Adonina Tardonh,d, Marina Polláni,d, Maria Salaa,c,d,
Autor para correspondencia
MSalaSerra@parcdesalutmar.cat

Autora para correspondencia.
, en nombre de los investigadores del MCC-Spain
a Servei d’Epidemiologia i Avaluació, Hospital del Mar, Parc de Salut Mar, Barcelona, España
b Centre for Research in Environmental Epidemiology (CREAL), Barcelona, España
c Hospital del Mar Research Institute (IMIM), Barcelona, España
d CIBER de Epidemología y Salud Pública (CIBERESP), España
e Subdirección de Salud Pública de Gipuzkoa, España
f Instituto de Salud Pública de Navarra, España
g Institut Català d’Oncologia, Barcelona, España
h Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Asturias, España
i Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España
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            "notaPie" => "<p class="elsevierStyleNotepara">Ver Anexo al final del art&#237;culo&#46;</p>"
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      "en" => array:1 [
        "titulo" => "Cancer screening practices and associated lifestyles in population controls of the Spanish multi-case control study"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">El abordaje del cribado de c&#225;ncer comporta gran complejidad organizativa asistencial&#44; tiene un importante impacto poblacional y est&#225; sujeto a un continuo debate cient&#237;fico-t&#233;cnico&#46; Actualmente hay cuatro tipos de c&#225;ncer en los que distintas sociedades cient&#237;ficas y organizaciones sanitarias realizan recomendaciones de cribado&#58; mama&#44; cuello uterino&#44; colon-recto y pr&#243;stata&#46; Las pruebas de cribado para estos c&#225;nceres presentan un grado de evidencia cient&#237;fica&#44; un nivel de implementaci&#243;n y una orientaci&#243;n distintos&#46; La efectividad del cribado de c&#225;ncer de mama mediante mamograf&#237;a est&#225; demostrada en mujeres de 50-69 a&#241;os de edad&#46; En Espa&#241;a&#44; existen programas poblacionales con cobertura casi total<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46; El cribado de c&#225;ncer de cuello uterino mediante citolog&#237;a tambi&#233;n est&#225; recomendado&#44; y se realiza de forma oportunista en casi todo el territorio&#46; Las pr&#225;cticas de cribado para estos dos c&#225;nceres son relativamente altas seg&#250;n las encuestas de salud&#58; un 68&#44;7&#37; de las mujeres de 45-65 a&#241;os de edad se ha realizado alguna mamograf&#237;a en los &#250;ltimos 2 a&#241;os y un 55&#44;2&#37; de las mujeres de 20 a&#241;os o m&#225;s se ha hecho una citolog&#237;a en los &#250;ltimos 5 a&#241;os&#44; seg&#250;n datos de la Encuesta Europea de Salud 2009 en Espa&#241;a &#40;EESE-2009&#41;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">La efectividad del cribado del c&#225;ncer colorrectal se ha demostrado con la prueba de sangre oculta en heces &#40;SOH&#41;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> y la Uni&#243;n Europea recomienda su realizaci&#243;n en la poblaci&#243;n de 50-74 a&#241;os de edad<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46; En Espa&#241;a&#44; 11 comunidades aut&#243;nomas han comenzado a implantar programas poblacionales con esta prueba&#46; Los primeros datos publicados en nuestro pa&#237;s indican que un 7&#44;4&#37; de los hombres y un 6&#44;3&#37; de las mujeres de 16 a&#241;os o m&#225;s se han realizado la prueba alguna vez<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#46; En cambio&#44; la efectividad del cribado de c&#225;ncer de pr&#243;stata con la prueba del ant&#237;geno espec&#237;fico de pr&#243;stata &#40;PSA&#41; no presenta resultados concluyentes en t&#233;rminos de reducci&#243;n de la mortalidad<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#44; y las recomendaciones de las organizaciones profesionales son contradictorias al respecto&#46; Hay muy pocos estudios sobre el uso de esta prueba&#44; pero sus resultados sugieren una pr&#225;ctica oportunista extendida<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">La participaci&#243;n en los programas de cribado de c&#225;ncer es esencial para su efectividad&#46; Los factores asociados con la participaci&#243;n pueden ser organizativos &#40;accesibilidad&#44; m&#233;todos de invitaci&#243;n&#44; extensi&#243;n del cribado oportunista&#41;&#44; sociodemogr&#225;ficos y personales &#40;estilos de vida y otros&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Las caracter&#237;sticas sociodemogr&#225;ficas asociadas a la participaci&#243;n est&#225;n relativamente establecidas&#44; y se ha encontrado una asociaci&#243;n positiva con mayor edad&#44; nivel de educaci&#243;n m&#225;s alto&#44; estar casado y mayor nivel socioecon&#243;mico<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Conocer la asociaci&#243;n entre cribado y estilos de vida puede ayudar a comprender el perfil relacionado con la participaci&#243;n&#46; Factores como el consumo de tabaco y alcohol<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#44; un &#237;ndice de masa corporal elevado<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&#44; una actividad f&#237;sica escasa y algunos patrones diet&#233;ticos &#40;bajo consumo de fruta y verdura&#44; mayor contenido en grasa&#41; han presentado una relaci&#243;n negativa con la participaci&#243;n en las pruebas de cribado<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&#46; Otras caracter&#237;sticas personales se han asociado de forma positiva a la participaci&#243;n en el cribado&#44; como los antecedentes familiares de c&#225;ncer&#44; conductas preventivas de enfermedades cr&#243;nicas &#40;control del colesterol y de la presi&#243;n arterial&#41;&#44; visita regular al m&#233;dico&#44; presencia de comorbilidad o realizaci&#243;n de otras pruebas de cribado<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;12</span></a>&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">En Espa&#241;a&#44; pocos estudios han evaluado los estilos de vida de la poblaci&#243;n que realiza pr&#225;cticas de detecci&#243;n precoz de c&#225;ncer&#44; especialmente del colorrectal y del de pr&#243;stata&#44; y existe escasa informaci&#243;n sobre la relaci&#243;n entre diferentes pruebas&#46; Esta informaci&#243;n puede ser muy &#250;til en el contexto actual de despliegue y evaluaci&#243;n de los programas de cribado&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">El objetivo de este estudio es estimar la prevalencia de pr&#225;cticas de cribado&#44; la relaci&#243;n entre ellas y evaluar su asociaci&#243;n con los estilos de vida en una muestra de controles poblacionales del estudio multi-caso control &#40;MCC-Spain&#41;&#44; un estudio multic&#233;ntrico sobre factores ambientales y c&#225;ncer&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">M&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Poblaci&#243;n de estudio</span><p id="par0040" class="elsevierStylePara elsevierViewall">El estudio MCC-Spain recoge casos incidentes de c&#225;ncer de mama&#44; colon-recto&#44; est&#243;mago-es&#243;fago&#44; pr&#243;stata y leucemia linfoc&#237;tica cr&#243;nica&#44; y controles poblacionales en las &#225;reas de influencia de 22 hospitales de 11 provincias espa&#241;olas&#46; Para el presente an&#225;lisis se ha obtenido informaci&#243;n de los 1505 controles poblacionales de las regiones disponibles&#44; reclutados