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"resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">La gripe es la mayor causa de morbimortalidad en el mundo. Actualmente, las vacunas contra la gripe son efectivas y seguras. Las intervenciones que reduzcan la carga de la enfermedad deben analizarse desde el punto de vista clínico y económico.</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Evaluar la eficiencia de un programa de vacunación contra la gripe en la población laboral española.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Modelo teórico de análisis de costes y beneficios en términos de ahorro para una cohorte de 1.000 trabajadores entre 16 y 65 años de edad vacunada, y otra no vacunada, a 1 año desde la perspectiva social. Intervenciones: vacunación contra la gripe respecto a no vacunación. Mediciones principales datos epidemiológicos y clínicos de incidencia de gripe y efectividad de la vacuna. Datos de uso de recursos directos (de atención primaria y especializada) e indirectos obtenidos por consenso de 5 expertos en medicina preventiva, microbiología, medicina del trabajo y economía de la salud. Datos de costes unitarios (euros de 2003). Se realizó un análisis de sensibilidad con la incidencia de gripe, la efectividad de la vacuna y los días de ausencia del trabajo por gripe.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">En el escenario base, la vacuna permite ahorrar 35 euros netos por trabajador (el 88% corresponde al ahorro en pérdidas de productividad evitadas). El análisis de sensibilidad indica que los valores umbral de incidencia de gripe y de ausencia del trabajo son del 6% y de 1,5 días, respectivamente, a partir de los cuales la vacunación se asocia con el ahorro neto.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Vacunar contra la gripe a la población laboral española puede comportar un ahorro neto a la sociedad.</p>"
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"resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Influenza is a major cause of morbidity and mortality worldwide. Currently, licensed influenza vaccines are safe and effective. Any intervention aimed at reducing the burden of illness is worth analyzing from a clinical and economic perspective.</p> <span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To assess the costs and benefits of an influenza vaccination program in the Spanish working population.</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">A theoretical model of costs and benefits in terms of productivity savings was developed to compare 2 strategies (vaccination and non-vaccination) in 2 cohorts of 1,000 workers each. The time horizon was 1 year and the study’s perspective was societal. Main outcome measures: epidemiological and clinical data on the incidence of influenza and the effectiveness of the vaccine. Data on the use of direct and indirect resources were obtained from an expert panel of 5 experts in preventive medicine, microbiology, occupational health, and health economics. Unit costs (euros 2003) were extracted from local databases. A sensitivity analysis was performed with the data on incidence, effectiveness, and work absenteeism due to influenza.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">In the base case scenario, influenza vaccine saved 35 Euros per worker, of which 88% were savings in work loss days avoided. Threshold values in the sensitivity analysis were 6% for the incidence of influenza and 1.5 days for absence from work, above which the vaccine leads to net savings.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Influenza vaccination in the Spanish working population might result in net resource savings to society at large.</p>"
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