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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A pesar del creciente reconocimiento de la potencial utilidad de los estudios de coste-efectividad&#44; en Espa&#241;a no existe ning&#250;n criterio que permita establecer si una determinada tecnolog&#237;a sanitaria puede considerarse rentable o no&#46; El objetivo de este trabajo es describir cu&#225;les han sido los l&#237;mites y criterios utilizados en Espa&#241;a para recomendar la adopci&#243;n o el rechazo de intervenciones sanitarias en funci&#243;n de su coste-efectividad&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; una revisi&#243;n de las evaluaciones econ&#243;micas de intervenciones sanitarias publicadas en Espa&#241;a desde 1990 hasta 2001&#46; Se seleccionaron las evaluaciones econ&#243;micas completas en las que el cociente coste-efectividad se hab&#237;a expresado como coste por a&#241;o de vida ganado &#40;AVG&#41;&#44; como coste por a&#241;o de vida ajustado por calidad &#40;AVAC&#41; o como coste por vida salvada&#46; Se analizaron las intervenciones sobre las que los autores establecieron alg&#250;n tipo de recomendaci&#243;n &#40;de adopci&#243;n o rechazo&#41;&#44; as&#237; como los criterios utilizados&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Veinte &#40;20&#37;&#41; de las 100 evaluaciones econ&#243;micas completas publicadas cumplieron con los criterios se&#241;alados&#46; En 16 de los estudios&#44; los resultados se expresaron como coste por AVG&#44; en 6 como coste por AVAC y en 1 como coste por vida salvada&#46; Se evaluaron un total de 82 intervenciones sanitarias&#44; en 44 de las cuales se realiz&#243; alg&#250;n tipo de recomendaci&#243;n&#46; Los autores recomendaron la adopci&#243;n de todas las intervenciones sanitarias con un coste-efectividad inferior a 30&#46;000 euros &#40;5 millones de pesetas&#41; por AVG&#46; Por encima de esa cifra no se apreci&#243; ninguna tendencia&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Si bien los resultados deben ser interpretados con mucha precauci&#243;n&#44; dadas las limitaciones del estudio&#44; los l&#237;mites de coste-efectividad presentados en este trabajo podr&#237;an constituir una primera referencia a lo que podr&#237;a considerarse como una intervenci&#243;n sanitaria eficiente en Espa&#241;a&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Despite the growing recognition of the potential applications of cost-effectiveness assessments&#44; a criterion to establish what is an efficient health technology does not exist in Spain&#46; The objective of this work is to describe the limits and the criteria used in Spain to recommend the adoption of health interventions&#46;</p> <span class="elsevierStyleSectionTitle">Method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A review of the economic evaluations of health technologies published in Spain from 1990 to 2001 was conducted&#46; Complete economic assessments in which the costeffectiveness ratio was expressed as cost per life-year gained &#40;LYG&#41;&#44; cost per quality-adjusted-life-year &#40;QALY&#41; or cost per saved live were selected&#46; Those interventions in which the authors established recommendations &#40;adoption or rejection&#41; and the criteria used were analyzed&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Twenty &#40;20&#37;&#41; of the 100 complete economic evaluations fulfilled the selection criteria&#46; In16 studies&#44; the results were expressed as cost per LYG&#44; in 6 studies as cost per QALY and in 1 as cost per saved live&#46; A total of 82 health interventions were assessed and some kind of recommendation was established in 44 of them&#46; All technologies with a cost-effectiveness ratio lower than 30&#44;000 euros &#40;5 million pesetas&#41; per LYG were recommended for adoption by the authors&#46; Up to that limit there was no a clear tendency&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Although the results must be interpreted with much precaution&#44; given the limitations of the study&#44; the limits of cost-effectiveness presented in this work could be a first reference to which would be an efficient health intervention in Spain&#46;</p>"
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                  0 => array:1 [
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                      "tituloSerie" => "Med Clin &#40;Barc&#41;"
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                      "paginaFinal" => "300"
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                      0 => array:2 [
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                        0 => array:2 [
                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10213735"
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                          2 => "F&#46; Anto&#241;anzas"
                          3 => "C&#46; Ju&#225;rez"
                          4 => "J&#46; Rovira"
                          5 => "M&#46; Figueras"
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                  ]
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                  0 => array:1 [
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                      "tituloSerie" => "Am J Hosp Pharm"
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                          3 => "P&#46;X&#46; Tugwell"
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                    "Revista" => array:5 [
                      "tituloSerie" => "Can Med Assoc J"
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                      "paginaFinal" => "481"
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                    "titulo" => "A comprehensive league table of cost-utility ratios and a sub-table of &#171;panel-worthy&#187; studies"
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                        "etal" => false
                        "autores" => array:5 [
                          0 => "R&#46;H&#46; Chapman"
                          1 => "P&#46;W&#46; Stone"
                          2 => "E&#46;A&#46; Sandberg"
                          3 => "C&#46; Bell"
                          4 => "P&#46;J&#46; Newmann"
                        ]
                      ]
                    ]
                  ]
                ]
                "host" => array:1 [
                  0 => array:1 [
                    "Revista" => array:6 [
                      "tituloSerie" => "Med Decis Making"
                      "fecha" => "2000"
                      "volumen" => "20"
                      "paginaInicial" => "451"
                      "paginaFinal" => "467"
                      "link" => array:1 [
                        0 => array:2 [
                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11059478"
                          "web" => "Medline"
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                    "titulo" => "Twenty years of health care economic analysis in Spain&#58; are we doing well&#63;"