desde el comienzo del estudio en 2008 hasta febrero de 2010&#46; Estos controles fueron seleccionados de forma aleatoria simple a partir de las listas de poblaci&#243;n asignada a los m&#233;dicos de familia de los centros de atenci&#243;n primaria escogidos del &#225;rea de referencia de los hospitales participantes&#44; seg&#250;n la distribuci&#243;n esperada de los casos en funci&#243;n del sexo y la edad&#44; considerando las tasas de incidencia de los tumores del estudio&#46; Todos los controles ten&#237;an entre 20 y 85 a&#241;os de edad&#44; resid&#237;an en el &#225;rea de influencia del hospital como m&#237;nimo desde 6 meses antes de la selecci&#243;n&#44; no ten&#237;an impedimentos para la comunicaci&#243;n y firmaron el consentimiento informado&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Se reclutaron controles poblacionales para el 91&#37; de los casos&#46; Este porcentaje no contempla las personas contactadas por cada control &#40;promedio&#58; 2&#41;&#46; Si se consideran todas las personas con las que se estableci&#243; comunicaci&#243;n&#44; la tasa de participaci&#243;n de los controles de nuestra poblaci&#243;n de estudio fue del 53&#37;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Variables de estudio</span><p id="par0050" class="elsevierStylePara elsevierViewall">Los datos recogidos por MCC-Spain&#44; de los que se seleccionaron las variables de inter&#233;s&#44; se obtuvieron mediante un cuestionario estructurado e informatizado&#44; administrado por entrevistadores entrenados mediante una entrevista personal de unos 90 minutos&#46; &#201;ste reuni&#243; informaci&#243;n sobre factores sociodemogr&#225;ficos&#44; estilos de vida&#44; dieta&#44; historia personal&#44; familiar y m&#233;dica&#46; El cuestionario inclu&#237;a preguntas sobre las pr&#225;cticas de cribado en los &#250;ltimos 5 a&#241;os&#44; especificando haberlas realizado sin estar enfermo ni tener s&#237;ntomas&#44; y concretamente sobre mamograf&#237;a &#40;mujeres&#41;&#44; citolog&#237;a cervicovaginal &#40;mujeres&#41;&#44; prueba de SOH&#44; colonoscopia&#47;sigmoidoscopia y PSA &#40;hombres&#41;&#46; Si la respuesta era positiva&#44; se recog&#237;a tambi&#233;n la fecha aproximada de la &#250;ltima prueba e informaci&#243;n relativa a &#233;sta&#46; Dicho cuestionario recogi&#243; tambi&#233;n informaci&#243;n sobre edad&#44; nivel de estudios&#44; ocupaci&#243;n&#44; estado civil&#44; peso y altura autonotificados &#40;obteniendo el &#237;ndice de masa corporal&#41;&#44; consumo de tabaco &#40;fumador&#44; ex fumador&#44; no fumador&#41;&#44; actividad f&#237;sica &#40;autonotificada&#44; especificando el tipo de actividad y la frecuencia semanal&#44; recodificada seg&#250;n recomendaciones semanales de las gu&#237;as de prevenci&#243;n de c&#225;ncer<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>&#41;&#44; comorbilidad &#40;enfermedades diferentes del c&#225;ncer&#41;&#44; antecedentes personales de c&#225;ncer &#40;tumores anteriores de diferente localizaci&#243;n&#41; y familiares &#40;al menos un familiar de cualquier grado&#41;&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Los participantes rellenaron adem&#225;s un cuestionario de frecuencia alimentaria autoadministrado&#44; adaptado de un cuestionario validado<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a>&#46; De &#233;ste se calcul&#243; la frecuencia del consumo de fruta y verdura &#40;recodificadas en una variable conjunta dicot&#243;mica&#41; y de alcohol&#44; por categor&#237;as de bebidas &#40;convertido a gramos de etanol&#47;d&#237;a&#44; recategorizado siguiendo las recomendaciones de consumo por sexo<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">An&#225;lisis estad&#237;stico</span><p id="par0060" class="elsevierStylePara elsevierViewall">C&#225;lculo de las frecuencias notificadas de pr&#225;cticas de cribado &#40;mamograf&#237;a&#44; citolog&#237;a&#44; pruebas de SOH y de PSA&#41; por tipo de prueba&#44; en funci&#243;n de estilos de vida y otras caracter&#237;sticas personales&#44; evaluando las diferencias con los que no realizan pruebas de cribado mediante la prueba de ji al cuadrado&#46; Las variables relevantes seg&#250;n la literatura o estad&#237;sticamente significativas &#40;p &#60; 0&#44;05&#41; se han incluido en modelos de regresi&#243;n log&#237;stica multivariada no condicional para obtener las <span class="elsevierStyleItalic">odds ratio</span> ajustadas &#40;OR<span class="elsevierStyleInf">a</span>&#41; de las variables de estudio y sus correspondientes intervalos de confianza del 95&#37; &#40;IC95&#37;&#41; en la realizaci&#243;n de la pr&#225;ctica de cribado espec&#237;fica&#44; ajustadas por edad&#44; nivel de estudios y regi&#243;n geogr&#225;fica del estudio&#46; Se ha utilizado el paquete estad&#237;stico SPSS v&#46;17&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Resultados</span><p id="par0065" class="elsevierStylePara elsevierViewall">Un 58&#37; de la poblaci&#243;n de estudio eran mujeres &#40;n &#61; 866&#41;&#44; la mediana de edad fue de 65 a&#241;os&#44; mayor en los hombres &#40;68 a&#241;os&#41; que en las mujeres &#40;62 a&#241;os&#41;&#46; &#201;stas y otras caracter&#237;sticas sociodemogr&#225;ficas&#44; de estilos de vida y pr&#225;ctica de cribado de la poblaci&#243;n analizada se muestran en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46; Un 85&#37; de los sujetos se hab&#237;a realizado alguna prueba de cribado &#40;mamograf&#237;a&#44; citolog&#237;a&#44; SOH&#44; colonoscopia&#47;sigmoidoscopia o PSA&#41; en los &#250;ltimos 5 a&#241;os&#44; porcentaje que fue de un 75&#37; en los hombres y un 93&#37; en las mujeres&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">La <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a> muestra los porcentajes de la poblaci&#243;n de estudio que declaran haber realizado pruebas de cribado en los &#250;ltimos 5 a&#241;os&#44; considerando la edad diana de cada prueba&#46; La mamograf&#237;a present&#243; una elevada prevalencia en mujeres &#40;98&#44;2&#37; en mujeres de 50-69 a&#241;os&#41;&#44; as&#237; como la citolog&#237;a &#40;94&#44;5&#37; en mujeres de 25-65 a&#241;os&#41;&#46; Aproximadamente la mitad de las mamograf&#237;as y citolog&#237;as se hab&#237;an realizado en el &#250;ltimo a&#241;o &#40;53&#44;2&#37; y 44&#44;1&#37;&#44; respectivamente&#41;&#46; La frecuencia de la prueba de SOH fue del 16&#44;2&#37; y el 11&#44;2&#37; en hombres y mujeres de 50-74 a&#241;os de edad&#44; respectivamente&#46; En las regiones en que hab&#237;an comenzado los programas de cribado poblacional la prevalencia fue superior&#46; El mayor porcentaje de estas pruebas se hab&#237;a realizado hac&#237;a m&#225;s de 3 a&#241;os&#46; Aunque no se muestran los datos por no ser la prueba de cribado de c&#225;ncer colorrectal poblacional recomendada&#44; la frecuencia declarada de colonoscopia o sigmoidoscopia en los &#250;ltimos 5 a&#241;os fue del 24&#44;9&#37; en los hombres y del 18&#44;7&#37; en las mujeres de 50 a&#241;os o m&#225;s de edad&#46; El PSA fue la prueba m&#225;s frecuente en los hombres &#40;71&#44;5&#37; en los de 50 a&#241;os o m&#225;s&#41;&#44; realizada principalmente en el &#250;ltimo a&#241;o &#40;70&#37;&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">La <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a> describe