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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Seleccionar y estudiar la aceptabilidad&#44; en t&#233;rminos de relevancia y pertinencia&#44; de ciertas situaciones cl&#237;nicas que puedan usarse como indicadores de riesgo de morbilidad prevenible causada por medicamentos y que sean utilizables en las farmacias comunitarias&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todo</span><p class="elsevierStyleSimplePara elsevierViewall">M&#233;todo Delphi&#44; en 2 rondas&#44; con un panel de 14 expertos m&#233;dicos y farmac&#233;uticos que valoraron la relevancia y pertinencia de 68 tipos de situaciones cl&#237;nicas como indicadores de morbilidad potencial relacionada con medicamentos&#44; detectable por el profesional en su medio&#44; con evidencia cient&#237;fica de resultado adverso previsible&#44; frecuentes en el medio ambulatorio y con causa y resultado controlables&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se consideraron utilizables y pertinentes 43 de los 68 indicadores estudiados&#44; que se refer&#237;an a 3 &#225;mbitos&#58; tipo de medicamento &#40;medicamentos de estrecho margen terap&#233;utico&#44; con dosis individualizada y con reacciones adversas frecuentes y graves&#41;&#44; problema de salud &#40;problemas cr&#243;nicos&#44; especialmente asma&#44; enfermedad card&#237;aca&#44; tiroidea&#44; prost&#225;tica y dolor&#41; y tipo de paciente &#40;ancianos y&#47;o polimedicados&#41;&#46; Los farmac&#233;uticos sobrevaloraron sistem&#225;ticamente ciertos indicadores en relaci&#243;n con los m&#233;dicos&#44; aunque las diferencias no fueron significativas&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Se identificaron 43 indicadores de morbilidad potencial relacionada con los medicamentos e identificables por los profesionales en su entorno&#46;</p>"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To select clinical situations that can be used as risk indicators of preventable morbidity caused by drugs at the community pharmacies&#44; and to study their acceptability&#44; in terms of pertinence and relevance&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We used the Delphi technique&#44; in 2 rounds&#44; by a panel of 14 medical doctors and pharmacists experts&#44; to study the relevance of 68 types of clinical situations as risk indicators of preventable morbidity related to drug utilization used by health professionals in community pharmacies&#44; with scientific evidence of foreseeable adverse result&#44; frequent situations in ambulatory care and with controllable cause and result&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">43 of the 68 indicators were considered usable and pertinent&#46; The indicators referred three areas&#58; drug type &#40;medications of narrow therapeutic margin&#44; with individualized dose and adverse reactions frequent and severe&#41;&#44; health problem &#40;chronic problems&#44; especially asthma&#44; cardiac&#44; thyroid and prostate illness&#44; and pain&#41;&#44; and patient &#40;old or with several medications&#46; Pharmacists systematically overvalued some indicators in relation to the doctors&#44; but differences were not significant&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Forty-three indicators were selected as valuable to identify situations of preventable morbidity related to drug utilization&#46;</p>"
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Indicadores de riesgo de morbilidad prevenible causada por medicamentos
Risk indicators of preventable morbidity related to drug utilization
Ana Dago Martíneza, Pedro Arcos Gonzáleza,
Autor para correspondencia
arcos@uniovi.es

Correspondencia: Pedro Arcos González. Departamento de Medicina. Universidad de Oviedo. Campus del Cristo. 33006 Oviedo. España.
