Participation rates in the selection of population controls in a case-control study of colorectal cancer using two recruitment methods

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Nieuwenhuijsen, Víctor Moreno, Estela Carrasco, Elisabet Guinó, Manolis Kogevinas, Cristina M. Villanueva" "autores" => array:7 [ 0 => array:4 [ "nombre" => "Gemma" "apellidos" => "Castaño-Vinyals" "email" => array:1 [ 0 => "gcastano@creal.cat" ] "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:2 [ "etiqueta" => "¿" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Mark J." "apellidos" => "Nieuwenhuijsen" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "Víctor" "apellidos" => "Moreno" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "d" "identificador" => "aff0020" ] 1 => array:2 [ "etiqueta" => "e" "identificador" => "aff0025" ] ] ] 3 => array:3 [ "nombre" => "Estela" "apellidos" => "Carrasco" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Elisabet" "apellidos" => "Guinó" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "d" "identificador" => "aff0020" ] ] ] 5 => array:3 [ "nombre" => "Manolis" "apellidos" => "Kogevinas" "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:2 [ "etiqueta" => "f" "identificador" => "aff0030" ] ] ] 6 => array:3 [ "nombre" => "Cristina M." "apellidos" => "Villanueva" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:6 [ 0 => array:3 [ "entidad" => "Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Municipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "CIBER de Epidemiología y Salud Pública (CIBERESP), Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Biostatistics and Bioinformatics Unit, IDIBELL-Catalan Institute of Oncology, L’Hospitalet de Llobregat, Barcelona, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "National School of Public Health, Athens, Greece" "etiqueta" => "f" "identificador" => "aff0030" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tasas de participación en la selección de controles poblacionales en un estudio de casos y controles de cáncer colorrectal usando dos métodos de reclutamiento" ] ] "textoCompleto" => "IntroductionIn many industrialized countries, there is a general perception that achieving high response rates in surveys is increasingly difficult<a class="elsevierStyleCrossRef" href="#bib0005">1</a>. An evaluation of 355 original epidemiological articles published in 10 high impact journals found that average participation in epidemiological studies has fallen in the last 30 years and that this decrease has particularly affected controls in population-based studies<a class="elsevierStyleCrossRef" href="#bib0010">2</a>. In recent years, response rates among population controls of around 50% have not been uncommon. Because of the difficulties in achieving high response rates and the potential biases resulting from self-selection, understanding the reasons for non-response and the application of methods for limiting non-response is indispensible.Within the framework of the Health Impacts of Long Term Exposure to Disinfection By-Products in Drinking Water (HI-WATE) project, we conducted a population-based case-control study in Spain to assess the risk of colorectal cancer associated with long-term exposure to disinfection by-products, including examination of gene-environment interactions.Low participation rates in the selection of population controls were a concern for the validity of the study. We conducted a pilot study to assess the recruitment rates of population controls and modified the recruitment methodology to increase participation. The procedure and performance of both methods are described.MethodsStudy subjectsCases were defined as patients with histologically-confirmed colorectal cancer aged between 20 and 85 years and living in the catchment area of one of the participating hospitals (Hospital del Mar, Barcelona). Controls consisted of persons living in the catchment area of the participating hospital, who were individually matched by age (±5 years) and gender to cases.Recruitment of population controlsWe used two methods to identify and contact potential controls:<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005">-Method 1: a list of persons living in the study area was provided by the Central Registry of Health Insured People in Catalonia (Spain) of the Catalan Health Service. This list included men and women between 20 and 85 years old, with information on gender, date of birth, complete address of residence, name, family names and telephone number. The interviewers selected potential controls from the list matched by gender and age to cases, who were contacted telephonically on behalf of the research center and invited to participate.</li><li class="elsevierStyleListItem" id="lsti0010">-Method 2: family practitioners from a primary health center in the study area were contacted and asked to provide their list of the quota of people assigned to him/her, with information on age, gender, address, and telephone number. The number of participating family practitioners was decided by the director of the center, based on the personal interest of the family practitioner in research. In this first primary health center contacted, we had access to the list of one family practitioner, with more than 2,000 persons. Potential controls matched by gender and age to cases fulfilling the inclusion criteria were contacted telephonically by the interviewers on behalf of their family practitioner and were invited to participate.