las prevalencias por tipo de prueba&#44; en funci&#243;n de los estilos de vida y otros factores&#46; En los hombres con sobrepeso se observ&#243; una mayor prevalencia del PSA frente a aquellos con normopeso o bajo peso &#40;72&#44;1&#37; y 60&#44;1&#37;&#41;&#44; y en sentido inverso en las mujeres que se hac&#237;an citolog&#237;as &#40;82&#44;3&#37; en las que ten&#237;an sobrepeso y 90&#44;8&#37; en las que no&#41;&#44; diferencias estad&#237;sticamente significativas &#40;p &#60; 0&#44;05&#41;&#46; El consumo de tabaco y la actividad f&#237;sica s&#243;lo presentaron relaci&#243;n estad&#237;sticamente significativa con la participaci&#243;n en citolog&#237;a&#59; el alcohol s&#243;lo lo hizo con la prueba de SOH en los hombres&#46; Las mamograf&#237;as y citolog&#237;as eran m&#225;s frecuentes en las mujeres que consum&#237;an tres o m&#225;s piezas de fruta y verdura al d&#237;a &#40;94&#44;6&#37; y 86&#44;1&#37;&#44; respectivamente&#41; que en las que no &#40;80&#44;8&#37; y 79&#44;6&#37;&#44; respectivamente&#44; p &#60; 0&#44;05&#41;&#46; La participaci&#243;n en las pruebas de cribado siempre fue superior entre los que presentaban comorbilidad&#44; excepto para la citolog&#237;a&#44; de forma estad&#237;sticamente significativa&#46; La prevalencia de la prueba del PSA fue mayor en los hombres con antecedentes personales de c&#225;ncer&#46; Ninguna pr&#225;ctica de cribado se asoci&#243; con los antecedentes familiares de c&#225;ncer&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">La <a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a> describe la distribuci&#243;n de la participaci&#243;n en diferentes pruebas de cribado de c&#225;ncer&#46; Se observ&#243; un porcentaje elevado de mamograf&#237;as en las mujeres que hab&#237;an realizado alguna de las otras pruebas de cribado &#40;89&#44;3&#37;&#59; IC95&#37;&#58; 87&#44;1-91&#44;5&#41;&#44; espec&#237;ficamente en las que se hab&#237;an hecho citolog&#237;as &#40;90&#44;4&#37;&#59; IC95&#37;&#58; 88&#44;3-92&#44;6&#41; y la prueba de SOH &#40;94&#44;3&#37;&#59; IC95&#37;&#58; 89&#44;4-99&#44;1&#41;&#46; La participaci&#243;n en citolog&#237;a s&#243;lo se asoci&#243; significativamente con mamograf&#237;a&#46; Entre los hombres con la prueba de SOH&#44; tambi&#233;n hab&#237;a una mayor realizaci&#243;n de la del PSA&#46; Entre los que se hab&#237;an hecho alguna colonoscopia&#47;sigmoidoscopia hab&#237;a mayores porcentajes de realizaci&#243;n de SOH que en los que no&#44; con diferencias significativas en las mujeres &#40;29&#44;5&#37; y 6&#44;2&#37;&#44; respectivamente&#41; y los hombres &#40;27&#44;8&#37; y 11&#44;2&#37;&#44; respectivamente&#41;&#46; De igual modo&#44; la proporci&#243;n de participaci&#243;n en la prueba del PSA en los &#250;ltimos 5 a&#241;os en los hombres que declararon haberse realizado otras pruebas de cribado de c&#225;ncer diferentes fue mayor que en los que no&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">La <a class="elsevierStyleCrossRef" href="#tbl0025">tabla 5</a> muestra las OR<span class="elsevierStyleInf">a</span> de realizar pruebas de cribado en funci&#243;n de los estilos de vida y la pr&#225;ctica de cribado&#46; El sobrepeso-obesidad se asoci&#243; &#250;nicamente a la realizaci&#243;n de la prueba del PSA &#40;OR<span class="elsevierStyleInf">a</span>&#58; 1&#44;88&#59; IC95&#37;&#58; 1&#44;15-3&#44;08&#41;&#46; Consumir al menos tres piezas de fruta y verdura al d&#237;a se asocia a la participaci&#243;n en mamograf&#237;as &#40;OR<span class="elsevierStyleInf">a</span>&#58; 5&#44;24&#59; IC95&#37;&#58; 1&#44;96-14&#44;07&#41;&#46; La presencia de comorbilidad present&#243; asociaci&#243;n estad&#237;sticamente significativa con la realizaci&#243;n de mamograf&#237;as en mujeres y la prueba de SOH en hombres&#46; Los antecedentes personales y familiares de c&#225;ncer no se asociaron de forma estad&#237;sticamente significativa con ninguna prueba de cribado&#46; En cuanto a la relaci&#243;n entre pruebas de cribado&#44; s&#243;lo se observa una asociaci&#243;n positiva y estad&#237;sticamente significativa entre la prueba de SOH y la colonoscopia en ambos sexos&#44; y entre la mamograf&#237;a y la citolog&#237;a&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Analizando estas asociaciones en los grupos de edad diana de cada prueba&#44; se observan resultados en la misma direcci&#243;n en general&#44; aunque ciertas asociaciones perd&#237;an significaci&#243;n estad&#237;stica &#40;resultados no mostrados&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discusi&#243;n</span><p id="par0095" class="elsevierStylePara elsevierViewall">Los resultados del presente estudio muestran una elevada prevalencia de pr&#225;cticas de cribado de c&#225;ncer de mama&#44; cuello uterino y pr&#243;stata&#44; y baja del c&#225;ncer colorrectal&#46; Indican que mientras la pr&#225;ctica de la mamograf&#237;a y la citolog&#237;a est&#225; relativamente bien establecida en la poblaci&#243;n diana&#44; la realizaci&#243;n de la prueba de SOH a&#250;n no est&#225; consolidada&#44; y la del PSA&#44; sin evidencia concluyente de beneficio&#44; est&#225; muy extendida&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Los datos de la EESE-2009 mostraron que un 83&#44;27&#37; de las mujeres de 45 a 55 a&#241;os de edad y un 93&#44;29&#37; de las de 55 a 65 a&#241;os declaran haberse realizado alguna mamograf&#237;a a lo largo de su vida<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#44; resultados coherentes con el presente estudio&#44; aunque nuestro marco temporal son los &#250;ltimos 5 a&#241;os&#46; Destaca la elevada prevalencia de esta prueba en las menores de 50 a&#241;os&#44; del 65&#44;8&#37; en nuestro estudio y del 43&#44;9&#37; en las mujeres de 35 a 45 a&#241;os de edad en la EESE-2009&#44; a pesar de no haber evidencia concluyente del beneficio del cribado de c&#225;ncer de mama en las menores de 50 a&#241;os<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>&#46; Sin embargo&#44; algunas comunidades aut&#243;nomas como Navarra&#44; incluida en el estudio&#44; inician el cribado poblacional a los 45 a&#241;os<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46; Tambi&#233;n es alta la realizaci&#243;n de citolog&#237;as&#44; coincidiendo con distintas encuestas de salud&#46; En la EESE-2009&#44; un 81&#44;2&#37; de las mujeres de 35 a 54 a&#241;os de edad se hab&#237;a hecho alguna en los &#250;ltimos 5 a&#241;os&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Muy poco evaluada hasta la fecha ha sido la pr&#225;ctica del cribado de c&#225;ncer colorrectal&#46; Los primeros resultados de prevalencia de la prueba de SOH son los de la EESE-2009&#44; inferiores a los nuestros&#44; aunque los datos de programas piloto de esta prueba muestran una participaci&#243;n del 17&#37; al 38&#37; entre los 50 y los 69 a&#241;os de edad<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>&#44; resultados coherentes con los de nuestro estudio en zonas donde han comenzado estos programas&#46; No obstante&#44; existe un intenso debate cient&#237;fico sobre si la sigmoidoscopia o colonoscopia podr&#237;an incrementar su e&#64257;ciencia&#46; Algunos autores recomiendan la colonoscopia&#44; que adem&#225;s es la prueba de cribado en la poblaci&#243;n de alto riesgo<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a>&#44; y seg&#250;n