array:23 [
  "pii" => "S0213911122001716"
  "issn" => "02139111"
  "doi" => "10.1016/j.gaceta.2022.102275"
  "estado" => "S300"
  "fechaPublicacion" => "2023-01-01"
  "aid" => "102275"
  "copyright" => "SESPAS"
  "copyrightAnyo" => "2022"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "fla"
  "cita" => "Gac Sanit. 2023;37C:"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0213911123000122"
    "issn" => "02139111"
    "doi" => "10.1016/j.gaceta.2023.102298"
    "estado" => "S300"
    "fechaPublicacion" => "2023-01-01"
    "aid" => "102298"
    "copyright" => "SESPAS"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Gac Sanit. 2023;37C:"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Protocol</span>"
      "titulo" => "Trends and determinants of social inequities in cardiovascular risk factors in Spain&#58; a mixed-methods study"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Tendencias y determinantes de las inequidades sociales en el riesgo cardiovascular en Espa&#241;a&#58; estudio de m&#233;todos mixtos"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig1"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 982
              "Ancho" => 2333
              "Tamanyo" => 206841
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Study design&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Julia D&#237;ez, Guillermo Taulet, Mario Font&#225;n-Vela, Yolanda Gonz&#225;lez-R&#225;bago, Luis Cereijo, Mar&#237;a Sand&#237;n-V&#225;zquez, Elena Rodr&#237;guez, Manuel Franco, Carme Borrell, Usama Bilal, Pedro Gull&#243;n"
          "autores" => array:11 [
            0 => array:2 [
              "nombre" => "Julia"
              "apellidos" => "D&#237;ez"
            ]
            1 => array:2 [
              "nombre" => "Guillermo"
              "apellidos" => "Taulet"
            ]
            2 => array:2 [
              "nombre" => "Mario"
              "apellidos" => "Font&#225;n-Vela"
            ]
            3 => array:2 [
              "nombre" => "Yolanda"
              "apellidos" => "Gonz&#225;lez-R&#225;bago"
            ]
            4 => array:2 [
              "nombre" => "Luis"
              "apellidos" => "Cereijo"
            ]
            5 => array:2 [
              "nombre" => "Mar&#237;a"
              "apellidos" => "Sand&#237;n-V&#225;zquez"
            ]
            6 => array:2 [
              "nombre" => "Elena"
              "apellidos" => "Rodr&#237;guez"
            ]
            7 => array:2 [
              "nombre" => "Manuel"
              "apellidos" => "Franco"
            ]
            8 => array:2 [
              "nombre" => "Carme"
              "apellidos" => "Borrell"
            ]
            9 => array:2 [
              "nombre" => "Usama"
              "apellidos" => "Bilal"
            ]
            10 => array:2 [
              "nombre" => "Pedro"
              "apellidos" => "Gull&#243;n"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911123000122?idApp=WGSE"
    "url" => "/02139111/000000370000000C/v4_202408221243/S0213911123000122/v4_202408221243/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0213911122001601"
    "issn" => "02139111"
    "doi" => "10.1016/j.gaceta.2022.102264"
    "estado" => "S300"
    "fechaPublicacion" => "2023-01-01"
    "aid" => "102264"
    "copyright" => "SESPAS"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Gac Sanit. 2023;37C:"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Protocolo</span>"
      "titulo" => "CVS-Q teen&#169;&#58; s&#237;ndrome visual inform&#225;tico en adolescentes y su relaci&#243;n con libros de texto digitales"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "CVS-Q teen&#169;&#58; computer vision syndrome in adolescents and its relationship with digital textbooks"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Mar Segu&#237;-Crespo, Natalia Cant&#243;-Sancho, Mar S&#225;nchez-Brau, Mari Carmen Dav&#243;-Blanes, Jos&#233; Miguel Mart&#237;nez, Pablo Caballero, Elena Ronda-P&#233;rez"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Mar"
              "apellidos" => "Segu&#237;-Crespo"
            ]
            1 => array:2 [
              "nombre" => "Natalia"
              "apellidos" => "Cant&#243;-Sancho"
            ]
            2 => array:2 [
              "nombre" => "Mar"
              "apellidos" => "S&#225;nchez-Brau"
            ]
            3 => array:2 [
              "nombre" => "Mari Carmen"
              "apellidos" => "Dav&#243;-Blanes"
            ]
            4 => array:2 [
              "nombre" => "Jos&#233; Miguel"
              "apellidos" => "Mart&#237;nez"
            ]
            5 => array:2 [
              "nombre" => "Pablo"
              "apellidos" => "Caballero"
            ]
            6 => array:2 [
              "nombre" => "Elena"
              "apellidos" => "Ronda-P&#233;rez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911122001601?idApp=WGSE"
    "url" => "/02139111/000000370000000C/v4_202408221243/S0213911122001601/v4_202408221243/es/main.assets"
  ]
  "en" => array:18 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Protocolo</span>"
    "titulo" => "Development of vaccines for Chagas disease &#40;CRUZIVAX&#41;&#58; stakeholders&#8217; preferences and potential impacts on healthcare"
    "tieneTextoCompleto" => true
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Francesco Ramponi, C&#233;line Aerts, Paula Sartor, Mar&#237;a Jes&#250;s Pinazo, H&#233;ctor Freilij, Carlos A&#46; Guzm&#225;n, Emilio Malchiodi, Elisa Sicuri"
        "autores" => array:8 [
          0 => array:3 [
            "nombre" => "Francesco"
            "apellidos" => "Ramponi"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "C&#233;line"
            "apellidos" => "Aerts"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Paula"
            "apellidos" => "Sartor"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Mar&#237;a Jes&#250;s"
            "apellidos" => "Pinazo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "H&#233;ctor"
            "apellidos" => "Freilij"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Carlos A&#46;"
            "apellidos" => "Guzm&#225;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff0025"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Emilio"
            "apellidos" => "Malchiodi"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">f</span>"
                "identificador" => "aff0030"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">g</span>"
                "identificador" => "aff0035"
              ]
            ]
          ]
          7 => array:4 [
            "nombre" => "Elisa"
            "apellidos" => "Sicuri"
            "email" => array:2 [
              0 => "elisa.sicuri@isglobal.org"
              1 => "e.sicuri@lse.ac.uk"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">h</span>"
                "identificador" => "aff0040"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:8 [
          0 => array:3 [
            "entidad" => "ISGlobal&#44; Hospital Cl&#237;nic&#44; Universitat de Barcelona&#44; Barcelona&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Regi&#243;n Sanitaria 5&#44; Ministerio de Salud del Chaco&#44; Juan Jos&#233; Castelli&#44; Chaco&#44; Argentina"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Universidad Nacional del Nordeste&#44; Facultad de Ciencias Exactas Naturales y Agrimensura&#44; Corrientes Capital&#44; Argentina"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Hospital de Ni&#241;os Ricardo Guti&#233;rrez&#44; Buenos Aires&#44; Argentina"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
          4 => array:3 [
            "entidad" => "Department of Vaccinology and Applied Microbiology&#44; Helmholtz Centre for Infection Research&#44; Braunschweig&#44; Germany"
            "etiqueta" => "e"
            "identificador" => "aff0025"
          ]
          5 => array:3 [
            "entidad" => "Universidad de Buenos Aires&#44; Facultad de Farmacia y Bioqu&#237;mica&#44; C&#225;tedra de Inmunolog&#237;a&#44; and Instituto de Estudios de la Inmunidad Humoral Ricardo A&#46; Margni &#40;IDEHU&#41;&#44; UBA-CONICET&#44; Buenos Aires&#44; Argentina"
            "etiqueta" => "f"
            "identificador" => "aff0030"
          ]
          6 => array:3 [
            "entidad" => "Universidad de Buenos Aires&#44; Facultad de Medicina&#44; Departamento de Microbiolog&#237;a&#44; Parasitolog&#237;a e Inmunolog&#237;a&#44; and Instituto de Microbiolog&#237;a y Parasitolog&#237;a M&#233;dica &#40;IMPaM&#41;&#44; UBA-CONICET&#44; Buenos Aires&#44; Argentina"
            "etiqueta" => "g"
            "identificador" => "aff0035"
          ]
          7 => array:3 [
            "entidad" => "LSE Health&#44; London School of Economics &#38; Political Science&#44; London&#44; United Kingdom"
            "etiqueta" => "h"
            "identificador" => "aff0040"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Desarrollo de vacunas para la enfermedad de Chagas &#40;CRUZIVAX&#41;&#58; preferencias de las partes interesadas y posibles impactos en la asistencia sanitaria"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Chagas disease is caused by infection with the <span class="elsevierStyleItalic">Trypanosoma cruzi</span> parasite and it is one of the 20 neglected tropical diseases recognized by the World Health Organization&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">1</span></a> Seventy million people worldwide are at risk of infection&#44; and 6-8 million people are affected by Chagas disease&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">2</span></a> Most of infected individuals live in Latin America&#44; and have low access to prevention&#44; diagnosis and treatment of the infection&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">3</span></a> Currently available treatments have substantial limitations&#44; and parasitological cure can only be achieved when treatment is delivered in the acute phase of the disease&#44; or at early stages of its chronic phase&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">4</span></a> A prophylactic vaccine against Chagas disease does not exist&#44; and the most effective prevention strategies are vector control&#44; and control of other routes of transmission&#46; However&#44; research is currently underway to develop a prophylactic and therapeutic vaccine for Chagas disease &#40;CRUZIVAX<span class="elsevierStyleSup">TM</span>&#41;&#46; Initial pre-clinical studies and results from laboratory studies are promising&#44;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">5&#44;6</span></a> and work aimed at first-in-man studies is undergoing&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">This study focuses on the Gran Chaco region&#44; which spans in Argentina&#44; Bolivia and Paraguay&#44; and has a very high burden of Chagas disease&#46; In many rural villages of this region&#44; <span class="elsevierStyleItalic">T&#46; cruzi</span> seroprevalence varies between 20&#37; and 50&#37; among children and adolescents under 15 years of age&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">7&#44;8</span></a> Because of migration&#44; Chagas disease has become a public health problem also in non-endemic areas&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">9&#8211;11</span></a> Therefore&#44; this study focuses on Spain&#44; which is the main destination of Latin American emigration to Europe&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">12</span></a> Because of the migration flows&#44; the number of cases of <span class="elsevierStyleItalic">T&#46; cruzi</span> infection diagnosed in Spain has increased dramatically in the last decade&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">11</span></a> For example&#44; in a neighborhood of Barcelona&#44; the prevalence of Chagas disease among primary care patients from Latin America reached 2&#46;87&#37; in 2011&#44;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">12</span></a> and a 3&#46;4&#37; infection prevalence in pregnant women and a 7&#46;3&#37; rate of transmission to their newborns were estimated in the maternity wards of two large hospitals&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">13</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The costs associated with Chagas disease can very high&#44;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">14&#8211;16</span></a> and the development of a vaccine could help to reduce the substantial impact of Chagas disease on health system resources&#46; However&#44; few studies have attempted to estimate the economic value of potential vaccines&#46;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">17&#8211;19</span></a> Furthermore&#44; little information is available on the preferences of the population affected by Chagas disease and their potential demand for technologies that are under development&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">20</span></a> Evidence on health-related quality of life &#40;HRQoL&#41; of