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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estimar la carga de enfermedad de las afecciones inmunoprevenibles y describir su importancia relativa en la salud de la poblaci&#243;n infantil y juvenil espa&#241;ola&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La unidad de medida es a&#241;os de vida ajustados por discapacidad &#40;AVAD&#41;&#46; Los AVAD resultan de sumar las p&#233;rdidas de salud por muerte prematura &#40;AVP&#41; y las p&#233;rdidas de salud por discapacidad &#40;AVD&#41;&#46; Se ha estimado los AVAD de la poblaci&#243;n espa&#241;ola menor de 15 a&#241;os para 1999 desagregados por&#58; enfermedades seg&#250;n el sistema de clasificaci&#243;n de carga global de enfermedad &#40;adaptada al objetivo del estudio&#41;&#44; por grupos de edad y sexo&#46; Las enfermedades objeto del estudio son las incluidas en calendario vacunal infantil&#44; la varicela y la enfermedad neumoc&#243;cica&#46; Las fuentes consultadas son&#58; para el c&#225;lculo de AVP&#44; el registro de mortalidad nacional&#59; para el c&#225;lculo de AVD de las enfermedades inmunoprevenibles&#44; datos de la RENAVE&#44; CMBD y fuentes bibliogr&#225;ficas&#44; y para los AVD de las no inmunoprevenibles&#44; inferencia de las estimaciones de la OMS &#40;Euro-A&#41; y&#44; en su defecto&#44; a partir de datos de incidencia de la EMH&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La tasa de AVAD global es de 46&#44;57&#47;1&#46;000 habitantes&#44; y las enfermedades objeto del estudio representan el 1&#44;2&#37; del total de la carga de enfermedad&#58; las enfermedades incluidas en el calendario de vacunaciones representan&#44; seg&#250;n el grupo de edad&#44; entre el 0&#44;00 y el 0&#44;03&#37;&#44; excepto la infecci&#243;n meningoc&#243;cica &#40;entre el 0&#44;5 y el 3&#44;3&#37;&#41;&#46; La meningitis neumoc&#243;cica representa el 0&#44;06-0&#44;65&#37; y la varicela&#44; el 0&#44;00-0&#44;15&#37;&#44; seg&#250;n el grupo de edad&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La carga de enfermedad es un buen indicador para definir la salud de la poblaci&#243;n infantojuvenil espa&#241;ola&#44; ya que es una medida &#171;sint&#233;tica&#187; que integra informaci&#243;n sobre mortalidad&#44; morbilidad y discapacidad de las enfermedades&#46; Los AVAD atribuibles a las enfermedades inmunoprevenibles incluidas en el calendario nos permiten afirmar que los programas de vacunaci&#243;n han conseguido su objetivo&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To estimate the burden of disease due to vaccinable diseases and the relative importance of these diseases in the health of the Spanish population aged less than 15 years old&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Disease burden was measured in disability-adjusted life years &#40;DALYs&#41;&#46; DALYs were computed by adding years of life lost &#40;YLL&#41; to years lived with disability &#40;YLD&#41;&#46; The DALYs of the Spanish population aged less than 15 years old were estimated for 1999 and were stratified by diseases according to the classification system of the Global Burden of Disease &#40;adapted to the aim of the study&#41;&#44; age group and gender&#46; Diseases included in the childhood vaccination schedule&#44; varicella&#44; and pneumococcal disease were targeted for this study&#46; The sources used were&#58; the national mortality register to compute YLL&#44; the Epidemiologic Surveillance National Network&#44; hospital discharge data &#40;CMBD&#41; and the scientific literature to compute YLD due to vaccinable diseases&#44; and World Health Organization estimates &#40;Euro-A&#41; or&#44; when these were lacking&#44; morbidity hospital data &#40;Hospital Morbidity Survey&#41; to compute the YLD due to non-vaccinable diseases&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The burden of disease due to vaccinable diseases was 1&#46;2&#37; of global DALYS &#40;the overall DALYs rate was 46&#44;57&#47;1&#44;000 habitants&#41;&#58; excluding meningococcal disease &#40;0&#46;5&#37; to 3&#46;3&#37;&#41;&#44; diseases included in the vaccination schedule represented 0&#46;00&#37; to 0&#46;03&#37;&#44; depending on age groups&#44; except meningococcal infection &#40;between 0&#46;5&#37; and 3&#46;3&#37;&#41;&#46; Pneumococcal meningitis represented 0&#46;06&#37; to 0&#46;65&#37; and varicella 0&#46;00&#37; to 0&#46;15&#37;&#44; also depending on age groups&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Disease burden due to vaccinable diseases is a good indicator of the health of the young population in Spain&#46; This measure summarizes and combines information on mortality&#44; morbidity and disability caused by diseases&#46; The DALYs attributable to diseases included in the vaccination schedule demonstrate that immunization programs have achieved their goals&#46;</p>"
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Carga de enfermedad atribuible a las afecciones inmunoprevenibles en la población infantojuvenil española
Disease burden due to vaccinable diseases in the Spanish population aged less than 15 years old
Marta Cortés
Autor para correspondencia
marta.sa@tiscali.es

Correspondencia: Sinesio Delgado, 6. Madrid. España.
