Compartir
array:24 [
"pii" => "S021391110571356X"
"issn" => "02139111"
"doi" => "10.1157/13075956"
"estado" => "S300"
"fechaPublicacion" => "2005-05-01"
"aid" => "71356"
"copyright" => "Sociedad Española de Salud Pública y Administración Sanitaria"
"copyrightAnyo" => "2005"
"documento" => "article"
"crossmark" => 0
"licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
"subdocumento" => "fla"
"cita" => "Gac Sanit. 2005;19:229-34"
"abierto" => array:3 [
"ES" => true
"ES2" => true
"LATM" => true
]
"gratuito" => true
"lecturas" => array:2 [
"total" => 3949
"formatos" => array:3 [
"EPUB" => 127
"HTML" => 3292
"PDF" => 530
]
]
"itemSiguiente" => array:19 [
"pii" => "S0213911105713571"
"issn" => "02139111"
"doi" => "10.1157/13075957"
"estado" => "S300"
"fechaPublicacion" => "2005-05-01"
"aid" => "71357"
"copyright" => "Sociedad Española de Salud Pública y Administración Sanitaria"
"documento" => "article"
"crossmark" => 0
"licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
"subdocumento" => "fla"
"cita" => "Gac Sanit. 2005;19:234-7"
"abierto" => array:3 [
"ES" => true
"ES2" => true
"LATM" => true
]
"gratuito" => true
"lecturas" => array:2 [
"total" => 2695
"formatos" => array:3 [
"EPUB" => 167
"HTML" => 1970
"PDF" => 558
]
]
"es" => array:9 [
"idiomaDefecto" => true
"cabecera" => "<span class="elsevierStyleTextfn">Originales</span>"
"titulo" => "Comentario: complejidades en la evaluación de intervenciones complejas"
"tienePdf" => "es"
"tieneTextoCompleto" => 0
"paginas" => array:1 [
0 => array:2 [
"paginaInicial" => "234"
"paginaFinal" => "237"
]
]
"titulosAlternativos" => array:1 [
"en" => array:1 [
"titulo" => "Comentary: complexities in the evaluation of complex interventions"
]
]
"contienePdf" => array:1 [
"es" => true
]
"autores" => array:1 [
0 => array:2 [
"autoresLista" => "Salvador Peiró"
"autores" => array:1 [
0 => array:2 [
"nombre" => "Salvador"
"apellidos" => "Peiró"
]
]
]
]
]
"idiomaDefecto" => "es"
"EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911105713571?idApp=WGSE"
"url" => "/02139111/0000001900000003/v2_201302051756/S0213911105713571/v2_201302051756/es/main.assets"
]
"itemAnterior" => array:19 [
"pii" => "S0213911105713558"
"issn" => "02139111"
"doi" => "10.1157/13075955"
"estado" => "S300"
"fechaPublicacion" => "2005-05-01"
"aid" => "71355"
"copyright" => "Sociedad Española de Salud Pública y Administración Sanitaria"
"documento" => "article"
"crossmark" => 0
"licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
"subdocumento" => "fla"
"cita" => "Gac Sanit. 2005;19:221-8"
"abierto" => array:3 [
"ES" => true
"ES2" => true
"LATM" => true
]
"gratuito" => true
"lecturas" => array:2 [
"total" => 2605
"formatos" => array:3 [
"EPUB" => 153
"HTML" => 1869
"PDF" => 583
]
]
"es" => array:11 [
"idiomaDefecto" => true
"cabecera" => "<span class="elsevierStyleTextfn">Originales</span>"
"titulo" => "Automatización de un registro hospitalario de tumores"
"tienePdf" => "es"
"tieneTextoCompleto" => 0
"tieneResumen" => array:2 [
0 => "es"
1 => "en"
]
"paginas" => array:1 [
0 => array:2 [
"paginaInicial" => "221"
"paginaFinal" => "228"