patients with Chagas disease is scarce&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">21</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The aim of this work is to provide health economic evidence to inform the initial phase of the vaccine development&#46; This study has three main objectives&#58; 1&#41; to estimate preferences and potential demand curve for the candidate vaccine CRUZIVAX<span class="elsevierStyleSup">TM</span> among individuals at-risk&#44; infected population&#44; and health policy makers&#59; 2&#41; to estimate the HRQoL of patients with Chagas disease and of people at risk of being infected in endemic and non-endemic areas&#59; and 3&#41; to assess lifetime costs of disease to estimate the potential savings generated by the CRUZIVAX<span class="elsevierStyleSup">TM</span> vaccine&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Method</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Design</span><p id="par0025" class="elsevierStylePara elsevierViewall">The theoretical demand will be characterized using a discrete choice experiment &#40;DCE&#41;&#46; The study will include four versions of the DCE&#58; 1&#41; DCE on the prophylactic vaccine&#44; addressed to health policy makers&#59; 2&#41; DCE on the prophylactic vaccine&#44; addressed to individuals at risk of infection or already infected&#59; 3&#41; DCE on the therapeutic vaccine&#44; addressed to health policy makers&#59; and 4&#41; DCE on the therapeutic vaccine&#44; addressed to individuals at risk of infection or already infected&#46; The content of the DCE for the individuals at risk looks at the specific characteristics of the vaccine &#40;<span class="elsevierStyleItalic">e&#46;g&#46;</span>&#44; the way the vaccine is administered&#44; the severity and duration of the adverse reaction&#44; and the price per vaccine dose&#41;&#44; and will be used to explore the relative importance of each attribute and its levels in the individual&#39;s decision of whether or not to get the vaccine for themselves&#44; or for a family member&#46; The content of the DCE targeted to health policy-makers focuses on characteristics of the health system and on financial issues &#40;<span class="elsevierStyleItalic">e&#46;g</span>&#46;&#44; the feasibility of adding the Chagas vaccine to national vaccination programs in endemic areas&#41;&#46; Of note&#44; the DCE for the preventive vaccine administered to policy makers refers only to Argentina&#46; A therapeutic vaccine would be of interest in both Argentina and Spain&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">To obtain information on HRQoL&#44; the EQ-5D questionnaire will be used&#44; which allows to estimate quality-adjusted life years&#46; HRQoL data and DCE responses will be collected from the same patients&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Data on the use of health care resources by patients with Chagas disease over time will be obtained from the clinical databases of the Hospital Cl&#237;nic of Barcelona &#40;Spain&#41;&#46; Unit costs and individual patient data on the use of healthcare resources will be used to estimate the costs of outpatient and inpatient interventions and total lifetime follow-up cost for patients&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Setting</span><p id="par0040" class="elsevierStylePara elsevierViewall">Data collection will take place in Barcelona &#40;Spain&#41; and in two Argentinian provinces&#58; San Juan &#40;Cuyo region&#44; west Argentina&#41; and Chaco &#40;Northeast region&#41;&#46; Both provinces are categorized as being at high risk of vector transmission&#46; Moreover&#44; &#8220;urban triatomism&#8221; &#40;<span class="elsevierStyleItalic">i&#46;e</span>&#46;&#44; <span class="elsevierStyleItalic">T&#46; cruzi</span> infection happening in urban areas&#41; is reported in San Juan&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">22</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Tools and materials for data collection</span><p id="par0045" class="elsevierStylePara elsevierViewall">Vaccine attributes and levels for the DCE were chosen using the Delphi method&#46; The most relevant attributes and levels of the vaccine were identified by a group of 16 experts&#46; DCE were created using series of 12 sets of options regarding the characteristics of the vaccine&#44; generated using a statistical software &#40;STATA&#41;&#46; For each set of options&#44; two alternatives were created&#44; which report different values for each of the vaccine characteristics&#46; Respondents can choose their preferred alternative in each set&#46; In the electronic version the DCE will be accompanied by drawings of each of the characteristics and their values&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In addition to the DCEs&#44; the data collection tool for patients includes the EQ-5D-3L questionnaire&#44; which assesses the following components of HRQoL&#58; mobility&#59; self-care&#59; activities of daily living&#59; pain&#47;discomfort&#59; and anxiety&#47;depression&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Questionnaires including DCEs for both prophylactic and therapeutic vaccination and the HRQoL questionnaire are provided in online <a class="elsevierStyleCrossRef" href="#sec0090">Appendices A and B</a>&#46; The questionnaires for patients in Argentina collect also socio-economic and demographic data&#44; such as age&#44; sex&#44; level of education&#44; occupation&#44; and housing characteristics&#44; as well as data on symptoms related to the progression of Chagas disease&#46; Data collected in Spain can be linked to the hospital database&#44; which contains clinical and socio-demographic information&#46; The DCE survey for health policy makers in Spain is reported in <a class="elsevierStyleCrossRef" href="#sec0090">online Appendix C</a>&#59; the survey for Argentinian and international policy makers is reported in <a class="elsevierStyleCrossRef" href="#sec0090">online Appendix D</a>&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Additional information on data collection and management is provided in <a class="elsevierStyleCrossRef" href="#sec0090">online Appendix E</a>&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Statistical analysis</span><p id="par0065" class="elsevierStylePara elsevierViewall">The data collected with the DCEs for the therapeutic and the prophylactic vaccines will be analyzed separately&#44; following good research practices in terms of the statistical models applied&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">23</span></a> Statistical analyses will be conducted using Stata&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">For the estimation of the HRQoL determinants of patients with Chagas disease and of people at risk of infection&#44; a multivariate model based on a Beta distribution will be adopted&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">24</span></a> In addition to clinical factors&#44; the analysis will control for sociodemographic characteristics to isolate the impact of the disease on quality of life&#46; For example&#44; we will explore differences between rural and urban settings&#44; and we will investigate whether gender&#44; ethnicity and socio-economic status are relevant factors affecting the HRQoL of patients affected by Chagas disease&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">To estimate the lifetime costs of Chagas disease&#44; the use of health care resources will be investigated using information from the clinical database of the Hospital Cl&#237;nic of Barcelona&#46; Clinical follow-up records of patients with <span class="elsevierStyleItalic">T&#46; cruzi</span> infection will be retrieved from the Hospital Cl&#237;nic database&#44; which includes information on patients&#8217; use of resources from the time of positive diagnosis&#46; Unit costs of the interventions will be obtained using costings list from the Hospital Clinic&#46; The costs associated with each contact with the health facility will be estimated from the provider&#39;s perspective&#46; The data analysis will follow the methods adopted by Basu and Manning<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">25</span></a> to estimate lifetime cost of illness by controlling for censoring cases&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Discussion</span><p id="par0080" class="elsevierStylePara elsevierViewall">We acknowledge that the COVID-19 pandemic might affect the capability of conducting the planned interviews with patients&#44; the duration of data collection and the minimum sample size targets&#46; Further&#44; we are aware that&#44; to generalize the findings of the case study analysis conducted at the Hospital Cl&#237;nic in Barcelona to endemic settings&#44; additional information and assumptions on the different unit costs&#44; health care practices&#44; patients&#8217; access to the health system and disease prevalence will be required&#46; However&#44; we believe that this study will provide new and crucial information on preferences around the new potential vaccines&#44; characteristics of the target population and potential impact on the health systems in endemic and non-endemic settings&#46; The results of the study may be useful to guide the development of new technologies&#44; with the aim of maximizing their coverage once they are ready and available on the market&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Ethics approval and consent to participate</span><p id="par0085" class="elsevierStylePara elsevierViewall">The study protocol&#44; tools for data collection and informed consents have been approved by the Ethics Committee of the Hospital Cl&#237;nic de Barcelona &#40;CEim Hospital Cl&#237;nic&#41; in Spain&#44; and by the Ethics Committee of the Ministry of Public Health of San Juan and Facultad de Ciencias Exactas&#44; Naturales y Agrimensura de la Universidad Nacional del Nordeste in Argentina &#40;see <a class="elsevierStyleCrossRef" href="#sec0090">online Appendix F</a>&#41;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Participants provided the informed consent to enter the study&#46; Information and informed consent forms are provided in <a class="elsevierStyleCrossRef" href="#sec0090">online Appendix G</a>&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Consent for publication</span><p id="par0095" class="elsevierStylePara elsevierViewall">Participants provided their consent for information about themselves to be published&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Availability of databases and material for replication</span><p id="par0100" class="elsevierStylePara elsevierViewall">Not applicable to this article&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Related articles</span><p id="par0105" class="elsevierStylePara elsevierViewall">No other publications containing the results of this study have already been published or submitted to any journal&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Study status</span><p id="par0110" class="elsevierStylePara elsevierViewall">At the time of this submission participant recruitment was not completed&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Editor in charge</span><p id="par0115" class="elsevierStylePara elsevierViewall">Carlos &#193;lvarez-Dardet&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Authorship contributions</span><p id="par0120" class="elsevierStylePara elsevierViewall">E&#46; Sicuri conceived the study&#46; E&#46; Sicuri&#44; C&#46; Aerts&#44; H&#46; Freilij&#44; C&#46;A&#46; Guzm&#225;n&#44; P&#46; Sartor&#44; M&#46;J&#46; Pinazo&#44; F&#46; Ramponi and E&#46; Malchiodi contributed to the study design&#46; E&#46; Sicuri and C&#46; Aerts designed the data collection tools and wrote the first draft of the protocol&#46; F&#46; Ramponi and E&#46; Sicuri wrote the final version of the manuscript with substantial intellectual contribution and by incorporating the contribution from all the authors&#46; All authors provided critical revision of the manuscript each one according to their respective expertise&#46; All authors approved the final version of the protocol&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Funding</span><p id="par0125" class="elsevierStylePara elsevierViewall">The CRUZIVAX project was funded by the European Commission within the Horizon 2020 framework &#40;Grant Number - 815418&#41;&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflicts of interest</span><p id="par0130" class="elsevierStylePara elsevierViewall">None&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:17 [
        0 => array:3 [
          "identificador" => "xres2227732"
          "titulo" => "Abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1865493"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres2227731"