</li></ul>The protocol for telephone contact was the same in both methods. We selected five persons as potential controls matched by age and gender to each case, who were telephoned in the order they were selected. Responses to the telephone call were grouped into three categories: 1) the person was reached; 2) the telephone was engaged, or the answering machine responded or nobody picked up the telephone; in this case, we made up to five further attempts; 3) the telephone number was wrong; in this case we checked the number in the telephone directory. Potential controls were telephoned consecutively according to the response of the previous person. The reasons for selecting a subsequent person on the list were refusal to participate or wrong contact information. People who accepted to participate were invited to the primary care center close to Hospital del Mar for an interview and blood extraction. If people refused to go to the primary care center, we offered to visit them at their homes.Our aim was to recruit 40 controls using each method. Response rates were calculated using the method described by Slattery et al<a class="elsevierStyleCrossRef" href="#bib0015">3</a>. Briefly, in the numerator we counted interviewed individuals, and in the denominator we included these individuals, as well as persons who refused to participate and individuals that could not be contacted.ResultsWhen method 1 was used, 90 persons were contacted and invited to participate in the study as potential controls (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Among the seven persons identified as not eligible, two had a previous diagnosis of colorectal cancer and five did not live in the hospital's catchment area. Among the 83 eligible individuals, 35 accepted to participate in the study and were interviewed (42% response rate) and 39 (47%) refused to participate. An average of 6.5 telephone calls was required to recruit one control. Among the 74 persons contacted, 35 (47%) accepted to participate. The aim of the study was to recruit 40 controls per method, taking into account that we had a list of five persons for each control. The final difference between method 1 and method 2 was due to the fact that we had to call fewer persons to recruit the 40 controls.<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>When the second method was used, 80 individuals were identified from the family practitioner's list and were contacted to participate as potential controls. Among these, 10 were not eligible. The response rate was 57% and the refusal rate was 13%. The main problem with the family practitioner's list consisted of difficulties in contacting the potential controls. With method 2, 30% of the persons could not be contacted, mainly due to incorrect telephone numbers in the registry (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Among the 49 persons contacted, 40 (81%) accepted to participate.The differences in participation rates between the two recruitment methods were statistically significant (chi-square test: 22.94; p<0.05).When method 1 was used, 47% of the persons contacted refused to participate in the study. The main reason for refusal (25% of total refusals) was not having time or having to travel too far to reach the primary care center for the interview (distance/time). Almost 21% of the persons contacted refused to participate without giving a specific reason. The third reason for refusal, accounting for 20% of the total, was refusal by the person answering the telephone, usually a relative (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). No differences were observed in reasons for refusal by gender. Stratification by age showed that the main reason for refusal among the youngest people (age≤65 years) was the distance/time, accounting for 63% of refusals. In the older group (age>65 years), 26% of individuals gave no reason and 19% of refusals were made by a relative.<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>When method 2 was used, only nine persons (13%) out of the 49 contacted refused to be interviewed. One-third (34%) gave no specific reason, while 22% reported not being interested in the study (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). The remaining persons (n=4) mentioned different reasons for refusing to participate. In the stratification by age, only two persons were aged 65 years or less, one reported not being interested in the study and the other accepted to be interviewed by telephone, but did not attend the appointment. Persons older than 65 years mainly refused to be interviewed without giving a specific reason (43%).Controls selected by method 1 were aged an average of 70 years (SD=10) and 57% were men, while controls selected by method 2 had an average age of 69 years (SD=10), but a higher percentage were men (67%).DiscussionWe conducted a study to assess two approaches to recruiting population-based controls and found that contact through the family practitioner provided higher response rates in population controls in the study area (57%) compared with contact via a general population register (42%). The reasons for refusal were similar in both methods and differed by age.Our response proportion was slightly higher than that reported by Stang et al<a class="elsevierStyleCrossRef" href="#bib0020">4</a> in 2005, in a study in Germany (53%), although the recruitment method differed slightly from our own. We only used telephone calls, while the first approach in the German study used a letter