]
]
"titulosAlternativos" => array:1 [
"en" => array:1 [
"titulo" => "Automatization of a hospital-based tumor registry"
]
]
"contieneResumen" => array:2 [
"es" => true
"en" => true
]
"contienePdf" => array:1 [
"es" => true
]
"autores" => array:1 [
0 => array:2 [
"autoresLista" => "Josepa Ribes, Jordi Gálvez, Àngels Melià, Ramon Clèries, Xavier Messeguer, Francesc Xavier Bosch"
"autores" => array:6 [
0 => array:2 [
"nombre" => "Josepa"
"apellidos" => "Ribes"
]
1 => array:2 [
"nombre" => "Jordi"
"apellidos" => "Gálvez"
]
2 => array:2 [
"nombre" => "Àngels"
"apellidos" => "Melià"
]
3 => array:2 [
"nombre" => "Ramon"
"apellidos" => "Clèries"
]
4 => array:2 [
"nombre" => "Xavier"
"apellidos" => "Messeguer"
]
5 => array:2 [
"nombre" => "Francesc"
"apellidos" => "Xavier Bosch"
]
]
]
]
]
"idiomaDefecto" => "es"
"EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911105713558?idApp=WGSE"
"url" => "/02139111/0000001900000003/v2_201302051756/S0213911105713558/v2_201302051756/es/main.assets"
]
"es" => array:15 [
"idiomaDefecto" => true
"cabecera" => "<span class="elsevierStyleTextfn">Originales</span>"
"titulo" => "Utilización de coxibs: una estrategia de intervención en la atención primaria"
"tieneTextoCompleto" => 0
"paginas" => array:1 [
0 => array:2 [
"paginaInicial" => "229"
"paginaFinal" => "234"
]
]
"autores" => array:1 [
0 => array:4 [
"autoresLista" => "Isabel Rosich, Maria Soler, Rosa Tomás, Dolors Crusat"
"autores" => array:4 [
0 => array:3 [
"nombre" => "Isabel"
"apellidos" => "Rosich"
"referencia" => array:1 [
0 => array:2 [
"etiqueta" => "<span class="elsevierStyleSup">a</span>"
"identificador" => "aff1"
]
]
]
1 => array:4 [
"nombre" => "Maria"
"apellidos" => "Soler"
"email" => array:1 [
0 => "msoler.cp.ics@gencat.net"
]
"referencia" => array:2 [
0 => array:2 [
"etiqueta" => "<span class="elsevierStyleSup">a</span>"
"identificador" => "aff1"
]
1 => array:2 [
"etiqueta" => "<span class="elsevierStyleSup">¿</span>"
"identificador" => "cor1"
]
]
]
2 => array:3 [
"nombre" => "Rosa"
"apellidos" => "Tomás"
"referencia" => array:1 [
0 => array:2 [
"etiqueta" => "<span class="elsevierStyleSup">a</span>"
"identificador" => "aff1"
]
]
]
3 => array:3 [
"nombre" => "Dolors"
"apellidos" => "Crusat"
"referencia" => array:1 [
0 => array:2 [
"etiqueta" => "<span class="elsevierStyleSup">b</span>"
"identificador" => "aff2"
]
]
]
]
"afiliaciones" => array:2 [
0 => array:3 [
"entidad" => "Servei d’Atenció Primària Alt Penedès Garraf. Institut Català de la Salut. Vilanova i la Geltrú. Barcelona. España"
"etiqueta" => "<span class="elsevierStyleSup">a</span>"
"identificador" => "aff1"
]
1 => array:3 [
"entidad" => "Servei d’Atenció Primària. Laboratorios. Institut Català de la Salut. Vilanova i la Geltrú. Barcelona. España"
"etiqueta" => "<span class="elsevierStyleSup">b</span>"
"identificador" => "aff2"
]
]
"correspondencia" => array:1 [
0 => array:3 [
"identificador" => "cor1"
"etiqueta" => "⁎"
"correspondencia" => "Correspondencia: María Soler Cera. Servei d’Atenció Primària Alt Penedès Garraf. Manuel Marqués, s/n. 08800 Vilanova i la Geltrú. Barcelona. España."
