array:24 [
  "pii" => "S0213911103717324"
  "issn" => "02139111"
  "doi" => "10.1016/S0213-9111(03)71732-4"
  "estado" => "S300"
  "fechaPublicacion" => "2003-05-01"
  "aid" => "71732"
  "copyright" => "Sociedad Española de Salud Pública y Administración Sanitaria"
  "copyrightAnyo" => "2003"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Gac Sanit. 2003;17:226-30"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3336
    "formatos" => array:3 [
      "EPUB" => 120
      "HTML" => 2513
      "PDF" => 703
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0213911103717336"
    "issn" => "02139111"
    "doi" => "10.1016/S0213-9111(03)71733-6"
    "estado" => "S300"
    "fechaPublicacion" => "2003-05-01"
    "aid" => "71733"
    "copyright" => "Sociedad Española de Salud Pública y Administración Sanitaria"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Gac Sanit. 2003;17:231-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 6303
      "formatos" => array:3 [
        "EPUB" => 172
        "HTML" => 5064
        "PDF" => 1067
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "La cartera de servicios en una organización de salud pública"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "231"
          "paginaFinal" => "237"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Portfolio of services in a public health organization"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J.R. Villalbí, J. Guix, A. Plasència, J.M. Armengou, X. Llebaría, L. Torralba"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "J.R."
              "apellidos" => "Villalbí"
            ]
            1 => array:2 [
              "nombre" => "J."
              "apellidos" => "Guix"
            ]
            2 => array:2 [
              "nombre" => "A."
              "apellidos" => "Plasència"
            ]
            3 => array:2 [
              "nombre" => "J.M."
              "apellidos" => "Armengou"
            ]
            4 => array:2 [
              "nombre" => "X."
              "apellidos" => "Llebaría"
            ]
            5 => array:2 [
              "nombre" => "L."
              "apellidos" => "Torralba"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911103717336?idApp=WGSE"
    "url" => "/02139111/0000001700000003/v1_201310251612/S0213911103717336/v1_201310251612/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0213911103717312"
    "issn" => "02139111"
    "doi" => "10.1016/S0213-9111(03)71731-2"
    "estado" => "S300"
    "fechaPublicacion" => "2003-05-01"
    "aid" => "71731"
    "copyright" => "Sociedad Española de Salud Pública y Administración Sanitaria"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Gac Sanit. 2003;17:218-25"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2350
      "formatos" => array:3 [
        "EPUB" => 144
        "HTML" => 1782
        "PDF" => 424
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Incremento de costes atribuible a la infección quirúrgica de la apendicectomía y colectomía"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "218"
          "paginaFinal" => "225"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Increase in costs attributable to surgical infection after appendicectomy and colectomy"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J. Ríos, C. Murillo, G. Carrasco, C. Humet"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "J."
              "apellidos" => "Ríos"
            ]
            1 => array:2 [
              "nombre" => "C."
              "apellidos" => "Murillo"
            ]
            2 => array:2 [
              "nombre" => "G."
              "apellidos" => "Carrasco"
            ]
            3 => array:2 [
              "nombre" => "C."
              "apellidos" => "Humet"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911103717312?idApp=WGSE"
    "url" => "/02139111/0000001700000003/v1_201310251612/S0213911103717312/v1_201310251612/es/main.assets"
  ]
  "es" => array:14 [
    "idiomaDefecto" => true
    "titulo" => "Cáncer de pulmón y tabaco en Asturias. Un estudio de casos y controles"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "226"
        "paginaFinal" => "230"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "M. Caicoya, J.A. Mirón"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "M."
            "apellidos" => "Caicoya"
            "email" => array:1 [
              0 => "mcaicoya@hmn.es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "J&#46;A&#46;"
            "apellidos" => "Mir&#243;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Prevenci&#243;n de Riesgos Laborales&#46; Hospital Monte Naranco&#46; Oviedo"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Departamento de Medicina Preventiva y Salud P&#250;blica&#46; Facultad de Medicina&#46; Universidad de Salamanca&#46; Salamanca&#46; Espa&#241;a"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#42;"
            "correspondencia" => "<span class="elsevierStyleItalic">Correspondencia</span>&#58; Dr&#46; M&#46; Caicoya&#46; Servicio de Prevenci&#243;n de Riesgos Laborales&#46; Hospital Monte Naranco&#46; Avda&#46; Doctores Fern&#225;ndez Vega 107&#46; 33012 Oviedo&#46; Espa&#241;a"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Lung cancer and smoking in Asturias&#44; Spain&#46; A case-control study"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2002-07-09"
    "fechaAceptado" => "2003-03-11"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec268758"
          "palabras" => array:6 [
            0 => "C&#225;ncer de pulm&#243;n"
            1 => "Estudio de casos y controles"
            2 => "Tabaco"
            3 => "Edad"
            4 => "Dosis-respuesta"
            5 => "Efecto del abandono del tabaco"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec268757"
          "palabras" => array:6 [
            0 => "Lung cancer"
            1 => "Case-control"
            2 => "Smoking"
            3 => "Age"
            4 => "Doseresponse"
