Enfermedad neumocócica invasiva en la población infantil de la Comunidad Valenciana
Invasive pneumococcal disease in children in the Community of Valencia, Spain
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Bueno-Cañigral" "autores" => array:6 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Goicoechea-Sáez" "email" => array:1 [ 0 => "mergoico@terra.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "A.M." "apellidos" => "Fullana-Montoro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "P." "apellidos" => "Momparler-Carrasco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "M.J." "apellidos" => "Redondo-Gallego" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "J." "apellidos" => "Brines-Solanes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "F.J." "apellidos" => "Bueno-Cañigral" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Salud Infantil y de la Mujer. Dirección General para la Salud Pública. Conselleria de Sanitat de la Comunidad Valenciana. Valencia" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Pediatría. Hospital Clínico Universitario de Valencia. Valencia" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Concejalía de Sanidad y Consumo. Ayuntamiento de Valencia. Valencia. España" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Pl. Poeta Eduardo Marquina, 4, pta. 20.<span class="elsevierStyleSup">a</span>. 46014 Valencia. España." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Invasive pneumococcal disease in children in the Community of Valencia, Spain" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2002-11-22" "fechaAceptado" => "2003-09-01" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec268685" "palabras" => array:2 [ 0 => "<span class="elsevierStyleItalic">Streptococcus pneumoniae</span>" 1 => "Enfermedad in" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec268686" "palabras" => array:5 [ 0 => "<span class="elsevierStyleItalic">Streptococcus pneumoniae</span>" 1 => "Invasive disease" 2 => "Infant" 3 => "Incidence" 4 => "Mortality" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La enfermedad neumocócica es una causa frecuente de morbilidad y mortalidad entre la población infantil. La reciente autorización de la vacuna conjugada heptavalente ha incrementado el interés científico que suscita esta enfermedad. El objetivo de este estudio es conocer las características epidemiológicas y clínicas, así como la evolución de esta enfermedad invasiva en la población infantil de la Comunidad Valenciana.</p> <span class="elsevierStyleSectionTitle">Método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Los datos se han obtenido de las historias clínicas de los niños menores de 15 años, con aislamiento del neumococo, atendidos en todos los hospitales públicos de la Comunidad Valenciana durante el período 1996-2000. La evolución de la incidencia se valoró mediante la comparación de tasas, los signos clínicos y su evolución (secuelas y letalidad) mediante la evaluación de la frecuencia y su distribución por edades.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se registró un total de 127 casos, lo que representa un promedio de tasa anual de 3,89/105 habitantes en los menores de 15 años y de 20,14 en los menores de 2 años. Presentaron antecedentes de problemas de salud un 29,1% de los pacientes. Las manifestaciones clínicas predominantes fueron sepsis/bacteriemia (38%), neumonía (31%) y meningitis (24%). Al alta, presentaban secuelas 10 niños, de los que el 75% eran menores de 2 años. Fallecieron 8 niños (letalidad del 6,3%).