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                        "autores" => array:1 [
                          0 => "A&#46; Garc&#237;a-Alt&#233;s"
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                      "tituloSerie" => "En&#58; Avances en la gesti&#243;n sanitaria&#46; XX Jornadas de Econom&#237;a de la Salud"
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                    ]
                  ]
                ]
              ]
            ]
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              0 => array:2 [
                "contribucion" => array:1 [
                  0 => array:2 [
                    "titulo" => "De la efectividad cl&#237;nica a la eficiencia social"
                    "autores" => array:1 [
                      0 => array:2 [
                        "etal" => false
                        "autores" => array:2 [
                          0 => "V&#46; Ort&#250;n"
                          1 => "F&#46; Rodr&#237;guez Artalejo"
                        ]
                      ]
                    ]
                  ]
                ]
                "host" => array:1 [
                  0 => array:1 [
                    "Revista" => array:5 [
                      "tituloSerie" => "Med Clin &#40;Barc&#41;"
                      "fecha" => "1990"
                      "volumen" => "95"
                      "paginaInicial" => "385"
                      "paginaFinal" => "388"
                    ]
                  ]
                ]
              ]
            ]
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          10 => array:3 [
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            "referencia" => array:1 [
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                "contribucion" => array:1 [
                  0 => array:2 [
                    "titulo" => "The changing healthcare environment&#46; Socioeconomic evaluation of drug therapy"
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                        "autores" => array:1 [
                          0 => "D&#46;B&#46; Evans"
                        ]
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                  0 => array:1 [
                    "Revista" => array:7 [
                      "tituloSerie" => "PharmacoEconomics"
                      "fecha" => "1992"
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                      "paginaInicial" => "5"
                      "paginaFinal" => "7"
                      "link" => array:1 [
                        0 => array:2 [
                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10147034"
                          "web" => "Medline"
                        ]
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                      "itemHostRev" => array:3 [
                        "pii" => "S0140673600049588"
                        "estado" => "S300"
                        "issn" => "01406736"
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                ]
              ]
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          11 => array:3 [
            "identificador" => "bib12"
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              0 => array:2 [
                "contribucion" => array:1 [
                  0 => array:2 [
                    "titulo" => "Costbenefit analysis of Haemophilus influenzae Tipe b vaccination in children in Spain"
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                        "etal" => false
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                          0 => "F&#46;J&#46; Jim&#233;nez"
                          1 => "P&#46; Guallar-Castill&#243;n"
                          2 => "C&#46; Rubio Terr&#233;s"
                          3 => "E&#46; Guallar"
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                      "paginaFinal" => "83"
                      "link" => array:1 [
                        0 => array:2 [
                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10345159"
                          "web" => "Medline"
                        ]
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              ]
            ]
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          12 => array:3 [
            "identificador" => "bib13"
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            "referencia" => array:1 [
              0 => array:2 [
                "contribucion" => array:1 [
                  0 => array:2 [
                    "titulo" => "&#191;Cu&#225;nto vale la pena gastarse para ganar un a&#241;o de vida ajustado por la calidad&#63; Un estudio emp&#237;rico"
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                      0 => array:2 [
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                          0 => "J&#46;L&#46; Pinto"
                          1 => "R&#46; Rodr&#237;guez"
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                "host" => array:1 [
                  0 => array:1 [
                    "LibroEditado" => array:2 [
                      "titulo" => "El valor monetario de la salud"
                      "serieFecha" => "2001"
                    ]
                  ]
                ]
              ]
            ]
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          13 => array:3 [
            "identificador" => "bib14"
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              0 => array:2 [
                "contribucion" => array:1 [
                  0 => array:2 [
                    "titulo" => "Coste-beneficio de estudios y proyectos de carreteras&#46;"
                    "autores" => array:1 [
                      0 => array:2 [
                        "colaboracion" => "Recomendaciones para la evaluaci&#243;n econ&#243;miva&#46;"
                        "etal" => false
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                ]
                "host" => array:1 [
                  0 => array:1 [
                    "Revista" => array:2 [
                      "tituloSerie" => "MOPTMA&#44; Madrid"
                      "fecha" => "1992"
                    ]
                  ]
                ]
              ]
            ]
          ]
          14 => array:3 [
            "identificador" => "bib15"
            "etiqueta" => "15&#46;"
            "referencia" => array:1 [
              0 => array:2 [
                "contribucion" => array:1 [
                  0 => array:2 [
                    "titulo" => "Infraestructuras y desarrollo regional&#58; efectos econ&#243;micos de la Autopista del Atl&#225;ntico&#46;"
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                      0 => array:2 [
                        "etal" => false
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                          0 => "E&#46; P&#233;rez Touri&#241;o"
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                    ]
