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Perspectivas en disrupción endocrina
Perspectives in endocrine disruption
N. Olea
Autor para correspondencia
nolea@ugr.es

Correspondencia: Dr. Nicolás Olea. Laboratorio de Investigaciones Médicas. Hospital Clínico. Universidad de Granada. 18071 Granada
, M.F. Fernández, P. Araque, F. Olea-Serrano
Laboratorio de Investigaciones Médicas. Hospital Clínico. Universidad de Granada
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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La descripci&#243;n de alteraciones en la funci&#243;n reproductora de algunas especies de animales salvajes&#44; junto a la demostraci&#243;n de la exposici&#243;n humana y animal a sustancias qu&#237;micas con actividad hormonal &#8211;agonista y antagonista&#8211; gener&#243;&#44; hace dos d&#233;cadas&#44; lo que se conoce hoy d&#237;a como hip&#243;tesis de disrupci&#243;n endocrina&#46; Se trata de un problema emergente de salud medioambiental que ha cuestionado algunos de los paradigmas en que se fundamenta el control y la regulaci&#243;n de uso de los compuestos qu&#237;micos&#46; La necesidad de incluir en los tests toxicol&#243;gicos habituales nuevos objetivos de investigaci&#243;n&#44; que se refieren espec&#237;ficamente al desarrollo y crecimiento de las especies y a la homeostasis y funcionalidad de los sistemas hormonales&#44; ha venido a complicar tanto la evaluaci&#243;n de los nuevos compuestos qu&#237;micos como la revaluaci&#243;n de los existentes&#46; Sus repercusiones sobre la reglamentaci&#243;n y el comercio internacional no se han hecho esperar y a ambos lados del Atl&#225;ntico se han dise&#241;ado y establecido sistemas de cribado de disruptores endocrinos y se han desarrollado programas de investigaci&#243;n con objeto de cualificar y cuantificar los efectos adversos sobre la salud humana y animal y poder actuar con medidas de prevenci&#243;n&#46;</p>"
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Two decades ago&#44; reports of alterations in the reproductive function of some wild animal species and clear evidence of human and animal exposure to chemical substances with hormonal activity &#8211;agonist and antagonist&#8211;generated what is known now as the hypothesis of endocrine disruption&#46; This is an emerging environmental health problem that has challenged some of the paradigms on which the control and regulation of the use of chemical compounds is based&#46; The need to include in routine toxicology tests new research objectives that specifically refer to the development and growth of species and to the homeostasis and functionality of hormonal systems&#44; has served to complicate both the evaluation of new compounds and the re-evaluation of existing ones&#46; The repercussions on regulation and international trade have not taken long to be felt&#46; On both sides of the Atlantic&#44; screening systems for endocrine disrupters have been designed and established&#44; and research programmes have been launched to characterise and quantify adverse effects on human and animal health and to develop preventive measures&#46;</p>"
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                      "titulo" => "The human effects of DDT &#40;dichloro diphenyl trichloroethane&#41; and PCBs &#40;polychlorinated bisphenyls&#41; and an overview of organochlorines in public health"
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                      "doi" => "10.1146/annurev.publhealth.18.1.211"
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                    0 => array:2 [
                      "titulo" => "Report on an opinion on human and wildlife health effects of endocrine disrupting chemicals&#59; with emphasis on wildlife and on eco-toxicology test methods"
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                      "titulo" => "European Workshops on Endocrine Disrupters&#59; 2001&#44; junio 18-20"
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                  "referenciaCompleta" => "Environmental Protection Agency&#46; Endocrine Disruptor Screening Program&#44; 2001 &#91;consultado 07&#47;02&#47;2002&#93;&#46; Disponible en&#58; <a class="elsevierStyleInterRef" href="http://oaspub.epa.gov/oscpmont/oscpendo">http&#58;&#47;&#47;oaspub&#46;epa&#46;gov&#47;oscpmont&#47;oscpendo</a>"
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                      "titulo" => "Identification of bisphenol-A chloroderivatives in chlorinated drinking water&#46; Estrogenic properties"
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                            0 => "M&#46; Schlumpf"
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Información del artículo
ISSN: 02139111
Idioma original: Español
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