            5 => "Effect of smoking cessation"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Examinar la relaci&#243;n entre el consumo de tabaco y c&#225;ncer de pulm&#243;n en Asturias&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; un estudio de casos y controles de base hospitalaria&#46; Los casos fueron pacientes con diagn&#243;stico nuevo de c&#225;ncer de pulm&#243;n &#40;casos incidentes&#41; y los controles proced&#237;an de los servicios quir&#250;rgicos&#46; La informaci&#243;n obtenida incluy&#243; el consumo de tabaco&#44; las exposiciones ocupacionales y las variables demogr&#225;ficas&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron en el an&#225;lisis 197 casos y 196 controles&#46; La odds ratio &#40;OR&#41; ajustada de c&#225;ncer de pulm&#243;n fue de 5&#44;77 &#40;intervalo de confianza &#91;IC&#93; del 95&#37;&#44; 2&#44;96-11&#44;22&#41; para el consumo de cigarrillos&#46; El riesgo aumentaba con la cantidad de cigarrillos fumados por d&#237;a&#44; el n&#250;mero de paquetes&#47; d&#237;a&#44; la edad de inicio del h&#225;bito&#44; y disminu&#237;a con el n&#250;mero de a&#241;os desde el abandono&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La relaci&#243;n entre el tabaco y el c&#225;ncer de pulm&#243;n en Asturias es similar a la encontrada en otros estudios llevados a cabo en el mundo occidental&#46; La magnitud de la asociaci&#243;n puede explicar la frecuencia de c&#225;ncer de pulm&#243;n en Asturias&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Lung cancer in Asturias is 1&#46;4-fold greater than the Spanish average&#44; while the proportion of smokers is similar&#46; The objective of this study was to examine the relationship between lung cancer and smoking in Asturias&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We performed a hospital-based&#44; incident case control study&#46; The cases were newly diagnosed lung cancer patients and controls were patients from the surgical wards&#46; Information was sought on smoking&#44; occupational exposures&#44; and demographic variables&#46; The analysis was performed by means of odds ratios &#40;OR&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">One hundred ninety-seven cases and 196 controls were included in the analysis&#46; The adjusted OR of cigarette smoking was 5&#46;77 &#40;95&#37; CI&#44; 2&#46;96-11&#46;22&#41;&#46; The risk increased with the number of cigarettes smoked per day &#40;&#967;<span class="elsevierStyleSup">2</span> &#61; 56&#46;3&#41;&#44; the number of packs&#47;year &#40;&#967;<span class="elsevierStyleSup">2</span> &#61; 48&#46;4&#41;&#44; and the age at which smoking started &#40;&#967;<span class="elsevierStyleSup">2</span> &#61; 76&#46;5&#41;&#46; The OR diminished with the number of years of cessation &#40;&#967;<span class="elsevierStyleSup">2</span> &#61; 39&#46;9&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The relationship between smoking and lung cancer in Asturias is similar to that found in other studies carried out in other parts of the western world&#46; The magnitude of the OR may explain the frequency of lung cancer in Asturias&#46; Greater efforts should be devoted to controlling this problem&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Biblograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:23 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Situaci&#243;n del c&#225;ncer en Asturias&#46; Descripci&#243;n epicemiol&#243;gica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Consejer&#237;a de Sanidad y Servicios Sociales"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:1 [
                        "serieFecha" => "1994"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "En&#58; Tobacco smoking&#46; IARC Monographs on the evaluation of the carcionogenic risk of chemical to humans&#46; Volume 38"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Epidemiological studies of cancer in humans"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:1 [
                        "serieFecha" => "1986"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung cancer risk in iron and steel foundry workers&#58; a nested case control studyin Asturias&#44; Spain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46; Rodr&#237;guez"
                            1 => "A&#46; Tardon"
                            2 => "M&#46; Kogevinas"
                            3 => "C&#46;S&#46; Prieto"
                            4 => "A&#46; Cueto"
                            5 => "M&#46; Garc&#237;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Ind Med"
                        "fecha" => "2000"
                        "volumen" => "38"
                        "paginaInicial" => "644"
                        "paginaFinal" => "650"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11071687"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tabaco y c&#225;ncer de pulm&#243;n&#46; Un estudio caso-control"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46; Pel&#225;ez Mena"
                            1 => "A&#46; Pinedo S&#225;nchez"
                            2 => "A&#46; Garc&#237;a Rodr&#237;guez"
                            3 => "J&#46; Fern&#225;ndez Crehuet Navajas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Rev Clin Esp"
                        "fecha" => "1989"
                        "volumen" => "185"
                        "paginaInicial" => "298"
                        "paginaFinal" => "302"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2623238"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S009167490200012X"
                          "estado" => "S300"
                          "issn" => "00916749"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung cancer and cigarette smoking in women&#58; a case-control study in Barcelona &#40;Spain&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Agudo"
                            1 => "A&#46; Barnadas"
                            2 => "C&#46; Pallares"
                            3 => "I&#46; Mart&#237;nez"