          "titulo" => "Resumen"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0010"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1865494"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Method"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Design"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Setting"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Tools and materials for data collection"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Statistical analysis"
            ]
          ]
        ]
        6 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Discussion"
        ]
        7 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Ethics approval and consent to participate"
        ]
        8 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Consent for publication"
        ]
        9 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Availability of databases and material for replication"
        ]
        10 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Related articles"
        ]
        11 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Study status"
        ]
        12 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Editor in charge"
        ]
        13 => array:2 [
          "identificador" => "sec0070"
          "titulo" => "Authorship contributions"
        ]
        14 => array:2 [
          "identificador" => "sec0075"
          "titulo" => "Funding"
        ]
        15 => array:2 [
          "identificador" => "sec0080"
          "titulo" => "Conflicts of interest"
        ]
        16 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2022-10-14"
    "fechaAceptado" => "2022-10-14"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1865493"
          "palabras" => array:9 [
            0 => "Chagas disease"
            1 => "Trypanosoma cruzi"
            2 => "Vaccines"
            3 => "Surveys and questionnaires"
            4 => "Quality of life"
            5 => "Patient preferences"
            6 => "Health care costs"
            7 => "Argentina"
            8 => "Spain"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1865494"
          "palabras" => array:9 [
            0 => "Enfermedad de Chagas"
            1 => "Trypanosoma cruzi"
            2 => "Vacunas"
            3 => "Encuestas y cuestionarios"
            4 => "Calidad de vida"
            5 => "Preferencias del paciente"
            6 => "Costes sanitarios"
            7 => "Argentina"
            8 => "Espa&#241;a"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A vaccine for Chagas disease does not currently exist&#46; This study aims to inform the development of two vaccines for the prevention and treatment of <span class="elsevierStyleItalic">Trypanosoma cruzi</span> infection&#44; and guide their pre-clinical phase up to clinical phase <span class="elsevierStyleSmallCaps">I</span>&#46; The three main objectives are&#58; 1&#41; to explore patients&#8217; and policy makers&#8217; preferences on the candidate vaccines in Argentina and Spain&#59; 2&#41; to investigate health-related quality of life of patients affected by Chagas disease&#59; and 3&#41; to assess the potential health provider savings associated with the vaccines&#44; in terms of resource use and health care costs&#46; Discrete choice experiments will be employed to estimate and characterize the theoretical demand for the vaccines and investigate patients&#8217; and policy makers&#8217; preferences&#46; Health-related quality of life will be assessed using the EQ-5D-3L questionnaire&#46; Resources use and costs associated with Chagas disease will be investigated using information from the databases of the Hospital Cl&#237;nic of Barcelona&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">No existen vacunas para la enfermedad de Chagas&#46; Este trabajo pretende informar la fase precl&#237;nica de dos vacunas para la prevenci&#243;n y el tratamiento de la infecci&#243;n por <span class="elsevierStyleItalic">Trypanosoma cruzi</span>&#46; Los objetivos principales son tres&#58; 1&#41; investigar las preferencias de los pacientes y de los responsables de pol&#237;ticas sanitarias en Argentina y Espa&#241;a&#59; 2&#41; investigar la calidad de vida relacionada con la salud de los pacientes afectados por la enfermedad de Chagas&#59; y 3&#41; estimar los ahorros potenciales asociados con las vacunas para los proveedores de salud&#46; Se usar&#225;n experimentos de elecci&#243;n discreta para estimar y caracterizar la demanda te&#243;rica de las vacunas e investigar las preferencias de los pacientes y de los responsables de las pol&#237;ticas sanitarias&#46; La calidad de vida relacionada con la salud se evaluar&#225; mediante el cuestionario EQ-5D-3L&#46; Se investigar&#225;n el uso de recursos y los costes asociados a la enfermedad de Chagas utilizando bases de datos del Hospital Cl&#237;nic de Barcelona&#46;</p></span>"
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0140" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="upi0005"></elsevierMultimedia><elsevierMultimedia ident="upi0010"></elsevierMultimedia><elsevierMultimedia ident="upi0015"></elsevierMultimedia><elsevierMultimedia ident="upi0020"></elsevierMultimedia><elsevierMultimedia ident="upi0025"></elsevierMultimedia><elsevierMultimedia ident="upi0030"></elsevierMultimedia><elsevierMultimedia ident="upi0035"></elsevierMultimedia><elsevierMultimedia ident="upi0040"></elsevierMultimedia><elsevierMultimedia ident="upi0045"></elsevierMultimedia><elsevierMultimedia ident="upi0050"></elsevierMultimedia><elsevierMultimedia ident="upi0055"></elsevierMultimedia><elsevierMultimedia ident="upi0060"></elsevierMultimedia><elsevierMultimedia ident="upi0065"></elsevierMultimedia></p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Supplementary data"
            "identificador" => "sec0090"
          ]
        ]
      ]
    ]
    "multimedia" => array:13 [
      0 => array:5 [
        "identificador" => "upi0005"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc1.doc"
          "ficheroTamanyo" => 72600
        ]
      ]
      1 => array:5 [
        "identificador" => "upi0010"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc2.doc"
          "ficheroTamanyo" => 60467
        ]
      ]
      2 => array:5 [
        "identificador" => "upi0015"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc3.doc"
          "ficheroTamanyo" => 18693
        ]
      ]
      3 => array:5 [
        "identificador" => "upi0020"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc4.doc"
          "ficheroTamanyo" => 23057
        ]
      ]
      4 => array:5 [
        "identificador" => "upi0025"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc5.doc"
          "ficheroTamanyo" => 29192
        ]
      ]
      5 => array:5 [
        "identificador" => "upi0030"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc6.pdf"
          "ficheroTamanyo" => 52884
        ]
      ]
      6 => array:5 [
        "identificador" => "upi0035"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc7.pdf"
          "ficheroTamanyo" => 66899
        ]
      ]
      7 => array:5 [
        "identificador" => "upi0040"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc8.pdf"
          "ficheroTamanyo" => 245394
        ]
      ]
      8 => array:5 [
        "identificador" => "upi0045"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc9.pdf"
          "ficheroTamanyo" => 680635
        ]
      ]
      9 => array:5 [
        "identificador" => "upi0050"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc10.doc"
          "ficheroTamanyo" => 43360
        ]
      ]
      10 => array:5 [
        "identificador" => "upi0055"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc11.doc"
          "ficheroTamanyo" => 41279
        ]
      ]
      11 => array:5 [
        "identificador" => "upi0060"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc12.doc"
          "ficheroTamanyo" => 40293
        ]
      ]
      12 => array:5 [
        "identificador" => "upi0065"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc13.doc"
          "ficheroTamanyo" => 39573
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:25 [
            0 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hunter&#39;s Tropical Medicine and Emerging Infectious Diseases&#46; E-Book"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46;T&#46; Ryan"
                            1 => "D&#46;R&#46; Hill"
                            2 => "T&#46; Solomon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:2 [
                        "fecha" => "2019"
                        "editorial" => "Elsevier Health Sciences"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "World Health Organization&#46; Chagas disease &#40;American trypanosomiasis&#41;&#46; WHO&#59; 2019&#46; Available at&#58; https&#58;&#47;&#47;www&#46;who&#46;int&#47;es&#47;news-room&#47;fact-sheets&#47;detail&#47;chagas-disease-&#40;american-trypanosomiasis&#46;"
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chagas disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;A&#46; Perez-Molina"
                            1 => "I&#46; Molina"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(17)31612-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet&#46;"
                        "fecha" => "2018"
                        "volumen" => "391"
                        "paginaInicial" => "82"
                        "paginaFinal" => "94"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28673423"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical and pharmacological profile of benznidazole for treatment of Chagas disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;M&#46; Kratz"
                            1 => "F&#46; Garcia Bournissen"
                            2 => "C&#46;J&#46; Forsyth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/17512433.2018.1509704"
                      "Revista" => array:6 [
                        "tituloSerie" => "Expert Rev Clin Pharmacol&#46;"
                        "fecha" => "2018"
                        "volumen" => "11"
                        "paginaInicial" => "943"
                        "paginaFinal" => "957"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30111183"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Engineered trivalent immunogen adjuvanted with a STING agonist confers protection against Trypanosoma cruzi infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Sanchez Alberti"
                            1 => "A&#46;E&#46; Bivona"
                            2 => "N&#46; Cerny"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/s41541-016-0001-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "npj Vaccines&#46;"
                        "fecha" => "2017"
                        "volumen" => "2"
                        "paginaInicial" => "1"
                        "paginaFinal" => "11"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29263862"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mucosal heterologous prime&#47;boost vaccination induces polyfunctional systemic immunity&#44; improving protection against Trypanosoma cruzi"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Sanchez Alberti"
                            1 => "A&#46;E&#46; Bivona"
                            2 => "M&#46;N&#46; Matos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fimmu.2020.00128"
                      "Revista" => array:5 [
                        "tituloSerie" => "Front Immunol&#46;"
                        "fecha" => "2020"
                        "volumen" => "11"
                        "paginaInicial" => "128"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32153562"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Improving access to Chagas disease diagnosis and etiologic treatment in remote rural communities of the Argentine Chaco through strengthened primary health care and broad social participation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "P&#46; Sartor"
                            1 => "I&#46; Colaianni"
                            2 => "M&#46;V&#46; Cardinal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS Negl Trop Dis&#46;"
                        "fecha" => "2017"
                        "volumen" => "11"
                        "paginaInicial" => "1"
                        "paginaFinal" => "18"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infection&#44; genetics and evolution Chagas&#8217; disease in Aboriginal and Creole communities from the Gran Chaco Region of Argentina&#58; seroprevalence and molecular parasitological characterization"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46;H&#46; Lucero"
                            1 => "B&#46;L&#46; Bruss"
                            2 => "C&#46;I&#46; Cura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.meegid.2016.03.028"
                      "Revista" => array:6 [
                        "tituloSerie" => "Infect Genet Evol&#46;"
                        "fecha" => "2016"
                        "volumen" => "41"
                        "paginaInicial" => "84"