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En nuestro medio, durante el período estudiado, la infección neumocócica se presenta sobre todo en los niños menores de 2 años, así como en los mayores de esta edad con antecedentes de problemas de salud. En estos últimos se ha encontrado una mayor mortalidad. Sería conveniente introducir la enfermedad neumocócica en el Sistema de Vigilancia Epidemiológica, lo que nos permitiría disponer de estimaciones más precisas de su evolución epidemiológica y valorar si la vacuna conjugada es la solución a los problemas que plantea esta bacteria en la actualidad.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Pneumococcal disease is an important cause of morbidity and mortality in children. The recent authorization of the heptavalent conjugate vaccine has increased interest in this disease. The objective of this study was to identify the epidemiological and clinical characteristics of this disease, as well as its outcome in the pediatric population of the Autonomous Community of Valencia.</p> <span class="elsevierStyleSectionTitle">Method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Data were obtained from the medical records of children aged less than 15 years who were positive for pneumococcus isolation on admission to hospital between 1996 and 2000. All the public hospitals of the Autonomous Community of Valencia were included. Changes in incidence were evaluated by comparing rates and outcomes (sequelae and lethality) through frequency and age distribution.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">One hundred twenty-seven cases were registered, giving a mean annual rate of 3.89/105 inhabitants aged less than 15 years. The rate was 20.14 in children aged less than 2 years. A total of 29.1% of the children had previous health problems. The main clinical manifestations included sepsis/ bacteremia (38%), pneumonia (31%) and meningitis (24%). At discharge sequelae were present in 10 children, 75% of whom were aged less than 2 years. Eight children died (6.3% lethality).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In the period and region studied, pneumococcal infection was present mainly in children aged less than 2 years and in those with previous health problems. In the last few years, mortality has increased. Thus, inclusion of pneumococcal disease in the epidemiological surveillance system would be appropriate to achieve more precise estimations of its epidemiological patterns and to determine whether the conjugate vaccine represents a solution to the problems currently associated with this bacteria.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:36 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 4 | 3 | 7 |
| 2024 Octubre | 56 | 38 | 94 |
| 2024 Septiembre | 49 | 19 | 68 |
| 2024 Agosto | 48 | 28 | 76 |
| 2024 Julio | 47 | 22 | 69 |
| 2024 Junio | 36 | 17 | 53 |
| 2024 Mayo | 75 | 24 | 99 |
| 2024 Abril | 26 | 9 | 35 |
| 2024 Marzo | 41 | 25 | 66 |
| 2024 Febrero | 37 | 43 | 80 |
| 2024 Enero | 22 | 18 | 40 |
| 2023 Diciembre | 58 | 17 | 75 |
| 2023 Noviembre | 25 | 12 | 37 |
| 2023 Octubre | 23 | 19 | 42 |
| 2023 Septiembre | 27 | 15 | 42 |
| 2023 Agosto | 22 | 9 | 31 |
| 2023 Julio | 41 | 24 | 65 |
| 2023 Junio | 35 | 28 | 63 |
| 2023 Mayo | 28 | 8 | 36 |
| 2023 Abril | 30 | 15 | 45 |
| 2023 Marzo | 41 | 36 | 77 |
| 2023 Febrero | 29 | 18 | 47 |
