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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La varicela es una enfermedad de distribuci&#243;n mundial con una elevada morbilidad y pocas complicaciones&#44; aunque puede presentar cuadros cl&#237;nicos graves en inmunodeprimidos y adultos sanos&#46; El objeto de este estudio es identificar y describir las caracter&#237;sticas y los costes de un brote epid&#233;mico en Extremadura&#44; cuya tasa anual de casos declarados al sistema de Enfermedades de Declaraci&#243;n Obligatoria &#40;EDO&#41; oscila en alrededor de 5 por 1&#46;000 habitantes&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio descriptivo con b&#250;squeda activa de casos entre los meses de noviembre del a&#241;o 2000 y marzo de 2001&#44; y de la susceptibilidad de la cohorte escolarizada del colegio de Herrera del Duque &#40;Badajoz&#41;&#46; Las definiciones de casos fueron recogidas de los protocolos de la Red de Vigilancia de la comunidad extreme&#241;a&#46; La confirmaci&#243;n microbiol&#243;gica se realiz&#243; por aislamiento del virus y por presencia de marcadores IgM e IgG en el suero del enfermo&#46; Se analizaron los costes tangibles directos e indirectos y los no tangibles del brote&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">De los 75 casos identificados&#44; 71 &#40;94&#44;7&#37;&#41; eran ni&#241;os de entre uno y 9 a&#241;os&#44; predominando el sexo masculino&#46; La tasa de ataque fue de 18&#44;5 casos por 1&#46;000 habitantes&#44; y del 68&#44;2&#37; en convivientes menores de 10 a&#241;os&#46; La evoluci&#243;n fue benigna&#44; sin ingresos hospitalarios ni complicaciones&#46; Se encontr&#243; un 71&#44;6&#37; de ni&#241;os susceptibles en los de entre 3 y 8 a&#241;os&#46; Se analiz&#243; una posible agregaci&#243;n temporal de casos en el colegio&#44; obteni&#233;ndose un riesgo relativo &#40;RR&#41; de 5&#44;01 &#40;p &#60; 0&#44;001&#41;&#46; Se aisl&#243; el virus en las 4 muestras de ves&#237;culas estudiadas y la serolog&#237;a &#40;IgM&#41; fue positiva en los 9 sueros estudiados&#46; El coste total de brote fue de 927&#44;21 e&#44; con una media de 12&#44;53 e por caso&#44; y 205 d&#237;as de p&#233;rdida escolar&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se confirm&#243; la existencia de un brote de varicela en el colegio de la localidad de Herrera del Duque&#44; con transmisi&#243;n persona a persona&#44; que afect&#243; a ni&#241;os de entre uno y 9 a&#241;os&#46; La elevada susceptibilidad del alumnado&#44; las caracter&#237;sticas de la docencia y las reuniones previas a los carnavales tuvieron un papel determinante en la propagaci&#243;n de la epidemia&#46;</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">El coste estimado para este brote se corresponde con un gasto un 76&#37; menor del producido por la vacunaci&#243;n con una dosis de los 75 casos de este brote&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Chickenpox is a worldwide disease with high morbidity but few complications&#44; although complications can be sevre in immunocompromised individuals and healthy adults&#46; The annual chickenpox rate declared to the National Notification Disease Surveillance System is approximately 5 cases per 1&#44;000 inhabitants in Extremadura &#40;Spain&#41;&#46; The aim of this study was to identify and describe the characteristics and cost of an epidemic outbreak of chickenpox in Extremadura&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Between November 2000 and March 2001&#44; a descriptive study was performed&#46; Cases of chickenpox were actively sought in a cohort of schoolchildren in Herrera del Duque &#40;Badajoz&#41;&#46; The protocols of the Monitoring Network of the Autonomous Community of Extremadura was used for case definition&#46; Microbiological confirmation was performed by isolation of the virus and the presence of IgM and IgG markers in serum&#46; We analyzed the direct and indirect tangible costs as well as the intangible costs of the outbreak&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Seventy-five cases were identified&#44; of which 94&#46;7&#37; occurred in children aged between 1-9 years&#44; mainly boys&#46; The attack rate was 18&#46;5 cases per 1&#44;000 inhabitants and 68&#46;2&#37; occurred in children aged less than 10 years charing a home&#46; The clinical course was benign&#44; without hospital admissions or complications&#46; A total of 71&#46;6&#37; of children aged between 3 and 8 years were susceptible&#46; A possible temporary aggregation of cases in the school was analyzed and a relative risk of 5&#46;01 &#40;p &#60; 