sugieren los datos hallados podr&#237;a ser relativamente habitual como prueba oportunista&#46; Como en otros estudios&#44; los hombres declaran mayor participaci&#243;n en pruebas de cribado de c&#225;ncer colorrectal<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">No hay datos de &#225;mbito nacional de pr&#225;cticas de cribado de c&#225;ncer de pr&#243;stata mediante la prueba del PSA&#46; Un estudio realizado en centros de atenci&#243;n primaria en Gij&#243;n<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> present&#243; una prevalencia de determinaciones de hasta un 45&#44;8&#37; anual&#44; seg&#250;n el centro&#44; en hombres mayores de 50 a&#241;os&#46; Contrasta&#44; pues&#44; la elevada frecuencia de cribado mediante esta prueba&#44; dado que no existe evidencia concluyente sobre su beneficio y s&#237; del sobrediagn&#243;stico que puede suponer<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a>&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">En relaci&#243;n con los estilos de vida&#44; no se observa un patr&#243;n com&#250;n para todas las pruebas de cribado&#44; sino que existen diferencias por sexo y tipo de prueba&#46; A pesar de la falta de poder estad&#237;stico para confirmar algunas asociaciones&#44; la relaci&#243;n entre el consumo de fruta y verdura y la participaci&#243;n en mamograf&#237;as concuerda con la literatura publicada<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> y se atribuye a un mayor autocuidado&#46; En el mismo sentido&#44; se observa una relaci&#243;n entre la presencia de comorbilidad y la realizaci&#243;n de mamografia y la prueba de SOH en los hombres&#44; que coincide con otros estudios<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;23</span></a>&#46; La hip&#243;tesis que se plantea es que la presencia de enfermedades&#44; en su mayor&#237;a cr&#243;nicas&#44; implica un mayor contacto con el m&#233;dico&#44; lo que predispone a la participaci&#243;n en el cribado&#46; No obstante&#44; en Espa&#241;a&#44; Jim&#233;nez-Garc&#237;a et al&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> presentaron resultados en sentido contrario en mujeres con diabetes&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Sin embargo&#44; la utilizaci&#243;n de la prueba del PSA no se asocia a la presencia de comorbilidad ni a otras variables de estilos de vida&#44; excepto sobrepeso-obesidad&#44; resultado que coincide con otros estudios<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> y parece indicar que no hay una mayor predisposici&#243;n al cuidado de la salud en los hombres que se realizan dicha prueba&#46; Esto puede verse afectado en parte porque&#44; a diferencia de las otras pruebas&#44; &#233;sta no requiere una participaci&#243;n activa por parte del paciente&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Predictores de participaci&#243;n en el cribado establecidos en otros estudios&#44; como el consumo de alcohol&#44; la actividad f&#237;sica<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> o los antecedentes familiares de c&#225;ncer&#44; no han presentado un patr&#243;n claro en el actual&#46; Esto puede atender a caracter&#237;sticas espec&#237;ficas del grupo de edad&#44; como la menor prevalencia de ejercicio f&#237;sico moderado&#44; as&#237; como a la codificaci&#243;n de la informaci&#243;n o la extensi&#243;n de ciertos cribados&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">En cuanto a la asociaci&#243;n entre distintas pr&#225;cticas de cribado&#44; se hall&#243; una estrecha relaci&#243;n entre mamograf&#237;a y citolog&#237;a&#44; coincidiendo con la literatura publicada<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a>&#46; En cambio&#44; la asociaci&#243;n entre mamograf&#237;a y el cribado de c&#225;ncer colorrectal desaparece al ajustar por el resto de variables en el an&#225;lisis multivariado&#44; aunque s&#237; se ha encontrado en otros estudios<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a>&#46; Una posible asociaci&#243;n entre estas pruebas&#44; ya sea positiva o negativa&#44; puede tener importantes implicaciones en el despliegue de este cribado y deber&#237;a evaluarse en un futuro&#46; La correlaci&#243;n entre la prueba de SOH y la colonoscopia&#47;sigmoidoscopia encontrada probablemente se debe a la realizaci&#243;n de colonoscopias de confirmaci&#243;n en SOH positivas y a la posible confusi&#243;n entre colonoscopia de cribado y diagn&#243;stica&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Aunque es necesaria mayor investigaci&#243;n&#44; estas asociaciones podr&#237;an no relacionarse con la edad de recomendaci&#243;n de las pruebas&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Al interpretar estos resultados es necesario tener en cuenta ciertas limitaciones&#44; ya que el estudio MCC-Spain no fue dise&#241;ado para evaluar la participaci&#243;n en pruebas de cribado&#46; Los controles poblacionales de este estudio podr&#237;an no ser representativos de la poblaci&#243;n general&#44; y esto llevar&#237;a a una sobreestimaci&#243;n de las pr&#225;cticas&#44; por estar m&#225;s representada la poblaci&#243;n en edad diana de algunas pruebas o haberse dado una cierta autoselecci&#243;n de la poblaci&#243;n participante&#46; Para minimizar estos sesgos&#44; se ha ajustado por edad y nivel de estudios&#46; Por otro lado&#44; la obtenci&#243;n de informaci&#243;n autonotificada sobre el uso de las pruebas de cribado&#44; utilizando adem&#225;s un cuestionario con preguntas no validadas&#44; puede conllevar cierta sobreestimaci&#243;n<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a>&#44; en parte debido a la confusi&#243;n entre las pruebas de cribado y las diagn&#243;sticas&#44; o las realizadas para el control de otras enfermedades&#46; En cualquier caso&#44; con el fin de reducir los sesgos&#44; las entrevistas se hicieron por personal especialmente entrenado&#44; con indicaciones para explicar que las pruebas de cribado son aquellas realizadas en ausencia de s&#237;ntomas&#44; aunque sin diferenciar entre cribado poblacional u oportunista<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a>&#46; Finalmente&#44; el car&#225;cter transversal del estudio no permite inferir una relaci&#243;n temporal o causal entre la participaci&#243;n en el cribado y ciertos estilos de vida&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">A pesar de dichas limitaciones&#44; el presente estudio aporta informaci&#243;n sobre la utilizaci&#243;n de las pruebas de cribado en la poblaci&#243;n espa&#241;ola de diferentes provincias&#44; con informaci&#243;n hasta ahora poco disponible&#44; principalmente en el cribado de c&#225;ncer colorrectal y de pr&#243;stata&#46; Los resultados apuntan ciertas discrepancias entre la pr&#225;ctica de cribado y lo recomendado seg&#250;n la evidencia&#44; as&#237; como su relaci&#243;n con los estilos de vida y la realizaci&#243;n de otras pruebas&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Esta informaci&#243;n puede ser &#250;til para orientar nuevos estudios sobre las pr&#225;cticas de cribado que puedan servir para mejorar la participaci&#243;n y revisar posibles ineficiencias del sistema&#44; considerando el momento actual de consolidaci&#243;n del cribado de c&#225;ncer de mama&#44; implantaci&#243;n del de c&#225;ncer colorrectal mediante la prueba de SOH