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                ]
                "host" => array:1 [
                  0 => array:1 [
                    "LibroEditado" => array:1 [
                      "serieFecha" => "1997"
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          15 => array:3 [
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            "referencia" => array:1 [
              0 => array:2 [
                "contribucion" => array:1 [
                  0 => array:2 [
                    "titulo" => "The value of risk to life and health"
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                      0 => array:2 [
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                        "autores" => array:1 [
                          0 => "W&#46;K&#46; Viscusi"
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                    ]
                  ]
                ]
                "host" => array:1 [
                  0 => array:1 [
                    "Revista" => array:5 [
                      "tituloSerie" => "J Econ Literature"
                      "fecha" => "1993"
                      "volumen" => "31"
                      "paginaInicial" => "1912"
                      "paginaFinal" => "1946"
                    ]
                  ]
                ]
              ]
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                  0 => array:2 [
                    "titulo" => "The cost to the British economy of work accidents and work-related ill health"
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                          0 => "N&#46;V&#46; Davies"
                          1 => "P&#46; Teaslade"
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                  ]
                ]
                "host" => array:1 [
                  0 => array:1 [
                    "LibroEditado" => array:1 [
                      "serieFecha" => "1994"
                    ]
                  ]
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              ]
            ]
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          17 => array:3 [
            "identificador" => "bib18"
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              0 => array:2 [
                "contribucion" => array:1 [
                  0 => array:2 [
                    "titulo" => "Cost-effectiveness analysis in a setting of budget constraints"
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                      0 => array:2 [
                        "etal" => false
                        "autores" => array:4 [
                          0 => "P&#46;A&#46; Ubel"
                          1 => "M&#46;L&#46; DeKay"
                          2 => "J&#46; Baron"
                          3 => "D&#46;A&#46; Asch"
                        ]
                      ]
                    ]
                  ]
                ]
                "host" => array:1 [
                  0 => array:1 [
                    "Revista" => array:5 [
                      "tituloSerie" => "Is it equitable&#63; N Engl J Med"
                      "fecha" => "1996"
                      "volumen" => "334"
                      "paginaInicial" => "1174"
                      "paginaFinal" => "1177"
                    ]
                  ]
                ]
              ]
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          18 => array:3 [
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                  0 => array:2 [
                    "titulo" => "El uso del an&#225;lisis coste-efectividad en el establecimiento de prioridades sanitarias"
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                          2 => "M&#46;L&#46; L&#243;pez"
                          3 => "A&#46; Cueto"
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                      "tituloSerie" => "Gac Sanit"
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                        0 => array:2 [
                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9707823"
                          "web" => "Medline"
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                          3 => "E&#46; Vavas"
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                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8991697"
                          "web" => "Medline"
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                          2 => "L&#46; Salleras"
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                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8564860"
                          "web" => "Medline"
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                      "link" => array:1 [
                        0 => array:2 [
                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8991882"
                          "web" => "Medline"
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                  0 => array:2 [
                    "titulo" => "Cost-effectiveness of dietary treatment of hypercholesterolemia in Spain"
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                        "etal" => false
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                          0 => "P&#46; Plans"
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                    "doi" => "10.1038/sj.ph.1900304"
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                        0 => array:2 [
                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9033222"
                          "web" => "Medline"
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                    "titulo" => "Estudio coste-efectividad de los tratamientos farmacol&#243;gicos hipolipemiantes"
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                          0 => "P&#46; Plans"
                          1 => "J&#46; Rovira"
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                          0 => "P&#46; Plans-Rubio"
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                "host" => array:1 [
                  0 => array:1 [
                    "Revista" => array:6 [
                      "tituloSerie" => "Int J Technol Assess Health Care"
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                      "paginaInicial" => "320"
                      "paginaFinal" => "330"
                      "link" => array:1 [
                        0 => array:2 [
                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9611906"
                          "web" => "Medline"
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                  0 => array:1 [
                    "Revista" => array:5 [
                      "tituloSerie" => "Farm Hosp"
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                ]
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                      "link" => array:1 [
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¿Qué es una tecnología sanitaria eficiente en España?