                            4 => "X&#46; Fabregat"
                            5 => "J&#46; Rosell&#243;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Cancer"
                        "fecha" => "1994"
                        "volumen" => "59"
                        "paginaInicial" => "165"
                        "paginaFinal" => "169"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7927913"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Consumo de vegetales y c&#225;ncer de pulm&#243;n en Asturias&#44; Espa&#241;a&#58; estudio de casos y controles"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Caicoya"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2002"
                        "volumen" => "13"
                        "numero" => "119"
                        "paginaInicial" => "206"
                        "paginaFinal" => "210"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Propuesta de un sistema de indicadores para la medici&#243;n de la clase social&#46; En&#58; La medici&#243;n de la clase social en ciencias de la salud"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Grupo de Trabajo de la SEE -&#193;lvarez-Dardet"
                            1 => "J&#46; Alonso"
                            2 => "A&#46; Domingo"
                            3 => "E&#46; Regidor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:1 [
                        "serieFecha" => "1995"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Case control studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;I&#46; Kelsey"
                            1 => "W&#46;D&#46; Thompson"
                            2 => "A&#46;S&#46; Evans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:2 [
                        "titulo" => "Methods in observational epidemiology"
                        "serieFecha" => "1986"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung cancer and cigarette smoking in Europe&#58; an update of risk estimates and an assessment of intercountry heterogeneity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Simonato"
                            1 => "A&#46; Agudo"
                            2 => "W&#46; Ahrens"
                            3 => "E&#46; Benhamou"
                            4 => "S&#46; Benhamou"
                            5 => "P&#46; Boffetta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ing J Cancer"
                        "fecha" => "2001"
                        "volumen" => "91"
                        "paginaInicial" => "876"
                        "paginaFinal" => "887"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Smoking and death rates-report on forty-four months of follow-up of 187&#44;783 men"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "E&#46;C&#46; Hammond"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "CA Cancer J Clin"
                        "fecha" => "1988"
                        "volumen" => "28"
                        "paginaInicial" => "28"
                        "paginaFinal" => "58"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Smoking in relation to the death of one milion men and women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "E&#46;C&#46; Hammond"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Natl Cancer Inst Monogr"
                        "fecha" => "1996"
                        "volumen" => "19"
                        "paginaInicial" => "127"
                        "paginaFinal" => "204"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cancer mortality among non-smokers in an insured group of U&#46;S&#46; veterans"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Rogot"
                            1 => "J&#46; Murray"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Natl Cancer Inst"
                        "fecha" => "1980"
                        "volumen" => "65"
                        "paginaInicial" => "1663"
                        "paginaFinal" => "1668"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mortality in relation to smoking&#58; 20 years&#39; observations on male British doctors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Doll"
                            1 => "R&#46; Peto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br Med J"
                        "fecha" => "1976"
                        "volumen" => "25"
                        "paginaInicial" => "1525"
                        "paginaFinal" => "1536"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Smoking as a risk factor for different cancer forms among 26&#44;000 Norwegian men and women&#46; A comparison of a material of smokers from the Norwegian Cancer Registry&#46; T Tidsskr Nor Laegeforen 1981&#59; 101&#58;1937-40&#46; Citado en&#58;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Lund"
                            1 => "T&#46; Zeiner-Henriksen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Tobacco&#46; A major international health hazard&#46; IARC Scientific Publication N1 74"
                        "paginaInicial" => "23"
                        "paginaFinal" => "32"
                        "serieFecha" => "1986"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The relationship of smoking and some social covariables to mortality and cancer morbidity&#46; A ten year follow up in a probability sample of 55000 swedish subjects&#44; agte 18-69&#46; Part 1 and 2&#44; Stockholm 1975&#44; Department of Enviromental Hygiene&#46; The Karolinska Institute&#46; Citado en&#58;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46; Cederl&#246;f"
                            1 => "L&#46; Friberg"
                            2 => "Z&#46; Huberc"
                            3 => "U&#46; Orich"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:2 [
                        "titulo" => "Tobacco&#46; A major international health hazard&#46; IARC Scientific Publication N1 74"
