Enfermedad neumocócica invasiva en niños de la Región de Murcia
(Invasive pneumococcal disease in children in the region of Murcia, Spain)
M.I. Espína,
, A. Sandovalb,†, J. Ruizc, J.A. Navarroa, J. Garcíad, D. Pérez Florese
Autor para correspondencia
isabel.espin@carm.es
Correspondencia: María Isabel Espín Rios. Consejería de Sanidad de Murcia. Ronda de Levante, 11. 30008 Murcia
Correspondencia: María Isabel Espín Rios. Consejería de Sanidad de Murcia. Ronda de Levante, 11. 30008 Murcia
a Servicio de Protección y Promoción de la Salud. Consejería de Sanidad y Consumo de Murcia
b Servicios Municipales de Salud. Ayuntamiento de Murcia
c Servicio de Microbiología. Hospital Virgen de la Arrixaca. Murcia
d Servicio de Epidemiología. Consejería de Sanidad y Consumo de Murcia
e Departamento de Bioestadística. Facultad de Medicina. Murcia
† In memoriam
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"apellidos" => "Sandoval" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">†</span>" "identificador" => "aff0030" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Ruiz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "J.A." "apellidos" => "Navarro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "J." "apellidos" => "García" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 5 => array:3 [ "nombre" => "D." "apellidos" => "Pérez Flores" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] ] "afiliaciones" => array:6 [ 0 => array:3 [ "entidad" => "Servicio de Protección y Promoción de la Salud. Consejería de Sanidad y Consumo de Murcia" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicios Municipales de Salud. Ayuntamiento de Murcia" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Microbiología. Hospital Virgen de la Arrixaca. Murcia" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Epidemiología. Consejería de Sanidad y Consumo de Murcia" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Departamento de Bioestadística. Facultad de Medicina. Murcia" "etiqueta" => "e" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "<span class="elsevierStyleItalic">In memoriam</span>" "etiqueta" => "†" "identificador" => "aff0030" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: María Isabel Espín Rios. Consejería de Sanidad de Murcia. Ronda de Levante, 11. 30008 Murcia" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "(Invasive pneumococcal disease in children in the region of Murcia, Spain)" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2002-02-22" "fechaAceptado" => "2002-06-25" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec268829" "palabras" => array:2 [ 0 => "Enfermedad neumocócica invasiva" 1 => "Vacuna neumocócica conjugada" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec268828" "palabras" => array:2 [ 0 => "Invasive pneumococcal disease epidemiology" 1 => "Conjugate pneumococcal vaccine" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Objetivo</span></span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La disponibilidad de una vacuna neumocócica conjugada plantea la necesidad de conocer la incidencia y características de la enfermedad neumocócica invasiva en niños de la Región de Murcia, con la finalidad de obtener información que pueda ser de utilidad para establecer adecuadamente las indicaciones de vacunación.</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Métodos</span></span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se ha realizado una búsqueda retrospectiva de casos de enfermedad invasiva por Streptococcus pneumoniae en menores de 15 años de edad atendidos en hospitales de la Región de Murcia durante el período 1991-2000. Las fuentes de datos utilizadas han sido las bases de datos de los Servicios de Microbiología, el Conjunto Mínimo de Datos Básicos, registro de altas pediátricas y Registro EDO.</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Resultados</span></span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La tasa de incidencia para el período 1996-2000 fue, para los menores de 1 año, de 18,25 por 105 personas-año en el caso de enfermedad invasiva (10,6 para meningitis); para los menores de 2 años, de 13,6 para enfermedad invasiva (6 para meningitis); para menores de 5 años, de 8,9 (1,35 para meningitis), y para los menores de 15 años, de 3,7 (1,3 para meningitis). El 28% de los casos presentaba factores de riesgo. Las complicaciones alcanzaron el 35,2% y las secuelas el 5%. La letalidad fue del 11,8%. Los serogrupos prevalentes fueron el 19, el 6, el 18, el 5, el 14 y el 23.