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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The wound healing process is a quality of tissue life process associated with the regeneration of tissue&#46; The physiological process takes place immediately after the wound occurs by activating the blood of the coagulation system&#46; The release of mediators from platelets&#44; namely Platelet Activating Factor &#40;PAF&#41; and Thromboxane which are then attached to the wound tissue that converts fibrin to fibrinogen so that blood clots last 5&#8211;10<span class="elsevierStyleHsp" style=""></span>min and after that vasodilation will occur&#44; capillary nerve stimulation synthesis &#40;local sensory-nerve endings&#41; occur in the inflammatory phase which ends on the 3rd day to 4th day&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In the phase of tissue structure&#44; improvement marked by angiogenesis occurs in the proliferation or re-epithelialization phase from 3rd day or 4th day and maximum to 14th day&#46; The final phase of wound healing occurs in 21 days to 1 year where there is a balance between the collagen produced and the one that is broken&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">1&#44;2</span></a> The wound healing process normally occurs if supported by nutrition&#44; immune system&#44; and wound care&#46; Wound care using natural materials has been done a long time ago&#44; including wound care using sodium chloride from seawater&#46; Soaking wounds in 7&#37; table salt concentration with osmotic salt properties can provide a drying effect on the wound so that the growth of new tissue accelerates skin contact more quickly&#46; Bacteriostatic salt properties in which streptococcus aureus causes the infection is unable to survive on sodium chloride&#44; which has a concentration of 7&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The 7&#37; table salt concentration in this study was made in a liquid to wash the wound&#44; which provides wound drying and anti-bacterial properties&#44; so the wound healing process becomes faster&#46; This study wanted to identify the effect of a 7&#37; concentration of table salt immersion on wound healing in the stomach of female mice &#40;<span class="elsevierStyleItalic">Mus Musculus</span>&#41;&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Method</span><p id="par0020" class="elsevierStylePara elsevierViewall">The 7&#37; table salt concentration is made from people&#39;s salt&#46; It is produced by salt farmers in Maccini Baji village&#44; Labbakkang sub-district&#44; Pangkep district&#44; and then makes the salt concentration in the oceanography laboratory of the Faculty of Oceanography Hasanuddin University&#46; A dose of 70<span class="elsevierStyleHsp" style=""></span>g of salt dissolved in boiled water into a 1-l sodium chloride solution&#46; Furthermore&#44; this concentration is used to soak the incision wound in mice with an incision area of approximately 1&#46;5<span class="elsevierStyleHsp" style=""></span>cm with a depth of all layers of skin and muscle cut off then sewn using catgut&#44; soaking process done once every day for seven days&#46; Observation and measurement are carried out until the wound heals&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The research subjects were Swiss Webster female mice aged 8&#8211;10 weeks with a weight of 20&#8211;25<span class="elsevierStyleHsp" style=""></span>g&#44; totaling twenty animals from the Laboratory of Animal Medicine Faculty of Hasanuddin University&#44; by considering the cleanliness of the cage&#44; the area of the cage by placing 5 mice for each group and adapted for one week&#44; with enough food and drink every day&#46; The mice were anesthetized by using a ketamine injection with a dose of 0&#46;2<span class="elsevierStyleHsp" style=""></span>ml&#47;kg BW before an abdominal wound was performed&#46; After being anesthetized&#44; the subject&#39;s abdominal surface is smeared with veet then the hair is shaved and cleaned with 70&#37; alcohol&#46; The cut was made by drawing using a ruler and a marker with a length of 1&#46;5<span class="elsevierStyleHsp" style=""></span>cm&#46; Then after mice are unconscious&#44; an incision is made in the stomach of the mice with the help of Chirurgie nippers&#44; a scalpel&#44; and scissors to made a wound on the part that has been drawn&#46; The skin and subcutaneous tissue are removed using tweezers until the mole&#39;s intestine is visible&#44; then sewn back using a catgut with 1&#8211;3 stitches&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Mice were divided into two groups&#58; the control and treatment groups that were given a 7&#37; concentration of table salt soaking&#46; The Control group was divided into three groups &#8211; each group consisted of 5 mice&#46; Then the treatment group was immersed for 5<span class="elsevierStyleHsp" style=""></span>min&#44; 10<span class="elsevierStyleHsp" style=""></span>min&#44; and 15<span class="elsevierStyleHsp" style=""></span>min at noon every day&#46; From the observation result&#44; the wound area on the 1st day and second day has not changed&#46; On the 3rd day&#44; the wound began to appear in the process of drying the wound&#44; and the diameter of the wound was getting smaller and mostly healed on the 7th day&#46; Measuring the diameter of the wound is done every day&#44; starting from the 1st day to 7th day&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Data analysis was performed using a one-way ANOVA test to determine whether there were differences in the average area of cut wounds in the control and treatment groups&#46; Then an independent <span class="elsevierStyleItalic">t</span>-test is performed if the data is normally distributed or the Mann&#8211;Whitney test if the data is not normally distributed&#46; Finally&#44; the data normality test uses the Shapiro&#8211;Wilk test&#46; The significance of the test results is determined based on a <span class="elsevierStyleItalic">p</span>-value &#60;0&#46;05&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">This research has been tested and deemed feasible to be carried out by the Health Research