Coste-efectividad de la vacunación antineumocócica 23-valente en Cataluña
(Cost-effectiveness of 23-valent antipneumococcical vaccination in Catalonia, Spain)
P. Plans*
Servei d'Avaluació de Programes. Direcció General de Salut Pública. Departament de Sanitat. Barcelona
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Espín, A. Sandoval, J. Ruiz, J.A. Navarro, J. García, D. Pérez Flores" "autores" => array:6 [ 0 => array:2 [ "nombre" => "M.I." "apellidos" => "Espín" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Sandoval" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Ruiz" ] 3 => array:2 [ "nombre" => "J.A." "apellidos" => "Navarro" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "García" ] 5 => array:2 [ "nombre" => "D." "apellidos" => "Pérez Flores" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021391110271947X?idApp=WGSE" "url" => "/02139111/0000001600000005/v1_201310251655/S021391110271947X/v1_201310251655/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Coste-efectividad de la vacunación antineumocócica 23-valente en Cataluña" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "392" "paginaFinal" => "400" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "P. Plans" "autores" => array:1 [ 0 => array:3 [ "nombre" => "P." "apellidos" => "Plans" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servei d'Avaluació de Programes. Direcció General de Salut Pública. Departament de Sanitat. Barcelona" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Pedro Plans Rubió. Servei d'Avaluació de Programes. Direcció General de Salut Pública. Travessera de les Corts, 131-159. 08028 Barcelona." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "(Cost-effectiveness of 23-valent antipneumococcical vaccination in Catalonia, Spain)" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2001-12-14" "fechaAceptado" => "2002-06-12" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec268831" "palabras" => array:4 [ 0 => "Vacunación antineumocócica" 1 => "Prevención" 2 => "Estudios evaluativos" 3 => "Coste-efectividad" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec268830" "palabras" => array:4 [ 0 => "Pneumococcal vaccination" 1 => "Prevention" 2 => "Evaluative studies" 3 => "Cost-effectiveness" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Objetivo</span></span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La vacunación antineumocócica es un procedimiento efectivo para prevenir la neumonía neumocócica. En este estudio se ha evaluado el coste-efectividad de las estrategias de vacunación antineumocócica (23 serotipos) en la población de 5 o más años de Cataluña.</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Métodos</span></span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El coste-efectividad se ha evaluado en términos de coste por año de vida ganado (AVG), comparando el coste neto del programa vacunal con su efectividad. El coste neto del programa vacunal se calculó restando a los costes de vacunar al 70% de la población la reducción de los costes sanitarios de la neumonía neumocócica que se puede conseguir con la vacunación. Los costes de vacunación se estimaron teniendo en cuenta un precio de 11,51 euros (1.915 ptas.) para la vacuna antineumocócica. Los costes y beneficios del programa vacunal se actualizaron para el año 1996 utilizando una tasa de descuento del 5%.