0&#46;0001&#41; was obtained&#46; The virus was isolated in the 4 vesicle samples studied and serology was positive &#40;IgM&#41; in the 9 serum samples studied&#46; The total cost of the outbreak was of 927&#44;21 e&#44; with a mean of 12&#44;53 e per case and 205 school days lost&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A chickenpox outbreack was confirmed in Herrera del Duque&#44; with person-to-person transmission&#44; affecting children aged between 1 and 9 years&#46; The high susceptibility of the pupils&#44; the characteristics of teaching&#44; and the meetings prior to the carnivals played a determining role in the transmission of the epidemic&#46; The estimated cost of this outbreak was 76&#37; less than the cost that would have been generated by single-dose vaccination of the 75 individuals who contracted the disease&#46;</p>"
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Brote de varicela en Herrera del Duque (Badajoz)
Chickenpox outbreak in Herrera del Duque, Badajoz, Spain
F.J. Valadésa,
Autor para correspondencia
fvalades@isciii.es

Correspondencia: Dr. F.J. Valadés Rodríguez. Centro Nacional de Epidemiología. Sinesio Delgado, 6. 28029 Madrid. España.
, A. Barrasaa, E. Peñaa, J.F. Sánchezb, C. Amelac, I. Pachónc, D. Herrerac, F. Martínez-Navarroc, J.M. Ramosb
a Programa de Epidemiología Aplicada de Campo. Centro Nacional de Epidemiología
b Servicio de Epidemiología. Dirección General de Salud Pública. Consejería de Sanidad y Consumo. Junta de Extremadura
c Centro Nacional de Epidemiología. Instituto de Salud Carlos III. Madrid. España
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            "correspondencia" => "<span class="elsevierStyleItalic">Correspondencia</span>&#58; Dr&#46; F&#46;J&#46; Valad&#233;s Rodr&#237;guez&#46; Centro Nacional de Epidemiolog&#237;a&#46; Sinesio Delgado&#44; 6&#46; 28029 Madrid&#46; Espa&#241;a&#46;"
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    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Chickenpox outbreak in Herrera del Duque&#44; Badajoz&#44; Spain"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2002-03-07"
    "fechaAceptado" => "2002-12-05"
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      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec268749"
          "palabras" => array:4 [
            0 => "Varicela"
            1 => "Brote"
            2 => "Costes"
            3 => "Extremadura"
          ]
        ]
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec268750"
          "palabras" => array:4 [
            0 => "Varicella"
            1 => "Outbreak"
            2 => "Costs"
            3 => "Extremadura &#40;Spain&#41;"
          ]
        ]
      ]
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    "resumen" => array:2 [
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La varicela es una enfermedad de distribuci&#243;n mundial con una elevada morbilidad y pocas complicaciones&#44; aunque puede presentar cuadros cl&#237;nicos graves en inmunodeprimidos y adultos sanos&#46; El objeto de este estudio es identificar y describir las caracter&#237;sticas y los costes de un brote epid&#233;mico en Extremadura&#44; cuya tasa anual de casos declarados al sistema de Enfermedades de Declaraci&#243;n Obligatoria &#40;EDO&#41; oscila en alrededor de 5 por 1&#46;000 habitantes&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio descriptivo con b&#250;squeda activa de casos entre los meses de noviembre del a&#241;o 2000 y marzo de 2001&#44; y de la susceptibilidad de la cohorte escolarizada del colegio de Herrera del Duque &#40;Badajoz&#41;&#46; Las definiciones de casos fueron recogidas de los protocolos de la Red de Vigilancia de la comunidad extreme&#241;a&#46; La confirmaci&#243;n microbiol&#243;gica se realiz&#243; por aislamiento del virus y por presencia de marcadores IgM e IgG en el suero del enfermo&#46; Se analizaron los costes tangibles directos e indirectos y los no tangibles del brote&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">De los 75 casos identificados&#44; 71 &#40;94&#44;7&#37;&#41; eran ni&#241;os de entre uno y 9 a&#241;os&#44; predominando el sexo masculino&#46; La tasa de ataque fue de 18&#44;5 casos por 1&#46;000 habitantes&#44; y del 68&#44;2&#37; en convivientes menores de 10 a&#241;os&#46; La evoluci&#243;n fue benigna&#44; sin ingresos hospitalarios ni complicaciones&#46; Se encontr&#243; un 71&#44;6&#37; de ni&#241;os susceptibles en los de entre 3 y 8 a&#241;os&#46; Se analiz&#243; una posible agregaci&#243;n temporal de casos en el colegio&#44; obteni&#233;ndose un riesgo relativo &#40;RR&#41; de 