Ethics Commission of the Medical Faculty of Hasanuddin University through letter Number&#58; 541&#47;UN4&#46;6&#46;4&#46;5&#46;31&#47;PP36&#47;2019&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="par0045" class="elsevierStylePara elsevierViewall">To find out the depiction of the results of observations that have been obtained&#44; then carried out a descriptive analysis of the area of the wound in mice from each control group and treatment group&#44; namely intervention 5<span class="elsevierStyleHsp" style=""></span>min&#44; 10<span class="elsevierStyleHsp" style=""></span>min&#44; and 15<span class="elsevierStyleHsp" style=""></span>min&#46; The following table compares the area of wounds between the control group and the treatment group&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Comparing the average injuries between the control group and the treatment group began to be different on the 3rd day to the 7th day&#46; The descriptive analysis shows that the wound in the treatment or intervention group is faster closed than the area of the wound in the control group &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">The differences in the average area of cut wounds in the treatment and control groups&#44; a one-way ANOVA analysis was performed&#46; The analysis was performed on the area of the wound area on the 3rd to 7th day for each treatment and control group&#46; This is because there is no change in the field of the wound on days one and two&#44; so it does not provide meaningful information&#46; In addition&#44; if the recording of days one and two are included in the analysis&#44; it can obscure the results of the analysis of variance that is carried out&#46; The results are as follows &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">Based on <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#44; it is known that the average wound area for the 5-minute intervention group is 0&#46;48&#44; the 10-min intervention is 0&#46;51&#44; the 15-min intervention is 0&#46;29&#44; and the control group is 0&#46;74&#46; From the results of the average wound area in the intervention or treatment group&#44; it is known that the longer the intervention is carried out&#44; the average wound area is also getting smaller&#46; In addition&#44; the average size of the wound area that has been given intervention or treatment is also smaller than the average wound area in the control group&#46; From the results of one-way ANOVA analysis&#44; the F-count is 5&#46;252&#44; and the <span class="elsevierStyleItalic">P</span>-value is 0&#46;002&#46; Because the <span class="elsevierStyleItalic">P</span>-value is smaller than &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#44; it can be concluded that there is a significant difference in the average area of mice wounds in the treatment group and the control group&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The Mann&#8211;Whitney test was performed to determine the significance of the difference in the average wound area of each treatment group to the control group if the data did not have a normal distribution&#46; The analysis was performed on the area of the wound area on the 3rd to 7th day for each treatment and control group&#46; The results are as follows&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Based on <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#44; it is known that the <span class="elsevierStyleItalic">P</span>-value from the Mann&#8211;Whitney test results for the comparison of the 5-min intervention group and the control group is 0&#46;020&#44; the 10-min intervention group and the control group is 0&#46;035&#44; and the 15-min intervention group and the control group are 0&#46;000&#46; Because of the <span class="elsevierStyleItalic">P</span>-value of &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#44; it can be concluded that the average wound area in each intervention group had a significant difference from the control group&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Discussion</span><p id="par0075" class="elsevierStylePara elsevierViewall">The wound healing process is a complex process that includes a series of biochemical&#44; cellular&#44; and physiological processes&#46; The process goes through several phases&#44; namely the hemostatic&#44; inflammatory&#44; proliferation&#44; and remodeling phases&#46; Proper wound care is one factor in the formation of new tissue&#46; Wound management using natural ingredients as medicine has been widely carried out today&#44; one of which is using seawater&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">2&#44;4&#44;5</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Seawater contains salt&#44; which is composed of sodium atoms and chloride atoms&#46; Types of bonds in the form of sodium chloride compounds are bonds of positive ions and negative ions&#46; In the process of fermentation of food ingredients&#44; sodium chloride is useful to limit the growth of spoilage organisms and prevent the growth of some microorganisms&#46; However&#44; certain bacteria can still grow in high saline solutions&#46; Seawater can be used in the treatment of external wounds&#44; which have an osmotic effect on the tissue so that the wound becomes dry&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">3&#44;6&#44;7</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Some principles in wound healing are that the body&#39;s ability to deal with tissue trauma is influenced by the extent of damage and the general condition of each person&#46; The body&#39;s response to the wound is more effective if the nutrients are maintained&#44; the body&#39;s response to the system to the trauma of blood flow to the wound tissue&#44; the integrity of the skin and mucous membranes are prepared as the first line to defend against microorganisms&#44; wound healing is enhanced when the wound is free of foreign matter including bacteria&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">8&#8211;10</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">In this study&#44; wound healing significantly increased in the treatment group compared to the control group &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; In the control and treatment groups&#44; there were differences in the extent of the wound on the 3rd day to the 7th day&#46; From the results of the one-way ANOVA analysis&#44; the <span class="elsevierStyleItalic">P</span>-value is 0&#46;002&#46; It can be concluded that there is a difference between the area of mice wounds in the group given the intervention compared to the control group by using the data recorded on days 3&#8211;7&#46; The results also showed that the longer the immersion&#44; the faster the wound closing process occurred&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">11</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conclusion</span><p id="par0095" class="elsevierStylePara elsevierViewall">This study revealed that a 7&#37; concentration of table salt soaking could increase the effectiveness of wound healing&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conflict of interest</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
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          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2021-06-28"
    "fechaAceptado" => "2021-07-30"
    "PalabrasClave" => array:1 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1456610"
          "palabras" => array:3 [
            0 => "Table salt"
            1 => "Wound"
            2 => "Healing"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:1 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Table salt &#40;sodium chloride&#41; is an ionic compound consisting of positive ions &#40;cations&#41; and negative ions &#40;anions&#41; to form neutral compounds that can provide a healing effect on wounds&#46; This study&#39;s purpose of seeing and test the impact of soaking 7&#37; sodium chloride concentration on people&#39;s salt toward the wound healing process&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">This study was an experimental laboratory using the One-Way ANOVA test and the Mann Whitney test conducted in the animal enclosure of the Faculty of Pharmacy&#44; Hasanuddin University&#44; Makassar&#46; The study was conducted from July to August 2019&#46; Samples of 20 mice &#40;<span class="elsevierStyleItalic">Mus Musculus</span>&#41; female swiss webster strains were sliced on the abdominal skin then divided into two groups&#58; the treatment group &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15&#41; and the control group &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>5&#41;&#46; The wound area was observed from the first day to the seventh day to see the wound closure process&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The research shows that soaking 7&#37; of table salt concentration can significantly accelerate the wound healing process compared to the control group&#44; with a decrease in wound diameter on the 3rd day and completely heal on the 7th day&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">7&#37; concentration of table Salt Soaking can increase the effectiveness of wound healing&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objective"
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          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Method"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusion"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Peer-review under responsibility of the scientific committee of the 3rd International Nursing&#44; Health Science Students &#38; Health Care Professionals Conference&#46; Full-text and the content of it is under responsibility of authors of the article&#46;</p>"
      ]
    ]
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        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
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        "tabla" => array:1 [
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            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Group&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Average wound area &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1st day&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>2nd day&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3rd day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>4th day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>5th day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>6th day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>7th day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">5-min intervention</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1st day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>2nd day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3rd day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>4th day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>5th day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>6th day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>7th day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">10-min intervention</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1st day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>2nd day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3rd day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>4th day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>5th day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>6th day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>7th day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">15-min intervention</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1st day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>2nd day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3rd day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;64&nbsp;\t\t\t\t\t\t\n
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The effectiveness of 7% table salt concentration test to increase collagen in the healing process of wound
Sitti Samidaha,
Autor para correspondencia
, Prihantonob, Mardiana Ahmada, Jamaluddin Jompac, Sitti Rafiaha, Andi Nilawati Usmana
a Department of Midwifery, Graduate School Hasanuddin University, Makassar, Indonesia
b Department of Oncology, Faculty of Medicine, Makassar, Indonesia