                        "serieFecha" => "1986"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung cancer and smoking in Shangai"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Y&#46;T&#46; Gao"
                            1 => "W&#46;J&#46; Bltt"
                            2 => "W&#46; Zheng"
                            3 => "J&#46;F&#46; Fraumeni"
                            4 => "C&#46;W&#46; Hsu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Epidemiol"
                        "fecha" => "1988"
                        "volumen" => "17"
                        "paginaInicial" => "277"
                        "paginaFinal" => "280"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2841252"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A case control study of lung cancer with special reference to effect on air pollution in Poland"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46; Jedrychowski"
                            1 => "H&#46; Bercher"
                            2 => "J&#46; Wahrendorf"
                            3 => "Z&#46; Basa-Cierpialek"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Epidemiol Community Health"
                        "fecha" => "1990"
                        "volumen" => "44"
                        "paginaInicial" => "114"
                        "paginaFinal" => "120"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2370498"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A case-control study of air pollution and tobacco smoking in lung cancer among women in Athens"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "K&#46; Katsouyanni"
                            1 => "D&#46; Trichopoulos"
                            2 => "A&#46; Kalandidi"
                            3 => "P&#46; Tonnos"
                            4 => "E&#46; Riboli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Prev Med"
                        "fecha" => "1991"
                        "volumen" => "20"
                        "paginaInicial" => "271"
                        "paginaFinal" => "278"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2057473"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cigarette smoking and male lung cancer in an area of very high incidence&#46; I Report of a case control study in West of Scotland"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46;R&#46; Gillis"
                            1 => "D&#46;J&#46; Hole"
                            2 => "P&#46; Boyle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Epidemiol Community Health"
                        "fecha" => "1988"
                        "volumen" => "42"
                        "paginaInicial" => "36"
                        "paginaFinal" => "43"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cigarette smoking and male lung cancer in an area of very high incidence&#46; II Report of a general population cohort study in West of Scotland"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46;R&#46; Gillis"
                            1 => "D&#46;J&#46; Hole"
                            2 => "V&#46;M&#46; Horne"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Epidemiol Community Health"
                        "fecha" => "1988"
                        "volumen" => "42"
                        "paginaInicial" => "44"
                        "paginaFinal" => "48"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3418285"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cigarette smoking and bronchial carcinoma&#58; dose and time relationship among regular smokers and lifelong nonsmokers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Doll"
                            1 => "R&#46; Peto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Epidemiol Community Health"
                        "fecha" => "1978"
                        "volumen" => "32"
                        "paginaInicial" => "303"
                        "paginaFinal" => "313"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/744822"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influence of dose and duration of smoking on lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Peto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:2 [
                        "titulo" => "Tobacco&#46; A major international health hazard&#46; IARC Scientific Publication N1 74"
                        "serieFecha" => "1986"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pattern of lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;H&#46; Lubin"
                            1 => "W&#46;J&#46; Blot"
                            2 => "F&#46; Berrino"
                            3 => "R&#46; Flamant"
                            4 => "C&#46;R&#46; Gillis"
                            5 => "M&#46; Kunze"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Cancer"
                        "fecha" => "1984"
                        "volumen" => "33"
                        "paginaInicial" => "569"
                        "paginaFinal" => "576"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6724735"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/02139111/0000001700000003/v1_201310251612/S0213911103717324/v1_201310251612/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "778"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Originales breves"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02139111/0000001700000003/v1_201310251612/S0213911103717324/v1_201310251612/es/main.pdf?idApp=WGSE&text.app=https://gacetasanitaria.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911103717324?idApp=WGSE"
]
Compartir
Publique en esta revista
Información de la revista
Vol. 17. Núm. 3.
Páginas 226-230 (mayo - junio 2003)
Respuestas rápidas
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 17. Núm. 3.
Páginas 226-230 (mayo - junio 2003)
Open Access
Cáncer de pulmón y tabaco en Asturias. Un estudio de casos y controles
Lung cancer and smoking in Asturias, Spain. A case-control study
Visitas
6886
M. Caicoyaa,
Autor para correspondencia
mcaicoya@hmn.es