, Flor Álvarez de Toledo Saavedraa, María Isabel Baena Parejob, José Martínez Olmosb, Íñigo Gorostiza Ormaetxec
a Área de Medicina Preventiva y Salud Pública, Departamento de Medicina, Universidad de Oviedo, Oviedo, España
b Grupo de investigación de Atención Farmacéutica, Universidad de Granada, Granada, España
c Red Española de Atención Primaria, Madrid, España
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Seleccionar y estudiar la aceptabilidad&#44; en t&#233;rminos de relevancia y pertinencia&#44; de ciertas situaciones cl&#237;nicas que puedan usarse como indicadores de riesgo de morbilidad prevenible causada por medicamentos y que sean utilizables en las farmacias comunitarias&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todo</span><p class="elsevierStyleSimplePara elsevierViewall">M&#233;todo Delphi&#44; en 2 rondas&#44; con un panel de 14 expertos m&#233;dicos y farmac&#233;uticos que valoraron la relevancia y pertinencia de 68 tipos de situaciones cl&#237;nicas como indicadores de morbilidad potencial relacionada con medicamentos&#44; detectable por el profesional en su medio&#44; con evidencia cient&#237;fica de resultado adverso previsible&#44; frecuentes en el medio ambulatorio y con causa y resultado controlables&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se consideraron utilizables y pertinentes 43 de los 68 indicadores estudiados&#44; que se refer&#237;an a 3 &#225;mbitos&#58; tipo de medicamento &#40;medicamentos de estrecho margen terap&#233;utico&#44; con dosis individualizada y con reacciones adversas frecuentes y graves&#41;&#44; problema de salud &#40;problemas cr&#243;nicos&#44; especialmente asma&#44; enfermedad card&#237;aca&#44; tiroidea&#44; prost&#225;tica y dolor&#41; y tipo de paciente &#40;ancianos y&#47;o polimedicados&#41;&#46; Los farmac&#233;uticos sobrevaloraron sistem&#225;ticamente ciertos indicadores en relaci&#243;n con los m&#233;dicos&#44; aunque las diferencias no fueron significativas&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Se identificaron 43 indicadores de morbilidad potencial relacionada con los medicamentos e identificables por los profesionales en su entorno&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To select clinical situations that can be used as risk indicators of preventable morbidity caused by drugs at the community pharmacies&#44; and to study their acceptability&#44; in terms of pertinence and relevance&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We used the Delphi technique&#44; in 2 rounds&#44; by a panel of 14 medical doctors and pharmacists experts&#44; to study the relevance of 68 types of clinical situations as risk indicators of preventable morbidity related to drug utilization used by health professionals in community pharmacies&#44; with scientific evidence of foreseeable adverse result&#44; frequent situations in ambulatory care and with controllable cause and result&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">43 of the 68 indicators were considered usable and pertinent&#46; The indicators referred three areas&#58; drug type &#40;medications of narrow therapeutic margin&#44; with individualized dose and adverse reactions frequent and severe&#41;&#44; health problem &#40;chronic problems&#44; especially asthma&#44; cardiac&#44; thyroid and prostate illness&#44; and pain&#41;&#44; and patient &#40;old or with several medications&#46; Pharmacists systematically overvalued some indicators in relation to the doctors&#44; but differences were not significant&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Forty-three indicators were selected as valuable to identify situations of preventable morbidity related to drug utilization&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
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        0 => array:1 [
          "bibliografiaReferencia" => array:35 [
            0 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
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            1 => array:3 [
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                      "autores" => array:1 [
                        0 => array:2 [
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                            0 => "L&#46; Tuneu Valls"
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            ]
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                      "autores" => array:1 [
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                      "autores" => array:1 [
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                        0 => array:2 [
                          "etal" => false
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                        0 => array:2 [
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                          ]
                        ]
                      ]
                    ]
                  ]
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                        0 => array:2 [
                          "etal" => false
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                        0 => array:2 [
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                        "fecha" => "1999"
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                      ]
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                ]
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                ]
              ]
            ]
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              "etiqueta" => "14&#46;"
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                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Comit&#233; de Consenso"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
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                    0 => array:1 [
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                        "fecha" => "2002"
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                            1 => "B&#46; Bosc&#225;"
                            2 => "M&#46;D&#46; San Mart&#237;n"
                            3 => "J&#46; Borr&#225;s"
                            4 => "A&#46; D&#237;ez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pharm Care Espa&#241;a"
                        "fecha" => "2002"
                        "volumen" => "4"
                        "paginaInicial" => "286"
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
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              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ingresos hospitalarios causados por medicamentos&#58; incidencia&#44; caracter&#237;sticas y coste"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Alonso"
                            1 => "M&#46;J&#46; Otero"
                            2 => "J&#46;A&#46; Maderuelo"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Farm Hosp"
                        "fecha" => "2002"
                        "volumen" => "26"
                        "paginaInicial" => "76"
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                      ]
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                  ]
                ]
              ]
            ]
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              "etiqueta" => "17&#46;"
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
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                            0 => "R&#46; Rascheti"
                            1 => "M&#46; Morgutti"
                            2 => "F&#46; Mennti-Ippolito"
                            3 => "A&#46; Belisari"
                            4 => "A&#46; Rossignoli"
                            5 => "P&#46; Longini"
                          ]
                        ]
                      ]
                    ]
                  ]
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                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
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              "etiqueta" => "18&#46;"
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                            0 => "M&#46;J&#46; Otero"
                            1 => "A&#46; Bajo"
                            2 => "J&#46;A&#46; Maderuelo"
                            3 => "A&#46; Dom&#237;nguez-Gil"
                          ]
                        ]
                      ]
                    ]
                  ]
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