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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Conocer la evoluci&#243;n y la variabilidad en el consumo de los antiinflamarios no esteroideos cl&#225;sicos &#40;AINE&#41; en las &#225;reas de salud de Costa Rica durante el per&#237;odo 2000-2005&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudiaron los siguientes medicamentos&#58; ibuprofeno&#44; indometacina&#44; penicilamina&#44; sulindaco&#44; tenoxican y diclofenaco s&#243;dico&#46; Se utiliz&#243; como medida de consumo la dosis diaria definida por 1&#46;000 habitantes y d&#237;a &#40;DHD&#41;&#44; y en el an&#225;lisis de variabilidad el coeficiente de variaci&#243;n ponderado por el tama&#241;o de poblaci&#243;n &#40;CVw&#41;&#44; el rango extremo&#44; el rango interpercentil&#44; los gr&#225;ficos de puntos y los mapas con categor&#237;as de consumo&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">En el per&#237;odo 2000-2005 el consumo de los AINE creci&#243; un 48&#37; y el coste anual se increment&#243; un 184&#37;&#46; Los medicamentos de mayor consumo y participaci&#243;n en el gasto fueron sulindaco e indometacina&#46; El consumo de los AINE vari&#243; entre 0&#44;1 y 60&#44;39 DHD seg&#250;n las &#225;reas de salud&#44; con un CVw del 66&#44;38&#37;&#46; Los medicamento con mayor variabilidad fueron penicilamina &#40;CVw del 449&#44;89&#37;&#41; y tenoxican &#40;CVw del 315&#44;26&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Hay un patr&#243;n geogr&#225;fico diferenciado en el consumo de AINE en el pa&#237;s&#44; y tasas muy diferentes dentro de una misma regi&#243;n&#46; Dos posibles factores asociados a esta variabilidad&#44; seg&#250;n los resultados obtenidos&#44; son la oferta de servicios m&#233;dicos y el porcentaje de poblaci&#243;n mayor de 65 a&#241;os adscrita al &#225;rea de salud&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To determine changing patterns and variability in consumption of classic nonsteroidal anti-inflammatory drugs &#40;NSAIDs&#41; among the health areas in Costa Rica between 2000 and 2005&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">The drugs studied were ibuprofen&#44; indomethacin&#44; penicillamine&#44; sulindac&#44; tenoxicam&#44; and diclofenac sodium&#46; To measure consumption&#44; we used the defined daily dose per 1&#44;000 inhabitants per day &#40;DID&#41;&#46; To analyze variability&#44; the coefficient of variation weighed by the population size &#40;CVw&#41;&#44; extremal ratio&#44; interquartile ratio&#44; dot plot and map graphs were used&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">From 2000-2005&#44; NSAID consumption increased by 48&#37; and the annual cost rose by 184&#37;&#46; The drugs with greatest consumption and participation in cost were sulindac and indomethacin&#46; NSAID consumption varied between 0&#46;1 and 61&#46;8 DID according to health areas&#44; with a CVw of 66&#46;8&#37;&#46; Variability was greatest with penicillamine &#40;CVw<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>449&#46;89&#37;&#41; and tenoxicam &#40;CVw<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>315&#46;26&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Clearly differentiated geographical patterns in NSAID consumption were found in Costa Rica&#44; with very different rates within the same region&#46; According to the results obtained&#44; two factors associated with this variability were the supply of health services and the percentage of the population aged 65 years or more within the catchment area&#46;</p>"
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Originales
Consumo de antiinflamatorios no esteroideos en atención primaria en Costa Rica: evolución y variabilidad geográfica
Consumption of nonsteroidal anti-inflammatory agents in primary care in Costa Rica: changing patterns and geographical variability
Melvin Morera Salasa, Amada Aparicio Llanosa, Yanira Xirinachs Salazarb,
Autor para correspondencia
yxirinac@cariari.ucr.ac.ur

Correspondencia: Yarina Xirinachs Salazar. Apartado de correos 332-1000. San José. Costa Rica.