]
]
]
]
"titulosAlternativos" => array:1 [
"en" => array:1 [
"titulo" => "Prescription of cyclooxygenase-2 inhibitors: an intervention strategy in primary care"
]
]
"pdfFichero" => "main.pdf"
"tienePdf" => true
"fechaRecibido" => "2004-04-13"
"fechaAceptado" => "2005-03-03"
"PalabrasClave" => array:2 [
"es" => array:1 [
0 => array:4 [
"clase" => "keyword"
"titulo" => "Palabras clave"
"identificador" => "xpalclavsec16898"
"palabras" => array:4 [
0 => "Coxibs"
1 => "Intervención"
2 => "Alertas de seguridad"
3 => "Atención primaria"
]
]
]
"en" => array:1 [
0 => array:4 [
"clase" => "keyword"
"titulo" => "Key words"
"identificador" => "xpalclavsec16899"
"palabras" => array:4 [
0 => "COXIBs"
1 => "Intervention"
2 => "Safety alerts"
3 => "Primary care"
]
]
]
]
"tieneResumen" => true
"resumen" => array:2 [
"es" => array:2 [
"titulo" => "Resumen"
"resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Evaluar una intervención dirigida a mejorar la prescripción de antiinflamatorios no esteroideos (AINE), fundamentalmente del grupo de los inhibidores de la ciclooxigenenasa-2 (coxibs).</p> <span class="elsevierStyleSectionTitle">Sujetos y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Estudio de intervención antes-después individual para médicos altamente prescriptores y grupal para el resto. Los datos sobre prescripción se obtuvieron del aplicativo de farmacia del Institut Català de la Salut. El período preintervención se comparó con el postintervención inmediato (que coincidió con la publicación de una alerta farmacológica sobre los efectos secundarios de los coxibs) y tardío. Se controlaron el gasto de coxibs, la dosis diaria definida (DDD) por 1.000 habitantes/día (DHD), el porcentaje DHD coxibs/total AINE, el porcentaje de AINE recomendados/total AINE, y el coste medio diario de la DDD de AINE.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">La reducción media mensual del gasto en coxibs fue de 19.480 €/mes en el período postintervención inmediato y de 18.555 €/mes en el tardío. La disminución de la DHD de coxibs fue del 35,4% (p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001), y fue estable en el tiempo. El porcentaje de AINE recomendados/total se incrementó un 14% a corto plazo y un 17% a largo plazo, mientras que el coste medio diario se redujo un 10,1 y 11,2%. La disminución de DHD de coxibs en los médicos entrevistados fue del 39,5% en el período inmediato y del 42,2% en el tardío, frente al 19,4 y al 12,4% en la intervención grupal.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La intervención educativa se asoció con una mejora en la prescripción de AINE, aunque la coincidencia con la alerta de seguridad limita la atribución causal a ésta.</p>"
]
"en" => array:2 [
"titulo" => "Abstract"
"resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To evaluate an intervention designed to rationalize prescription of nonsteroidal anti-inflammatory drugs (NSAIDs), especially cyclooxygenase-2 inhibitors (COXIBs).</p> <span class="elsevierStyleSectionTitle">Subjects and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We performed a before-after intervention study. Face-to-face educational outreach visits were conducted in general practitioners who were heavy prescribers and group intervention for the remaining. Data on prescribing habits were obtained from the pharmacy database of the Catalan Health Institute. The pre-intervention period (period 1) was compared with the immediate postintervention period (period 2, which coincided with the publication of a safety alert on the adverse effects of COXIBs) and the late postintervention period (period 3). The data monitored were: <span class="elsevierStyleItalic">a)</span> expenditure due to COXIBs; <span class="elsevierStyleItalic">b)</span> consumption in daily defined doses (DDD) per 1,000 habitants/ day (DHD); <span class="elsevierStyleItalic">c)</span> the percentage of COXIBs/total NSAIDs and the percentage of recommended NSAIDs/total NSAIDs, and <span class="elsevierStyleItalic">d)</span> the mean daily cost of DHD of NSAIDs.