5&#44;01 &#40;p &#60; 0&#44;001&#41;&#46; Se aisl&#243; el virus en las 4 muestras de ves&#237;culas estudiadas y la serolog&#237;a &#40;IgM&#41; fue positiva en los 9 sueros estudiados&#46; El coste total de brote fue de 927&#44;21 e&#44; con una media de 12&#44;53 e por caso&#44; y 205 d&#237;as de p&#233;rdida escolar&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se confirm&#243; la existencia de un brote de varicela en el colegio de la localidad de Herrera del Duque&#44; con transmisi&#243;n persona a persona&#44; que afect&#243; a ni&#241;os de entre uno y 9 a&#241;os&#46; La elevada susceptibilidad del alumnado&#44; las caracter&#237;sticas de la docencia y las reuniones previas a los carnavales tuvieron un papel determinante en la propagaci&#243;n de la epidemia&#46;</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">El coste estimado para este brote se corresponde con un gasto un 76&#37; menor del producido por la vacunaci&#243;n con una dosis de los 75 casos de este brote&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Chickenpox is a worldwide disease with high morbidity but few complications&#44; although complications can be sevre in immunocompromised individuals and healthy adults&#46; The annual chickenpox rate declared to the National Notification Disease Surveillance System is approximately 5 cases per 1&#44;000 inhabitants in Extremadura &#40;Spain&#41;&#46; The aim of this study was to identify and describe the characteristics and cost of an epidemic outbreak of chickenpox in Extremadura&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Between November 2000 and March 2001&#44; a descriptive study was performed&#46; Cases of chickenpox were actively sought in a cohort of schoolchildren in Herrera del Duque &#40;Badajoz&#41;&#46; The protocols of the Monitoring Network of the Autonomous Community of Extremadura was used for case definition&#46; Microbiological confirmation was performed by isolation of the virus and the presence of IgM and IgG markers in serum&#46; We analyzed the direct and indirect tangible costs as well as the intangible costs of the outbreak&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Seventy-five cases were identified&#44; of which 94&#46;7&#37; occurred in children aged between 1-9 years&#44; mainly boys&#46; The attack rate was 18&#46;5 cases per 1&#44;000 inhabitants and 68&#46;2&#37; occurred in children aged less than 10 years charing a home&#46; The clinical course was benign&#44; without hospital admissions or complications&#46; A total of 71&#46;6&#37; of children aged between 3 and 8 years were susceptible&#46; A possible temporary aggregation of cases in the school was analyzed and a relative risk of 5&#46;01 &#40;p &#60; 0&#46;0001&#41; was obtained&#46; The virus was isolated in the 4 vesicle samples studied and serology was positive &#40;IgM&#41; in the 9 serum samples studied&#46; The total cost of the outbreak was of 927&#44;21 e&#44; with a mean of 12&#44;53 e per case and 205 school days lost&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A chickenpox outbreack was confirmed in Herrera del Duque&#44; with person-to-person transmission&#44; affecting children aged between 1 and 9 years&#46; The high susceptibility of the pupils&#44; the characteristics of teaching&#44; and the meetings prior to the carnivals played a determining role in the transmission of the epidemic&#46; The estimated cost of this outbreak was 76&#37; less than the cost that would have been generated by single-dose vaccination of the 75 individuals who contracted the disease&#46;</p>"
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                      "titulo" => "Cost effectiveness of vaccination strategies in adults without a history of chickenpox"
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                        0 => array:2 [
                          "etal" => false
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                            1 => "M&#46;S&#46; Roberts"
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                      "titulo" => "Committee on Infectious Diseases&#46; Varicella vaccine update"
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                        "tituloSerie" => "Pediatrics"
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                    0 => array:2 [
                      "titulo" => "The cost-effectivenesse of varicella vacine programs for Australia"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;A&#46; Schuffham"
                            1 => "A&#46;V&#46; Lowin"
                            2 => "M&#46;A&#46; Burgess"