c Graduate School, Hasanuddin University, Indonesia
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The wound healing process is a quality of tissue life process associated with the regeneration of tissue&#46; The physiological process takes place immediately after the wound occurs by activating the blood of the coagulation system&#46; The release of mediators from platelets&#44; namely Platelet Activating Factor &#40;PAF&#41; and Thromboxane which are then attached to the wound tissue that converts fibrin to fibrinogen so that blood clots last 5&#8211;10<span class="elsevierStyleHsp" style=""></span>min and after that vasodilation will occur&#44; capillary nerve stimulation synthesis &#40;local sensory-nerve endings&#41; occur in the inflammatory phase which ends on the 3rd day to 4th day&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In the phase of tissue structure&#44; improvement marked by angiogenesis occurs in the proliferation or re-epithelialization phase from 3rd day or 4th day and maximum to 14th day&#46; The final phase of wound healing occurs in 21 days to 1 year where there is a balance between the collagen produced and the one that is broken&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">1&#44;2</span></a> The wound healing process normally occurs if supported by nutrition&#44; immune system&#44; and wound care&#46; Wound care using natural materials has been done a long time ago&#44; including wound care using sodium chloride from seawater&#46; Soaking wounds in 7&#37; table salt concentration with osmotic salt properties can provide a drying effect on the wound so that the growth of new tissue accelerates skin contact more quickly&#46; Bacteriostatic salt properties in which streptococcus aureus causes the infection is unable to survive on sodium chloride&#44; which has a concentration of 7&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The 7&#37; table salt concentration in this study was made in a liquid to wash the wound&#44; which provides wound drying and anti-bacterial properties&#44; so the wound healing process becomes faster&#46; This study wanted to identify the effect of a 7&#37; concentration of table salt immersion on wound healing in the stomach of female mice &#40;<span class="elsevierStyleItalic">Mus Musculus</span>&#41;&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Method</span><p id="par0020" class="elsevierStylePara elsevierViewall">The 7&#37; table salt concentration is made from people&#39;s salt&#46; It is produced by salt farmers in Maccini Baji village&#44; Labbakkang sub-district&#44; Pangkep district&#44; and then makes the salt concentration in the oceanography laboratory of the Faculty of Oceanography Hasanuddin University&#46; A dose of 70<span class="elsevierStyleHsp" style=""></span>g of salt dissolved in boiled water into a 1-l sodium chloride solution&#46; Furthermore&#44; this concentration is used to soak the incision wound in mice with an incision area of approximately 1&#46;5<span class="elsevierStyleHsp" style=""></span>cm with a depth of all layers of skin and muscle cut off then sewn using catgut&#44; soaking process done once every day for seven days&#46; Observation and measurement are carried out until the wound heals&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The research subjects were Swiss Webster female mice aged 8&#8211;10 weeks with a weight of 20&#8211;25<span class="elsevierStyleHsp" style=""></span>g&#44; totaling twenty animals from the Laboratory of Animal Medicine Faculty of Hasanuddin University&#44; by considering the cleanliness of the cage&#44; the area of the cage by placing 5 mice for each group and adapted for one week&#44; with enough food and drink every day&#46; The mice were anesthetized by using a ketamine injection with a dose of 0&#46;2<span class="elsevierStyleHsp" style=""></span>ml&#47;kg BW before an abdominal wound was performed&#46; After being anesthetized&#44; the subject&#39;s abdominal surface is smeared with veet then the hair is shaved and cleaned with 70&#37; alcohol&#46; The cut was made by drawing using a ruler and a marker with a length of 1&#46;5<span class="elsevierStyleHsp" style=""></span>cm&#46; Then after mice are unconscious&#44; an incision is made in the stomach of the mice with the help of Chirurgie nippers&#44; a scalpel&#44; and scissors to made a wound on the part that has been drawn&#46; The skin and subcutaneous tissue are removed using tweezers until the mole&#39;s intestine is visible&#44; then sewn back using a catgut with 1&#8211;3 stitches&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Mice were divided into two groups&#58; the control and treatment groups that were given a 7&#37; concentration of table salt soaking&#46; The Control group was divided into three groups &#8211; each group consisted of 5 mice&#46; Then the treatment group was immersed for 5<span class="elsevierStyleHsp" style=""></span>min&#44; 10<span class="elsevierStyleHsp" style=""></span>min&#44; and 15<span class="elsevierStyleHsp" style=""></span>min at noon every day&#46; From the observation result&#44; the wound area on the 1st day and second day has not changed&#46; On the 3rd day&#44; the wound began to appear in the process of drying the wound&#44; and the diameter of the wound was getting smaller and mostly healed on the 7th day&#46; Measuring the diameter of the wound is done every day&#44; starting from the 1st day to 7th day&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Data analysis was performed using a one-way ANOVA test to determine whether there were differences in the average area of cut wounds in the control and treatment groups&#46; Then an independent <span class="elsevierStyleItalic">t</span>-test is performed if the data is normally distributed or the Mann&#8211;Whitney test if the data is not normally distributed&#46; Finally&#44; the data normality test uses the Shapiro&#8211;Wilk test&#46; The significance of the test results is determined based on a <span class="elsevierStyleItalic">p</span>-value &#60;0&#46;05&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">This research has been tested and deemed feasible to be carried out by the