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The mean monthly reduction in expenditure on COXIBs was 19,480 €/month in period 2 and was 18,555 €/month in period 3. The percentage of reduction in DHD of COXIBs was 35.4% (p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001), which remained stable throughout the study. The percentage of recommended NSAIDs/total NSAIDs increased 14% in the short term and 17% in the long term while the mean daily cost was reduced by 10.1% and 11.2%. The decrease in DHD of COXIBs in the face-to-face intervention group was 39.5% in period 2 and was 42.2% period 3 compared with 19.4% and 12.4% in the group intervention.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The educational intervention was associated with improvements in prescription of NSAIDs, although some of the improvement was probably due to the safety alert issued during the study period.</p>"
]
]
"bibliografia" => array:2 [
"titulo" => "Bibliografía"
"seccion" => array:1 [
0 => array:1 [
"bibliografiaReferencia" => array:26 [
0 => array:3 [
"identificador" => "bib1"
"etiqueta" => "1."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Factores condicionantes del gasto en farmacia en los centros de atención primaria de un área de salud"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:2 [
0 => "M. Aspiazu"
1 => "L. García"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "Aten Primaria"
"fecha" => "2002"
"volumen" => "29"
"paginaInicial" => "84"
"paginaFinal" => "89"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/11844424"
"web" => "Medline"
]
]
]
]
]
]
]
]
1 => array:3 [
"identificador" => "bib2"
"etiqueta" => "2."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Prescribing new drugs: qualitative study of influences on consultants and general practicioners"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:3 [
0 => "M.I. Jones"
1 => "S.M. Greenfield"
2 => "C.P. Bradley"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "BMJ"
"fecha" => "2001"
"volumen" => "323"
"paginaInicial" => "1"
"paginaFinal" => "7"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/11440920"
"web" => "Medline"
]
]
]
]
]
]
]
]
2 => array:3 [
"identificador" => "bib3"
"etiqueta" => "3."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Adopción de los nuevos medicamentos por los médicos prescriptores. El medico innovador"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:5 [
0 => "M.A. García Lirola"
1 => "J. Cabeza Barrera"
2 => "M. Rodríguez Espejo"
3 => "E. Alegre del Rey"
4 => "A. Rabadán Asensio"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "Aten Primaria"
"fecha" => "2000"
"volumen" => "25"
"paginaInicial" => "22"
"paginaFinal" => "28"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/10730454"
"web" => "Medline"
]
]
]
]
]
]
]
]
3 => array:3 [
"identificador" => "bib4"
"etiqueta" => "4."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Gasto farmacéutico en atención primaria reformada: implicación de las actividades formativas en el ahorro en farmacia"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:1 [
0 => "F.J. Mengibar Torres"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "Gac Sanit"
"fecha" => "2000"
"volumen" => "14"
"paginaInicial" => "277"
"paginaFinal" => "286"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/11094844"
"web" => "Medline"
]
]
]
]
]
]
]
]
4 => array:3 [
"identificador" => "bib5"
"etiqueta" => "5."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Gasto farmacéutico en atención primaria: variables asociadas y asignación de presupuestos de farmacia por zonas de salud"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:2 [
0 => "A. García-Sempere"
1 => "S. Peiró"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "Gac Sanit"
"fecha" => "2001"
"volumen" => "15"
"paginaInicial" => "32"
"paginaFinal" => "40"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/11333623"
"web" => "Medline"
]
]
]
]
]
]
]
]
5 => array:3 [
"identificador" => "bib6"
"etiqueta" => "6."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Educational outreach visits: effects on professional practice and health care outcomes (Cochrane Review)"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:6 [
0 => "M.A. Thomson O’Brien"
1 => "A.D. Oxman"
2 => "D.A. Davis"
3 => "R.B. Haynes"
4 => "N. Freemantle"
5 => "E.L. Harvey"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Libro" => array:4 [
"titulo" => "The Cochrane Library"
"fecha" => "2004"
"editorial" => "John Wiley & Sons, Ltd."