</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Resultados</span></span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se obtuvo una razón coste-efectividad de 9.023,27 euros por AVG para la vacunación universal de la población. El coste-efectividad fue de 113.177,12 euros por AVG en los individuos de 5-24 años; de 19.482,51 euros por AVG en los de 25-44 años, de 7.122,80 euros por AVG en los de 45-64, e inferior a cero en los mayores de 65 años. En el grupo > 65 años, la reducción de los costes de la enfermedad superaba los costes de vacunación con una razón ahorro:coste de 1,58. Los resultados del análisis coste-efectividad eran sensibles al precio de la vacuna, la eficacia vacunal y el porcentaje de neumonías causadas por el neumococo, siendo menos sensibles a los costes de la neumonía neumocócica la tasa de ingreso hospitalario en los pacientes con neumonías adquiridas en la comunidad y la cobertura vacunal.</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Conclusión</span></span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los resultados de este estudio demuestran que la vacunación antineumocócica debería ser una intervención preventiva prioritaria en los individuos de 65 o más años y los de 45 a 64 años.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Objectives</span></span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Pneumococcal vaccination is an effective procedure for preventing pneumococcal pneumonia. In this study we evaluate the cost-effectiveness of pneumococcal vaccination strategies (23 serotypes) in the population aged 5 years and older in Catalonia.</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Methods</span></span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Cost-effectiveness was evaluated in terms of cost per year of life gained (YLG) by comparing the net cost of the vaccination program with its effectiveness. The net cost of the vaccination program was calculated by subtracting 70% of the population from the vaccination costs, representing the reduction in health costs due to pneumococcal pneumonia that can ve achieved with vaccination. Vaccination costs were estimated based on a price of 12.41 euros (1,915 ptas.) for pneumococcal vaccine. The costs and benefits of the vaccination program were updated for 1996 by using a discount rate of 5%.</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Results</span></span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A cost-effectiveness ratio of 9,023.27 euros per YLG was achieved for universal vaccination of the population. Cost-effectiveness was 11,3177.12 euros per YLG in individuals aged 5-24 years, 19,482.51 euros per TLG in those aged 25-44 years, 7,122.80 euros per YLG in those aged 45-64 years and less than 0 in those aged 65 years and older. In this group the reduction in cost of the disease was greater than the vaccination costs with a cost-benefit ratio of 1.58. The results of the cost-efecctiveness analysis were sensitive to vaccine costs and efficacy and the percentage of pneumonias caused by pneumococcus but were less sensitive to the costs of pneumococcal pneumonia, the rate of hospital admission among patients with community-acquired pneumonia and vaccine coverage.</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Conclusion</span></span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The results of this study show that pneumococcal vaccination should be a priority in individuals aged 65 years and older and in those aged 45-64 years.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:40 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 6 | 5 | 11 |
| 2024 Octubre | 53 | 30 | 83 |
| 2024 Septiembre | 44 | 26 | 70 |
| 2024 Agosto | 49 | 23 | 72 |
| 2024 Julio | 32 | 22 | 54 |
| 2024 Junio | 35 | 21 | 56 |
| 2024 Mayo | 44 | 32 | 76 |
| 2024 Abril | 23 | 14 | 37 |
| 2024 Marzo | 40 | 28 | 68 |
| 2024 Febrero | 37 | 24 | 61 |
| 2024 Enero | 24 | 18 | 42 |