</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Conclusiones</span></span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El alto porcentaje de casos con factores de riesgo de enfermedad neumocócica invasiva aconseja la implantación de programas de vacunación dirigidos a todos los niños con factores de riesgo. La incidencia de enfermedad neu-mocócica invasiva encontrada en la Región de Murcia difiere de la de otras zonas geográficas; sin embargo, la incidencia de meningitis es similar a la de otros estudios. La gravedad de la enfermedad justifica la realización de estudios coste-efectividad para valorar la posible incorporación de la vacuna en el calendario vacunal.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Objective</span></span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Because of the availability of a conjugate pneumococcal vaccine, the incidence and characteristics of invasive pneumococcal disease in children in the region of Murcia should be determined. This would provide information that could be useful for properly establishing the indications for vaccination.</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Methods</span></span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A retrospective search was conducted for cases of invasive Streptococcus pneumoniae in children aged less 15 years old treated in hospitals in Murcia from 1991-2000. The data sources were the databases of the microbiology services, the Minimum Data Set, the Pediatric Admissions Register and the EDO Register.</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Results</span></span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The incidence rate for the period 1996-2000 was 18.25 per 105 children per year for children aged under 1 year in the case of invasive disease (10.6 for meningitis), 13.6 for those under 2 years for invasive disease (6 for meningitis), 8.9 for those under 5 years (1.35 for meningitis) and 3.7 for those under 15 years (1.3 for meningitis). Twenty-eight percent of the patients presented risk factors. Complications occurred in 35.2% and sequelae occurred in 5%. The mortality rate was 11.8%. The prevalent serogroups were 19, 6, 18, 5, 14 and 23.</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Conclusions</span></span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The high percentage of patients with risk factors for invasive pneumococcal disease suggests the need to implement vaccination programs aimed at risk groups. Although the incidence of invasive pneumococcal disease in the region of Murcia differs from that in other areas, the incidence of meningitis is similar to that reported by other studies. Because of the severity of the disease, cost-effectiveness studies to evaluate the possible incorporation of the vaccine in the vaccination calendar are justified.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:26 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pneumococcal vaccines" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "WHO" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Wkly Epidemiol Rec" "fecha" => "1999" "volumen" => "74" "paginaInicial" => "177" "paginaFinal" => "184" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10437429" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pneumococcal Infections" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "American Academy of Pediatrics" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "titulo" => "2000 Red Book: Report of the Committee on Infections Diseases" "paginaInicial" => "453" "serieFecha" => "2000" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Black" 1 => "H. Shinefield" 2 => "B. Fireman" 3 => "E. Lewis" 4 => "P. Ray" 5 => "P. Elvin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pediatric Infect Dis J" "fecha" => "2000" "volumen" => "19" "paginaInicial" => "187" "paginaFinal" => "195" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Streptococcus pneumoniae" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.M. Musher" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Principles and practice of infectious diseases" "paginaInicial" => "2134" "edicion" => "5<span class="elsevierStyleSup">th</span>" "serieFecha" => "2000" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Practical statistics for medical research" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.G. Altman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:1 [ "serieFecha" => "1991" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Preventing pneumococcal disease among infants and young children" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Centers for Disease Control and Prevention" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Re-comendations of the Advisory Committee on Immunization Practices (ACIP) Morb Mortal Wky Rep" "fecha" => "2000" "volumen" => "49" "numero" => "RR-9" "paginaInicial" => "1" "paginaFinal" => "35" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Invasive