y la pr&#225;ctica extendida del cribado oportunista no recomendado de c&#225;ncer de pr&#243;stata&#46; Por otro lado&#44; tambi&#233;n ser&#225; &#250;til para generar hip&#243;tesis sobre la posible relaci&#243;n entre ciertos estilos de vida&#44; algunos a su vez factores de riesgo de c&#225;ncer&#44; y la utilizaci&#243;n de la detecci&#243;n precoz de esta enfermedad&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Responsabilidades &#233;ticas</span><p id="par0155" class="elsevierStylePara elsevierViewall">El estudio fue aprobado por el Comit&#233; de &#201;tica de todos los centros participantes&#46; En la realizaci&#243;n del estudio se cumpli&#243; con las normas &#233;ticas de la Declaraci&#243;n de Helsinki y con la normativa legal sobre confidencialidad de datos &#40;Ley Org&#225;nica 15&#47;1999 del 13 de diciembre de Protecci&#243;n de Datos de Car&#225;cter Personal &#91;LOPD&#93;&#41;&#46;<elsevierMultimedia ident="tb0005"></elsevierMultimedia></p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Contribuciones de autor&#237;a</span><p id="par0190" class="elsevierStylePara elsevierViewall">M&#46;D&#46; Perea ha realizado la revisi&#243;n bibliogr&#225;fica del tema&#44; ha efectuado el an&#225;lisis y ha escrito las sucesivas versiones del manuscrito&#46; M&#46; Sala ha participado en la concepci&#243;n del estudio sobre pr&#225;cticas de cribado y supervisado&#44; junto con G&#46; Casta&#241;o-Vinyals&#44; todo el proceso de an&#225;lisis y redacci&#243;n del manuscrito&#46; M&#46; Poll&#225;n es coinvestigadora principal del estudio MCC-Spain&#58; junto con J&#46;M&#46; Altzibar&#44; N&#46; Ascunce&#44; V&#46; Moreno y A&#46; Tard&#243;n son investigadores del proyecto en Madrid&#44; Gipuzkoa&#44; Navarra&#44; Barcelona y Oviedo&#46; Todos ellos han participado en la concepci&#243;n del estudio y han supervisado el trabajo de campo de MCC-Spain&#46; Todos los autores han participado en la revisi&#243;n del art&#237;culo y han aceptado la versi&#243;n final&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Financiaci&#243;n</span><p id="par0175" class="elsevierStylePara elsevierViewall">El estudio ha sido parcialmente financiado por la Acci&#243;n Transversal del C&#225;ncer del Consejo de Ministros del 11&#47;10&#47;2007&#44; por el Instituto de Salud Carlos III-FEDER &#40;PI08&#47;1770&#41; y por el CIBER de Epidemiolog&#237;a y Salud P&#250;blica &#40;FIS multic&#233;ntrico&#58; PS09&#47;00773&#44; Cantabria&#59; PS09&#47;01286&#44; Le&#243;n&#59; PS09&#47;01903&#44; Valencia&#59; PS09&#47;02078&#59; PS09&#47;01662&#41;&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflictos de intereses</span><p id="par0180" class="elsevierStylePara elsevierViewall">Ninguno&#46;</p></span></span>"
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            0 => "Detecci&#243;n precoz del c&#225;ncer"
            1 => "Cribado poblacional"
            2 => "Estilo de vida"
            3 => "Comorbilidad"
            4 => "Factores de riesgo"
            5 => "Mamograf&#237;a"
            6 => "Ant&#237;geno espec&#237;fico de pr&#243;stata"
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            0 => "Early detection of cancer"
            1 => "Mass screening"
            2 => "Lifestyle"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estimar la prevalencia de pr&#225;cticas de cribado de c&#225;ncer en los controles del estudio multi-caso control &#40;MCC-Spain&#41; y evaluar su asociaci&#243;n con los estilos de vida&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">An&#225;lisis transversal de 1505 controles poblacionales del estudio MCC-Spain&#44; de 20-85 a&#241;os&#44; recogidos entre 2008-2010 en cinco &#225;reas de Espa&#241;a&#46; Se ha calculado la prevalencia de pruebas de cribado en los &#250;ltimos 5 a&#241;os&#44; evaluando la relaci&#243;n con los estilos de vida y analizando su asociaci&#243;n mediante modelos de regresi&#243;n log&#237;stica&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Las pruebas m&#225;s prevalentes en las mujeres fueron mamograf&#237;a &#40;98&#44;2&#37;&#44; en mujeres de 50-69 a&#241;os&#41; y citolog&#237;a &#40;94&#44;5&#37;&#44; en las de 25-65 a&#241;os&#41;&#44; y ant&#237;geno espec&#237;fico de pr&#243;stata en los hombres &#40;71&#44;5&#37;&#44; 50 a&#241;os o m&#225;s&#41;&#46; La realizaci&#243;n de la prueba de sangre oculta en heces fue muy inferior &#40;11&#44;2&#37; y 16&#44;2&#37;&#44; en mujeres y hombres de 50-74 a&#241;os&#44; respectivamente&#41;&#46; Consumir al menos tres raciones de fruta y verdura al d&#237;a se asocia con una mayor participaci&#243;n en mamograf&#237;as &#40;<span class="elsevierStyleItalic">odds ratio</span> ajustadas &#91;OR<span class="elsevierStyleInf">a</span>&#93;&#58; 5&#44;24&#59; intervalo de confianza del 95&#37; &#91;IC95&#37;&#93;&#58; 1&#44;96-14&#44;07&#41;&#46; En los hombres&#44; el sobrepeso-obesidad se relaciona con la mayor realizaci&#243;n de la prueba del ant&#237;geno espec&#237;fico de pr&#243;stata &#40;OR<span class="elsevierStyleInf">a</span>&#58; 1&#44;88&#59; IC95&#37;&#58; 1&#44;15-3&#44;08&#41;&#46; En general&#44; destaca la presencia de comorbilidad asociada con la realizaci&#243;n de pruebas de cribado&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Este estudio muestra una elevada prevalencia de pr&#225;cticas de cribado de c&#225;ncer de mama&#44; cuello uterino y pr&#243;stata&#44; y baja del c&#225;ncer colorrectal&#46; No se observa un patr&#243;n com&#250;n de estilos de vida asociado al cribado&#44; sino que hay diferencias por sexo y tipo de prueba&#46; Estos resultados pueden ser &#250;tiles para orientar nuevos estudios sobre las pr&#225;cticas de cribado y revisar posibles ineficiencias&#46;</p>"
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      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To estimate the prevalence of screening practices in the population controls of the multi-case control study &#40;MCC-Spain&#41; study and to evaluate its association with lifestyles&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We carried out a cross-sectional analysis of 1505 population controls of the MCC-Spain study&#44; aged 20-85&#44; enrolled from 2008-2010 in five areas of Spain&#46; The prevalence of screening tests in the last 5 years was estimated and its association with lifestyles was assessed using logistic regression models&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The most prevalent tests were mammography &#40;98&#46;2&#37;&#44; age 50-69 years&#41; and cytology &#40;94&#46;5&#37;&#44; age 25-65 years&#41; in women and prostate-specific antigen in men &#40;71&#46;5&#37;&#44; age 50 or over&#41;&#46; Participation in fecal occult blood testing was lower &#40;11&#46;2&#37; and 16&#46;2&#37; in women and men aged 50-74&#44; respectively&#41;&#46; Eating at least three pieces of fruit and vegetables per day was associated with higher participation in mammography &#40;ORa&#58; 5&#46;24&#44; 95&#37; CI&#58; 1&#46;96-14&#46;07&#41;&#46; In men&#44; overweight-obesity was linked to higher participation in prostate-specific antigen testing &#40;ORa&#58; 1&#46;88&#59; 95&#37; CI&#58; 1&#46;15-3&#46;08&#41;&#46; In general&#44; the presence of comorbidities was associated with utilization of cancer screening tests&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The prevalence of screening practices was high for breast&#44; cervical and prostate cancer and was low for colorectal cancer&#46; No common lifestyle patterns were associated with participation&#44; although differences were found by sex and type of screening test&#46; These results may be useful to guide further studies on screening practices and review possible inefficiencies&#46;</p>"