and only persons not responding after a second written invitation were telephoned. We could not assess the characteristics of non-respondents apart from sex, age and reason for refusal.In 2008, Ruano-Ravina et al<a class="elsevierStyleCrossRef" href="#bib0025">5</a> conducted a case-control study in Spain of recruitment of population controls and compared the response rates with hospital controls. These authors reported response rates for population controls of 61.6% and 100% for hospital controls, although there was no description of the method used to calculate these response rates. The main difference with our study was that the interviews were conducted at home, and people were not asked to attend the primary health center, unlike in our study. Similarly, another study in Cornellà (Barcelona) reported a response rate of 64.3% for a telephone interview conducted within the framework of a cohort study<a class="elsevierStyleCrossRef" href="#bib0030">6</a>. In recent years, achieving high response rates in surveys has become increasingly difficult in many industrialized countries<a class="elsevierStyleCrossRef" href="#bib0035">7</a>. An evaluation of 355 original epidemiological papers published in 10 high impact journals found that average participation in epidemiological studies has fallen in the last 30 years and that this decrease has particularly affected controls in population-based studies<a class="elsevierStyleCrossRef" href="#bib0010">2</a>. In recent years, response rates among population controls of around 50% have not been uncommon.This is one of the first studies to explain in detail the entire process of recruiting controls, unlike most of the studies published in the literature. The response rates obtained in recruiting population controls were moderate. Although recruitment of population controls is more time consuming than that of hospital controls, validity is believed to be higher through avoidance of selection bias<a class="elsevierStyleCrossRef" href="#bib0040">8</a>.The higher response rate obtained with method 2 can be attributed to the involvement of the family practitioner, even though this involvement was indirect, compared with the more anonymous method 1. In view of the response rates obtained in this study, we decided to recruit population controls in the main study by using the second method. In addition, if the errors in the contact telephone numbers in the lists of family practitioners tended to be random (a hypothesis that is probable but which we could not test), the response rates for method 2 would have been much higher, since 23% of persons with errors should have been identified as not eligible. The reason for this high percentage of errors, according to the family practitioner and the director of the primary health center, was that the area has high rates of migration and considerable population movement.Our results show that participation rates of population controls in case-control studies could increase through the use of recruitment methods that include personalized contacts, such as family practitioners.Authors contributionsG. Castaño-Vinyals, M. Nieuwenhuijsen, V. Moreno, E. Guinó, M. Kogevinas and C. Villanueva participated in the design of the study, supervised the data collection and participated in the analysis. E. Carrasco collected the data and participated in the analysis. G. Castaño-Vinyals wrote the first draft of the manuscript. All authors reviewed critically the manuscript and approved the final version. G. Castaño-Vinyals is the corresponding author.Financial supportThis study was funded by the HI-WATE project - FP6-2005-FOOD-4B (Reg. No. 036224) and Instituto de Salud Carlos III FEDER (PI080533 and PI081770).Conflict of interestThe authors have no conflict of interest to declare." "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:2 [ "identificador" => "xres11541" "titulo" => array:5 [ 0 => "Abstract" 1 => "Objectives" 2 => "Methods" 3 => "Results" 4 => "Conclusions" ] ] 1 => array:2 [ "identificador" => "xpalclavsec13002" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres11542" "titulo" => array:5 [ 0 => "Resumen" 1 => "Objetivos" 2 => "Métodos" 3 => "Resultados" 4 => "Conclusiones" ] ] 3 => array:2 [ "identificador" => "xpalclavsec13001" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Methods" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Study subjects" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Recruitment of population controls" ] ] ] 6 => array:2 [ "identificador" => "sec0025" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0030" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0035" "titulo" => "Authors contributions" ] 9 => array:2 [ "identificador" => "sec0040" "titulo" => "Financial support" ] 10 => array:2 [ "identificador" => "sec0045" "titulo" => "Conflict of interest" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-02-05" "fechaAceptado" => "2010-05-07" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec13002" "palabras" => array:3 [ 0 => "Patient participation rates" 1 => "Population controls" 2 => "Case-control study" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec13001" "palabras" => array:3 [ 0 => "Tasas de participación de pacientes" 1 => "Controles poblacionales" 2 => "Estudio de casos y controles" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "ObjectivesLow participation rates in the selection of population controls are an increasing concern for the validity of case-control studies worldwide. MethodsWe