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        "resumen" => "<span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Objetivo</span></span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La disponibilidad de una vacuna neumoc&#243;cica conjugada plantea la necesidad de conocer la incidencia y caracter&#237;sticas de la enfermedad neumoc&#243;cica invasiva en ni&#241;os de la Regi&#243;n de Murcia&#44; con la finalidad de obtener informaci&#243;n que pueda ser de utilidad para establecer adecuadamente las indicaciones de vacunaci&#243;n&#46;</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">M&#233;todos</span></span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se ha realizado una b&#250;squeda retrospectiva de casos de enfermedad invasiva por Streptococcus pneumoniae en menores de 15 a&#241;os de edad atendidos en hospitales de la Regi&#243;n de Murcia durante el per&#237;odo 1991-2000&#46; Las fuentes de datos utilizadas han sido las bases de datos de los Servicios de Microbiolog&#237;a&#44; el Conjunto M&#237;nimo de Datos B&#225;sicos&#44; registro de altas pedi&#225;tricas y Registro EDO&#46;</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Resultados</span></span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La tasa de incidencia para el per&#237;odo 1996-2000 fue&#44; para los menores de 1 a&#241;o&#44; de 18&#44;25 por 105 personas-a&#241;o en el caso de enfermedad invasiva &#40;10&#44;6 para meningitis&#41;&#59; para los menores de 2 a&#241;os&#44; de 13&#44;6 para enfermedad invasiva &#40;6 para meningitis&#41;&#59; para menores de 5 a&#241;os&#44; de 8&#44;9 &#40;1&#44;35 para meningitis&#41;&#44; y para los menores de 15 a&#241;os&#44; de 3&#44;7 &#40;1&#44;3 para meningitis&#41;&#46; El 28&#37; de los casos presentaba factores de riesgo&#46; Las complicaciones alcanzaron el 35&#44;2&#37; y las secuelas el 5&#37;&#46; La letalidad fue del 11&#44;8&#37;&#46; Los serogrupos prevalentes fueron el 19&#44; el 6&#44; el 18&#44; el 5&#44; el 14 y el 23&#46;</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Conclusiones</span></span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El alto porcentaje de casos con factores de riesgo de enfermedad neumoc&#243;cica invasiva aconseja la implantaci&#243;n de programas de vacunaci&#243;n dirigidos a todos los ni&#241;os con factores de riesgo&#46; La incidencia de enfermedad neu-moc&#243;cica invasiva encontrada en la Regi&#243;n de Murcia difiere de la de otras zonas geogr&#225;ficas&#59; sin embargo&#44; la incidencia de meningitis es similar a la de otros estudios&#46; La gravedad de la enfermedad justifica la realizaci&#243;n de estudios coste-efectividad para valorar la posible incorporaci&#243;n de la vacuna en el calendario vacunal&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Objective</span></span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Because of the availability of a conjugate pneumococcal vaccine&#44; the incidence and characteristics of invasive pneumococcal disease in children in the region of Murcia should be determined&#46; This would provide information that could be useful for properly establishing the indications for vaccination&#46;</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Methods</span></span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A retrospective search was conducted for cases of invasive Streptococcus pneumoniae in children aged less 15 years old treated in hospitals in Murcia from 1991-2000&#46; The data sources were the databases of the microbiology services&#44; the Minimum Data Set&#44; the Pediatric Admissions Register and the EDO Register&#46;</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Results</span></span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The incidence rate for the period 1996-2000 was 18&#46;25 per 105 children per year for children aged under 1 year in the case of invasive disease &#40;10&#46;6 for meningitis&#41;&#44; 13&#46;6 for those under 2 years for invasive disease &#40;6 for meningitis&#41;&#44; 8&#46;9 for those under 5 years &#40;1&#46;35 for meningitis&#41; and 3&#46;7 for those under 15 years &#40;1&#46;3 for meningitis&#41;&#46; Twenty-eight percent of the patients presented risk factors&#46; Complications occurred in 35&#46;2&#37; and sequelae occurred in 5&#37;&#46; The mortality rate was 11&#46;8&#37;&#46; The prevalent serogroups were 19&#44; 6&#44; 18&#44; 5&#44; 14 and 23&#46;</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Conclusions</span></span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The high percentage of patients with risk factors for invasive pneumococcal disease suggests the need to implement vaccination programs aimed at risk groups&#46; Although the incidence of invasive pneumococcal disease in the region of Murcia differs from that in other areas&#44; the incidence of meningitis is similar to that reported by other studies&#46; Because of the severity of the disease&#44; cost-effectiveness studies to evaluate the possible incorporation of the vaccine in the vaccination calendar are justified&#46;</p>"
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Vol. 16. Núm. 5.
Páginas 385-391 (septiembre - octubre 2002)
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Vol. 16. Núm. 5.
Páginas 385-391 (septiembre - octubre 2002)
Open Access
Enfermedad neumocócica invasiva en niños de la Región de Murcia
(Invasive pneumococcal disease in children in the region of Murcia, Spain)
Visitas
5706
M.I. Espína,
Autor para correspondencia
isabel.espin@carm.es