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            "apendice" => "<p id="par0185" class="elsevierStylePara elsevierViewall">Los investigadores del MCC-Spain en este art&#237;culo son&#58; M&#46; Dolores Perea &#40;Servei d&#8217;Epidemiologia i Avaluaci&#243;&#44; Hospital del Mar&#44; Parc de Salut Mar&#44; Barcelona&#41;&#44; Gemma Casta&#241;o-Vinyals &#40;Centre for Research in Environmental Epidemiology&#44; CREAL&#44; Hospital del Mar Research Institute&#44; IMIM&#44; Barcelona&#59; CIBER de Epidemolog&#237;a y Salud P&#250;blica&#44; CIBERESP&#41;&#44; Nuria Aragon&#233;s &#40;Centro Nacional de Epidemiolog&#237;a&#44; Instituto de Salud Carlos III&#44; Madrid&#59; CIBER de Epidemolog&#237;a y Salud P&#250;blica&#44; CIBERESP&#41;&#44; Beatriz P&#233;rez-G&#243;mez &#40;Centro Nacional de Epidemiolog&#237;a&#44; Instituto de Salud Carlos III&#44; Madrid&#59; CIBER de Epidemolog&#237;a y Salud P&#250;blica&#44; CIBERESP&#41;&#44; Jone M&#46; Altzibar &#40;Subdirecci&#243;n de Salud P&#250;blica de Gipuzkoa&#59; CIBER de Epidemolog&#237;a y Salud P&#250;blica&#44; CIBERESP&#41;&#44; Victor Moreno &#40;Institut Catal&#224; d&#8217;Oncologia&#44; Barcelona&#59; CIBER de Epidemolog&#237;a y Salud P&#250;blica&#44; CIBERESP&#41;&#44; Nieves Ascunce &#40;Instituto de Salud P&#250;blica de Navarra&#59; CIBER de Epidemiolog&#237;a y Salud P&#250;blica&#44; CIBERESP&#41;&#44; Adonina Tard&#243;n &#40;Instituto Universitario de Oncolog&#237;a&#44; Universidad de Oviedo&#44; Asturias&#59; CIBER de Epidemolog&#237;a y Salud P&#250;blica&#44; CIBERESP&#41;&#44; Antoni Castells &#40;Hospital Cl&#237;nic de Barcelona&#59; CIBER de Enfermedades Hep&#225;ticas y Digestivas&#44; CIBEREHD&#41;&#44; Xavier Castells &#40;Servei d&#8217;Epidemiologia i Avaluaci&#243;&#44; Hospital del Mar&#44; Parc de Salut Mar&#44; Barcelona&#59; CIBER de Epidemolog&#237;a y Salud P&#250;blica&#44; CIBERESP&#41;&#44; Marina Poll&#225;n &#40;Centro Nacional de Epidemiolog&#237;a&#44; Instituto de Salud Carlos III&#44; Madrid&#59; CIBER de Epidemolog&#237;a y Salud P&#250;blica&#44; CIBERESP&#41;&#44; Manolis Kogevinas &#40;Centre for Research in Environmental Epidemiology&#44; CREAL&#59; Hospital del Mar Research Institute&#44; IMIM&#44; Barcelona&#59; CIBER de Epidemolog&#237;a y Salud P&#250;blica&#44; CIBERESP&#59; National School of Public Health&#44; Athens&#41; y Mar&#237;a Sala &#40;Servei d&#8217;Epidemiologia i Avaluaci&#243;&#44; Hospital del Mar&#44; Parc de Salut Mar&#44; Barcelona&#59; CIBER de Epidemolog&#237;a y Salud P&#250;blica&#46; CIBERESP&#41;&#46;</p>"
            "etiqueta" => "Anexo"
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Inferiores a primarios&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Primarios completos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Superiores a primarios&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Soltero&#47;a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Casado&#47;a-viviendo con compa&#241;ero&#47;a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Separado&#47;a o divorciado&#47;a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Viudo&#47;a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">&#205;ndice de masa corporal</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Normopeso-bajo peso&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sobrepeso-obesidad&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Consumo de tabaco</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No fumador&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">528&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;61&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">170&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;26&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">698&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;46&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ex fumador&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">185&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;21&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">347&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;54&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">532&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;35&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fumador actual&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">150&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;17&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">122&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;19&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">272&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;18&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Consumo de alcohol</span><a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bajo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">559&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;81&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">331&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;63&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">890&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;73&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Alto&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">129&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;18&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">187&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;36&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">316&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;26&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Actividad f&#237;sica</span><a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">d</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Baja&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">570&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;65&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">337&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;52&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">907&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Alta&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">296&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;34&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">302&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;47&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;39&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Consumo de frutas y