, Patricia Barber Pérezc
a Caja Costarricense de Seguro Social y Proyecto de Investigación en Farmacoeconomía, Universidad de Costa Rica, Costa Rica
b Proyecto de Investigación en Farmacoeconomía, Centro Centroamericano de Población, Posgrado en Economía, Universidad de Costa Rica, Costa Rica
c Departamento de Métodos Cuantitativos, Universidad de Las Palmas Gran Canaria, Las Palmas Gran Canaria, España
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            0 => "Antiinflamatorios no esteroideos"
            1 => "Variabilidad en la pr&#225;ctica m&#233;dica"
            2 => "Dosis diarias definidas por 1&#46;000 habitantes y d&#237;a"
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            4 => "Econom&#237;a de la salud"
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            0 => "Nonsteroidal anti-inflammatory drugs"
            1 => "Variations in physician practice"
            2 => "Defined daily dose per 1&#44;000 inhabitants per day"
            3 => "Pharmacoeconomics"
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        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Conocer la evoluci&#243;n y la variabilidad en el consumo de los antiinflamarios no esteroideos cl&#225;sicos &#40;AINE&#41; en las &#225;reas de salud de Costa Rica durante el per&#237;odo 2000-2005&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudiaron los siguientes medicamentos&#58; ibuprofeno&#44; indometacina&#44; penicilamina&#44; sulindaco&#44; tenoxican y diclofenaco s&#243;dico&#46; Se utiliz&#243; como medida de consumo la dosis diaria definida por 1&#46;000 habitantes y d&#237;a &#40;DHD&#41;&#44; y en el an&#225;lisis de variabilidad el coeficiente de variaci&#243;n ponderado por el tama&#241;o de poblaci&#243;n &#40;CVw&#41;&#44; el rango extremo&#44; el rango interpercentil&#44; los gr&#225;ficos de puntos y los mapas con categor&#237;as de consumo&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">En el per&#237;odo 2000-2005 el consumo de los AINE creci&#243; un 48&#37; y el coste anual se increment&#243; un 184&#37;&#46; Los medicamentos de mayor consumo y participaci&#243;n en el gasto fueron sulindaco e indometacina&#46; El consumo de los AINE vari&#243; entre 0&#44;1 y 60&#44;39 DHD seg&#250;n las &#225;reas de salud&#44; con un CVw del 66&#44;38&#37;&#46; Los medicamento con mayor variabilidad fueron penicilamina &#40;CVw del 449&#44;89&#37;&#41; y tenoxican &#40;CVw del 315&#44;26&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Hay un patr&#243;n geogr&#225;fico diferenciado en el consumo de AINE en el pa&#237;s&#44; y tasas muy diferentes dentro de una misma regi&#243;n&#46; Dos posibles factores asociados a esta variabilidad&#44; seg&#250;n los resultados obtenidos&#44; son la oferta de servicios m&#233;dicos y el porcentaje de poblaci&#243;n mayor de 65 a&#241;os adscrita al &#225;rea de salud&#46;</p>"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To determine changing patterns and variability in consumption of classic nonsteroidal anti-inflammatory drugs &#40;NSAIDs&#41; among the health areas in Costa Rica between 2000 and 2005&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">The drugs studied were ibuprofen&#44; indomethacin&#44; penicillamine&#44; sulindac&#44; tenoxicam&#44; and diclofenac sodium&#46; To measure consumption&#44; we used the defined daily dose per 1&#44;000 inhabitants per day &#40;DID&#41;&#46; To analyze variability&#44; the coefficient of variation weighed by the population size &#40;CVw&#41;&#44; extremal ratio&#44; interquartile ratio&#44; dot plot and map graphs were used&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">From 2000-2005&#44; NSAID consumption increased by 48&#37; and the annual cost rose by 184&#37;&#46; The drugs with greatest consumption and participation in cost were sulindac and indomethacin&#46; NSAID consumption varied between 0&#46;1 and 61&#46;8 DID according to health areas&#44; with a CVw of 66&#46;8&#37;&#46; Variability was greatest with penicillamine &#40;CVw<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>449&#46;89&#37;&#41; and tenoxicam &#40;CVw<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>315&#46;26&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Clearly differentiated geographical patterns in NSAID consumption were found in Costa Rica&#44; with very different rates within the same region&#46; According to the results obtained&#44; two factors associated with this variability were the supply of health services and the percentage of the population aged 65 years or more within the catchment area&#46;</p>"
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                  "referenciaCompleta" => "Wennberg J&#44; Wennberg D&#46; Practice variations and the use of prescription drugs&#46; En&#58; Dartmounth Atlas of Health Care in Michigan&#46; Detroit&#58; Blue Cross&#44; Blue Shield of Michigan and Blue Care Network&#59; 2000&#46; Disponible en&#58; <a class="elsevierStyleInterRef" href="http://www.bcbsm.com/atlas/pdf/practice.pdf%23search=">http&#58;&#47;&#47;www&#46;bcbsm&#46;com&#47;atlas&#47;pdf&#47;practice&#46;pdf&#35;search&#61;</a>&#8217;practice variations and the use of prescription drugs&#8217;"
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                    0 => array:2 [
                      "titulo" => "Association between nonsteroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding&#47;perforation&#46; An overview of epidemiologic studies published in the 1990s"
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                  "referenciaCompleta" => "Bandolier editors&#46; More on NSAID adverse effects&#46; Bandolier&#46; 2000&#59;79&#58;6-8&#46; Disponible en&#58; <a class="elsevierStyleInterRef" href="http://bandolier/band79/b79-6.html">http&#58;&#47;&#47;bandolier&#47;band79&#47;b79-6&#46;html</a>"
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                  "referenciaCompleta" => "Centro de Informaci&#243;n Toxicol&#243;gica y de Medicamentos de la Facultad de Medicina de la Pontificia Universidad Cat&#243;lica de Chile&#46; Memoria 2004&#46; Santiago de Chile&#58; CITUC&#59; 2004&#46;"
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                      "titulo" => "ABC of the upper gastrointestinal tract&#58; indigestion and non-steroidal anti-inflammatory drugs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                            0 => "J&#46;M&#46; Seager"
                            1 => "C&#46;J&#46; Hawkey"
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                      ]
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                      "Revista" => array:6 [
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                  "referenciaCompleta" => "IMS Health&#46; Intelligence&#46; 2005&#46; Report N&#46;&#176; 360&#46; Disponible en&#58; <a class="elsevierStyleInterRef" href="http://www.imshealth.com/vgn/images/portal/CIT_40000873/3/5%20/81567513i360_final.pdf">http&#58;&#47;&#47;www&#46;imshealth&#46;com&#47;vgn&#47;images&#47;portal&#47;CIT&#95;40000873&#47;3&#47;5 &#47;81567513i360&#95;final&#46;pdf</a>"
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                      "titulo" => "Guidelines for ATC classification and DDD assignment"
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                        0 => array:3 [
                          "colaboracion" => "por el grupo VPMIRYSS"
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                          "etal" => false
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Información del artículo
ISSN: 02139111
Idioma original: Español
Datos actualizados diariamente
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Idiomas
Gaceta Sanitaria
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?