(What is an efficient health technology in Spain?)
J.A. Sacristána,
Autor para correspondencia
sacristan_jose@lilly.com

Correspondencia: José Antonio Sacristán. Dpto. de Investigación Clínica, Lilly S.A. Avda. de la Industria, 30. 28108 Alcobendas. Madrid.
, J. Olivab,c, J. Del Llanoc, L. Prietoa, J.L. Pintod
a Departamento de Investigación Clínica, Lilly S.A. Madrid
b Fundación Gaspar Casal. Madrid
c Universidad Carlos III. Madrid
d Universitat Pompeu Fabra. Barcelona
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            1 => "Coste-efectividad"
            2 => "Evaluaci&#243;n"
            3 => "Tecnolog&#237;a sanitaria"
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          "clase" => "keyword"
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            0 => "Efficiency"
            1 => "Cost-effectiveness"
            2 => "Evaluation"
            3 => "Health technology"
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        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A pesar del creciente reconocimiento de la potencial utilidad de los estudios de coste-efectividad&#44; en Espa&#241;a no existe ning&#250;n criterio que permita establecer si una determinada tecnolog&#237;a sanitaria puede considerarse rentable o no&#46; El objetivo de este trabajo es describir cu&#225;les han sido los l&#237;mites y criterios utilizados en Espa&#241;a para recomendar la adopci&#243;n o el rechazo de intervenciones sanitarias en funci&#243;n de su coste-efectividad&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; una revisi&#243;n de las evaluaciones econ&#243;micas de intervenciones sanitarias publicadas en Espa&#241;a desde 1990 hasta 2001&#46; Se seleccionaron las evaluaciones econ&#243;micas completas en las que el cociente coste-efectividad se hab&#237;a expresado como coste por a&#241;o de vida ganado &#40;AVG&#41;&#44; como coste por a&#241;o de vida ajustado por calidad &#40;AVAC&#41; o como coste por vida salvada&#46; Se analizaron las intervenciones sobre las que los autores establecieron alg&#250;n tipo de recomendaci&#243;n &#40;de adopci&#243;n o rechazo&#41;&#44; as&#237; como los criterios utilizados&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Veinte &#40;20&#37;&#41; de las 100 evaluaciones econ&#243;micas completas publicadas cumplieron con los criterios se&#241;alados&#46; En 16 de los estudios&#44; los resultados se expresaron como coste por AVG&#44; en 6 como coste por AVAC y en 1 como coste por vida salvada&#46; Se evaluaron un total de 82 intervenciones sanitarias&#44; en 44 de las cuales se realiz&#243; alg&#250;n tipo de recomendaci&#243;n&#46; Los autores recomendaron la adopci&#243;n de todas las intervenciones sanitarias con un coste-efectividad inferior a 30&#46;000 euros &#40;5 millones de pesetas&#41; por AVG&#46; Por encima de esa cifra no se apreci&#243; ninguna tendencia&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Si bien los resultados deben ser interpretados con mucha precauci&#243;n&#44; dadas las limitaciones del estudio&#44; los l&#237;mites de coste-efectividad presentados en este trabajo podr&#237;an constituir una primera referencia a lo que podr&#237;a considerarse como una intervenci&#243;n sanitaria eficiente en Espa&#241;a&#46;</p>"
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      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Despite the growing recognition of the potential applications of cost-effectiveness assessments&#44; a criterion to establish what is an efficient health technology does not exist in Spain&#46; The objective of this work is to describe the limits and the criteria used in Spain to recommend the adoption of health interventions&#46;</p> <span class="elsevierStyleSectionTitle">Method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A review of the economic evaluations of health technologies published in Spain from 1990 to 2001 was conducted&#46; Complete economic assessments in which the costeffectiveness ratio was expressed as cost per life-year gained &#40;LYG&#41;&#44; cost per quality-adjusted-life-year &#40;QALY&#41; or cost per saved live were selected&#46; Those interventions in which the authors established recommendations &#40;adoption or rejection&#41; and the criteria used were analyzed&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Twenty &#40;20&#37;&#41; of the 100 complete economic evaluations fulfilled the selection criteria&#46; In16 studies&#44; the results were expressed as cost per LYG&#44; in 6 studies as cost per QALY and in 1 as cost per saved live&#46; A total of 82 health interventions were assessed and some kind of recommendation was established in 44 of them&#46; All technologies with a cost-effectiveness ratio lower than 30&#44;000 euros &#40;5 million pesetas&#41; per LYG were recommended for adoption by the authors&#46; Up to that limit there was no a clear tendency&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Although the results must be interpreted with much precaution&#44; given the limitations of the study&#44; the limits of cost-effectiveness presented in this work could be a first reference to which would be an efficient health intervention in Spain&#46;</p>"
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                          0 => "V&#46; Ort&#250;n Rubio"
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                  0 => array:1 [
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                      "tituloSerie" => "Med Clin &#40;Barc&#41;"
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                      "paginaFinal" => "300"
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              0 => array:2 [
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                  0 => array:2 [
                    "titulo" => "Medicina coste-efectiva y medicina basada en la evidencia&#58; su impacto en el proceso de decisiones cl&#237;nicas"
                    "autores" => array:1 [
                      0 => array:2 [
                        "etal" => false
                        "autores" => array:2 [
                          0 => "J&#46; Del Llano"
                          1 => "J&#46; Oliva"
                        ]
                      ]
                    ]
                  ]
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                  0 => array:1 [
                    "Revista" => array:6 [
                      "tituloSerie" => "Med Clin &#40;Barc&#41;"
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                      "numero" => "Supl 3"