conducted a pilot study to assess two approaches to recruiting population controls in a study of colorectal cancer, including a face-to-face interview and blood sample collection. In the first approach, persons identified through a population roster were invited to participate through a telephone call by an interviewer telephoning on behalf of our research center. In the second approach, individuals were identified from the lists of selected family practitioners and were telephoned on behalf of the family practitioner. ResultsWhen the second method was used, participation rates increased from 42% to 57% and the percentage of refusals decreased from 47% to 13%. The reasons for refusing to participate did not differ significantly between the two methods. ConclusionsContact through the family practitioner yielded higher response rates in population controls in the study area." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "ObjetivosLas bajas tasas de participación de controles poblacionales son una preocupación para la validez de los estudios de casos y controles. MétodosRealizamos un estudio piloto utilizando dos estrategias de reclutamiento de controles poblacionales en un estudio de cáncer colorrectal, incluyendo una entrevista personal y una extracción de sangre. Con la primera estrategia, una entrevistadora llamaba en nombre del centro de investigación a los sujetos de un censo. Con la segunda estrategia, los sujetos fueron seleccionados a partir de los listados de población asignada a los médicos de familia y la llamada se hacía en nombre del médico. ResultadosLas tasas de participación aumentaron del 42% al 57% usando el segundo método; el porcentaje de rechazos disminuyó del 47% al 13%. Las razones de rechazo no diferían según la estrategia. ConclusionesEl contacto a través del médico de familia reportó mayores tasas de respuesta para los controles poblacionales del área de estudio." ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Method 1 (general roster; research center calling)</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Method 2 (family practitioner list; calling on behalf of the family practitioner</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="5" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Telephone contact attempts</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Total calls made \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">180 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">167 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Number of calls to contact 1 person, mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.8 (1.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.9 (1.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Number of calls to contact 1 control, mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.5 (2.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.1 (4.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Total number of people called \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">90 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">80 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-eligible (among contacted individuals) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Final result of the calls among eligible persons \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">83 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">70 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Interviews completed \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">42% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">57% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Person refused interview \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">47% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Contact not established: \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">30% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Wrong phone number \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Answering machine \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Person could not be reached \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4% \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab10947.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Results of the telephone calls to recruit population controls." ] ] 1 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Method 1 (general roster; research center calling) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Method 2 (family practitioner list; calling on behalf of the family practitioner) \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No reason \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 (21%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (33%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Distance/time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 (26%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (11%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Refusal by a relative \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 (18%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (11%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Not interested in the study \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (15%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (22%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Too ill \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n 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Original article