                        "paginaFinal" => "92"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27057620"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Urban Chagas disease in children and women in primary care centres in Buenos Aires"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46; Moscatelli"
                            1 => "A&#46; Berenstein"
                            2 => "A&#46; Tarlovsky"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Argentina&#46; Mem Inst Oswaldo Cruz&#46;"
                        "fecha" => "2015"
                        "volumen" => "110"
                        "paginaInicial" => "644"
                        "paginaFinal" => "648"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of migration on the occurrence of new cases of Chagas disease in Buenos Aires city"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46; Moscatelli"
                            1 => "F&#46;G&#46; Bournissen"
                            2 => "H&#46; Freilij"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Argentina&#46; J Infect Dev Ctries&#46;"
                        "fecha" => "2013"
                        "volumen" => "7"
                        "paginaInicial" => "635"
                        "paginaFinal" => "637"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of Chagas disease in Latin- American migrants living in Europe&#58; a systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Requena-M&#233;ndez"
                            1 => "E&#46; Aldasoro"
                            2 => "E&#46;D&#46; Lazzari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS Negl Tropical Dis&#46;"
                        "fecha" => "2015"
                        "volumen" => "9"
                        "paginaInicial" => "1"
                        "paginaFinal" => "15"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chagas Disease among the Latin American adult population attending in a primary care center in Barcelona"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46; Roca"
                            1 => "M&#46;J&#46; Pinazo"
                            2 => "P&#46; Lpez-Chejade"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pntd.0001135"
                      "Revista" => array:5 [
                        "tituloSerie" => "Spain&#46; PLoS Negl Trop Dis&#46;"
                        "fecha" => "2011"
                        "volumen" => "5"
                        "paginaInicial" => "e1135"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21572511"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence and vertical transmission of Trypanosoma cruzi infection among pregnant Latin American women attending 2 maternity clinics in Barcelona"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46; Mu&#241;oz"
                            1 => "O&#46; Coll"
                            2 => "T&#46; Juncosa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/599223"
                      "Revista" => array:6 [
                        "tituloSerie" => "Spain&#46; Clin Infect Dis&#46;"
                        "fecha" => "2009"
                        "volumen" => "48"
                        "paginaInicial" => "1736"
                        "paginaFinal" => "1740"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19438393"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The costs of preventing and treating Chagas disease in Colombia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Castillo-Riquelme"
                            1 => "F&#46; Guhl"
                            2 => "B&#46; Turriago"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pntd.0000336"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS Negl Trop Dis&#46;"
                        "fecha" => "2008"
                        "volumen" => "2"
                        "paginaInicial" => "e336"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19015725"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chagas&#8217; cardiomyopathy&#58; the economic burden of an expensive and neglected disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Abuhab"
                            1 => "E&#46; Trindade"
                            2 => "G&#46;B&#46; Aulicino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijcard.2013.01.262"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Cardiol&#46;"
                        "fecha" => "2013"
                        "volumen" => "168"
                        "paginaInicial" => "2375"
                        "paginaFinal" => "2380"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23465560"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Global economic burden of Chagas disease&#58; a computational simulation model"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "B&#46;Y&#46; Lee"
                            1 => "K&#46;M&#46; Bacon"
                            2 => "M&#46;E&#46; Bottazzi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1473-3099(13)70002-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet Infect Dis&#46;"
                        "fecha" => "2013"
                        "volumen" => "13"
                        "paginaInicial" => "342"
                        "paginaFinal" => "348"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23395248"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Economic value of a therapeutic Chagas vaccine for indeterminate and Chagasic cardiomyopathy patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;M&#46; Bartsch"
                            1 => "M&#46;E&#46; Bottazzi"
                            2 => "L&#46; Asti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.vaccine.2019.05.028"
                      "Revista" => array:6 [
                        "tituloSerie" => "Vaccine&#46;"
                        "fecha" => "2019"
                        "volumen" => "37"
                        "paginaInicial" => "3704"
                        "paginaFinal" => "3714"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31104883"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The potential economic value of a Trypanosoma cruzi &#40;Chagas disease&#41; vaccine in Latin America"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "B&#46;Y&#46; Lee"
                            1 => "K&#46;M&#46; Bacon"
                            2 => "D&#46;L&#46; Connor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS Negl Trop Dis&#46;"
                        "fecha" => "2010"
                        "volumen" => "4"
                        "paginaInicial" => "3"
                        "paginaFinal" => "10"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Modeling the economic value of a Chagas&#8217; disease therapeutic vaccine"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "B&#46;Y&#46; Lee"
                            1 => "K&#46;M&#46; Bacon"
                            2 => "A&#46;R&#46; Wateska"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4161/hv.20966"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Vaccin Immunother&#46;"
                        "fecha" => "2012"
                        "volumen" => "8"
                        "paginaInicial" => "1293"
                        "paginaFinal" => "1301"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22894964"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Consumer willingness to pay for a hypothetical Chagas disease vaccine in Brazil&#58; a cross-sectional study and the implications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46;S&#46; Athie"
                            1 => "G&#46;C&#46; Nascimento"
                            2 => "M&#46;J&#46; Labis da Costa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2217/cer-2020-0241"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Comp Eff Res&#46;"
                        "fecha" => "2021"
                        "volumen" => "10"
                        "paginaInicial" => "659"
                        "paginaFinal" => "672"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33851872"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Health-related quality of life in patients with Chagas disease&#58; a review of the evidence"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46;R&#46; Sousa"
                            1 => "H&#46;S&#46; Costa"
                            2 => "A&#46;C&#46; Souza"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/0037-8682-0244-2014"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Soc Bras Med Trop&#46;"
                        "fecha" => "2015"
                        "volumen" => "48"
                        "paginaInicial" => "121"
                        "paginaFinal" => "128"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25992924"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Urban infestation by Triatoma infestans &#40;Hemiptera&#58; Reduviidae&#41;&#44; an overlooked phenomena for Chagas disease in Argentina"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "Y&#46;M&#46; Provecho"
                            1 => "M&#46;D&#46;P&#46; Fern&#225;ndez"
                            2 => "L&#46; Salva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/0074-02760210056"
                      "Revista" => array:5 [
                        "tituloSerie" => "Mem Inst Oswaldo Cruz&#46;"
                        "fecha" => "2021"
                        "volumen" => "116"
                        "paginaInicial" => "e210056"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34105689"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Statistical methods for the analysis of discrete choice experiments&#58; a report of the ISPOR Conjoint Analysis Good Research Practices Task Force"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;B&#46; Hauber"
                            1 => "J&#46;M&#46; Gonz&#225;lez"
                            2 => "C&#46;G&#46; Groothuis-Oudshoorn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jval.2016.04.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Value Health&#46;"
                        "fecha" => "2016"
                        "volumen" => "19"
                        "paginaInicial" => "300"
                        "paginaFinal" => "315"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27325321"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differences in health-related quality of life between HIV-positive and HIV-negative people in Zambia and South Africa&#58; a cross-sectional baseline survey of the HPTN 071 &#40;PopART&#41; trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46; Thomas"
                            1 => "R&#46; Burger"
                            2 => "A&#46; Harper"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Lancet Glob Health&#46;"
                        "fecha" => "2017"
                        "volumen" => "5"
                        "paginaInicial" => "e1133"
                        "paginaFinal" => "e1141"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estimating lifetime or episode-of-illness costs under censoring"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Basu"
                            1 => "W&#46;G&#46; Manning"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Health Econ&#46;"
                        "fecha" => "2010"
                        "volumen" => "1028"
                        "paginaInicial" => "1010"
                        "paginaFinal" => "1028"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/02139111/000000370000000C/v4_202408221243/S0213911122001716/v4_202408221243/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "92462"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Protocolos"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02139111/000000370000000C/v4_202408221243/S0213911122001716/v4_202408221243/en/main.pdf?idApp=WGSE&text.app=https://gacetasanitaria.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911122001716?idApp=WGSE"
]
Compartir
Publique en esta revista
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Protocolo
Development of vaccines for Chagas disease (CRUZIVAX): stakeholders’ preferences and potential impacts on healthcare
Desarrollo de vacunas para la enfermedad de Chagas (CRUZIVAX): preferencias de las partes interesadas y posibles impactos en la asistencia sanitaria
Francesco Ramponia, Céline Aertsa, Paula Sartorb,c, María Jesús Pinazoa, Héctor Freilijd, Carlos A. Guzmáne, Emilio Malchiodif,g, Elisa Sicuria,h,
Autor para correspondencia
a ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
b Región Sanitaria 5, Ministerio de Salud del Chaco, Juan José Castelli, Chaco, Argentina
c Universidad Nacional del Nordeste, Facultad de Ciencias Exactas Naturales y Agrimensura, Corrientes Capital, Argentina
d Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina
e Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany
f Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Inmunología, and Instituto de Estudios de la Inmunidad Humoral Ricardo A. Margni (IDEHU), UBA-CONICET, Buenos Aires, Argentina