, Joaquín Pereira, Isabel Peña-Rey, Ricard Génova, Carmen Amela
Centro Nacional de Epidemiología (CNE). Instituto de Salud Carlos III. Madrid. España
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estimar la carga de enfermedad de las afecciones inmunoprevenibles y describir su importancia relativa en la salud de la poblaci&#243;n infantil y juvenil espa&#241;ola&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La unidad de medida es a&#241;os de vida ajustados por discapacidad &#40;AVAD&#41;&#46; Los AVAD resultan de sumar las p&#233;rdidas de salud por muerte prematura &#40;AVP&#41; y las p&#233;rdidas de salud por discapacidad &#40;AVD&#41;&#46; Se ha estimado los AVAD de la poblaci&#243;n espa&#241;ola menor de 15 a&#241;os para 1999 desagregados por&#58; enfermedades seg&#250;n el sistema de clasificaci&#243;n de carga global de enfermedad &#40;adaptada al objetivo del estudio&#41;&#44; por grupos de edad y sexo&#46; Las enfermedades objeto del estudio son las incluidas en calendario vacunal infantil&#44; la varicela y la enfermedad neumoc&#243;cica&#46; Las fuentes consultadas son&#58; para el c&#225;lculo de AVP&#44; el registro de mortalidad nacional&#59; para el c&#225;lculo de AVD de las enfermedades inmunoprevenibles&#44; datos de la RENAVE&#44; CMBD y fuentes bibliogr&#225;ficas&#44; y para los AVD de las no inmunoprevenibles&#44; inferencia de las estimaciones de la OMS &#40;Euro-A&#41; y&#44; en su defecto&#44; a partir de datos de incidencia de la EMH&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La tasa de AVAD global es de 46&#44;57&#47;1&#46;000 habitantes&#44; y las enfermedades objeto del estudio representan el 1&#44;2&#37; del total de la carga de enfermedad&#58; las enfermedades incluidas en el calendario de vacunaciones representan&#44; seg&#250;n el grupo de edad&#44; entre el 0&#44;00 y el 0&#44;03&#37;&#44; excepto la infecci&#243;n meningoc&#243;cica &#40;entre el 0&#44;5 y el 3&#44;3&#37;&#41;&#46; La meningitis neumoc&#243;cica representa el 0&#44;06-0&#44;65&#37; y la varicela&#44; el 0&#44;00-0&#44;15&#37;&#44; seg&#250;n el grupo de edad&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La carga de enfermedad es un buen indicador para definir la salud de la poblaci&#243;n infantojuvenil espa&#241;ola&#44; ya que es una medida &#171;sint&#233;tica&#187; que integra informaci&#243;n sobre mortalidad&#44; morbilidad y discapacidad de las enfermedades&#46; Los AVAD atribuibles a las enfermedades inmunoprevenibles incluidas en el calendario nos permiten afirmar que los programas de vacunaci&#243;n han conseguido su objetivo&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To estimate the burden of disease due to vaccinable diseases and the relative importance of these diseases in the health of the Spanish population aged less than 15 years old&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Disease burden was measured in disability-adjusted life years &#40;DALYs&#41;&#46; DALYs were computed by adding years of life lost &#40;YLL&#41; to years lived with disability &#40;YLD&#41;&#46; The DALYs of the Spanish population aged less than 15 years old were estimated for 1999 and were stratified by diseases according to the classification system of the Global Burden of Disease &#40;adapted to the aim of the study&#41;&#44; age group and gender&#46; Diseases included in the childhood vaccination schedule&#44; varicella&#44; and pneumococcal disease were targeted for this study&#46; The sources used were&#58; the national mortality register to compute YLL&#44; the Epidemiologic Surveillance National Network&#44; hospital discharge data &#40;CMBD&#41; and the scientific literature to compute YLD due to