| 2023 Enero | 30 | 13 | 43 |
| 2022 Diciembre | 29 | 30 | 59 |
| 2022 Noviembre | 43 | 48 | 91 |
| 2022 Octubre | 26 | 24 | 50 |
| 2022 Septiembre | 24 | 32 | 56 |
| 2022 Agosto | 39 | 48 | 87 |
| 2022 Julio | 25 | 42 | 67 |
| 2022 Junio | 19 | 40 | 59 |
| 2022 Mayo | 27 | 47 | 74 |
| 2022 Abril | 26 | 26 | 52 |
| 2022 Marzo | 22 | 40 | 62 |
| 2022 Febrero | 25 | 25 | 50 |
| 2022 Enero | 19 | 39 | 58 |
| 2021 Diciembre | 22 | 30 | 52 |
| 2021 Noviembre | 30 | 37 | 67 |
| 2021 Octubre | 21 | 38 | 59 |
| 2021 Septiembre | 22 | 38 | 60 |
| 2021 Agosto | 12 | 34 | 46 |
| 2021 Julio | 22 | 25 | 47 |
| 2021 Junio | 21 | 30 | 51 |
| 2021 Mayo | 12 | 32 | 44 |
| 2021 Abril | 66 | 29 | 95 |
| 2021 Marzo | 26 | 28 | 54 |
| 2021 Febrero | 21 | 18 | 39 |
| 2021 Enero | 17 | 20 | 37 |
| 2020 Diciembre | 20 | 18 | 38 |
| 2020 Noviembre | 21 | 20 | 41 |
| 2020 Octubre | 22 | 14 | 36 |
| 2020 Septiembre | 14 | 15 | 29 |
| 2020 Agosto | 12 | 18 | 30 |
| 2020 Julio | 18 | 12 | 30 |
| 2020 Junio | 11 | 17 | 28 |
| 2020 Mayo | 10 | 14 | 24 |
| 2020 Abril | 15 | 14 | 29 |
| 2020 Marzo | 14 | 12 | 26 |
| 2020 Febrero | 12 | 15 | 27 |
| 2020 Enero | 17 | 20 | 37 |
| 2019 Diciembre | 17 | 14 | 31 |
| 2019 Noviembre | 11 | 13 | 24 |
| 2019 Octubre | 16 | 3 | 19 |
| 2019 Septiembre | 12 | 5 | 17 |
| 2019 Agosto | 14 | 9 | 23 |
| 2019 Julio | 7 | 7 | 14 |
| 2019 Junio | 3 | 8 | 11 |
| 2019 Mayo | 11 | 9 | 20 |
| 2019 Abril | 8 | 17 | 25 |
| 2019 Marzo | 4 | 8 | 12 |
| 2019 Febrero | 7 | 7 | 14 |
| 2019 Enero | 0 | 5 | 5 |
| 2018 Diciembre | 0 | 10 | 10 |
| 2018 Noviembre | 11 | 14 | 25 |
| 2018 Octubre | 32 | 24 | 56 |
| 2018 Septiembre | 12 | 18 | 30 |
| 2018 Agosto | 19 | 11 | 30 |
| 2018 Julio | 24 | 11 | 35 |
| 2018 Junio | 20 | 8 | 28 |
| 2018 Mayo | 28 | 11 | 39 |
| 2018 Abril | 19 | 6 | 25 |
| 2018 Marzo | 10 | 6 | 16 |
| 2018 Febrero | 13 | 7 | 20 |
| 2018 Enero | 11 | 2 | 13 |
| 2017 Diciembre | 19 | 11 | 30 |
| 2017 Noviembre | 14 | 8 | 22 |
| 2017 Octubre | 8 | 12 | 20 |
| 2017 Septiembre | 13 | 14 | 27 |
| 2017 Agosto | 10 | 10 | 20 |
| 2017 Julio | 20 | 13 | 33 |
| 2017 Junio | 18 | 11 | 29 |
| 2017 Mayo | 20 | 6 | 26 |
| 2017 Abril | 32 | 12 | 44 |
| 2017 Marzo | 13 | 8 | 21 |
| 2017 Febrero | 4 | 5 | 9 |
| 2017 Enero | 10 | 5 | 15 |
| 2016 Diciembre | 24 | 5 | 29 |
| 2016 Noviembre | 20 | 12 | 32 |
| 2016 Octubre | 26 | 11 | 37 |
| 2016 Septiembre | 23 | 6 | 29 |
| 2016 Agosto | 35 | 11 | 46 |
| 2016 Julio | 14 | 3 | 17 |
| 2016 Mayo | 2 | 0 | 2 |
| 2016 Abril | 1 | 0 | 1 |
| 2016 Marzo | 1 | 0 | 1 |
| 2016 Febrero | 3 | 0 | 3 |
| 2015 Diciembre | 1 | 0 | 1 |
| 2015 Noviembre | 3 | 0 | 3 |
| 2015 Octubre | 3 | 0 | 3 |
| 2015 Agosto | 1 | 0 | 1 |
| 2015 Julio | 5 | 0 | 5 |
| 2015 Junio | 3 | 0 | 3 |
| 2015 Mayo | 6 | 0 | 6 |
| 2015 Abril | 2 | 0 | 2 |
| 2015 Febrero | 3 | 0 | 3 |
| 2015 Enero | 2 | 0 | 2 |
| 2014 Diciembre | 6 | 0 | 6 |
| 2014 Noviembre | 7 | 0 | 7 |
| 2014 Octubre | 10 | 0 | 10 |
| 2014 Septiembre | 8 | 1 | 9 |
| 2014 Agosto | 12 | 0 | 12 |
| 2014 Julio | 16 | 1 | 17 |
| 2014 Junio | 6 | 1 | 7 |
| 2014 Mayo | 10 | 1 | 11 |
| 2014 Abril | 8 | 1 | 9 |
| 2014 Marzo | 8 | 0 | 8 |
| 2014 Febrero | 15 | 1 | 16 |
| 2014 Enero | 8 | 2 | 10 |
| 2013 Diciembre | 8 | 1 | 9 |
| 2013 Noviembre | 28 | 4 | 32 |
| 2013 Octubre | 31 | 4 | 35 |
| 2013 Septiembre | 20 | 2 | 22 |
| 2013 Agosto | 30 | 3 | 33 |
| 2013 Julio | 26 | 0 | 26 |
| 2003 Noviembre | 814 | 0 | 814 |
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