"editorialLocalizacion" => "Chichester"
]
]
]
]
]
]
6 => array:3 [
"identificador" => "bib7"
"etiqueta" => "7."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Quality assurance for drug prescribing"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:3 [
0 => "S.B. Soumerai"
1 => "T.J. McLaughlin"
2 => "J. Avorn"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "Qual Assur Health Care"
"fecha" => "1990"
"volumen" => "2"
"paginaInicial" => "37"
"paginaFinal" => "58"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/2103870"
"web" => "Medline"
]
]
]
]
]
]
]
]
7 => array:3 [
"identificador" => "bib8"
"etiqueta" => "8."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Changing physician performance. A systematic review of the effect of continuing medical education strategies"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:4 [
0 => "D.A. Davis"
1 => "M.A. Thomson"
2 => "A.D. Oxman"
3 => "R.B. Haynes"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "JAMA"
"fecha" => "1995"
"volumen" => "274"
"paginaInicial" => "700"
"paginaFinal" => "705"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/7650822"
"web" => "Medline"
]
]
]
]
]
]
]
]
8 => array:3 [
"identificador" => "bib9"
"etiqueta" => "9."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "GP prescribing support"
"autores" => array:1 [
0 => array:3 [
"colaboracion" => "Changing prescribing in practice. A review of the evidence"
"etal" => false
"autores" => array:1 [
0 => "S. Braybrook"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Libro" => array:4 [
"titulo" => "A resource document and guide for the New NHS"
"fecha" => "1998"
"editorial" => "National Prescribing Center"
"editorialLocalizacion" => "London"
]
]
]
]
]
]
9 => array:3 [
"identificador" => "bib10"
"etiqueta" => "10."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "One-to-one versus group sessions to improve prescription in primary care: a pragmatic randomized controlled trial"
"autores" => array:1 [
0 => array:2 [
"etal" => true
"autores" => array:6 [
0 => "A. Figueiras"
1 => "I. Sastre"
2 => "F. Tato"
3 => "C. Rodríguez"
4 => "E. Lado"
5 => "F. Caamano"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "Med Care"
"fecha" => "2001"
"volumen" => "39"
"paginaInicial" => "158"
"paginaFinal" => "167"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/11176553"
"web" => "Medline"
]
]
]
]
]
]
]
]
10 => array:3 [
"identificador" => "bib11"
"etiqueta" => "11."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Changing provider behavior: an overview of systematic reviews of interventions"
"autores" => array:1 [
0 => array:2 [
"etal" => true
"autores" => array:6 [
0 => "J.M. Grimshaw"
1 => "L. Shirran"
2 => "R. Thomas"
3 => "G. Mowatt"
4 => "C. Fraser"
5 => "R. Grilli"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:5 [
"tituloSerie" => "Med Care"
"fecha" => "2001"
"volumen" => "39"
"paginaInicial" => "2"
"paginaFinal" => "45"
]
]
]
]
]
]
11 => array:3 [
"identificador" => "bib12"
"etiqueta" => "12."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Influencing NSAID prescribing in primary care using different feedback strategies"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:2 [
0 => "S. Braybrook"
1 => "R. Walker"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "Pharm World Sci"
"fecha" => "2000"
"volumen" => "22"
"paginaInicial" => "39"
"paginaFinal" => "46"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/10849921"
"web" => "Medline"
]
]
]
]
]
]
]
]
12 => array:3 [
"identificador" => "bib13"
"etiqueta" => "13."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "The cyclooxygenase-2 inhibitors: safety and effectiveness"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:2 [
0 => "B. Kaplan-Machlis"
1 => "B.S. Klostermeyer"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "Ann Pharmacother"