g Universidad de Buenos Aires, Facultad de Medicina, Departamento de Microbiología, Parasitología e Inmunología, and Instituto de Microbiología y Parasitología Médica (IMPaM), UBA-CONICET, Buenos Aires, Argentina
h LSE Health, London School of Economics & Political Science, London, United Kingdom
Leído
3755
Veces
se ha leído el artículo
952
Total PDF
2803
Total HTML
Compartir estadísticas
 array:23 [
  "pii" => "S0213911122001716"
  "issn" => "02139111"
  "doi" => "10.1016/j.gaceta.2022.102275"
  "estado" => "S300"
  "fechaPublicacion" => "2023-01-01"
  "aid" => "102275"
  "copyright" => "SESPAS"
  "copyrightAnyo" => "2022"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "fla"
  "cita" => "Gac Sanit. 2023;37C:"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0213911123000122"
    "issn" => "02139111"
    "doi" => "10.1016/j.gaceta.2023.102298"
    "estado" => "S300"
    "fechaPublicacion" => "2023-01-01"
    "aid" => "102298"
    "copyright" => "SESPAS"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Gac Sanit. 2023;37C:"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Protocol</span>"
      "titulo" => "Trends and determinants of social inequities in cardiovascular risk factors in Spain&#58; a mixed-methods study"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Tendencias y determinantes de las inequidades sociales en el riesgo cardiovascular en Espa&#241;a&#58; estudio de m&#233;todos mixtos"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig1"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 982
              "Ancho" => 2333
              "Tamanyo" => 206841
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Study design&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Julia D&#237;ez, Guillermo Taulet, Mario Font&#225;n-Vela, Yolanda Gonz&#225;lez-R&#225;bago, Luis Cereijo, Mar&#237;a Sand&#237;n-V&#225;zquez, Elena Rodr&#237;guez, Manuel Franco, Carme Borrell, Usama Bilal, Pedro Gull&#243;n"
          "autores" => array:11 [
            0 => array:2 [
              "nombre" => "Julia"
              "apellidos" => "D&#237;ez"
            ]
            1 => array:2 [
              "nombre" => "Guillermo"
              "apellidos" => "Taulet"
            ]
            2 => array:2 [
              "nombre" => "Mario"
              "apellidos" => "Font&#225;n-Vela"
            ]
            3 => array:2 [
              "nombre" => "Yolanda"
              "apellidos" => "Gonz&#225;lez-R&#225;bago"
            ]
            4 => array:2 [
              "nombre" => "Luis"
              "apellidos" => "Cereijo"
            ]
            5 => array:2 [
              "nombre" => "Mar&#237;a"
              "apellidos" => "Sand&#237;n-V&#225;zquez"
            ]
            6 => array:2 [
              "nombre" => "Elena"
              "apellidos" => "Rodr&#237;guez"
            ]
            7 => array:2 [
              "nombre" => "Manuel"
              "apellidos" => "Franco"
            ]
            8 => array:2 [
              "nombre" => "Carme"
              "apellidos" => "Borrell"
            ]
            9 => array:2 [
              "nombre" => "Usama"
              "apellidos" => "Bilal"
            ]
            10 => array:2 [
              "nombre" => "Pedro"
              "apellidos" => "Gull&#243;n"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911123000122?idApp=WGSE"
    "url" => "/02139111/000000370000000C/v4_202408221243/S0213911123000122/v4_202408221243/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0213911122001601"
    "issn" => "02139111"
    "doi" => "10.1016/j.gaceta.2022.102264"
    "estado" => "S300"
    "fechaPublicacion" => "2023-01-01"
    "aid" => "102264"
    "copyright" => "SESPAS"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Gac Sanit. 2023;37C:"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Protocolo</span>"
      "titulo" => "CVS-Q teen&#169;&#58; s&#237;ndrome visual inform&#225;tico en adolescentes y su relaci&#243;n con libros de texto digitales"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "CVS-Q teen&#169;&#58; computer vision syndrome in adolescents and its relationship with digital textbooks"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Mar Segu&#237;-Crespo, Natalia Cant&#243;-Sancho, Mar S&#225;nchez-Brau, Mari Carmen Dav&#243;-Blanes, Jos&#233; Miguel Mart&#237;nez, Pablo Caballero, Elena Ronda-P&#233;rez"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Mar"
              "apellidos" => "Segu&#237;-Crespo"
            ]
            1 => array:2 [
              "nombre" => "Natalia"
              "apellidos" => "Cant&#243;-Sancho"
            ]
            2 => array:2 [
              "nombre" => "Mar"
              "apellidos" => "S&#225;nchez-Brau"
            ]
            3 => array:2 [
              "nombre" => "Mari Carmen"
              "apellidos" => "Dav&#243;-Blanes"
            ]
            4 => array:2 [
              "nombre" => "Jos&#233; Miguel"
              "apellidos" => "Mart&#237;nez"
            ]
            5 => array:2 [
              "nombre" => "Pablo"
              "apellidos" => "Caballero"
            ]
            6 => array:2 [
              "nombre" => "Elena"
              "apellidos" => "Ronda-P&#233;rez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911122001601?idApp=WGSE"
    "url" => "/02139111/000000370000000C/v4_202408221243/S0213911122001601/v4_202408221243/es/main.assets"
  ]
  "en" => array:18 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Protocolo</span>"
    "titulo" => "Development of vaccines for Chagas disease &#40;CRUZIVAX&#41;&#58; stakeholders&#8217; preferences and potential impacts on healthcare"
    "tieneTextoCompleto" => true
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Francesco Ramponi, C&#233;line Aerts, Paula Sartor, Mar&#237;a Jes&#250;s Pinazo, H&#233;ctor Freilij, Carlos A&#46; Guzm&#225;n, Emilio Malchiodi, Elisa Sicuri"
        "autores" => array:8 [
          0 => array:3 [
            "nombre" => "Francesco"
            "apellidos" => "Ramponi"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "C&#233;line"
            "apellidos" => "Aerts"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Paula"
            "apellidos" => "Sartor"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Mar&#237;a Jes&#250;s"
            "apellidos" => "Pinazo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "H&#233;ctor"
            "apellidos" => "Freilij"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Carlos A&#46;"
            "apellidos" => "Guzm&#225;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff0025"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Emilio"
            "apellidos" => "Malchiodi"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">f</span>"
                "identificador" => "aff0030"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">g</span>"
                "identificador" => "aff0035"
              ]
            ]
          ]
          7 => array:4 [
            "nombre" => "Elisa"
            "apellidos" => "Sicuri"
            "email" => array:2 [
              0 => "elisa.sicuri@isglobal.org"
              1 => "e.sicuri@lse.ac.uk"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">h</span>"
                "identificador" => "aff0040"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:8 [
          0 => array:3 [
            "entidad" => "ISGlobal&#44; Hospital Cl&#237;nic&#44; Universitat de Barcelona&#44; Barcelona&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Regi&#243;n Sanitaria 5&#44; Ministerio de Salud del Chaco&#44; Juan Jos&#233; Castelli&#44; Chaco&#44; Argentina"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Universidad Nacional del Nordeste&#44; Facultad de Ciencias Exactas Naturales y Agrimensura&#44; Corrientes Capital&#44; Argentina"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Hospital de Ni&#241;os Ricardo Guti&#233;rrez&#44; Buenos Aires&#44; Argentina"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
          4 => array:3 [
            "entidad" => "Department of Vaccinology and Applied Microbiology&#44; Helmholtz Centre for Infection Research&#44; Braunschweig&#44; Germany"
            "etiqueta" => "e"
            "identificador" => "aff0025"
          ]
          5 => array:3 [
            "entidad" => "Universidad de Buenos Aires&#44; Facultad de Farmacia y Bioqu&#237;mica&#44; C&#225;tedra de Inmunolog&#237;a&#44; and Instituto de Estudios de la Inmunidad Humoral Ricardo A&#46; Margni &#40;IDEHU&#41;&#44; UBA-CONICET&#44; Buenos Aires&#44; Argentina"
            "etiqueta" => "f"
            "identificador" => "aff0030"
          ]
          6 => array:3 [
            "entidad" => "Universidad de Buenos Aires&#44; Facultad de Medicina&#44; Departamento de Microbiolog&#237;a&#44; Parasitolog&#237;a e Inmunolog&#237;a&#44; and Instituto de Microbiolog&#237;a y Parasitolog&#237;a M&#233;dica &#40;IMPaM&#41;&#44; UBA-CONICET&#44; Buenos Aires&#44; Argentina"
            "etiqueta" => "g"
            "identificador" => "aff0035"
          ]
          7 => array:3 [
            "entidad" => "LSE Health&#44; London School of Economics &#38; Political Science&#44; London&#44; United Kingdom"
            "etiqueta" => "h"
            "identificador" => "aff0040"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Desarrollo de vacunas para la enfermedad de Chagas &#40;CRUZIVAX&#41;&#58; preferencias de las partes interesadas y posibles impactos en la asistencia sanitaria"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Chagas disease is caused by infection with the <span class="elsevierStyleItalic">Trypanosoma cruzi</span> parasite and it is one of the 20 neglected tropical diseases recognized by the World Health Organization&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">1</span></a> Seventy million people worldwide are at risk of infection&#44; and 6-8 million people are affected by Chagas disease&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">2</span></a> Most of infected individuals live in Latin America&#44; and have low access to prevention&#44; diagnosis and treatment of the infection&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">3</span></a> Currently available treatments have substantial limitations&#44; and parasitological cure can only be achieved when treatment is delivered in the acute phase of the disease&#44; or at early stages of its chronic phase&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">4</span></a> A prophylactic vaccine against Chagas disease does not exist&#44; and the most effective prevention strategies are vector control&#44; and control of other routes of transmission&#46; However&#44; research is currently underway to develop a prophylactic and therapeutic vaccine for Chagas disease &#40;CRUZIVAX<span class="elsevierStyleSup">TM</span>&#41;&#46; Initial pre-clinical studies and results from laboratory studies are promising&#44;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">5&#44;6</span></a> and work aimed at first-in-man studies is undergoing&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">This study focuses on the Gran Chaco region&#44; which spans in Argentina&#44; Bolivia and Paraguay&#44; and has a very high burden of Chagas disease&#46; In many rural villages of this region&#44; <span class="elsevierStyleItalic">T&#46; cruzi</span> seroprevalence varies between 20&#37; and 50&#37; among children and adolescents under 15 years of age&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">7&#44;8</span></a> Because of migration&#44; Chagas disease has become a public health problem also in non-endemic areas&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">9&#8211;11</span></a> Therefore&#44; this study focuses on Spain&#44; which is the main destination of Latin American emigration to Europe&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">12</span></a> Because of the migration flows&#44; the number of cases of <span class="elsevierStyleItalic">T&#46; cruzi</span> infection diagnosed in Spain has increased dramatically in the last decade&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">11</span></a> For example&#44; in a neighborhood of Barcelona&#44; the prevalence of Chagas disease among primary care patients from Latin America reached 2&#46;87&#37; in 2011&#44;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">12</span></a> and a 3&#46;4&#37; infection prevalence in pregnant women and a 7&#46;3&#37; rate of transmission to their newborns were estimated in the maternity wards of two large hospitals&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">13</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The costs associated with Chagas disease can very high&#44;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">14&#8211;16</span></a> and the development of a vaccine could help to reduce the substantial impact of Chagas disease on health system resources&#46; However&#44; few studies have attempted to estimate the economic value of potential