Participation rates in the selection of population controls in a case-control study of colorectal cancer using two recruitment methods

Tasas de participación en la selección de controles poblacionales en un estudio de casos y controles de cáncer colorrectal usando dos métodos de reclutamiento

Gemma Castaño-Vinyalsa,b,c,

Autor para correspondencia

gcastano@creal.cat

Corresponding author.

, Mark J. Nieuwenhuijsena,b,c, Víctor Morenod,e, Estela Carrascoa,b, Elisabet Guinód, Manolis Kogevinasa,b,c,f, Cristina M. Villanuevaa,b,c

a Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain

b Municipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona, Spain

c CIBER de Epidemiología y Salud Pública (CIBERESP), Spain

d Biostatistics and Bioinformatics Unit, IDIBELL-Catalan Institute of Oncology, L’Hospitalet de Llobregat, Barcelona, Spain

e Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain

f National School of Public Health, Athens, Greece

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        "titulo" => "Tasas de participaci&#243;n en la selecci&#243;n de controles poblacionales en un estudio de casos y controles de c&#225;ncer colorrectal usando dos m&#233;todos de reclutamiento"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">In many industrialized countries&#44; there is a general perception that achieving high response rates in surveys is increasingly difficult<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46; An evaluation of 355 original epidemiological articles published in 10 high impact journals found that average participation in epidemiological studies has fallen in the last 30 years and that this decrease has particularly affected controls in population-based studies<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#46; In recent years&#44; response rates among population controls of around 50&#37; have not been uncommon&#46; Because of the difficulties in achieving high response rates and the potential biases resulting from self-selection&#44; understanding the reasons for non-response and the application of methods for limiting non-response is indispensible&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Within the framework of the Health Impacts of Long Term Exposure to Disinfection By-Products in Drinking Water &#40;HI-WATE&#41; project&#44; we conducted a population-based case-control study in Spain to assess the risk of colorectal cancer associated with long-term exposure to disinfection by-products&#44; including examination of gene-environment interactions&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Low participation rates in the selection of population controls were a concern for the validity of the study&#46; We conducted a pilot study to assess the recruitment rates of population controls and modified the recruitment methodology to increase participation&#46; The procedure and performance of both methods are described&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Study subjects</span><p id="par0020" class="elsevierStylePara elsevierViewall">Cases were defined as patients with histologically-confirmed colorectal cancer aged between 20 and 85 years and living in the catchment area of one of the participating hospitals &#40;Hospital del Mar&#44; Barcelona&#41;&#46; Controls consisted of persons living in the catchment area of the participating hospital&#44; who were individually matched by age &#40;&#177;5 years&#41; and gender to cases&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Recruitment of population controls</span><p id="par0025" class="elsevierStylePara elsevierViewall">We used two methods to identify and contact potential controls&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0030" class="elsevierStylePara elsevierViewall">Method 1&#58; a list of persons living in the study area was provided by the Central Registry of Health Insured People in Catalonia &#40;Spain&#41; of the Catalan Health Service&#46; This list included men and women between 20 and 85 years old&#44; with information on gender&#44; date of birth&#44; complete address of residence&#44; name&#44; family names and telephone number&#46; The interviewers selected potential controls from the list matched by gender and age to cases&#44; who were contacted telephonically on behalf of the research center and invited to participate&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0035" class="elsevierStylePara elsevierViewall">Method 2&#58; family practitioners from a primary health center in the study area were contacted and asked to provide their list of the quota of people assigned to him&#47;her&#44; with information on age&#44; gender&#44; address&#44; and telephone number&#46; The number of participating family practitioners was decided by the director of the center&#44; based on the personal interest of the family practitioner in research&#46; In this first primary health center contacted&#44; we had access to the list of one family practitioner&#44; with more than 2&#44;000 persons&#46; Potential controls matched by gender and age to cases fulfilling the inclusion criteria were contacted telephonically by the interviewers on behalf of their family practitioner and were invited to participate&#46;</p></li></ul></p><p id="par0040" class="elsevierStylePara elsevierViewall">The protocol for telephone contact was the same in both methods&#46; We selected five persons as potential controls matched by age and gender to each case&#44; who were telephoned in the order they were selected&#46; Responses to the telephone call were grouped into three categories&#58; <span class="elsevierStyleItalic">1&#41;</span> the person was reached&#59; <span class="elsevierStyleItalic">2&#41;</span> the telephone was engaged&#44; or the answering machine responded or nobody picked up the telephone&#59; in this case&#44; we made