Correspondencia: Dr. M. Caicoya. Servicio de Prevención de Riesgos Laborales. Hospital Monte Naranco. Avda. Doctores Fernández Vega 107. 33012 Oviedo. España
, J.A. Mirónb
a Servicio de Prevención de Riesgos Laborales. Hospital Monte Naranco. Oviedo
b Departamento de Medicina Preventiva y Salud Pública. Facultad de Medicina. Universidad de Salamanca. Salamanca. España
Este artículo ha recibido

Under a Creative Commons license
Información del artículo
Resumen
Objetivo

Examinar la relación entre el consumo de tabaco y cáncer de pulmón en Asturias.

Material y métodos

Se realizó un estudio de casos y controles de base hospitalaria. Los casos fueron pacientes con diagnóstico nuevo de cáncer de pulmón (casos incidentes) y los controles procedían de los servicios quirúrgicos. La información obtenida incluyó el consumo de tabaco, las exposiciones ocupacionales y las variables demográficas.

Resultados

Se incluyeron en el análisis 197 casos y 196 controles. La odds ratio (OR) ajustada de cáncer de pulmón fue de 5,77 (intervalo de confianza [IC] del 95%, 2,96-11,22) para el consumo de cigarrillos. El riesgo aumentaba con la cantidad de cigarrillos fumados por día, el número de paquetes/ día, la edad de inicio del hábito, y disminuía con el número de años desde el abandono.

Conclusiones

La relación entre el tabaco y el cáncer de pulmón en Asturias es similar a la encontrada en otros estudios llevados a cabo en el mundo occidental. La magnitud de la asociación puede explicar la frecuencia de cáncer de pulmón en Asturias.

Palabras clave:
Cáncer de pulmón
Estudio de casos y controles
Tabaco
Edad
Dosis-respuesta
Efecto del abandono del tabaco
Abstract
Objective

Lung cancer in Asturias is 1.4-fold greater than the Spanish average, while the proportion of smokers is similar. The objective of this study was to examine the relationship between lung cancer and smoking in Asturias.

Material and methods

We performed a hospital-based, incident case control study. The cases were newly diagnosed lung cancer patients and controls were patients from the surgical wards. Information was sought on smoking, occupational exposures, and demographic variables. The analysis was performed by means of odds ratios (OR).

Results

One hundred ninety-seven cases and 196 controls were included in the analysis. The adjusted OR of cigarette smoking was 5.77 (95% CI, 2.96-11.22). The risk increased with the number of cigarettes smoked per day (χ2 = 56.3), the number of packs/year (χ2 = 48.4), and the age at which smoking started (χ2 = 76.5). The OR diminished with the number of years of cessation (χ2 = 39.9).

Conclusions

The relationship between smoking and lung cancer in Asturias is similar to that found in other studies carried out in other parts of the western world. The magnitude of the OR may explain the frequency of lung cancer in Asturias. Greater efforts should be devoted to controlling this problem.