vaccines&#46;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">17&#8211;19</span></a> Furthermore&#44; little information is available on the preferences of the population affected by Chagas disease and their potential demand for technologies that are under development&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">20</span></a> Evidence on health-related quality of life &#40;HRQoL&#41; of patients with Chagas disease is scarce&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">21</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The aim of this work is to provide health economic evidence to inform the initial phase of the vaccine development&#46; This study has three main objectives&#58; 1&#41; to estimate preferences and potential demand curve for the candidate vaccine CRUZIVAX<span class="elsevierStyleSup">TM</span> among individuals at-risk&#44; infected population&#44; and health policy makers&#59; 2&#41; to estimate the HRQoL of patients with Chagas disease and of people at risk of being infected in endemic and non-endemic areas&#59; and 3&#41; to assess lifetime costs of disease to estimate the potential savings generated by the CRUZIVAX<span class="elsevierStyleSup">TM</span> vaccine&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Method</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Design</span><p id="par0025" class="elsevierStylePara elsevierViewall">The theoretical demand will be characterized using a discrete choice experiment &#40;DCE&#41;&#46; The study will include four versions of the DCE&#58; 1&#41; DCE on the prophylactic vaccine&#44; addressed to health policy makers&#59; 2&#41; DCE on the prophylactic vaccine&#44; addressed to individuals at risk of infection or already infected&#59; 3&#41; DCE on the therapeutic vaccine&#44; addressed to health policy makers&#59; and 4&#41; DCE on the therapeutic vaccine&#44; addressed to individuals at risk of infection or already infected&#46; The content of the DCE for the individuals at risk looks at the specific characteristics of the vaccine &#40;<span class="elsevierStyleItalic">e&#46;g&#46;</span>&#44; the way the vaccine is administered&#44; the severity and duration of the adverse reaction&#44; and the price per vaccine dose&#41;&#44; and will be used to explore the relative importance of each attribute and its levels in the individual&#39;s decision of whether or not to get the vaccine for themselves&#44; or for a family member&#46; The content of the DCE targeted to health policy-makers focuses on characteristics of the health system and on financial issues &#40;<span class="elsevierStyleItalic">e&#46;g</span>&#46;&#44; the feasibility of adding the Chagas vaccine to national vaccination programs in endemic areas&#41;&#46; Of note&#44; the DCE for the preventive vaccine administered to policy makers refers only to Argentina&#46; A therapeutic vaccine would be of interest in both Argentina and Spain&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">To obtain information on HRQoL&#44; the EQ-5D questionnaire will be used&#44; which allows to estimate quality-adjusted life years&#46; HRQoL data and DCE responses will be collected from the same patients&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Data on the use of health care resources by patients with Chagas disease over time will be obtained from the clinical databases of the Hospital Cl&#237;nic of Barcelona &#40;Spain&#41;&#46; Unit costs and individual patient data on the use of healthcare resources will be used to estimate the costs of outpatient and inpatient interventions and total lifetime follow-up cost for patients&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Setting</span><p id="par0040" class="elsevierStylePara elsevierViewall">Data collection will take place in Barcelona &#40;Spain&#41; and in two Argentinian provinces&#58; San Juan &#40;Cuyo region&#44; west Argentina&#41; and Chaco &#40;Northeast region&#41;&#46; Both provinces are categorized as being at high risk of vector transmission&#46; Moreover&#44; &#8220;urban triatomism&#8221; &#40;<span class="elsevierStyleItalic">i&#46;e</span>&#46;&#44; <span class="elsevierStyleItalic">T&#46; cruzi</span> infection happening in urban areas&#41; is reported in San Juan&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">22</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Tools and materials for data collection</span><p id="par0045" class="elsevierStylePara elsevierViewall">Vaccine attributes and levels for the DCE were chosen using the Delphi method&#46; The most relevant attributes and levels of the vaccine were identified by a group of 16 experts&#46; DCE were created using series of 12 sets of options regarding the characteristics of the vaccine&#44; generated using a statistical software &#40;STATA&#41;&#46; For each set of options&#44; two alternatives were created&#44; which report different values for each of the vaccine characteristics&#46; Respondents can choose their preferred alternative in each set&#46; In the electronic version the DCE will be accompanied by drawings of each of the characteristics and their values&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In addition to the DCEs&#44; the data collection tool for patients includes the EQ-5D-3L questionnaire&#44; which assesses the following components of HRQoL&#58; mobility&#59; self-care&#59; activities of daily living&#59; pain&#47;discomfort&#59; and anxiety&#47;depression&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Questionnaires including DCEs for both prophylactic and therapeutic vaccination and the HRQoL questionnaire are provided in online <a class="elsevierStyleCrossRef" href="#sec0090">Appendices A and B</a>&#46; The questionnaires for patients in Argentina collect also socio-economic and demographic data&#44; such as age&#44; sex&#44; level of education&#44; occupation&#44; and housing characteristics&#44; as well as data on symptoms related to the progression of Chagas disease&#46; Data collected in Spain can be linked to the hospital database&#44; which contains clinical and socio-demographic information&#46; The DCE survey for health policy makers in Spain is reported in <a class="elsevierStyleCrossRef" href="#sec0090">online Appendix C</a>&#59; the survey for Argentinian and international policy makers is reported in <a class="elsevierStyleCrossRef" href="#sec0090">online Appendix D</a>&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Additional information on data collection and management is provided in <a class="elsevierStyleCrossRef" href="#sec0090">online Appendix E</a>&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Statistical analysis</span><p id="par0065" class="elsevierStylePara elsevierViewall">The data collected with the DCEs for the therapeutic and the prophylactic vaccines will be analyzed separately&#44; following good research practices in terms of the statistical models applied&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">23</span></a> Statistical analyses will be conducted using Stata&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">For the estimation of the HRQoL determinants of patients with Chagas disease and of people at risk of infection&#44; a multivariate model based on a Beta distribution will be adopted&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">24</span></a> In addition to clinical factors&#44; the analysis will control for sociodemographic characteristics to isolate the impact of the disease on quality of life&#46; For example&#44; we will explore differences between rural and urban settings&#44; and we will investigate whether gender&#44; ethnicity and socio-economic status are relevant factors affecting the HRQoL of patients affected by Chagas disease&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">To estimate the lifetime costs of Chagas disease&#44; the use of health care resources will be investigated using information from the clinical database of the Hospital Cl&#237;nic of Barcelona&#46; Clinical follow-up records of patients with <span class="elsevierStyleItalic">T&#46; cruzi</span> infection will be retrieved from the Hospital Cl&#237;nic database&#44; which includes information on patients&#8217; use of resources from the time of positive diagnosis&#46; Unit costs of the interventions will be obtained using costings list from the Hospital Clinic&#46; The costs associated with each contact with the health facility will be estimated from the provider&#39;s perspective&#46; The data analysis will follow the methods adopted by Basu and Manning<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">25</span></a> to estimate lifetime cost of illness by controlling for censoring cases&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Discussion</span><p id="par0080" class="elsevierStylePara elsevierViewall">We acknowledge that the COVID-19 pandemic might affect the capability of conducting the planned interviews with patients&#44; the duration of data collection and the minimum sample size targets&#46; Further&#44; we are aware that&#44; to generalize the findings of the case study analysis conducted at the Hospital Cl&#237;nic in Barcelona to endemic settings&#44; additional information and assumptions on the different unit costs&#44; health care practices&#44; patients&#8217; access to the health system and disease prevalence will be required&#46; However&#44; we believe that this study will provide new and crucial information on preferences around the new potential vaccines&#44; characteristics of the target population and potential impact on the health systems in endemic and non-endemic settings&#46; The results of the study may be useful to guide the development of new technologies&#44; with the aim of maximizing their coverage once they are ready and available on the market&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Ethics approval and consent to participate</span><p id="par0085" class="elsevierStylePara elsevierViewall">The study protocol&#44; tools for data collection and informed consents have been approved by the Ethics Committee of the Hospital Cl&#237;nic de Barcelona &#40;CEim Hospital Cl&#237;nic&#41; in Spain&#44; and by the Ethics Committee of the Ministry of Public Health of San Juan and Facultad de Ciencias Exactas&#44; Naturales y Agrimensura de la Universidad Nacional del Nordeste in Argentina &#40;see <a class="elsevierStyleCrossRef" href="#sec0090">online Appendix F</a>&#41;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Participants provided the informed consent to enter the study&#46; Information and informed consent forms are provided in <a class="elsevierStyleCrossRef" href="#sec0090">online Appendix G</a>&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Consent for publication</span><p id="par0095" class="elsevierStylePara elsevierViewall">Participants provided their consent for information about themselves to be published&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Availability of databases and material for replication</span><p id="par0100" class="elsevierStylePara elsevierViewall">Not applicable to this article&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Related articles</span><p id="par0105" class="elsevierStylePara elsevierViewall">No other publications containing the results of this study have already been published or submitted to any journal&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Study status</span><p id="par0110" class="elsevierStylePara elsevierViewall">At the time of this submission participant recruitment was not completed&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Editor in charge</span><p id="par0115" class="elsevierStylePara elsevierViewall">Carlos &#193;lvarez-Dardet&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Authorship contributions</span><p id="par0120" class="elsevierStylePara elsevierViewall">E&#46; Sicuri conceived the study&#46; E&#46; Sicuri&#44; C&#46; Aerts&#44; H&#46; Freilij&#44; C&#46;A&#46; Guzm&#225;n&#44; P&#46; Sartor&#44; M&#46;J&#46; Pinazo&#44; F&#46; Ramponi and E&#46; Malchiodi contributed to the study design&#46; E&#46; Sicuri and C&#46; Aerts designed the data collection tools and wrote the first draft of the protocol&#46; F&#46; Ramponi and E&#46; Sicuri wrote the final version of the manuscript with substantial intellectual contribution and by incorporating the contribution from all the authors&#46; All authors provided critical revision of the manuscript each one according to their respective expertise&#46; All authors approved the final version of the protocol&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Funding</span><p id="par0125" class="elsevierStylePara elsevierViewall">The CRUZIVAX project was funded by the European Commission within the Horizon 2020 framework &#40;Grant Number - 815418&#41;&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflicts of interest</span><p id="par0130" class="elsevierStylePara elsevierViewall">None&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:17 [
        0 => array:3 [