pneumococcal disease in England and Wales: vaccination implications" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Sleeman" 1 => "K. Knox" 2 => "R. George" 3 => "E. Miller" 4 => "P. Waigth" 5 => "D. Griffiths" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Epidemiol Infect" "fecha" => "2000" "volumen" => "183" "paginaInicial" => "239" "paginaFinal" => "246" "itemHostRev" => array:3 [ "pii" => "S0091674902000556" "estado" => "S300" "issn" => "00916749" ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proportion of invasive pneumococcal infections in German children preventable by pneumococcal conjugate vaccines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Von Kries" 1 => "A. Siedler" 2 => "H.J. Schmitt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/313984" "Revista" => array:6 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2000" "volumen" => "31" "paginaInicial" => "482" "paginaFinal" => "487" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10987709" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "and the Swiss Pneumococcal Study Group. Paediatric invasive pneumococcal disease in Switzerland, 1985-1994" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "I. Venetz" 1 => "K. Schopfer" 2 => "K. Mühleman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Epidemiol" "fecha" => "1998" "volumen" => "27" "paginaInicial" => "1101" "paginaFinal" => "1104" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10024210" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Childhood invasive pneumococcal disease in Valencia, Spain. Population-Based Surveillance System" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Díez Domingo" 1 => "A. Morant" 2 => "I. Pereiro" 3 => "C. Gimeno" 4 => "J. Brines" 5 => "A. González" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Actas del 17th Annual Meeting of the European Society for Paediatric Infectious Diseases; 1999 mayo 19-21. Heraklion, Greece" "fecha" => "1999" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of invasive pneumococcal disease in infants in Catalonia (Spain). [poster abstract session II]. Actas del 19th Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID); 2001, marzo 26-28" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Domínguez" 1 => "P. Ciruela" 2 => "G. Martínez" 3 => "G. Carmoña" 4 => "N. Torner" 5 => "N. Cardeñosa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Istambul" "fecha" => "2001" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Three-year multicenter surveillance of systemic pneumococcal infections in children" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.L. Kaplan" 1 => "E.D. Mason" 2 => "W.J. Barson" 3 => "E.R. Wald" 4 => "M. Arditi" 5 => "E.R. Wald" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "1998" "volumen" => "102" "paginaInicial" => "538" "paginaFinal" => "545" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9738174" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of invasive pneumococcal infections in children in Finland" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Eskola" 1 => "A.K. Takala" 2 => "E. Kela" 3 => "E. Pekkanen" 4 => "R. Kailliokoski" 5 => "M. Leinomen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1992" "volumen" => "268" "paginaInicial" => "3323" "paginaFinal" => "3327" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1453524" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Talbot J and members of the Canadian Paediatric Society/Laboratory Centre for Disease Control Immunization Monitoring Program. Invasive pneumococcal infections in Canadian children, 1991-1998: implications for new vaccination strategies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Scheifele" 1 => "S. Halperin" 2 => "L. Pelletier" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/313923" "Revista" => array:6 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2000" "volumen" => "31" "paginaInicial" => "58" "paginaFinal" => "64" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10913397" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of invasive pneumococcal infections in infants and young children in Metropolitan Santiago, Chile, a newly industrialising country" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.M. Levine" 1 => "R. Lagos" 2 => "O.S. Levine" 3 => "I. Heitmann" 4 => "N. Enriquez" 5 => "M.E. Pinto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "1998" "volumen" => "17" "paginaInicial" => "287" "paginaFinal" => "293" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9576382" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Meningitis neumocócica: características epidemiológicas, clínicas y bacteriológicas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.A. Soult" 1 => "C. Rangel" 2 => "M. Muñoz" 