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                    0 => array:1 [
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                        "tituloSerie" => "Vaccine"
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              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The cost-effectiveness of introducing a varicella vaccine to the New Zealand immunisation schedule"
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                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46; Scuffham"
                            1 => "N&#46; Devlin"
                            2 => "J&#46; Eberhart-Phillips"
                            3 => "R&#46; Wilson-Salt"
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                    0 => array:1 [
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                        "tituloSerie" => "Soc Sci Med"
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                    0 => array:2 [
                      "titulo" => "A cost benefit analisis or routine varicella vaccination in Spain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; D&#237;ez Domingo"
                            1 => "M&#46; Ridao"
                            2 => "J&#46; Latour"
                            3 => "A&#46; Ballester"
                            4 => "A&#46; Morant"
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                    0 => array:2 [
                      "titulo" => "Varicella&#58; the vaccine and the public health debate"
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                          "autores" => array:1 [
                            0 => "V&#46;P&#46; Niedershauser"
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                        "fecha" => "1999"
                        "volumen" => "24"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10100242"
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            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The value of varicella vaccination in healthy children&#58; cost-benefit an&#225;lisis of the situation in France"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46; Coudeville"
                            1 => "F&#46; Paree"
                            2 => "T&#46; Lebrun"
                            3 => "J&#46; Sailly"
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                        ]
                      ]
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                ]
              ]
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                      "titulo" => "Acost-benefit analysis of a routine varicella vaccination program for United States Air Force Academy cadets"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46;R&#46; Burham"
                            1 => "T&#46;S&#46; Wells"
                            2 => "J&#46;R&#46; Riddle"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Mil Med"
                        "fecha" => "1998"
                        "volumen" => "163"
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                  ]
                ]
              ]
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            14 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Varicella susceptibility and vaccination strategies in young adults"
                      "autores" => array:1 [
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Información del artículo
ISSN: 02139111
Idioma original: Español
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2017 Diciembre 22 10 32
2017 Noviembre 21 9 30
2017 Octubre 9 11 20
2017 Septiembre 17 10 27
2017 Agosto 10 7 17
2017 Julio 19 9 28
2017 Junio 21 12 33
2017 Mayo 15 9 24
2017 Abril 20 6 26
2017 Marzo 17 8 25
2017 Febrero 7 0 7
2017 Enero 8 6 14
2016 Diciembre 19 7 26
2016 Noviembre 17 5 22
2016 Octubre 14 14 28
2016 Septiembre 17 4 21
2016 Agosto 24 4 28
2016 Julio 13 4 17
2016 Febrero 1 0 1
2015 Diciembre 1 0 1
2015 Octubre 1 0 1
2015 Septiembre 1 0 1
2015 Junio 2 0 2
2015 Abril 2 0 2
2015 Marzo 3 0 3
2015 Febrero 3 0 3
2015 Enero 1 0 1
2014 Diciembre 4 0 4
2014 Noviembre 7 0 7
2014 Octubre 5 0 5
2014 Septiembre 5 0 5
2014 Agosto 10 0 10
2014 Julio 7 0 7
2014 Junio 5 0 5
2014 Mayo 7 0 7
2014 Abril 9 0 9
2014 Marzo 4 0 4
2014 Febrero 11 1 12
2014 Enero 18 0 18
2013 Diciembre 18 1 19
2013 Noviembre 22 1 23
2013 Octubre 30 3 33
2013 Septiembre 14 9 23
2013 Agosto 23 8 31
2013 Julio 24 1 25
2003 Abril 932 0 932
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Gaceta Sanitaria
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?