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                      "paginaFinal" => "41"
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                ]
              ]
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              0 => array:2 [
                "contribucion" => array:1 [
                  0 => array:2 [
                    "titulo" => "Definitions of efficiency"
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                      0 => array:2 [
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                        "autores" => array:2 [
                          0 => "S&#46; Palmer"
                          1 => "D&#46; Torgerson"
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                      ]
                    ]
                  ]
                ]
                "host" => array:1 [
                  0 => array:1 [
                    "Revista" => array:5 [
                      "tituloSerie" => "BMJ"
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                      "paginaInicial" => "1136"
                      "link" => array:1 [
                        0 => array:2 [
                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10213735"
                          "web" => "Medline"
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                ]
              ]
            ]
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              0 => array:2 [
                "contribucion" => array:1 [
                  0 => array:2 [
                    "titulo" => "Impacto de los estudios de evaluaci&#243;n econ&#243;mica en la toma de decisiones sanitarias en atenci&#243;n primaria"
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                      0 => array:2 [
                        "etal" => true
                        "autores" => array:6 [
                          0 => "J&#46; Oliva"
                          1 => "J&#46; Del Llano"
                          2 => "F&#46; Anto&#241;anzas"
                          3 => "C&#46; Ju&#225;rez"
                          4 => "J&#46; Rovira"
                          5 => "M&#46; Figueras"
                        ]
                      ]
                    ]
                  ]
                ]
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                  0 => array:1 [
                    "Revista" => array:3 [
                      "tituloSerie" => "Cuadernos de Gesti&#243;n para el Profesional de AP"
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                      "volumen" => "7"
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                    "titulo" => "Impacto de los estudios de evaluaci&#243;n econ&#243;mica en la toma de decisiones sanitarias en el &#225;mbito hospitalario"
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                      0 => array:2 [
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                        "autores" => array:6 [
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                          1 => "J&#46; Del Llano"
                          2 => "F&#46; Anto&#241;anzas"
                          3 => "C&#46; Ju&#225;rez"
                          4 => "J&#46; Rovira"
                          5 => "M&#46; Figueras"
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                  0 => array:2 [
                    "titulo" => "Interpretation of cost-effectiveness and soundness of economic evaluations in the pharmacy literature"
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                        "autores" => array:2 [
                          0 => "J&#46;T&#46; Lee"
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                  0 => array:1 [
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                      "tituloSerie" => "Am J Hosp Pharm"
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                      "paginaFinal" => "2627"
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                        0 => array:2 [
                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1814204"
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                  0 => array:2 [
                    "titulo" => "How attractive does a new technology have to be to warrant adoption and utilization&#63; Tentative guidelines for using clinical and economic evaluations"
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                      0 => array:2 [
                        "etal" => false
                        "autores" => array:4 [
                          0 => "A&#46; Laupacis"
                          1 => "D&#46; Fenny"
                          2 => "A&#46; Detsky"
                          3 => "P&#46;X&#46; Tugwell"
                        ]
                      ]
                    ]
                  ]
                ]
                "host" => array:1 [
                  0 => array:1 [
                    "Revista" => array:5 [
                      "tituloSerie" => "Can Med Assoc J"
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                      "paginaInicial" => "473"
                      "paginaFinal" => "481"
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                  ]
                ]
              ]
            ]
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                  0 => array:2 [
                    "titulo" => "A comprehensive league table of cost-utility ratios and a sub-table of &#171;panel-worthy&#187; studies"
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                      0 => array:2 [
                        "etal" => false
                        "autores" => array:5 [
                          0 => "R&#46;H&#46; Chapman"
                          1 => "P&#46;W&#46; Stone"
                          2 => "E&#46;A&#46; Sandberg"
                          3 => "C&#46; Bell"
                          4 => "P&#46;J&#46; Newmann"
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                      ]
                    ]
                  ]
                ]
                "host" => array:1 [
                  0 => array:1 [
                    "Revista" => array:6 [
                      "tituloSerie" => "Med Decis Making"
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                      "paginaInicial" => "451"
                      "paginaFinal" => "467"
                      "link" => array:1 [
                        0 => array:2 [
                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11059478"
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                  0 => array:2 [