vaccinable diseases&#44; and World Health Organization estimates &#40;Euro-A&#41; or&#44; when these were lacking&#44; morbidity hospital data &#40;Hospital Morbidity Survey&#41; to compute the YLD due to non-vaccinable diseases&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The burden of disease due to vaccinable diseases was 1&#46;2&#37; of global DALYS &#40;the overall DALYs rate was 46&#44;57&#47;1&#44;000 habitants&#41;&#58; excluding meningococcal disease &#40;0&#46;5&#37; to 3&#46;3&#37;&#41;&#44; diseases included in the vaccination schedule represented 0&#46;00&#37; to 0&#46;03&#37;&#44; depending on age groups&#44; except meningococcal infection &#40;between 0&#46;5&#37; and 3&#46;3&#37;&#41;&#46; Pneumococcal meningitis represented 0&#46;06&#37; to 0&#46;65&#37; and varicella 0&#46;00&#37; to 0&#46;15&#37;&#44; also depending on age groups&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Disease burden due to vaccinable diseases is a good indicator of the health of the young population in Spain&#46; This measure summarizes and combines information on mortality&#44; morbidity and disability caused by diseases&#46; The DALYs attributable to diseases included in the vaccination schedule demonstrate that immunization programs have achieved their goals&#46;</p>"
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2022 Octubre 25 43 68
2022 Septiembre 36 40 76
2022 Agosto 37 44 81
2022 Julio 24 36 60
2022 Junio 27 29 56
2022 Mayo 35 40 75
2022 Abril 21 32 53
2022 Marzo 31 35 66
2022 Febrero 33 36 69
2022 Enero 24 35 59
2021 Diciembre 33 39 72
2021 Noviembre 23 37 60
2021 Octubre 30 44 74
2021 Septiembre 35 44 79
2021 Agosto 21 27 48
2021 Julio 15 32 47
2021 Junio 25 33 58
2021 Mayo 26 25 51
2021 Abril 36 27 63
2021 Marzo 51 31 82
2021 Febrero 20 15 35
2021 Enero 22 24 46
2020 Diciembre 28 21 49
2020 Noviembre 18 11 29
2020 Octubre 23 19 42
2020 Septiembre 25 9 34
2020 Agosto 48 16 64
2020 Julio 36 11 47
2020 Junio 12 6 18
2020 Mayo 11 6 17
2020 Abril 20 15 35
2020 Marzo 7 3 10
2020 Febrero 16 19 35
2020 Enero 12 11 23
2019 Diciembre 21 26 47
2019 Noviembre 14 5 19
2019 Octubre 13 12 25
2019 Septiembre 9 6 15
2019 Agosto 11 9 20
2019 Julio 20 5 25
2019 Junio 8 7 15
2019 Mayo 10 13 23
2019 Abril 11 6 17
2019 Marzo 13 8 21
2019 Febrero 14 10 24
2019 Enero 6 8 14
2018 Diciembre 8 13 21
2018 Noviembre 22 9 31
2018 Octubre 32 15 47
2018 Septiembre 22 15 37
2018 Agosto 16 9 25
2018 Julio 24 9 33
2018 Junio 20 10 30
2018 Mayo 19 6 25
2018 Abril 16 7 23
2018 Marzo 18 10 28
2018 Febrero 10 5 15
2018 Enero 11 7 18
2017 Diciembre 12 5 17
2017 Noviembre 20 10 30
2017 Octubre 14 9 23
2017 Septiembre 16 11 27
2017 Agosto 13 8 21
2017 Julio 16 10 26
2017 Junio 27 21 48
2017 Mayo 29 11 40
2017 Abril 21 19 40
2017 Marzo 26 10 36
2017 Febrero 12 4 16
2017 Enero 7 4 11
2016 Diciembre 24 3 27
2016 Noviembre 30 7 37
2016 Octubre 23 13 36
2016 Septiembre 20 10 30
2016 Agosto 19 6 25
2016 Julio 15 4 19
2016 Junio 0 12 12
2016 Mayo 0 7 7
2016 Abril 1 0 1
2016 Marzo 1 0 1
2016 Febrero 1 0 1
2016 Enero 0 5 5
2015 Diciembre 2 11 13
2015 Noviembre 1 0 1
2015 Octubre 1 13 14
2015 Septiembre 1 11 12
2015 Agosto 3 0 3
2015 Julio 2 7 9
2015 Junio 2 0 2
2015 Mayo 3 1 4
2015 Abril 3 0 3
2015 Marzo 1 0 1
2015 Febrero 2 2 4
2015 Enero 1 4 5
2014 Diciembre 4 1 5
2014 Noviembre 5 1 6
2014 Octubre 6 2 8
2014 Septiembre 6 4 10
2014 Agosto 20 4 24
2014 Julio 21 4 25
2014 Junio 22 3 25
2014 Mayo 21 4 25
2014 Abril 14 2 16
2014 Marzo 6 2 8
2014 Febrero 14 1 15
2014 Enero 17 0 17
2013 Diciembre 11 3 14
2013 Noviembre 24 3 27
2013 Octubre 61 5 66
2013 Septiembre 21 3 24
2013 Agosto 51 3 54
2013 Julio 23 3 26
2004 Junio 1171 0 1171
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