          "identificador" => "xres2227732"
          "titulo" => "Abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1865493"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres2227731"
          "titulo" => "Resumen"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0010"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1865494"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Method"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Design"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Setting"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Tools and materials for data collection"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Statistical analysis"
            ]
          ]
        ]
        6 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Discussion"
        ]
        7 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Ethics approval and consent to participate"
        ]
        8 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Consent for publication"
        ]
        9 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Availability of databases and material for replication"
        ]
        10 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Related articles"
        ]
        11 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Study status"
        ]
        12 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Editor in charge"
        ]
        13 => array:2 [
          "identificador" => "sec0070"
          "titulo" => "Authorship contributions"
        ]
        14 => array:2 [
          "identificador" => "sec0075"
          "titulo" => "Funding"
        ]
        15 => array:2 [
          "identificador" => "sec0080"
          "titulo" => "Conflicts of interest"
        ]
        16 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2022-10-14"
    "fechaAceptado" => "2022-10-14"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1865493"
          "palabras" => array:9 [
            0 => "Chagas disease"
            1 => "Trypanosoma cruzi"
            2 => "Vaccines"
            3 => "Surveys and questionnaires"
            4 => "Quality of life"
            5 => "Patient preferences"
            6 => "Health care costs"
            7 => "Argentina"
            8 => "Spain"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1865494"
          "palabras" => array:9 [
            0 => "Enfermedad de Chagas"
            1 => "Trypanosoma cruzi"
            2 => "Vacunas"
            3 => "Encuestas y cuestionarios"
            4 => "Calidad de vida"
            5 => "Preferencias del paciente"
            6 => "Costes sanitarios"
            7 => "Argentina"
            8 => "Espa&#241;a"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A vaccine for Chagas disease does not currently exist&#46; This study aims to inform the development of two vaccines for the prevention and treatment of <span class="elsevierStyleItalic">Trypanosoma cruzi</span> infection&#44; and guide their pre-clinical phase up to clinical phase <span class="elsevierStyleSmallCaps">I</span>&#46; The three main objectives are&#58; 1&#41; to explore patients&#8217; and policy makers&#8217; preferences on the candidate vaccines in Argentina and Spain&#59; 2&#41; to investigate health-related quality of life of patients affected by Chagas disease&#59; and 3&#41; to assess the potential health provider savings associated with the vaccines&#44; in terms of resource use and health care costs&#46; Discrete choice experiments will be employed to estimate and characterize the theoretical demand for the vaccines and investigate patients&#8217; and policy makers&#8217; preferences&#46; Health-related quality of life will be assessed using the EQ-5D-3L questionnaire&#46; Resources use and costs associated with Chagas disease will be investigated using information from the databases of the Hospital Cl&#237;nic of Barcelona&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">No existen vacunas para la enfermedad de Chagas&#46; Este trabajo pretende informar la fase precl&#237;nica de dos vacunas para la prevenci&#243;n y el tratamiento de la infecci&#243;n por <span class="elsevierStyleItalic">Trypanosoma cruzi</span>&#46; Los objetivos principales son tres&#58; 1&#41; investigar las preferencias de los pacientes y de los responsables de pol&#237;ticas sanitarias en Argentina y Espa&#241;a&#59; 2&#41; investigar la calidad de vida relacionada con la salud de los pacientes afectados por la enfermedad de Chagas&#59; y 3&#41; estimar los ahorros potenciales asociados con las vacunas para los proveedores de salud&#46; Se usar&#225;n experimentos de elecci&#243;n discreta para estimar y caracterizar la demanda te&#243;rica de las vacunas e investigar las preferencias de los pacientes y de los responsables de las pol&#237;ticas sanitarias&#46; La calidad de vida relacionada con la salud se evaluar&#225; mediante el cuestionario EQ-5D-3L&#46; Se investigar&#225;n el uso de recursos y los costes asociados a la enfermedad de Chagas utilizando bases de datos del Hospital Cl&#237;nic de Barcelona&#46;</p></span>"
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0140" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="upi0005"></elsevierMultimedia><elsevierMultimedia ident="upi0010"></elsevierMultimedia><elsevierMultimedia ident="upi0015"></elsevierMultimedia><elsevierMultimedia ident="upi0020"></elsevierMultimedia><elsevierMultimedia ident="upi0025"></elsevierMultimedia><elsevierMultimedia ident="upi0030"></elsevierMultimedia><elsevierMultimedia ident="upi0035"></elsevierMultimedia><elsevierMultimedia ident="upi0040"></elsevierMultimedia><elsevierMultimedia ident="upi0045"></elsevierMultimedia><elsevierMultimedia ident="upi0050"></elsevierMultimedia><elsevierMultimedia ident="upi0055"></elsevierMultimedia><elsevierMultimedia ident="upi0060"></elsevierMultimedia><elsevierMultimedia ident="upi0065"></elsevierMultimedia></p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Supplementary data"
            "identificador" => "sec0090"
          ]
        ]
      ]
    ]
    "multimedia" => array:13 [
      0 => array:5 [
        "identificador" => "upi0005"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc1.doc"
          "ficheroTamanyo" => 72600
        ]
      ]
      1 => array:5 [
        "identificador" => "upi0010"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc2.doc"
          "ficheroTamanyo" => 60467
        ]
      ]
      2 => array:5 [
        "identificador" => "upi0015"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc3.doc"
          "ficheroTamanyo" => 18693
        ]
      ]
      3 => array:5 [
        "identificador" => "upi0020"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc4.doc"
          "ficheroTamanyo" => 23057
        ]
      ]
      4 => array:5 [
        "identificador" => "upi0025"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc5.doc"
          "ficheroTamanyo" => 29192
        ]
      ]
      5 => array:5 [
        "identificador" => "upi0030"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc6.pdf"
          "ficheroTamanyo" => 52884
        ]
      ]
      6 => array:5 [
        "identificador" => "upi0035"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc7.pdf"
          "ficheroTamanyo" => 66899
        ]
      ]
      7 => array:5 [
        "identificador" => "upi0040"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc8.pdf"
          "ficheroTamanyo" => 245394
        ]
      ]
      8 => array:5 [
        "identificador" => "upi0045"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc9.pdf"
          "ficheroTamanyo" => 680635
        ]
      ]
      9 => array:5 [
        "identificador" => "upi0050"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc10.doc"
          "ficheroTamanyo" => 43360
        ]
      ]
      10 => array:5 [
        "identificador" => "upi0055"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc11.doc"
          "ficheroTamanyo" => 41279
        ]
      ]
      11 => array:5 [
        "identificador" => "upi0060"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc12.doc"
          "ficheroTamanyo" => 40293
        ]
      ]
      12 => array:5 [
        "identificador" => "upi0065"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc13.doc"
          "ficheroTamanyo" => 39573
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:25 [
            0 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hunter&#39;s Tropical Medicine and Emerging Infectious Diseases&#46; E-Book"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46;T&#46; Ryan"
                            1 => "D&#46;R&#46; Hill"
                            2 => "T&#46; Solomon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:2 [
                        "fecha" => "2019"
                        "editorial" => "Elsevier Health Sciences"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "World Health Organization&#46; Chagas disease &#40;American trypanosomiasis&#41;&#46; WHO&#59; 2019&#46; Available at&#58; https&#58;&#47;&#47;www&#46;who&#46;int&#47;es&#47;news-room&#47;fact-sheets&#47;detail&#47;chagas-disease-&#40;american-trypanosomiasis&#46;"
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chagas disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;A&#46; Perez-Molina"
                            1 => "I&#46; Molina"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(17)31612-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet&#46;"
                        "fecha" => "2018"
                        "volumen" => "391"
                        "paginaInicial" => "82"
                        "paginaFinal" => "94"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28673423"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical and pharmacological profile of benznidazole for treatment of Chagas disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;M&#46; Kratz"
                            1 => "F&#46; Garcia Bournissen"
                            2 => "C&#46;J&#46; Forsyth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/17512433.2018.1509704"
                      "Revista" => array:6 [
                        "tituloSerie" => "Expert Rev Clin Pharmacol&#46;"
                        "fecha" => "2018"
                        "volumen" => "11"
                        "paginaInicial" => "943"
                        "paginaFinal" => "957"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30111183"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Engineered trivalent immunogen adjuvanted with a STING agonist confers protection against Trypanosoma cruzi infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Sanchez Alberti"
                            1 => "A&#46;E&#46; Bivona"
                            2 => "N&#46; Cerny"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/s41541-016-0001-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "npj Vaccines&#46;"
                        "fecha" => "2017"
                        "volumen" => "2"
                        "paginaInicial" => "1"
                        "paginaFinal" => "11"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29263862"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mucosal heterologous prime&#47;boost vaccination induces polyfunctional systemic immunity&#44; improving protection against Trypanosoma cruzi"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Sanchez Alberti"
                            1 => "A&#46;E&#46; Bivona"
                            2 => "M&#46;N&#46; Matos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fimmu.2020.00128"
                      "Revista" => array:5 [
                        "tituloSerie" => "Front Immunol&#46;"
                        "fecha" => "2020"
                        "volumen" => "11"
                        "paginaInicial" => "128"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32153562"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Improving access to Chagas disease diagnosis and etiologic treatment in remote rural communities of the Argentine Chaco through strengthened primary health care and broad social participation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "P&#46; Sartor"
                            1 => "I&#46; Colaianni"
                            2 => "M&#46;V&#46; Cardinal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS Negl Trop Dis&#46;"
                        "fecha" => "2017"
                        "volumen" => "11"
                        "paginaInicial" => "1"
                        "paginaFinal" => "18"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infection&#44; genetics and evolution Chagas&#8217; disease in Aboriginal and Creole communities from the Gran Chaco Region of Argentina&#58; seroprevalence and molecular parasitological characterization"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46;H&#46; Lucero"
                            1 => "B&#46;L&#46; Bruss"