                    "titulo" => "Twenty years of health care economic analysis in Spain&#58; are we doing well&#63;"
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                        "etal" => false
                        "autores" => array:1 [
                          0 => "A&#46; Garc&#237;a-Alt&#233;s"
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                    "Revista" => array:2 [
                      "tituloSerie" => "En&#58; Avances en la gesti&#243;n sanitaria&#46; XX Jornadas de Econom&#237;a de la Salud"
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                  0 => array:2 [
                    "titulo" => "De la efectividad cl&#237;nica a la eficiencia social"
                    "autores" => array:1 [
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                        "etal" => false
                        "autores" => array:2 [
                          0 => "V&#46; Ort&#250;n"
                          1 => "F&#46; Rodr&#237;guez Artalejo"
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                      "tituloSerie" => "Med Clin &#40;Barc&#41;"
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                      "volumen" => "95"
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                      "paginaFinal" => "388"
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                    "titulo" => "The changing healthcare environment&#46; Socioeconomic evaluation of drug therapy"
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                        "etal" => false
                        "autores" => array:1 [
                          0 => "D&#46;B&#46; Evans"
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                    "Revista" => array:7 [
                      "tituloSerie" => "PharmacoEconomics"
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                      "paginaFinal" => "7"
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              0 => array:2 [
                "contribucion" => array:1 [
                  0 => array:2 [
                    "titulo" => "Costbenefit analysis of Haemophilus influenzae Tipe b vaccination in children in Spain"
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                        "etal" => false
                        "autores" => array:4 [
                          0 => "F&#46;J&#46; Jim&#233;nez"
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                          2 => "C&#46; Rubio Terr&#233;s"
                          3 => "E&#46; Guallar"
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                    "Revista" => array:6 [
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                    "titulo" => "&#191;Cu&#225;nto vale la pena gastarse para ganar un a&#241;o de vida ajustado por la calidad&#63; Un estudio emp&#237;rico"
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                      0 => array:2 [
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                        "autores" => array:2 [
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                  0 => array:1 [
                    "LibroEditado" => array:2 [
                      "titulo" => "El valor monetario de la salud"
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                  0 => array:2 [
                    "titulo" => "Coste-beneficio de estudios y proyectos de carreteras&#46;"
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                      0 => array:2 [
                        "colaboracion" => "Recomendaciones para la evaluaci&#243;n econ&#243;miva&#46;"
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                      "tituloSerie" => "MOPTMA&#44; Madrid"
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              ]
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              0 => array:2 [
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                  0 => array:2 [
                    "titulo" => "Infraestructuras y desarrollo regional&#58; efectos econ&#243;micos de la Autopista del Atl&#225;ntico&#46;"
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                        "etal" => false
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                  0 => array:1 [
                    "LibroEditado" => array:1 [
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                  0 => array:2 [
                    "titulo" => "The value of risk to life and health"
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                        "autores" => array:1 [
                          0 => "W&#46;K&#46; Viscusi"
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                  0 => array:1 [
                    "Revista" => array:5 [
                      "tituloSerie" => "J Econ Literature"
                      "fecha" => "1993"
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                      "paginaInicial" => "1912"
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                  0 => array:2 [
                    "titulo" => "The cost to the British economy of work accidents and work-related ill health"
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                        "etal" => false
                        "autores" => array:2 [
                          0 => "N&#46;V&#46; Davies"
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                ]
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                    "titulo" => "Cost-effectiveness analysis in a setting of budget constraints"
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                        "autores" => array:4 [
                          0 => "P&#46;A&#46; Ubel"
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                          3 => "D&#46;A&#46; Asch"
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                "host" => array:1 [
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                    "Revista" => array:5 [
                      "tituloSerie" => "Is it equitable&#63; N Engl J Med"
                      "fecha" => "1996"
                      "volumen" => "334"
                      "paginaInicial" => "1174"
                      "paginaFinal" => "1177"
                    ]
                  ]
                ]
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                          "web" => "Medline"
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                          1 => "L&#46; Casademont"
                          2 => "A&#46; Tar&#237;n"
                          3 => "E&#46; Vavas"