verduras</span><a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">e</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bajo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">480&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;70&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&#40;79&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">893&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;74&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Alto&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">203&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;29&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">108&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#40;20&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">311&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#40;25&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Comorbilidad</span><a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">f</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">157&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;18&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;14&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">250&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;16&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">707&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;81&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">546&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;85&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1253&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;83&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Familiares con c&#225;ncer</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">230&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;26&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">220&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;34&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">450&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;30&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">629&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;73&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">415&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;65&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1044&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;69&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Otro c&#225;ncer anterior</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">759&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;92&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">555&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;89&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1314&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;91&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;7&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;10&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">126&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;8&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Alguna prueba de cribado</span><a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">g</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">804&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;93&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">480&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;75&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1284&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;85&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;40 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;97&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;16&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;87&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>40-49 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">154&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;95&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;25&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">160&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;86&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>50-59 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#8805; 70 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Fecha de la prueba</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>1-3 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#62; 3 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Fecha de la prueba</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>1-3 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#62; 3 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#8805; 75 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Fecha de la prueba</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>1-3 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Regi&#243;n cribado de c&#225;ncer colorrectal</span><a class="elsevierStyleCrossRef" href="#tblfn0045"><span class="elsevierStyleSup">b</span></a></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Prueba del ant&#237;geno espec&#237;fico de pr&#243;stata</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Grupo de edad</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">423&#47;592&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="right" valign="\n
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                  \t\t\t\t">&#40;71&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Fecha de la prueba</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#60; 1 a&#241;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">294&#47;420&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>1-3 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr></tbody></table>
                  """
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              "nota" => "<p class="elsevierStyleNotepara">Residentes en regiones donde han comenzado programas de cribado de c&#225;ncer colorrectal mediante prueba de SOH&#58; No &#40;Madrid&#44; Navarra y Asturias&#41;&#44; S&#237; &#40;Barcelona y Gipuzkoa&#41;&#46; Diferencias significativas &#40;ji al cuadrado&#44; p &#60; 0&#44;05&#41; para controles de ambos sexos&#46;</p>"
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          "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Pr&#225;cticas de cribado por tipo de prueba en los &#250;ltimos 5 a&#241;os en la poblaci&#243;n de estudio</p>"
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          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">IC95&#37;&#58; intervalo de confianza del 95&#37;&#46;</p>"
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            0 => array:2 [
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                0 => """
                  <table border="0" frame="\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caracter&#237;sticas de estilos de vida y otros<a class="elsevierStyleCrossRef" href="#tblfn0050"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Mamograf&#237;a &#40;727&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Citolog&#237;a &#40;712&#41;</td><td class="td" title="\n
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                  \t\t\t\t  " colspan="8" align="center" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Prueba de sangre oculta en heces</td><td class="td" title="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Prueba del ant&#237;geno espec&#237;fico de pr&#243;stata &#40;426&#41;</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Mujeres &#40;87&#41;</td><td class="td" title="\n
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                  \t\t\t\t  " colspan="4" align="center" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Hombres &#40;96&#41;</td><td class="td" title="\n