                            2 => "C&#46;I&#46; Cura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.meegid.2016.03.028"
                      "Revista" => array:6 [
                        "tituloSerie" => "Infect Genet Evol&#46;"
                        "fecha" => "2016"
                        "volumen" => "41"
                        "paginaInicial" => "84"
                        "paginaFinal" => "92"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27057620"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Urban Chagas disease in children and women in primary care centres in Buenos Aires"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46; Moscatelli"
                            1 => "A&#46; Berenstein"
                            2 => "A&#46; Tarlovsky"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Argentina&#46; Mem Inst Oswaldo Cruz&#46;"
                        "fecha" => "2015"
                        "volumen" => "110"
                        "paginaInicial" => "644"
                        "paginaFinal" => "648"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of migration on the occurrence of new cases of Chagas disease in Buenos Aires city"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46; Moscatelli"
                            1 => "F&#46;G&#46; Bournissen"
                            2 => "H&#46; Freilij"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Argentina&#46; J Infect Dev Ctries&#46;"
                        "fecha" => "2013"
                        "volumen" => "7"
                        "paginaInicial" => "635"
                        "paginaFinal" => "637"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of Chagas disease in Latin- American migrants living in Europe&#58; a systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Requena-M&#233;ndez"
                            1 => "E&#46; Aldasoro"
                            2 => "E&#46;D&#46; Lazzari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS Negl Tropical Dis&#46;"
                        "fecha" => "2015"
                        "volumen" => "9"
                        "paginaInicial" => "1"
                        "paginaFinal" => "15"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chagas Disease among the Latin American adult population attending in a primary care center in Barcelona"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46; Roca"
                            1 => "M&#46;J&#46; Pinazo"
                            2 => "P&#46; Lpez-Chejade"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pntd.0001135"
                      "Revista" => array:5 [
                        "tituloSerie" => "Spain&#46; PLoS Negl Trop Dis&#46;"
                        "fecha" => "2011"
                        "volumen" => "5"
                        "paginaInicial" => "e1135"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21572511"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence and vertical transmission of Trypanosoma cruzi infection among pregnant Latin American women attending 2 maternity clinics in Barcelona"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46; Mu&#241;oz"
                            1 => "O&#46; Coll"
                            2 => "T&#46; Juncosa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/599223"
                      "Revista" => array:6 [
                        "tituloSerie" => "Spain&#46; Clin Infect Dis&#46;"
                        "fecha" => "2009"
                        "volumen" => "48"
                        "paginaInicial" => "1736"
                        "paginaFinal" => "1740"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19438393"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The costs of preventing and treating Chagas disease in Colombia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Castillo-Riquelme"
                            1 => "F&#46; Guhl"
                            2 => "B&#46; Turriago"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pntd.0000336"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS Negl Trop Dis&#46;"
                        "fecha" => "2008"
                        "volumen" => "2"
                        "paginaInicial" => "e336"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19015725"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chagas&#8217; cardiomyopathy&#58; the economic burden of an expensive and neglected disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Abuhab"
                            1 => "E&#46; Trindade"
                            2 => "G&#46;B&#46; Aulicino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijcard.2013.01.262"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Cardiol&#46;"
                        "fecha" => "2013"
                        "volumen" => "168"
                        "paginaInicial" => "2375"
                        "paginaFinal" => "2380"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23465560"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Global economic burden of Chagas disease&#58; a computational simulation model"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "B&#46;Y&#46; Lee"
                            1 => "K&#46;M&#46; Bacon"
                            2 => "M&#46;E&#46; Bottazzi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1473-3099(13)70002-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet Infect Dis&#46;"
                        "fecha" => "2013"
                        "volumen" => "13"
                        "paginaInicial" => "342"
                        "paginaFinal" => "348"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23395248"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Economic value of a therapeutic Chagas vaccine for indeterminate and Chagasic cardiomyopathy patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;M&#46; Bartsch"
                            1 => "M&#46;E&#46; Bottazzi"
                            2 => "L&#46; Asti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.vaccine.2019.05.028"
                      "Revista" => array:6 [
                        "tituloSerie" => "Vaccine&#46;"
                        "fecha" => "2019"
                        "volumen" => "37"
                        "paginaInicial" => "3704"
                        "paginaFinal" => "3714"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31104883"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The potential economic value of a Trypanosoma cruzi &#40;Chagas disease&#41; vaccine in Latin America"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "B&#46;Y&#46; Lee"
                            1 => "K&#46;M&#46; Bacon"
                            2 => "D&#46;L&#46; Connor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS Negl Trop Dis&#46;"
                        "fecha" => "2010"
                        "volumen" => "4"
                        "paginaInicial" => "3"
                        "paginaFinal" => "10"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Modeling the economic value of a Chagas&#8217; disease therapeutic vaccine"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "B&#46;Y&#46; Lee"
                            1 => "K&#46;M&#46; Bacon"
                            2 => "A&#46;R&#46; Wateska"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4161/hv.20966"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Vaccin Immunother&#46;"
                        "fecha" => "2012"
                        "volumen" => "8"
                        "paginaInicial" => "1293"
                        "paginaFinal" => "1301"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22894964"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Consumer willingness to pay for a hypothetical Chagas disease vaccine in Brazil&#58; a cross-sectional study and the implications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46;S&#46; Athie"
                            1 => "G&#46;C&#46; Nascimento"
                            2 => "M&#46;J&#46; Labis da Costa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2217/cer-2020-0241"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Comp Eff Res&#46;"
                        "fecha" => "2021"
                        "volumen" => "10"
                        "paginaInicial" => "659"
                        "paginaFinal" => "672"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33851872"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Health-related quality of life in patients with Chagas disease&#58; a review of the evidence"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46;R&#46; Sousa"
                            1 => "H&#46;S&#46; Costa"
                            2 => "A&#46;C&#46; Souza"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/0037-8682-0244-2014"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Soc Bras Med Trop&#46;"
                        "fecha" => "2015"
                        "volumen" => "48"
                        "paginaInicial" => "121"
                        "paginaFinal" => "128"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25992924"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Urban infestation by Triatoma infestans &#40;Hemiptera&#58; Reduviidae&#41;&#44; an overlooked phenomena for Chagas disease in Argentina"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "Y&#46;M&#46; Provecho"
                            1 => "M&#46;D&#46;P&#46; Fern&#225;ndez"
                            2 => "L&#46; Salva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/0074-02760210056"
                      "Revista" => array:5 [
                        "tituloSerie" => "Mem Inst Oswaldo Cruz&#46;"
                        "fecha" => "2021"
                        "volumen" => "116"
                        "paginaInicial" => "e210056"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34105689"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Statistical methods for the analysis of discrete choice experiments&#58; a report of the ISPOR Conjoint Analysis Good Research Practices Task Force"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;B&#46; Hauber"
                            1 => "J&#46;M&#46; Gonz&#225;lez"
                            2 => "C&#46;G&#46; Groothuis-Oudshoorn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jval.2016.04.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Value Health&#46;"
                        "fecha" => "2016"
                        "volumen" => "19"
                        "paginaInicial" => "300"
                        "paginaFinal" => "315"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27325321"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differences in health-related quality of life between HIV-positive and HIV-negative people in Zambia and South Africa&#58; a cross-sectional baseline survey of the HPTN 071 &#40;PopART&#41; trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46; Thomas"
                            1 => "R&#46; Burger"
                            2 => "A&#46; Harper"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Lancet Glob Health&#46;"
                        "fecha" => "2017"
                        "volumen" => "5"
                        "paginaInicial" => "e1133"
                        "paginaFinal" => "e1141"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estimating lifetime or episode-of-illness costs under censoring"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Basu"
                            1 => "W&#46;G&#46; Manning"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Health Econ&#46;"
                        "fecha" => "2010"
                        "volumen" => "1028"
                        "paginaInicial" => "1010"
                        "paginaFinal" => "1028"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/02139111/000000370000000C/v4_202408221243/S0213911122001716/v4_202408221243/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "92462"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Protocolos"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02139111/000000370000000C/v4_202408221243/S0213911122001716/v4_202408221243/en/main.pdf?idApp=WGSE&text.app=https://gacetasanitaria.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911122001716?idApp=WGSE"
]
Información del artículo
ISSN: 02139111
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Octubre 44 26 70
2024 Septiembre 96 42 138
2024 Agosto 110 52 162
2024 Julio 85 40 125
2024 Junio 90 29 119
2024 Mayo 91 44 135
2024 Abril 81 29 110
2024 Marzo 72 29 101
2024 Febrero 83 45 128
2024 Enero 148 39 187
2023 Diciembre 130 30 160
2023 Noviembre 201 47 248
2023 Octubre 146 105 251
2023 Septiembre 154 58 212
2023 Agosto 115 49 164
2023 Julio 155 64 219
2023 Junio 126 28 154
2023 Mayo 123 58 181
2023 Abril 156 41 197
2023 Marzo 214 62 276
2023 Febrero 158 35 193
2023 Enero 128 0 128
2022 Diciembre 97 0 97
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Gaceta Sanitaria
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?