up to five further attempts&#59; <span class="elsevierStyleItalic">3&#41;</span> the telephone number was wrong&#59; in this case we checked the number in the telephone directory&#46; Potential controls were telephoned consecutively according to the response of the previous person&#46; The reasons for selecting a subsequent person on the list were refusal to participate or wrong contact information&#46; People who accepted to participate were invited to the primary care center close to Hospital del Mar for an interview and blood extraction&#46; If people refused to go to the primary care center&#44; we offered to visit them at their homes&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Our aim was to recruit 40 controls using each method&#46; Response rates were calculated using the method described by Slattery et al<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46; Briefly&#44; in the numerator we counted interviewed individuals&#44; and in the denominator we included these individuals&#44; as well as persons who refused to participate and individuals that could not be contacted&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results</span><p id="par0050" class="elsevierStylePara elsevierViewall">When method 1 was used&#44; 90 persons were contacted and invited to participate in the study as potential controls &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Among the seven persons identified as not eligible&#44; two had a previous diagnosis of colorectal cancer and five did not live in the hospital&#39;s catchment area&#46; Among the 83 eligible individuals&#44; 35 accepted to participate in the study and were interviewed &#40;42&#37; response rate&#41; and 39 &#40;47&#37;&#41; refused to participate&#46; An average of 6&#46;5 telephone calls was required to recruit one control&#46; Among the 74 persons contacted&#44; 35 &#40;47&#37;&#41; accepted to participate&#46; The aim of the study was to recruit 40 controls per method&#44; taking into account that we had a list of five persons for each control&#46; The final difference between method 1 and method 2 was due to the fact that we had to call fewer persons to recruit the 40 controls&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">When the second method was used&#44; 80 individuals were identified from the family practitioner&#39;s list and were contacted to participate as potential controls&#46; Among these&#44; 10 were not eligible&#46; The response rate was 57&#37; and the refusal rate was 13&#37;&#46; The main problem with the family practitioner&#39;s list consisted of difficulties in contacting the potential controls&#46; With method 2&#44; 30&#37; of the persons could not be contacted&#44; mainly due to incorrect telephone numbers in the registry &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Among the 49 persons contacted&#44; 40 &#40;81&#37;&#41; accepted to participate&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The differences in participation rates between the two recruitment methods were statistically significant &#40;chi-square test&#58; 22&#46;94&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">When method 1 was used&#44; 47&#37; of the persons contacted refused to participate in the study&#46; The main reason for refusal &#40;25&#37; of total refusals&#41; was not having time or having to travel too far to reach the primary care center for the interview &#40;distance&#47;time&#41;&#46; Almost 21&#37; of the persons contacted refused to participate without giving a specific reason&#46; The third reason for refusal&#44; accounting for 20&#37; of the total&#44; was refusal by the person answering the telephone&#44; usually a relative &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; No differences were observed in reasons for refusal by gender&#46; Stratification by age showed that the main reason for refusal among the youngest people &#40;age<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>65 years&#41; was the distance&#47;time&#44; accounting for 63&#37; of refusals&#46; In the older group &#40;age<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>65 years&#41;&#44; 26&#37; of individuals gave no reason and 19&#37; of refusals were made by a relative&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">When method 2 was used&#44; only nine persons &#40;13&#37;&#41; out of the 49 contacted refused to be interviewed&#46; One-third &#40;34&#37;&#41; gave no specific reason&#44; while 22&#37; reported not being interested in the study &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; The remaining persons &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>4&#41; mentioned different reasons for refusing to participate&#46; In the stratification by age&#44; only two persons were aged 65 years or less&#44; one reported not being interested in the study and the other accepted to be interviewed by telephone&#44; but did not attend the appointment&#46; Persons older than 65 years mainly refused to be interviewed without giving a specific reason &#40;43&#37;&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Controls selected by method 1 were aged an average of 70 years &#40;SD<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>10&#41; and 57&#37; were men&#44; while controls selected by method 2 had an average age of 69 years &#40;SD<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>10&#41;&#44; but a higher percentage were men &#40;67&#37;&#41;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0080" class="elsevierStylePara elsevierViewall">We conducted a study to assess two approaches to recruiting population-based controls and found that contact through the family practitioner provided higher response rates in population controls in the study area &#40;57&#37;&#41; compared with contact via a general population register &#40;42&#37;&#41;&#46; The reasons for refusal were similar in both methods and differed by age&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Our response proportion was slightly higher than that reported by Stang et al<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> in 2005&#44; in a study in Germany &#40;53&#37;&#41;&#44; although the recruitment method differed slightly from our own&#46; We only used telephone calls&#44; while the first approach in the German study used a letter and only persons not responding after a second written invitation were telephoned&#46; We could not assess the characteristics of non-respondents apart from sex&#44; age and reason for refusal&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">In 2008&#44; Ruano-Ravina et al<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> conducted a case-control study in Spain of recruitment of population controls and compared the response rates with hospital controls&#46; These authors reported response rates for population controls of 61&#46;6&#37; and 100&#37; for hospital controls&#44; although there was no description of the method used to calculate these response rates&#46; The main difference with our study was that the interviews were conducted at home&#44; and people were not asked to attend the primary health center&#44; unlike in our study&#46; Similarly&#44; another study in Cornell&#224; &#40;Barcelona&#41; reported a response rate of 64&#46;3&#37; for a telephone interview conducted within the framework of a cohort study<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&#46; In recent years&#44; achieving high response rates in surveys has become increasingly difficult in many industrialized countries<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#46; An evaluation of 355 original epidemiological papers published in 10 high impact journals found that average participation in epidemiological studies has fallen in the last 30 years and that this decrease has particularly affected controls in population-based studies<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#46; In recent years&#44; response rates among population controls of around 50&#37; have not been uncommon&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">This is one of the first studies to explain in detail the entire process of recruiting controls&#44; unlike most of the studies published in the literature&#46; The response rates obtained in recruiting population controls were moderate&#46; Although recruitment of population controls is more time consuming than that of hospital controls&#44; validity is believed to be higher through avoidance of selection bias<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">The higher response rate obtained with method 2 can be attributed to the involvement of the family practitioner&#44; even though this involvement was indirect&#44; compared with the more anonymous method 1&#46; In view of the response rates obtained in this study&#44; we decided to recruit population controls in the main study by using the second method&#46; In addition&#44; if the errors in the contact telephone numbers in the lists of family practitioners tended to be random &#40;a hypothesis that is probable but which we could not test&#41;&#44; the response rates for method 2 would have been much higher&#44; since 23&#37; of persons with errors should have been identified as not eligible&#46; The reason for this high percentage of errors&#44; according to the family practitioner and the director of the primary health center&#44; was that the area has high rates of migration and considerable population movement&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Our results show that participation rates of population controls in case-control studies could increase through the use of recruitment methods that include personalized contacts&#44; such as family practitioners&#46;<span class="elsevierStyleVsp" style="height:0.5px"></span></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Authors contributions</span><p id="par0110" class="elsevierStylePara elsevierViewall">G&#46; Casta&#241;o-Vinyals&#44; M&#46; Nieuwenhuijsen&#44; V&#46; Moreno&#44; E&#46; Guin&#243;&#44; M&#46; Kogevinas and C&#46; Villanueva participated in the design of the study&#44; supervised the data collection and participated in the analysis&#46; E&#46; Carrasco collected the data and participated in the analysis&#46; G&#46; Casta&#241;o-Vinyals wrote the first draft of the manuscript&#46; All authors reviewed critically the manuscript and approved the final version&#46; G&#46; Casta&#241;o-Vinyals is the corresponding author&#46;<span class="elsevierStyleVsp" style="height:0.5px"></span></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Financial support</span><p id="par0115" class="elsevierStylePara elsevierViewall">This study was funded by the HI-WATE project - FP6-2005-FOOD-4B &#40;Reg&#46; No&#46; 036224&#41; and Instituto de Salud Carlos III FEDER &#40;PI080533 and PI081770&#41;&#46;<span class="elsevierStyleVsp" style="height:0.5px"></span></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of interest</span><p id="par0120" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare&#46;<span class="elsevierStyleVsp" style="height:0.5px"></span></p></span></span>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Low participation rates in the selection of population controls are an increasing concern for the validity of case-control studies worldwide&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We conducted a pilot study to assess two approaches to recruiting population controls in a study of colorectal cancer&#44; including a face-to-face interview and blood sample collection&#46; In the first approach&#44; persons identified through a population roster were invited to participate