"fecha" => "1999"
"volumen" => "33"
"paginaInicial" => "979"
"paginaFinal" => "988"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/10492503"
"web" => "Medline"
]
]
]
]
]
]
]
]
13 => array:3 [
"identificador" => "bib14"
"etiqueta" => "14."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "A randomized trial comparing the effect of rofecoxib, a cyclooxigenase 2-specific inhibitor, with that of ibuprofen on the gastroduodenal mucosa of patients with osteoarthritis. Rofecoxib Osteoarthritis Endoscopy Study Group"
"autores" => array:1 [
0 => array:2 [
"etal" => true
"autores" => array:6 [
0 => "L. Laine"
1 => "S. Harper"
2 => "T. Simon"
3 => "R. Bath"
4 => "J. Johanson"
5 => "H. Schwartz"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:5 [
"tituloSerie" => "Gastroenterol"
"fecha" => "1999"
"volumen" => "117"
"paginaInicial" => "776"
"paginaFinal" => "783"
]
]
]
]
]
]
14 => array:3 [
"identificador" => "bib15"
"etiqueta" => "15."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis ans rheumatoid arthritis. The CLASS study: a randomized controlled trial. Celecoxib Long-term Arthritis Safety Study"
"autores" => array:1 [
0 => array:2 [
"etal" => true
"autores" => array:6 [
0 => "F.E. Silverstein"
1 => "G. Faich"
2 => "J.L. Goldstein"
3 => "L.S. Simon"
4 => "T. Pincus"
5 => "A. Whelton"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "JAMA"
"fecha" => "2000"
"volumen" => "284"
"paginaInicial" => "1247"
"paginaFinal" => "1255"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/10979111"
"web" => "Medline"
]
]
]
]
]
]
]
]
15 => array:3 [
"identificador" => "bib16"
"etiqueta" => "16."
"referencia" => array:1 [
0 => array:1 [
"referenciaCompleta" => "Institut Català de la Salut. Arguments per millorar l’ús dels nous medicaments. Els coxibs a debat. Barcelona: Institut Català de la Salut; 2001."
]
]
]
16 => array:3 [
"identificador" => "bib17"
"etiqueta" => "17."
"referencia" => array:1 [
0 => array:1 [
"referenciaCompleta" => "Agencia Española del Medicamento. Nota informativa de la Agencia Española del medicamento sobre riesgos cardiovasculares de celecoxib y rofecoxib. Septiembre 2001 (Ref: 2001/09)."
]
]
]
17 => array:3 [
"identificador" => "bib18"
"etiqueta" => "18."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Predictors of physician prescribing change in an educational experiment to improve medication use"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:2 [
0 => "S.B. Soumerai"
1 => "J. Avorn"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "Med Care"
"fecha" => "1987"
"volumen" => "25"
"paginaInicial" => "210"
"paginaFinal" => "221"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/3821226"
"web" => "Medline"
]
]
]
]
]
]
]
]
18 => array:3 [
"identificador" => "bib19"
"etiqueta" => "19."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Impact of safety warnings on drug utilization: marketplace life span of cisapride and troglitazone"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:3 [
0 => "J.J. Wilkinson"
1 => "R.W. Force"
2 => "P.S. Cady"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:5 [
"tituloSerie" => "Pharmacother"
"fecha" => "2004"
"volumen" => "24"
"paginaInicial" => "978"
"paginaFinal" => "986"
]
]
]
]
]
]
19 => array:3 [
"identificador" => "bib20"
"etiqueta" => "20."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Impact of safety alerts upon prescribing of cisapride to children in New Zealand"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:3 [
0 => "M. De la Porte"
1 => "D. Reith"
2 => "M. Tilyard"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:4 [
"tituloSerie" => "NZ Med J"
"fecha" => "2002"
"volumen" => "115"
"paginaInicial" => "24U"
]
]
]
]
]
]
20 => array:3 [
"identificador" => "bib21"
"etiqueta" => "21."
