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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Evaluar la eficiencia del &#225;cido acetilsalic&#237;lico &#40;AAS&#41; m&#225;s esomeprazol frente a clopidogrel en la prevenci&#243;n de la hemorragia gastrointestinal&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">An&#225;lisis coste-efectividad &#40;&#225;rbol de decisi&#243;n de 2 ramas&#58; AAS m&#225;s esomeprazol y clopidogrel&#41; respecto a la evitaci&#243;n de casos de hemorragia gastrointestinal en 2 a&#241;os&#44; y an&#225;lisis de sensibilidad&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El coste total del tratamiento con AAS m&#225;s esomeprazol &#40;2&#46;865 S por paciente libre de hemorragia&#41; fue inferior al clopidogrel &#40;2&#46;965 S&#41;&#46; El tratamiento con AAS result&#243; dominante&#46; En todos los an&#225;lisis de sensibilidad la combinaci&#243;n sigui&#243; siendo dominante&#46; Al sustituir esomeprazol 40<span class="elsevierStyleHsp" style=""></span>mg por omeprazol 40<span class="elsevierStyleHsp" style=""></span>mg&#44; el coste del tratamiento combinado descendi&#243; hasta 1&#46;934S&#47;por episodio evitado&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La asociaci&#243;n de esomeprazol y AAS es m&#225;s coste-efectiva que clopidogrel en la prevenci&#243;n de la hemorragia gastrointestinal&#46; La combinaci&#243;n con omeprazol resulta a&#250;n m&#225;s coste-efectiva&#46;</p>"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To evaluate the use of aspirin plus esomeprazole vs&#46; clopidogrel in the prevention of gastrointestinal bleeding&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We performed a cost-effectiveness analysis &#40;two-branch decision tree&#58; aspirin plus esomeprazole or clopidogrel&#41; of prevention of gastrointestinal bleeding over a 2-year period&#44; as well as sensitivity analyses&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The total cost of aspirin plus esomeprazole treatment &#40;2&#44;865S&#47;patient free of hemorrhage&#41; was lower than that of clopidogrel &#40;2&#44;965S&#41;&#46; Aspirin treatment was dominant&#46; The combination continued to be dominant in all sensitivity analyses&#46; When esomeprazole 40<span class="elsevierStyleHsp" style=""></span>mg was substituted by omeprazole 40<span class="elsevierStyleHsp" style=""></span>mg&#44; the cost of combination therapy decreased to 1&#44;934 &#8364;&#47;prevented hemorrhage&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The association of esomeprazole and aspirin is more cost-effective than clopidogrel in preventing gastrointestinal bleeding&#46; Aspirin plus omeprazole was even more cost-effective&#46;</p>"
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