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                      "paginaInicial" => "15"
                      "paginaFinal" => "23"
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                          0 => "P&#46; Plans"
                          1 => "P&#46; Garrido"
                          2 => "L&#46; Salleras"
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                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8564860"
                          "web" => "Medline"
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              ]
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                          1 => "F&#46; Anton"
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                      "paginaFinal" => "142"
                      "link" => array:1 [
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                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8991882"
                          "web" => "Medline"
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                    "titulo" => "Coste-efectividad de los m&#233;todos de cesaci&#243;n tab&#225;quica"
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                          1 => "E&#46; Navas"
                          2 => "A&#46; Tar&#237;n"
                          3 => "N&#46; Rodr&#237;guez"
                          4 => "N&#46; Gal&#237;"
                          5 => "R&#46; Gayta"
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                      "fecha" => "1995"
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                      "paginaInicial" => "49"
                      "paginaFinal" => "53"
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              0 => array:2 [
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                  0 => array:2 [
                    "titulo" => "Cost-effectiveness of dietary treatment of hypercholesterolemia in Spain"
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                        "etal" => false
                        "autores" => array:1 [
                          0 => "P&#46; Plans"
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                    "Revista" => array:6 [
                      "tituloSerie" => "Public Health"
                      "fecha" => "1997"
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                      "paginaFinal" => "40"
                      "link" => array:1 [
                        0 => array:2 [
                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9033222"
                          "web" => "Medline"
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                    "titulo" => "Estudio coste-efectividad de los tratamientos farmacol&#243;gicos hipolipemiantes"
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                        "etal" => false
                        "autores" => array:2 [
                          0 => "P&#46; Plans"
                          1 => "J&#46; Rovira"
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                      "tituloSerie" => "Med Clin &#40;Barc&#41;"
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                      "paginaFinal" => "333"
                    ]
                  ]
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                  0 => array:2 [
                    "titulo" => "Cost-effectiveness of cardiovascular prevention programs in Spain"
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                        "autores" => array:1 [
                          0 => "P&#46; Plans-Rubio"
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                "host" => array:1 [
                  0 => array:1 [
                    "Revista" => array:6 [
                      "tituloSerie" => "Int J Technol Assess Health Care"
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                      "paginaInicial" => "320"
                      "paginaFinal" => "330"
                      "link" => array:1 [
                        0 => array:2 [
                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9611906"
                          "web" => "Medline"
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              ]
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                          1 => "F&#46; Ferriols"
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                  ]
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                  0 => array:1 [
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                      "tituloSerie" => "Farm Hosp"
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                      "paginaInicial" => "232"
                      "paginaFinal" => "240"
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                  ]
                ]
              ]
            ]
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          9 => array:3 [
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                    "titulo" => "Coste-efectividad de alteplasa versus estreptoquinasa en el infarto de miocardio"
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                        "etal" => false
                        "autores" => array:6 [
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                          1 => "M&#46;F&#46; Errecalde"
                          2 => "N&#46; Jaio"
                          3 => "C&#46; S&#225;iz de Rozas"
                          4 => "A&#46; Arana"
                          5 => "O&#46; Ibarra"
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                ]
                "host" => array:1 [
                  0 => array:1 [
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                      "tituloSerie" => "Rev Esp Farmacoeconom"
                      "fecha" => "1995"
                      "volumen" => "1"
                      "paginaInicial" => "23"
                      "paginaFinal" => "32"
                    ]
                  ]
                ]
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                        "etal" => false
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                          2 => "L&#46; Fosbrook"
                          3 => "R&#46; Esteban"
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                "host" => array:1 [
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                    "Revista" => array:6 [
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                      "paginaInicial" => "161"
