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"titulo" => "Enfermedad neumocócica invasiva en niños de la Región de Murcia"
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"titulo" => "(Invasive pneumococcal disease in children in the region of Murcia, Spain)"
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"autoresLista" => "M.I. Espín, A. Sandoval, J. Ruiz, J.A. Navarro, J. García, D. Pérez Flores"
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"titulo" => "Coste-efectividad de la vacunación antineumocócica 23-valente en Cataluña"
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"titulo" => "(Cost-effectiveness of 23-valent antipneumococcical vaccination in Catalonia, Spain)"
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1 => "Prevención"
2 => "Estudios evaluativos"
3 => "Coste-efectividad"
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"clase" => "keyword"
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1 => "Prevention"
2 => "Evaluative studies"
3 => "Cost-effectiveness"
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"resumen" => "<span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Objetivo</span></span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La vacunación antineumocócica es un procedimiento efectivo para prevenir la neumonía neumocócica. En este estudio se ha evaluado el coste-efectividad de las estrategias de vacunación antineumocócica (23 serotipos) en la población de 5 o más años de Cataluña.</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Métodos</span></span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El coste-efectividad se ha evaluado en términos de coste por año de vida ganado (AVG), comparando el coste neto del programa vacunal con su efectividad. El coste neto del programa vacunal se calculó restando a los costes de vacunar al 70% de la población la reducción de los costes sanitarios de la neumonía neumocócica que se puede conseguir con la vacunación. Los costes de vacunación se estimaron teniendo en cuenta un precio de 11,51 euros (1.915 ptas.) para la vacuna antineumocócica. Los costes y beneficios del programa vacunal se actualizaron para el año 1996 utilizando una tasa de descuento del 5%.</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Resultados</span></span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se obtuvo una razón coste-efectividad de 9.023,27 euros por AVG para la vacunación universal de la población. El coste-efectividad fue de 113.177,12 euros por AVG en los individuos de 5-24 años; de 19.482,51 euros por AVG en los de 25-44 años, de 7.122,80 euros por AVG en los de 45-64, e inferior a cero en los mayores de 65 años. En el grupo > 65 años, la reducción de los costes de la enfermedad superaba los costes de vacunación con una razón ahorro:coste de 1,58. Los resultados del análisis coste-efectividad eran sensibles al precio de la vacuna, la eficacia vacunal y el porcentaje de neumonías causadas por el neumococo, siendo menos sensibles a los costes de la neumonía neumocócica la tasa de ingreso hospitalario en los pacientes con neumonías adquiridas en la comunidad y la cobertura vacunal.</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Conclusión</span></span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los resultados de este estudio demuestran que la vacunación antineumocócica debería ser una intervención preventiva prioritaria en los individuos de 65 o más años y los de 45 a 64 años.</p>"
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"en" => array:2 [
"titulo" => "Summary"
"resumen" => "<span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Objectives</span></span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Pneumococcal vaccination is an effective procedure for preventing pneumococcal pneumonia. In this study we evaluate the cost-effectiveness of pneumococcal vaccination strategies (23 serotypes) in the population aged 5 years and older in Catalonia.</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Methods</span></span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Cost-effectiveness was evaluated in terms of cost per year of life gained (YLG) by comparing the net cost of the vaccination program with its effectiveness. The net cost of the vaccination program was calculated by subtracting 70% of the population from the vaccination costs, representing the reduction in health costs due to pneumococcal pneumonia that can ve achieved with vaccination. Vaccination costs were estimated based on a price of 12.41 euros (1,915 ptas.) for pneumococcal vaccine. The costs and benefits of the vaccination program were updated for 1996 by using a discount rate of 5%.</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Results</span></span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A cost-effectiveness ratio of 9,023.27 euros per YLG was achieved for universal vaccination of the population. Cost-effectiveness was 11,3177.12 euros per YLG in individuals aged 5-24 years, 19,482.51 euros per TLG in those aged 25-44 years, 7,122.80 euros per YLG in those aged 45-64 years and less than 0 in those aged 65 years and older. In this group the reduction in cost of the disease was greater than the vaccination costs with a cost-benefit ratio of 1.58. The results of the cost-efecctiveness analysis were sensitive to vaccine costs and efficacy and the percentage of pneumonias caused by pneumococcus but were less sensitive to the costs of pneumococcal pneumonia, the rate of hospital admission among patients with community-acquired pneumonia and vaccine coverage.</p> <span class="elsevierStyleSectionTitle"><span class="elsevierStyleItalic">Conclusion</span></span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The results of this study show that pneumococcal vaccination should be a priority in individuals aged 65 years and older and in those aged 45-64 years.</p>"
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"titulo" => "Informe sobre la vacuna neumocócica"
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"titulo" => "Recomendaciones para la vacunación neumocócica"
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"tituloSerie" => "Boletín Epidemiológico y Mi-crobiológico"
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"titulo" => "Vacunaciones preventivas. Principios y aplicaciones"
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"titulo" => "Antimicrobial resistance with Streptococcus pneumoniae in the United States, 1997-98"
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"titulo" => "Salleras Sanmartí L. Coste-efectividad de la vacunación neumocócica en Cataluña"
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0 => "M.R. Gold"
1 => "J.E. Siegel"
2 => "L.B. Russell"
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"titulo" => "Anàlisi de la la mortalitat a Catalunya 1996"
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"colaboracion" => "Departament de Sanitat"
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"titulo" => "The protective efficacy of polivalent pneumococcal polysacharide pneumonia"
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"etal" => true
"autores" => array:5 [
0 => "E.D. Shapiro"
1 => "A.T. Berg"
2 => "R. Austrian"
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4 => "A. Parcells V Margolis"
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"doi" => "10.1056/NEJM199111213252101"
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"tituloSerie" => "N Engl J Med"
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"titulo" => "Antibody to capsular polysaccharides of Streptococcus pneumoniae: prevalence, persistence and response to revaccination"
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"tituloSerie" => "Clin Infec Dis"
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"titulo" => "Cost-effectiveness of vaccination against pneumococcal pneumonia"
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2 => "M.A. Riddiough"
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