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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Actualmente&#44; los programas de mantenimiento con metadona &#40;PMM&#41; son la mejor alternativa de tratamiento para los adictos a opi&#225;ceos&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Se pretende valorar el coste-efectividad de tres PMM que ofrec&#237;an diferentes servicios auxiliares utilizando como medida de efectividad el incremento de la calidad de vida&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio de seguimiento a 12 meses de 586 pacientes que iniciaron tratamiento con metadona en los centros de atenci&#243;n y seguimiento municipales de Barcelona&#46; Para medir la evoluci&#243;n de la calidad de vida se utiliz&#243; el Perfil de Salud de Nottingham &#40;PSN&#41;&#46; Se calcularon los costes unitarios est&#225;ndar y el coste total por paciente a partir de los registros de actividad&#46; Los datos sociodemogr&#225;ficos&#44; de salud y toxicol&#243;gicos se obtuvieron a trav&#233;s de una entrevista semiestructurada&#46; El an&#225;lisis coste-efectividad se realiz&#243; mediante dos modelos multivariados con id&#233;nticas variables de ajuste&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Cuanto mayor es la intensidad de programa&#44; m&#225;s elevado es el coste&#46; Los modelos ajustados detectaron un aumento significativo de la calidad de vida &#40;mejora de un 8&#37; en el PSN&#41; y de los costes &#40;17&#37;&#41; entre el programa de intensidad baja y el de intensidad media&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El programa de media intensidad demostr&#243; la mejor relaci&#243;n coste-efectividad pero&#44; dadas las limitaciones del estudio&#44; es dif&#237;cil ser taxativo en la generalizaci&#243;n de sus resultados&#46;</p>"
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