"referencia" => array:1 [
0 => array:1 [
"referenciaCompleta" => "Libro de ponencias de la SEFAP. VIII Congreso Nacional del la Sociedad Española de Farmacéuticos de Atención Primaria. Málaga, 22-24 de octubre de 2003. p. 135 y 165."
]
]
]
21 => array:3 [
"identificador" => "bib22"
"etiqueta" => "22."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Evidence based educational outreach visits: effects on prescriptions on non-steroidal anti-inflammatory drugs"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:4 [
0 => "E. Bernal-Delgado"
1 => "M. Galeote-Mayor"
2 => "F. Pradas-Arnal"
3 => "S. Peiró-Moreno"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "J Epidemiol Community Health"
"fecha" => "2002"
"volumen" => "56"
"paginaInicial" => "653"
"paginaFinal" => "658"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/12177080"
"web" => "Medline"
]
]
]
]
]
]
]
]
22 => array:3 [
"identificador" => "bib23"
"etiqueta" => "23."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Improving the quality of antibiotic prescription patterns in general practice. The role of educational intervention"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:5 [
0 => "G. De Santis"
1 => "K.J. Harvey"
2 => "D. Howard"
3 => "M.L. Mashford"
4 => "R.F. Moulds"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "Med J Aust"
"fecha" => "1994"
"volumen" => "160"
"paginaInicial" => "502"
"paginaFinal" => "505"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/8170427"
"web" => "Medline"
]
]
]
]
]
]
]
]
23 => array:3 [
"identificador" => "bib24"
"etiqueta" => "24."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "A controlled trial educational visiting to improve benzodiazepine prescribing in general practice"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:6 [
0 => "S. De Burgh"
1 => "A. Mant"
2 => "R.P. Mattick"
3 => "N. Donnelly"
4 => "W. Hall"
5 => "C. Bridges-Webb"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "Aust J Public Health"
"fecha" => "1995"
"volumen" => "19"
"paginaInicial" => "142"
"paginaFinal" => "148"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/7786939"
"web" => "Medline"
]
]
]
]
]
]
]
]
24 => array:3 [
"identificador" => "bib25"
"etiqueta" => "25."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Prescripción inducida, ¿excusa o realidad?"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:2 [
0 => "F. Cordón Granados"
1 => "J.A. García Vicente"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:5 [
"tituloSerie" => "Aten Primaria"
"fecha" => "1998"
"volumen" => "22"
"paginaInicial" => "9"
"paginaFinal" => "21"
]
]
]
]
]
]
25 => array:3 [
"identificador" => "bib26"
"etiqueta" => "26."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "¿Desde qué nivel asistencial se prescriben los inhibidores de la ciclooxigenasa 2?"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:6 [
0 => "M.J. Montero Fernández"
1 => "F.J. Rodríguez Alcalá"
2 => "N. Vallés Fernández"
3 => "F. López de Castro"
4 => "M. Esteban Tudela"
5 => "B. Cordero García"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "Aten Primaria"
"fecha" => "2002"
"volumen" => "30"
"paginaInicial" => "363"
"paginaFinal" => "367"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/12396942"
"web" => "Medline"
]
]
]
]
]
]
]
]
]
]
]
]
]
"idiomaDefecto" => "es"
"url" => "/02139111/0000001900000003/v2_201302051756/S021391110571356X/v2_201302051756/es/main.assets"
"Apartado" => array:4 [
"identificador" => "764"
"tipo" => "SECCION"
"es" => array:2 [
"titulo" => "Originales"
"idiomaDefecto" => true
]
"idiomaDefecto" => "es"
]
"PDF" => "https://static.elsevier.es/multimedia/02139111/0000001900000003/v2_201302051756/S021391110571356X/v2_201302051756/es/main.pdf?idApp=WGSE&text.app=https://gacetasanitaria.org/"
"EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021391110571356X?idApp=WGSE"
]