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                  \t\t\t\t  " colspan="21" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">&#205;ndice de masa corporal</span><a class="elsevierStyleCrossRef" href="#tblfn0055"><span class="elsevierStyleSup">b</span></a></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Normopeso-bajo peso&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sobrepeso-obesidad&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Consumo de tabaco</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="21" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Actividad f&#237;sica</span><a class="elsevierStyleCrossRef" href="#tblfn0065"><span class="elsevierStyleSup">d</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Baja&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;11&#44;0-18&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Alta&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;64&#44;5-75&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="21" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Consumo de fruta y verdura</span><a class="elsevierStyleCrossRef" href="#tblfn0070"><span class="elsevierStyleSup">e</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bajo&nbsp;\t\t\t\t\t\t\n
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                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab10667.png"
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              "identificador" => "tblfn0050"
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              "nota" => "<p class="elsevierStyleNotepara">Porcentaje de p&#233;rdidas en todas las variables &#60; 20&#37;&#46;</p>"
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            1 => array:3 [
              "identificador" => "tblfn0055"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara">Normopeso-bajo peso &#40;&#60; 25<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#44; sobrepeso-obesidad &#40;&#8805; 25<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0060"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara">Bajo&#58; &#8804; 20<span class="elsevierStyleHsp" style=""></span>g etanol&#47;d&#237;a &#40;hombres&#41; y &#8804; 10<span class="elsevierStyleHsp" style=""></span>g etanol&#47;d&#237;a &#40;mujeres&#41;&#59; alto&#58; &#62; 20<span class="elsevierStyleHsp" style=""></span>g etanol&#47;d&#237;a &#40;hombres&#41; y &#62; 10<span class="elsevierStyleHsp" style=""></span>g etanol&#47;d&#237;a &#40;mujeres&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p>"
            ]
            3 => array:3 [
              "identificador" => "tblfn0065"
              "etiqueta" => "d"
              "nota" => "<p class="elsevierStyleNotepara">Baja&#58; &#60; 2<span class="elsevierStyleHsp" style=""></span>h 30<span class="elsevierStyleHsp" style=""></span>min de actividad f&#237;sica moderada-alta&#47;semana&#59; alta&#58; &#8805; 2<span class="elsevierStyleHsp" style=""></span>h 30<span class="elsevierStyleHsp" style=""></span>min de actividad f&#237;sica moderada-alta&#47;semana&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a></p>"
            ]
            4 => array:3 [
              "identificador" => "tblfn0070"
              "etiqueta" => "e"
              "nota" => "<p class="elsevierStyleNotepara">Bajo&#58; menos de tres piezas de fruta y verdura&#47;d&#237;a&#59; alto&#58; tres o m&#225;s piezas de fruta y verdura&#47;d&#237;a&#46;</p>"
            ]
            5 => array:3 [
              "identificador" => "tblfn0075"
              "etiqueta" => "f"
              "nota" => "<p class="elsevierStyleNotepara">Comorbilidad&#58; diabetes&#44; hipertensi&#243;n&#44; colesterol&#44; angina pecho&#44; infarto&#44; ictus&#44; otras del aparato circulatorio&#44; artritis&#44; gota&#44; migra&#241;a&#44; colitis ulcerosa&#44; enfermedad de Crohn&#44; colon irritable&#44; litiasis renal&#44; piedras en la ves&#237;cula&#44; asma&#44; enfermedad pulmonar obstructiva cr&#243;nica&#44; anemia&#44; diverticulitis&#44; enfermedad cel&#237;aca&#46;</p>"
            ]
            6 => array:3 [
              "identificador" => "tblfn0080"
              "etiqueta" => "g"
              "nota" => "<p class="elsevierStyleNotepara">Valor p &#40;prueba ji al cuadrado&#41;&#46; Nivel de significaci&#243;n &#60; 0&#44;05&#46;</p>"
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          ]
        ]
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          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Pr&#225;ctica de cribado por prueba espec&#237;fica en funci&#243;n de los estilos de vida y otros factores</p>"
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      ]
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caracter&#237;sticas de estilos de vida y otros<a class="elsevierStyleCrossRef" href="#tblfn0085"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="8" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Prueba de sangre oculta en heces</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Prueba del ant&#237;geno espec&#237;fico de pr&#243;stata &#40;426&#41;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Mamograf&#237;a &#40;727&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Citolog&#237;a &#40;712&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Mujeres &#40;87&#41;</td><td class="td" title="\n
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                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Hombres &#40;96&#41;</td><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Otras pruebas de cribado</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&#40;IC95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;18-1&#44;61&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Alcohol</span><a class="elsevierStyleCrossRef" href="#tblfn0100"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Familiar con c&#225;ncer</span><a class="elsevierStyleCrossRef" href="#tblfn0105"><span class="elsevierStyleSup">d</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Otro c&#225;ncer anterior</span><a class="elsevierStyleCrossRef" href="#tblfn0105"><span class="elsevierStyleSup">d</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;0&#44;30-1&#44;80&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;0&#44;95-5&#44;08&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;12&#44;41-112&#44;41&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#40;0&#44;66-9&#44;07&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Citolog&#237;a</span><a class="elsevierStyleCrossRef" href="#tblfn0110"><span class="elsevierStyleSup">e</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&#40;14&#44;98-141&#44;11&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Sangre oculta en heces</span><a class="elsevierStyleCrossRef" href="#tblfn0110"><span class="elsevierStyleSup">e</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Colonoscopia&#47;sigmoidoscopia</span><a class="elsevierStyleCrossRef" href="#tblfn0110"><span class="elsevierStyleSup">e</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Ant&#237;geno espec&#237;fico de pr&#243;stata</span><a class="elsevierStyleCrossRef" href="#tblfn0110"><span class="elsevierStyleSup">e</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#40;0&#44;79-3&#44;18&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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