Key words:
Lung cancer
Case-control
Smoking
Age
Doseresponse
Effect of smoking cessation
El Texto completo está disponible en PDF
Biblografía
[1.]
Consejería de Sanidad y Servicios Sociales.
Situación del cáncer en Asturias. Descripción epicemiológica.
[2.]
Epidemiological studies of cancer in humans.
En: Tobacco smoking. IARC Monographs on the evaluation of the carcionogenic risk of chemical to humans. Volume 38.
[3.]
V. Rodríguez, A. Tardon, M. Kogevinas, C.S. Prieto, A. Cueto, M. García, et al.
Lung cancer risk in iron and steel foundry workers: a nested case control studyin Asturias, Spain.
Am J Ind Med, 38 (2000), pp. 644-650
[4.]
G. Peláez Mena, A. Pinedo Sánchez, A. García Rodríguez, J. Fernández Crehuet Navajas.
Tabaco y cáncer de pulmón. Un estudio caso-control.
Rev Clin Esp, 185 (1989), pp. 298-302
[5.]
A. Agudo, A. Barnadas, C. Pallares, I. Martínez, X. Fabregat, J. Roselló, et al.
Lung cancer and cigarette smoking in women: a case-control study in Barcelona (Spain).
Int J Cancer, 59 (1994), pp. 165-169
[6.]
M. Caicoya.
Consumo de vegetales y cáncer de pulmón en Asturias, España: estudio de casos y controles.
Med Clin (Barc), 13 (2002), pp. 206-210
[7.]
C. Grupo de Trabajo de la SEE -Álvarez-Dardet, J. Alonso, A. Domingo, E. Regidor.
Propuesta de un sistema de indicadores para la medición de la clase social. En: La medición de la clase social en ciencias de la salud.
[8.]
J.I. Kelsey, W.D. Thompson, A.S. Evans.
Case control studies.
Methods in observational epidemiology,
[9.]
L. Simonato, A. Agudo, W. Ahrens, E. Benhamou, S. Benhamou, P. Boffetta, et al.
Lung cancer and cigarette smoking in Europe: an update of risk estimates and an assessment of intercountry heterogeneity.
Ing J Cancer, 91 (2001), pp. 876-887
[10.]
E.C. Hammond.
Smoking and death rates-report on forty-four months of follow-up of 187,783 men.
CA Cancer J Clin, 28 (1988), pp. 28-58
[11.]
E.C. Hammond.
Smoking in relation to the death of one milion men and women.
J Natl Cancer Inst Monogr, 19 (1996), pp. 127-204
[12.]
E. Rogot, J. Murray.
Cancer mortality among non-smokers in an insured group of U.S. veterans.
J Natl Cancer Inst, 65 (1980), pp. 1663-1668
[13.]
R. Doll, R. Peto.
Mortality in relation to smoking: 20 years' observations on male British doctors.
Br Med J, 25 (1976), pp. 1525-1536
[14.]
E. Lund, T. Zeiner-Henriksen.
Smoking as a risk factor for different cancer forms among 26,000 Norwegian men and women. A comparison of a material of smokers from the Norwegian Cancer Registry. T Tidsskr Nor Laegeforen 1981; 101:1937-40. Citado en:.
Tobacco. A major international health hazard. IARC Scientific Publication N1 74, pp. 23-32
[15.]
R. Cederlöf, L. Friberg, Z. Huberc, U. Orich.
The relationship of smoking and some social covariables to mortality and cancer morbidity. A ten year follow up in a probability sample of 55000 swedish subjects, agte 18-69. Part 1 and 2, Stockholm 1975, Department of Enviromental Hygiene. The Karolinska Institute. Citado en:.
Tobacco. A major international health hazard. IARC Scientific Publication N1 74,
[16.]
Y.T. Gao, W.J. Bltt, W. Zheng, J.F. Fraumeni, C.W. Hsu.
Lung cancer and smoking in Shangai.
Int J Epidemiol, 17 (1988), pp. 277-280
[17.]
W. Jedrychowski, H. Bercher, J. Wahrendorf, Z. Basa-Cierpialek.
A case control study of lung cancer with special reference to effect on air pollution in Poland.
J Epidemiol Community Health, 44 (1990), pp. 114-120
[18.]
K. Katsouyanni, D. Trichopoulos, A. Kalandidi, P. Tonnos, E. Riboli.
A case-control study of air pollution and tobacco smoking in lung cancer among women in Athens.
Prev Med, 20 (1991), pp. 271-278
[19.]
C.R. Gillis, D.J. Hole, P. Boyle.
Cigarette smoking and male lung cancer in an area of very high incidence. I Report of a case control study in West of Scotland.
J Epidemiol Community Health, 42 (1988), pp. 36-43
[20.]
C.R. Gillis, D.J. Hole, V.M. Horne.
Cigarette smoking and male lung cancer in an area of very high incidence. II Report of a general population cohort study in West of Scotland.
J Epidemiol Community Health, 42 (1988), pp. 44-48
[21.]
R. Doll, R. Peto.
Cigarette smoking and bronchial carcinoma: dose and time relationship among regular smokers and lifelong nonsmokers.
J Epidemiol Community Health, 32 (1978), pp. 303-313
[22.]
R. Peto.
Influence of dose and duration of smoking on lung cancer.
Tobacco. A major international health hazard. IARC Scientific Publication N1 74,
[23.]
J.H. Lubin, W.J. Blot, F. Berrino, R. Flamant, C.R. Gillis, M. Kunze, et al.
Pattern of lung cancer.
Int J Cancer, 33 (1984), pp. 569-576
Copyright © 2003. Sociedad Española de Salud Pública y Administración Sanitaria
Descargar PDF
Idiomas
Gaceta Sanitaria
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?