Health Research Ethics Commission of the Medical Faculty of Hasanuddin University through letter Number&#58; 541&#47;UN4&#46;6&#46;4&#46;5&#46;31&#47;PP36&#47;2019&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="par0045" class="elsevierStylePara elsevierViewall">To find out the depiction of the results of observations that have been obtained&#44; then carried out a descriptive analysis of the area of the wound in mice from each control group and treatment group&#44; namely intervention 5<span class="elsevierStyleHsp" style=""></span>min&#44; 10<span class="elsevierStyleHsp" style=""></span>min&#44; and 15<span class="elsevierStyleHsp" style=""></span>min&#46; The following table compares the area of wounds between the control group and the treatment group&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Comparing the average injuries between the control group and the treatment group began to be different on the 3rd day to the 7th day&#46; The descriptive analysis shows that the wound in the treatment or intervention group is faster closed than the area of the wound in the control group &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">The differences in the average area of cut wounds in the treatment and control groups&#44; a one-way ANOVA analysis was performed&#46; The analysis was performed on the area of the wound area on the 3rd to 7th day for each treatment and control group&#46; This is because there is no change in the field of the wound on days one and two&#44; so it does not provide meaningful information&#46; In addition&#44; if the recording of days one and two are included in the analysis&#44; it can obscure the results of the analysis of variance that is carried out&#46; The results are as follows &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">Based on <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#44; it is known that the average wound area for the 5-minute intervention group is 0&#46;48&#44; the 10-min intervention is 0&#46;51&#44; the 15-min intervention is 0&#46;29&#44; and the control group is 0&#46;74&#46; From the results of the average wound area in the intervention or treatment group&#44; it is known that the longer the intervention is carried out&#44; the average wound area is also getting smaller&#46; In addition&#44; the average size of the wound area that has been given intervention or treatment is also smaller than the average wound area in the control group&#46; From the results of one-way ANOVA analysis&#44; the F-count is 5&#46;252&#44; and the <span class="elsevierStyleItalic">P</span>-value is 0&#46;002&#46; Because the <span class="elsevierStyleItalic">P</span>-value is smaller than &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#44; it can be concluded that there is a significant difference in the average area of mice wounds in the treatment group and the control group&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The Mann&#8211;Whitney test was performed to determine the significance of the difference in the average wound area of each treatment group to the control group if the data did not have a normal distribution&#46; The analysis was performed on the area of the wound area on the 3rd to 7th day for each treatment and control group&#46; The results are as follows&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Based on <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#44; it is known that the <span class="elsevierStyleItalic">P</span>-value from the Mann&#8211;Whitney test results for the comparison of the 5-min intervention group and the control group is 0&#46;020&#44; the 10-min intervention group and the control group is 0&#46;035&#44; and the 15-min intervention group and the control group are 0&#46;000&#46; Because of the <span class="elsevierStyleItalic">P</span>-value of &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#44; it can be concluded that the average wound area in each intervention group had a significant difference from the control group&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Discussion</span><p id="par0075" class="elsevierStylePara elsevierViewall">The wound healing process is a complex process that includes a series of biochemical&#44; cellular&#44; and physiological processes&#46; The process goes through several phases&#44; namely the hemostatic&#44; inflammatory&#44; proliferation&#44; and remodeling phases&#46; Proper wound care is one factor in the formation of new tissue&#46; Wound management using natural ingredients as medicine has been widely carried out today&#44; one of which is using seawater&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">2&#44;4&#44;5</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Seawater contains salt&#44; which is composed of sodium atoms and chloride atoms&#46; Types of bonds in the form of sodium chloride compounds are bonds of positive ions and negative ions&#46; In the process of fermentation of food ingredients&#44; sodium chloride is useful to limit the growth of spoilage organisms and prevent the growth of some microorganisms&#46; However&#44; certain bacteria can still grow in high saline solutions&#46; Seawater can be used in the treatment of external wounds&#44; which have an osmotic effect on the tissue so that the wound becomes dry&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">3&#44;6&#44;7</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Some principles in wound healing are that the body&#39;s ability to deal with tissue trauma is influenced by the extent of damage and the general condition of each person&#46; The body&#39;s response to the wound is more effective if the nutrients are maintained&#44; the body&#39;s response to the system to the trauma of blood flow to the wound tissue&#44; the integrity of the skin and mucous membranes are prepared as the first line to defend against microorganisms&#44; wound healing is enhanced when the wound is free of foreign matter including bacteria&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">8&#8211;10</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">In this study&#44; wound healing significantly increased in the treatment group compared to the control group &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; In the control and treatment groups&#44; there were differences in the extent of the wound on the 3rd day to the 7th day&#46; From the results of the one-way ANOVA analysis&#44; the <span class="elsevierStyleItalic">P</span>-value is 0&#46;002&#46; It can be concluded that there is a difference between the area of mice wounds in the group given the intervention compared to the control group by using the data recorded on days 3&#8211;7&#46; The results also showed that the longer the immersion&#44; the faster the wound closing process occurred&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">11</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conclusion</span><p id="par0095" class="elsevierStylePara elsevierViewall">This study revealed that a 7&#37; concentration of table salt soaking could increase the effectiveness of wound healing&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conflict of interest</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
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          "identificador" => "xpalclavsec1456610"
          "titulo" => "Keywords"
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        2 => array:2 [
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          "titulo" => "Introduction"
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          "identificador" => "sec0010"
          "titulo" => "Method"
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          "titulo" => "Conclusion"
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          "identificador" => "sec0030"
          "titulo" => "Conflict of interest"
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          "titulo" => "References"
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    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2021-06-28"
    "fechaAceptado" => "2021-07-30"
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          "clase" => "keyword"
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          "palabras" => array:3 [
            0 => "Table salt"
            1 => "Wound"
            2 => "Healing"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Table salt &#40;sodium chloride&#41; is an ionic compound consisting of positive ions &#40;cations&#41; and negative ions &#40;anions&#41; to form neutral compounds that can provide a healing effect on wounds&#46; This study&#39;s purpose of seeing and test the impact of soaking 7&#37; sodium chloride concentration on people&#39;s salt toward the wound healing process&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">This study was an experimental laboratory using the One-Way ANOVA test and the Mann Whitney test conducted in the animal enclosure of the Faculty of Pharmacy&#44; Hasanuddin University&#44; Makassar&#46; The study was conducted from July to August 2019&#46; Samples of 20 mice &#40;<span class="elsevierStyleItalic">Mus Musculus</span>&#41; female swiss webster strains were sliced on the abdominal skin then divided into two groups&#58; the treatment group &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15&#41; and the control group &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>5&#41;&#46; The wound area was observed from the first day to the seventh day to see the wound closure process&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The research shows that soaking 7&#37; of table salt concentration can significantly accelerate the wound healing process compared to the control group&#44; with a decrease in wound diameter on the 3rd day and completely heal on the 7th day&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">7&#37; concentration of table Salt Soaking can increase the effectiveness of wound healing&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Peer-review under responsibility of the scientific committee of the 3rd International Nursing&#44; Health Science Students &#38; Health Care Professionals Conference&#46; Full-text and the content of it is under responsibility of authors of the article&#46;</p>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Group&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Average wound area &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1st day&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>2nd day&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3rd day&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>4th day&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>5th day&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>6th day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>7th day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">5-min intervention</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1st day&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>2nd day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3rd day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>4th day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>5th day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>6th day&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>7th day&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="2" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">10-min intervention</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1st day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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    "bibliografia" => array:2 [
      "titulo" => "References"
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        0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Innovations and advances in wound healing &#8211; infection&#44; debridement and biofilm"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
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                      "Revista" => array:4 [
                        "tituloSerie" => "Innov Adv Wound Heal"
                        "fecha" => "2015"
                        "paginaInicial" => "1"
                        "paginaFinal" => "287"
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                  ]
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