Correspondencia: María Isabel Espín Rios. Consejería de Sanidad de Murcia. Ronda de Levante, 11. 30008 Murcia
, A. Sandovalb,, J. Ruizc, J.A. Navarroa, J. Garcíad, D. Pérez Florese
a Servicio de Protección y Promoción de la Salud. Consejería de Sanidad y Consumo de Murcia
b Servicios Municipales de Salud. Ayuntamiento de Murcia
c Servicio de Microbiología. Hospital Virgen de la Arrixaca. Murcia
d Servicio de Epidemiología. Consejería de Sanidad y Consumo de Murcia
e Departamento de Bioestadística. Facultad de Medicina. Murcia
In memoriam
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Información del artículo
Resumen
Bibliografía
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Resumen
Objetivo

La disponibilidad de una vacuna neumocócica conjugada plantea la necesidad de conocer la incidencia y características de la enfermedad neumocócica invasiva en niños de la Región de Murcia, con la finalidad de obtener información que pueda ser de utilidad para establecer adecuadamente las indicaciones de vacunación.

Métodos

Se ha realizado una búsqueda retrospectiva de casos de enfermedad invasiva por Streptococcus pneumoniae en menores de 15 años de edad atendidos en hospitales de la Región de Murcia durante el período 1991-2000. Las fuentes de datos utilizadas han sido las bases de datos de los Servicios de Microbiología, el Conjunto Mínimo de Datos Básicos, registro de altas pediátricas y Registro EDO.

Resultados

La tasa de incidencia para el período 1996-2000 fue, para los menores de 1 año, de 18,25 por 105 personas-año en el caso de enfermedad invasiva (10,6 para meningitis); para los menores de 2 años, de 13,6 para enfermedad invasiva (6 para meningitis); para menores de 5 años, de 8,9 (1,35 para meningitis), y para los menores de 15 años, de 3,7 (1,3 para meningitis). El 28% de los casos presentaba factores de riesgo. Las complicaciones alcanzaron el 35,2% y las secuelas el 5%. La letalidad fue del 11,8%. Los serogrupos prevalentes fueron el 19, el 6, el 18, el 5, el 14 y el 23.

Conclusiones

El alto porcentaje de casos con factores de riesgo de enfermedad neumocócica invasiva aconseja la implantación de programas de vacunación dirigidos a todos los niños con factores de riesgo. La incidencia de enfermedad neu-mocócica invasiva encontrada en la Región de Murcia difiere de la de otras zonas geográficas; sin embargo, la incidencia de meningitis es similar a la de otros estudios. La gravedad de la enfermedad justifica la realización de estudios coste-efectividad para valorar la posible incorporación de la vacuna en el calendario vacunal.

Palabras clave:
Enfermedad neumocócica invasiva
Vacuna neumocócica conjugada
Summary
Objective

Because of the availability of a conjugate pneumococcal vaccine, the incidence and characteristics of invasive pneumococcal disease in children in the region of Murcia should be determined. This would provide information that could be useful for properly establishing the indications for vaccination.

Methods

A retrospective search was conducted for cases of invasive Streptococcus pneumoniae in children aged less 15 years old treated in hospitals in Murcia from 1991-2000. The data sources were the databases of the microbiology services, the Minimum Data Set, the Pediatric Admissions Register and the EDO Register.

Results

The incidence rate for the period 1996-2000 was 18.25 per 105 children per year for children aged under 1 year in the case of invasive disease (10.6 for meningitis), 13.6 for those under 2 years for invasive disease (6 for meningitis), 8.9 for those under 5 years (1.35 for meningitis) and 3.7 for those under 15 years (1.3 for meningitis). Twenty-eight percent of the patients presented risk factors. Complications occurred in 35.2% and sequelae occurred in 5%. The mortality rate was 11.8%. The prevalent serogroups were 19, 6, 18, 5, 14 and 23.

Conclusions

The high percentage of patients with risk factors for invasive pneumococcal disease suggests the need to implement vaccination programs aimed at risk groups. Although the incidence of invasive pneumococcal disease in the region of Murcia differs from that in other areas, the incidence of meningitis is similar to that reported by other studies. Because of the severity of the disease, cost-effectiveness studies to evaluate the possible incorporation of the vaccine in the vaccination calendar are justified.

Key words:
Invasive pneumococcal disease epidemiology
Conjugate pneumococcal vaccine
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Copyright © 2002. Sociedad Española de Salud Pública y Administración Sanitaria
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