| 2023 Diciembre | 27 | 18 | 45 |
| 2023 Noviembre | 21 | 16 | 37 |
| 2023 Octubre | 28 | 15 | 43 |
| 2023 Septiembre | 32 | 16 | 48 |
| 2023 Agosto | 34 | 15 | 49 |
| 2023 Julio | 33 | 17 | 50 |
| 2023 Junio | 37 | 10 | 47 |
| 2023 Mayo | 31 | 12 | 43 |
| 2023 Abril | 26 | 19 | 45 |
| 2023 Marzo | 28 | 33 | 61 |
| 2023 Febrero | 20 | 13 | 33 |
| 2023 Enero | 26 | 30 | 56 |
| 2022 Diciembre | 30 | 29 | 59 |
| 2022 Noviembre | 37 | 34 | 71 |
| 2022 Octubre | 30 | 31 | 61 |
| 2022 Septiembre | 25 | 34 | 59 |
| 2022 Agosto | 32 | 62 | 94 |
| 2022 Julio | 35 | 39 | 74 |
| 2022 Junio | 22 | 36 | 58 |
| 2022 Mayo | 27 | 43 | 70 |
| 2022 Abril | 24 | 31 | 55 |
| 2022 Marzo | 27 | 39 | 66 |
| 2022 Febrero | 22 | 34 | 56 |
| 2022 Enero | 21 | 28 | 49 |
| 2021 Diciembre | 29 | 34 | 63 |
| 2021 Noviembre | 22 | 37 | 59 |
| 2021 Octubre | 25 | 40 | 65 |
| 2021 Septiembre | 24 | 43 | 67 |
| 2021 Agosto | 14 | 23 | 37 |
| 2021 Julio | 24 | 25 | 49 |
| 2021 Junio | 13 | 24 | 37 |
| 2021 Mayo | 20 | 21 | 41 |
| 2021 Abril | 23 | 45 | 68 |
| 2021 Marzo | 24 | 27 | 51 |
| 2021 Febrero | 18 | 11 | 29 |
| 2021 Enero | 11 | 15 | 26 |
| 2020 Diciembre | 15 | 9 | 24 |
| 2020 Noviembre | 15 | 9 | 24 |
| 2020 Octubre | 12 | 14 | 26 |
| 2020 Septiembre | 21 | 8 | 29 |
| 2020 Agosto | 9 | 14 | 23 |
| 2020 Julio | 23 | 12 | 35 |
| 2020 Junio | 12 | 13 | 25 |
| 2020 Mayo | 10 | 10 | 20 |
| 2020 Abril | 19 | 16 | 35 |
| 2020 Marzo | 14 | 6 | 20 |
| 2020 Febrero | 14 | 43 | 57 |
| 2020 Enero | 14 | 16 | 30 |
| 2019 Diciembre | 17 | 20 | 37 |
| 2019 Noviembre | 14 | 4 | 18 |
| 2019 Octubre | 9 | 7 | 16 |
| 2019 Septiembre | 12 | 5 | 17 |
| 2019 Agosto | 18 | 10 | 28 |
| 2019 Julio | 10 | 4 | 14 |
| 2019 Junio | 9 | 4 | 13 |
| 2019 Mayo | 8 | 12 | 20 |
| 2019 Abril | 5 | 9 | 14 |
| 2019 Marzo | 7 | 6 | 13 |
| 2019 Febrero | 12 | 9 | 21 |
| 2019 Enero | 9 | 11 | 20 |
| 2018 Diciembre | 11 | 16 | 27 |
| 2018 Noviembre | 55 | 15 | 70 |
| 2018 Octubre | 40 | 25 | 65 |
| 2018 Septiembre | 28 | 18 | 46 |
| 2018 Agosto | 16 | 11 | 27 |
| 2018 Julio | 25 | 11 | 36 |
| 2018 Junio | 19 | 9 | 28 |
| 2018 Mayo | 27 | 16 | 43 |
| 2018 Abril | 13 | 7 | 20 |
| 2018 Marzo | 18 | 11 | 29 |
| 2018 Febrero | 14 | 6 | 20 |
| 2018 Enero | 15 | 5 | 20 |
| 2017 Diciembre | 18 | 10 | 28 |
| 2017 Noviembre | 28 | 9 | 37 |
| 2017 Octubre | 11 | 6 | 17 |
| 2017 Septiembre | 14 | 11 | 25 |
| 2017 Agosto | 13 | 8 | 21 |
| 2017 Julio | 19 | 15 | 34 |
| 2017 Junio | 33 | 11 | 44 |
| 2017 Mayo | 24 | 6 | 30 |
| 2017 Abril | 23 | 12 | 35 |
| 2017 Marzo | 12 | 8 | 20 |
| 2017 Febrero | 8 | 12 | 20 |
| 2017 Enero | 6 | 4 | 10 |
| 2016 Diciembre | 14 | 2 | 16 |
| 2016 Noviembre | 15 | 10 | 25 |
| 2016 Octubre | 20 | 15 | 35 |
| 2016 Septiembre | 18 | 10 | 28 |
| 2016 Agosto | 20 | 11 | 31 |
| 2016 Julio | 14 | 4 | 18 |
| 2015 Diciembre | 1 | 0 | 1 |
| 2015 Octubre | 1 | 0 | 1 |
| 2015 Septiembre | 4 | 0 | 4 |
| 2015 Agosto | 1 | 0 | 1 |
| 2015 Julio | 1 | 0 | 1 |
| 2015 Mayo | 2 | 0 | 2 |
| 2015 Marzo | 2 | 0 | 2 |
| 2015 Febrero | 1 | 0 | 1 |
| 2015 Enero | 5 | 0 | 5 |
| 2014 Diciembre | 3 | 0 | 3 |
| 2014 Noviembre | 4 | 1 | 5 |
| 2014 Octubre | 5 | 0 | 5 |
| 2014 Septiembre | 5 | 1 | 6 |
| 2014 Agosto | 15 | 4 | 19 |
| 2014 Julio | 18 | 1 | 19 |
| 2014 Junio | 14 | 2 | 16 |
| 2014 Mayo | 13 | 2 | 15 |
| 2014 Abril | 11 | 3 | 14 |
| 2014 Marzo | 11 | 2 | 13 |
| 2014 Febrero | 16 | 0 | 16 |
| 2014 Enero | 13 | 0 | 13 |
| 2013 Diciembre | 13 | 1 | 14 |
| 2013 Noviembre | 31 | 4 | 35 |
| 2013 Octubre | 60 | 3 | 63 |
| 2013 Septiembre | 28 | 3 | 31 |
| 2013 Agosto | 47 | 4 | 51 |
| 2013 Julio | 24 | 3 | 27 |
| 2002 Agosto | 1183 | 0 | 1183 |
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