3 => "J.S. Parrilla" 4 => "F. Diaz" 5 => "J.D. López" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "An Esp Pediat" "fecha" => "2001" "volumen" => "4" "paginaInicial" => "315" "paginaFinal" => "320" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Meningitis neumocócicas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "F. Asensi" 1 => "M.C. Otero" 2 => "D. Pérez" 3 => "P. Gregori" 4 => "A. Orti" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "An Esp Pediatr" "fecha" => "2001" "volumen" => "54" "paginaInicial" => "120" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11181207" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcomes of bacterial meningitis in children: a meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.J. Baraff" 1 => "S.I. Lee" 2 => "D.L. Schriger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "1993" "volumen" => "12" "paginaInicial" => "389" "paginaFinal" => "394" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8327300" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evolution of Streptococcuspneu-moniae serotypes and antibiotic resistance in Spain: update (1990 to 1996)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Fenoll" 1 => "I. Jado" 2 => "D. Vicioso" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Microbiol" "fecha" => "1988" "volumen" => "36" "paginaInicial" => "3447" "paginaFinal" => "3454" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9817852" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "and the Spanish Surveillance Group for Respiratory Pathogens. Streptococcus pneumoniae in community-acquired respiratory tract infections in Spain: the impact of serotype and geographical, seasonal and clinical factors on its susceptibility to the most commonly prescribed antibiotics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F. Marco" 1 => "E. Bouza" 2 => "J. Garcia de Lomas" 3 => "L. Aguilar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Antimicrob Chemother" "fecha" => "2000" "volumen" => "46" "paginaInicial" => "557" "paginaFinal" => "564" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11020252" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mas-trantonio P Antibiotic susceptibility and serotype distribution of Streptococcus pneumoniae Causing Meningitis in Italy, 19971999" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Pantosti" 1 => "F. D’Ambrosio" 2 => "A. Tarasi" 3 => "S. Recchia" 4 => "G. Orefici" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Inf Dis" "fecha" => "2000" "volumen" => "31" "paginaInicial" => "1373" "paginaFinal" => "1379" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estudio prospectivo de las cepas invasivas de Streptococcus pneumoniae aisladas en 16 hospitales de Cataluña durante 1996" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Latorre" 1 => "M. Sierra" 2 => "J. Lite" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Enferm Infecc Microbiol Clin" "fecha" => "1999" "volumen" => "17" "paginaInicial" => "286" "paginaFinal" => "291" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10439539" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Streptococcus pneumoniae in children in Spain: 1990-1999" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Fenoll" 1 => "I. Jado" 2 => "D. Vicioso" 3 => "S. Berrón" 4 => "J.E. Yuste" 5 => "J. Casal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Paediatr" "fecha" => "2000" "volumen" => "435" "numero" => "Suppl" "paginaInicial" => "44" "paginaFinal" => "50" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular epidemiology of Streptococcus pneumoniae causing invasive disease in 5 countries" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Henriques" 1 => "M. Kalin" 2 => "A. Örtqvist" 3 => "B.O. Liljequist" 4 => "M. Almela" 5 => "T.J. Marrie" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/315761" "Revista" => array:6 [ "tituloSerie" => "J Infect Dis" "fecha" => "2000" "volumen" => "182" "paginaInicial" => "833" "paginaFinal" => "839" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10950778" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of invasive pneumococcal disease in Southern California: implications for the design and conduct of a pneumococ-cal conjugate vaccine efficacy trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K.M. Zangwill" 1 => "C.M. Vadheim" 2 => "A.M. Vannier" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Infect Dis" "fecha" => "1996" "volumen" => "174" "paginaInicial" => "752" "paginaFinal" => "759" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8843213" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Incidencia de enfermedad invasiva por Haemophilus influenzae tipo b en la Región de Murcia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.I. Espin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Boletin Epidemiológico de Murcia" "fecha" => "1997" "volumen" => "18" "paginaInicial" => "17" "paginaFinal" => "23" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/02139111/0000001600000005/v1_201310251655/S021391110271947X/v1_201310251655/es/main.assets" "Apartado" => array:4 [ "identificador" => "18705" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02139111/0000001600000005/v1_201310251655/S021391110271947X/v1_201310251655/es/main.pdf?idApp=WGSE&text.app=https://gacetasanitaria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021391110271947X?idApp=WGSE" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 4 | 3 | 7 |