                      "paginaFinal" => "168"
                      "link" => array:1 [
                        0 => array:2 [
                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9633175"
                          "web" => "Medline"
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                  0 => array:2 [
                    "titulo" => "Costeffectiveness therapy for na&#239;ve patientes with chronic hepatitis C&#46;"
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                          4 => "R&#46; Esteban"
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                  ]
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                  0 => array:1 [
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                      "paginaFinal" => "658"
                      "link" => array:1 [
                        0 => array:2 [
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                          "web" => "Medline"
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                    "titulo" => "Mechanical ventilation of patients on long-term oxygen therapy with acute exacerbations of chronic obstructive pulmonary disease&#58; prognosis and cost-utility analysis"
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                      "tituloSerie" => "Intensive Care Med"
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                      "paginaInicial" => "452"
                      "paginaFinal" => "457"
                      "link" => array:1 [
                        0 => array:2 [
                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10401937"
                          "web" => "Medline"
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          13 => array:3 [
            "identificador" => "bib014"
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                  0 => array:2 [
                    "titulo" => "Cost-effectiveness of transfusing virus-inactivated plasma instead of standard plasma"
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                          0 => "A&#46; Pereira"
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                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10335997"
                          "web" => "Medline"
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                  0 => array:2 [
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          15 => array:3 [
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              0 => array:2 [
                "contribucion" => array:1 [
                  0 => array:1 [
                    "autores" => array:1 [
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                      "paginaFinal" => "2352"
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                ]
                "host" => array:1 [
                  0 => array:1 [
                    "Revista" => array:6 [
                      "tituloSerie" => "Int J Technol Assess Health Care"
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                      "volumen" => "7"
                      "paginaInicial" => "379"
                      "paginaFinal" => "402"
                      "link" => array:1 [
                        0 => array:2 [
                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1834602"
                          "web" => "Medline"
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                ]
              ]
            ]
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              0 => array:1 [
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              ]
            ]
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          18 => array:3 [
            "identificador" => "bib019"
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              0 => array:2 [
                "contribucion" => array:1 [
                  0 => array:2 [
                    "titulo" => "Rifabutina&#58; profilaxis de la infecci&#243;n diseminada por CMAI en pacientes con infecci&#243;n por VIH avanzada&#46; An&#225;lisis de decisi&#243;n"
                    "autores" => array:1 [
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                          3 => "S&#225;iz de Rozas"
                          4 => "O&#46; Ibarra"
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                ]
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                    "Revista" => array:5 [
                      "tituloSerie" => "Rev Esp Farmacoeconom"
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                      "volumen" => "2"
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                      "paginaFinal" => "38"
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                  ]
                ]
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            "identificador" => "bib020"
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            "referencia" => array:1 [
              0 => array:2 [
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                  0 => array:2 [
                    "titulo" => "Cost-effectiveness analysis of paclitaxel and cisplatin versus cyclophosphamide and cisplatin as first-line therapy in advanced ovarian cancer&#46; A European perspective"
                    "autores" => array:1 [
                      0 => array:2 [
                        "etal" => false
                        "autores" => array:3 [
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                          1 => "T&#46; Fischer"
                          2 => "T&#46;D&#46; Szucs"
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                  ]
                ]
                "host" => array:1 [
                  0 => array:1 [
                    "Revista" => array:6 [
                      "tituloSerie" => "Eur J Cancer"
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                      "volumen" => "34"
                      "paginaInicial" => "1894"
                      "paginaFinal" => "1901"
                      "link" => array:1 [
                        0 => array:2 [
                          "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10023312"
                          "web" => "Medline"
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Información del artículo
ISSN: 02139111
Idioma original: Español
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2013 Octubre 27 3 30
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2013 Julio 19 4 23
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