through a telephone call by an interviewer telephoning on behalf of our research center&#46; In the second approach&#44; individuals were identified from the lists of selected family practitioners and were telephoned on behalf of the family practitioner&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">When the second method was used&#44; participation rates increased from 42&#37; to 57&#37; and the percentage of refusals decreased from 47&#37; to 13&#37;&#46; The reasons for refusing to participate did not differ significantly between the two methods&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Contact through the family practitioner yielded higher response rates in population controls in the study area&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Las bajas tasas de participaci&#243;n de controles poblacionales son una preocupaci&#243;n para la validez de los estudios de casos y controles&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Realizamos un estudio piloto utilizando dos estrategias de reclutamiento de controles poblacionales en un estudio de c&#225;ncer colorrectal&#44; incluyendo una entrevista personal y una extracci&#243;n de sangre&#46; Con la primera estrategia&#44; una entrevistadora llamaba en nombre del centro de investigaci&#243;n a los sujetos de un censo&#46; Con la segunda estrategia&#44; los sujetos fueron seleccionados a partir de los listados de poblaci&#243;n asignada a los m&#233;dicos de familia y la llamada se hac&#237;a en nombre del m&#233;dico&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Las tasas de participaci&#243;n aumentaron del 42&#37; al 57&#37; usando el segundo m&#233;todo&#59; el porcentaje de rechazos disminuy&#243; del 47&#37; al 13&#37;&#46; Las razones de rechazo no difer&#237;an seg&#250;n la estrategia&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El contacto a trav&#233;s del m&#233;dico de familia report&#243; mayores tasas de respuesta para los controles poblacionales del &#225;rea de estudio&#46;</p>"
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                  \t\t\t\t" style="border-bottom: 2px solid black">Method 2 &#40;family practitioner list&#59; calling on behalf of the family practitioner</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Telephone contact attempts</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Total calls made</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">180&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">167&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Number of calls to contact 1 person&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;8 &#40;1&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;9 &#40;1&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Number of calls to contact 1 control&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;5 &#40;2&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;1 &#40;4&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Total number of people called</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Non-eligible &#40;among contacted individuals&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Final result of the calls among eligible persons</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Interviews completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Person refused interview&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Contact not established&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Wrong phone number&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Answering machine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Person could not be reached&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                0 => "xTab10947.png"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Results of the telephone calls to recruit population controls&#46;</p>"
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      1 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Method 1 &#40;general roster&#59; research center calling&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Method 2 &#40;family practitioner list&#59; calling on behalf of the family practitioner&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No reason&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;21&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;33&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Distance&#47;time&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;26&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;11&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Refusal by a relative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;18&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;11&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Not interested in the study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;15&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;22&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Too ill&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;11&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">In a retirement home&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Accepted by telephone but did not attend&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;11&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                        0 => array:2 [
                          "etal" => true
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                      "titulo" => "Participation in population studies"
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                      "doi" => "10.1097/01.ede.0000209441.24307.92"
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Información del artículo

ISSN: 02139111
Idioma original: Inglés

DOI:10.1016/j.gaceta.2010.05.011

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