| 2024 Octubre | 50 | 26 | 76 |
| 2024 Septiembre | 40 | 21 | 61 |
| 2024 Agosto | 53 | 27 | 80 |
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| 2024 Junio | 33 | 21 | 54 |
| 2024 Mayo | 32 | 26 | 58 |
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| 2024 Marzo | 39 | 27 | 66 |
| 2024 Febrero | 33 | 23 | 56 |
| 2024 Enero | 23 | 12 | 35 |
| 2023 Diciembre | 25 | 23 | 48 |
| 2023 Noviembre | 22 | 15 | 37 |
| 2023 Octubre | 27 | 20 | 47 |
| 2023 Septiembre | 36 | 20 | 56 |
| 2023 Agosto | 36 | 15 | 51 |
| 2023 Julio | 36 | 17 | 53 |
| 2023 Junio | 27 | 21 | 48 |
| 2023 Mayo | 35 | 17 | 52 |
| 2023 Abril | 35 | 18 | 53 |
| 2023 Marzo | 33 | 38 | 71 |
| 2023 Febrero | 36 | 19 | 55 |
| 2023 Enero | 31 | 22 | 53 |
| 2022 Diciembre | 39 | 33 | 72 |
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| 2022 Septiembre | 25 | 39 | 64 |
| 2022 Agosto | 38 | 57 | 95 |
| 2022 Julio | 36 | 37 | 73 |
| 2022 Junio | 25 | 42 | 67 |
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| 2022 Abril | 25 | 33 | 58 |
| 2022 Marzo | 27 | 46 | 73 |
| 2022 Febrero | 32 | 27 | 59 |
| 2022 Enero | 24 | 42 | 66 |
| 2021 Diciembre | 23 | 37 | 60 |
| 2021 Noviembre | 30 | 34 | 64 |
| 2021 Octubre | 76 | 34 | 110 |
| 2021 Septiembre | 30 | 39 | 69 |
| 2021 Agosto | 24 | 21 | 45 |
| 2021 Julio | 26 | 24 | 50 |
| 2021 Junio | 24 | 27 | 51 |
| 2021 Mayo | 10 | 20 | 30 |
| 2021 Abril | 35 | 32 | 67 |
| 2021 Marzo | 37 | 23 | 60 |
| 2021 Febrero | 18 | 22 | 40 |
| 2021 Enero | 10 | 21 | 31 |
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| 2020 Noviembre | 16 | 10 | 26 |
| 2020 Octubre | 16 | 9 | 25 |
| 2020 Septiembre | 14 | 7 | 21 |
| 2020 Agosto | 14 | 11 | 25 |
| 2020 Julio | 11 | 14 | 25 |
| 2020 Junio | 6 | 8 | 14 |
| 2020 Mayo | 13 | 9 | 22 |
| 2020 Abril | 9 | 16 | 25 |
| 2020 Marzo | 9 | 25 | 34 |
| 2020 Febrero | 8 | 50 | 58 |
| 2020 Enero | 9 | 10 | 19 |
| 2019 Diciembre | 8 | 12 | 20 |
| 2019 Noviembre | 11 | 8 | 19 |
| 2019 Octubre | 19 | 6 | 25 |
| 2019 Septiembre | 3 | 1 | 4 |
| 2019 Agosto | 10 | 10 | 20 |
| 2019 Julio | 9 | 5 | 14 |
| 2019 Junio | 7 | 5 | 12 |
| 2019 Mayo | 9 | 9 | 18 |
| 2019 Abril | 8 | 6 | 14 |
| 2019 Marzo | 6 | 7 | 13 |
| 2019 Febrero | 8 | 12 | 20 |
| 2019 Enero | 7 | 11 | 18 |
| 2018 Diciembre | 9 | 19 | 28 |
| 2018 Noviembre | 5 | 16 | 21 |
| 2018 Octubre | 18 | 19 | 37 |
| 2018 Septiembre | 19 | 9 | 28 |
| 2018 Agosto | 14 | 8 | 22 |
| 2018 Julio | 25 | 6 | 31 |
| 2018 Junio | 19 | 11 | 30 |
| 2018 Mayo | 18 | 12 | 30 |
| 2018 Abril | 16 | 9 | 25 |
| 2018 Marzo | 13 | 7 | 20 |
| 2018 Febrero | 15 | 6 | 21 |
| 2018 Enero | 15 | 4 | 19 |
| 2017 Diciembre | 15 | 8 | 23 |
| 2017 Noviembre | 27 | 10 | 37 |
| 2017 Octubre | 12 | 7 | 19 |
| 2017 Septiembre | 9 | 13 | 22 |
| 2017 Agosto | 14 | 14 | 28 |
| 2017 Julio | 18 | 13 | 31 |
| 2017 Junio | 25 | 10 | 35 |
| 2017 Mayo | 19 | 6 | 25 |
| 2017 Abril | 29 | 20 | 49 |
| 2017 Marzo | 32 | 52 | 84 |
| 2017 Febrero | 15 | 3 | 18 |
| 2017 Enero | 10 | 5 | 15 |
| 2016 Diciembre | 20 | 7 | 27 |
| 2016 Noviembre | 26 | 6 | 32 |
| 2016 Octubre | 23 | 12 | 35 |
| 2016 Septiembre | 24 | 5 | 29 |
| 2016 Agosto | 34 | 10 | 44 |
| 2016 Julio | 15 | 2 | 17 |
| 2015 Diciembre | 1 | 0 | 1 |
| 2015 Octubre | 3 | 0 | 3 |
| 2015 Septiembre | 2 | 0 | 2 |
| 2015 Agosto | 2 | 0 | 2 |
| 2015 Julio | 2 | 0 | 2 |
| 2015 Junio | 1 | 0 | 1 |
| 2015 Mayo | 1 | 0 | 1 |
| 2015 Marzo | 3 | 0 | 3 |
| 2015 Febrero | 2 | 0 | 2 |
| 2015 Enero | 2 | 0 | 2 |
| 2014 Diciembre | 2 | 0 | 2 |
| 2014 Noviembre | 2 | 0 | 2 |
| 2014 Octubre | 3 | 1 | 4 |
| 2014 Septiembre | 1 | 0 | 1 |
| 2014 Agosto | 12 | 2 | 14 |
| 2014 Julio | 10 | 2 | 12 |
| 2014 Junio | 13 | 2 | 15 |
| 2014 Mayo | 10 | 0 | 10 |
| 2014 Abril | 14 | 1 | 15 |
| 2014 Marzo | 8 | 1 | 9 |
| 2014 Febrero | 15 | 1 | 16 |
| 2014 Enero | 14 | 1 | 15 |
| 2013 Diciembre | 15 | 2 | 17 |
| 2013 Noviembre | 29 | 2 | 31 |
| 2013 Octubre | 31 | 5 | 36 |
| 2013 Septiembre | 23 | 5 | 28 |
| 2013 Agosto | 48 | 5 | 53 |
| 2013 Julio | 29 | 3 | 32 |
| 2002 Agosto | 1226 | 0 | 1226 |
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