Búsqueda avanzada
 array:24 [
  "pii" => "S0213911107719842"
  "issn" => "02139111"
  "doi" => "10.1157/13101034"
  "estado" => "S300"
  "fechaPublicacion" => "2007-03-01"
  "aid" => "71984"
  "copyright" => "Sociedad Española de Salud Pública y Administración Sanitaria"
  "copyrightAnyo" => "2007"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Gac Sanit. 2007;21:97-104"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3571
    "formatos" => array:3 [
      "EPUB" => 131
      "HTML" => 2873
      "PDF" => 567
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0213911107719854"
    "issn" => "02139111"
    "doi" => "10.1157/13101035"
    "estado" => "S300"
    "fechaPublicacion" => "2007-03-01"
    "aid" => "71985"
    "copyright" => "Sociedad Española de Salud Pública y Administración Sanitaria"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Gac Sanit. 2007;21:105"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2879
      "formatos" => array:3 [
        "EPUB" => 116
        "HTML" => 2288
        "PDF" => 475
      ]
    ]
    "es" => array:9 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>"
      "titulo" => "Comentario&#46; Eficiencia de la acarbosa asociada con el tratamiento oral de la diabetes mellitus tipo 2 en Espa&#241;a"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "105"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Comment&#46; Efficiency of acarbose associated with oral treatment of type 2 diabetes in Spain"
        ]
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Fernando Anto&#241;anzas Villar"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Fernando"
              "apellidos" => "Anto&#241;anzas Villar"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911107719854?idApp=WGSE"
    "url" => "/02139111/0000002100000002/v1_201301241548/S0213911107719854/v1_201301241548/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0213911107719830"
    "issn" => "02139111"
    "doi" => "10.1157/13101033"
    "estado" => "S300"
    "fechaPublicacion" => "2007-03-01"
    "aid" => "71983"
    "copyright" => "Sociedad Espa&#241;ola de Salud P&#250;blica y Administraci&#243;n Sanitaria"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "edi"
    "cita" => "Gac Sanit. 2007;21:95-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4221
      "formatos" => array:3 [
        "EPUB" => 134
        "HTML" => 3353
        "PDF" => 734
      ]
    ]
    "es" => array:9 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>"
      "titulo" => "Evaluaci&#243;n en salud p&#250;blica&#58; &#191;todo vale&#63;"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "95"
          "paginaFinal" => "96"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Evaluation in public health&#58; does anything go&#63;"
        ]
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Manel Nebot"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Manel"
              "apellidos" => "Nebot"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911107719830?idApp=WGSE"
    "url" => "/02139111/0000002100000002/v1_201301241548/S0213911107719830/v1_201301241548/es/main.assets"
  ]
  "es" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>"
    "titulo" => "Coste-efectividad de la adici&#243;n de acarbosa al tratamiento de pacientes con diabetes tipo 2 en Espa&#241;a"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "97"
        "paginaFinal" => "104"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Carme Pi&#241;ol, Stephane Roze, William Valentine, Thomas Evers"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Carme"
            "apellidos" => "Pi&#241;ol"
            "email" => array:1 [
              0 => "carmen&#46;pinol&#46;cp&#64;bayer&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Stephane"
            "apellidos" => "Roze"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "William"
            "apellidos" => "Valentine"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Thomas"
            "apellidos" => "Evers"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Qu&#237;mica Farmac&#233;utica Bayer&#44; S&#46; A&#46;&#44; Barcelona&#44; Espa&#241;a"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "CORE-Center for Outcomes Research&#44; Basilea&#44; Suiza"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
          2 => array:3 [
            "entidad" => "Bayer Healthcare AG&#44; Wuppertal&#44; Alemania"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff3"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspondencia&#58; Carme Pi&#241;ol&#46; Unidad de Farmacoeconom&#237;a y Relaciones Institucionales&#46; Departamento de Investigaci&#243;n y Desarrollo&#46; Qu&#237;mica Farmac&#233;utica Bayer&#44; S&#46; A&#46; Pau Claris&#44; 196&#46; 08037 Barcelona&#46; Espa&#241;a&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Cost-effectiveness of the addition of acarbose to the treatment of patients with type-2 diabetes in Spain"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2006-01-13"
    "fechaAceptado" => "2006-05-22"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec13855"
          "palabras" => array:4 [
            0 => "Coste efectividad"
            1 => "Diabetes tipo 2"
            2 => "Acarbosa"
            3 => "A&#241;os de vida ajustados por calidad"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec13856"
          "palabras" => array:4 [
            0 => "Cost-effectiveness"
            1 => "Type 2 diabetes"
            2 => "Acarbose"
            3 => "Quality-adjusted life years"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Evaluar el coste-efectividad de la adici&#243;n de acarbosa al tratamiento de pacientes con diabetes mellitus tipo 2 &#40;DM2&#41; en Espa&#241;a&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se utiliz&#243; el CORE Diabetes Model &#40;modelo de simulaci&#243;n inform&#225;tica publicado y validado&#41; para proyectar a largo plazo los resultados cl&#237;nicos y de costes de la DM2&#46; Las probabilidades de transici&#243;n y los riesgos se obtuvieron de distintas publicaciones&#46; Los efectos del tratamiento y las caracter&#237;sticas basales de la cohorte se obtuvieron de un metaan&#225;lisis&#46; Los costes directos se extrajeron de diversas publicaciones y se proyectaron a lo largo de la vida de los pacientes bajo la perspectiva del Sistema Nacional de Salud de Espa&#241;a&#46; Los costes y beneficios fueron descontados en un 3&#37; anual&#46; Se realizaron an&#225;lisis de sensibilidad&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El tratamiento con acarbosa se asoci&#243; con mejoras en la esperanza de vida &#40;0&#44;23 a&#241;os&#41; y en los a&#241;os de vida ajustados por calidad &#40;AVAC&#41; &#40;0&#44;21 a&#241;os&#41;&#46; Los costes directos fueron en promedio&#44; por paciente&#44; de 468 A m&#225;s caros con acarbosa que con placebo&#46; La raz&#243;n de coste-efectividad incremental fue de 2&#46;002 &#8364;&#47;a&#241;o de vida ganado y de 2&#46;199 &#8364;&#47;AVAC ganado&#46; La curva de aceptabilidad mostr&#243; que con una disponibilidad a pagar de 20&#46;000 &#8364;&#44; generalmente aceptada como muy buen valor monetario&#44; el tratamiento con acarbosa se asoci&#243; con una probabilidad del 93&#44;5&#37; de ser costeefectiva&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Este estudio econ&#243;mico a largo plazo mostr&#243; que la adici&#243;n de acarbosa al tratamiento de pacientes con DM2 produjo mejoras en la esperanza de vida y en los AVAC de estos pacientes&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">To assess the cost-effectiveness of the addition of acarbose to existing treatment in patients with type 2 diabetes mellitus &#40;DM2&#41; in Spain&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">The CORE Diabetes Model &#40;a published and validated computer simulation model&#41; was used to project longterm clinical and cost outcomes in DM2&#46; Transition probabilities and risk adjustments were derived from published sources&#46; Treatment effects and baseline cohort characteristics were based on a meta-analysis&#46; Direct costs were retrieved from published sources and projected over patient lifetimes from the perspective of the Spanish National Health Service&#46; Costs and clinical benefits were discounted at 3&#37; per year&#46; Sensitivity analyses were performed&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Acarbose treatment was associated with improved life expectancy &#40;0&#46;23 years&#41; and quality-adjusted life years &#40;QALY&#41; &#40;0&#46;21 years&#41;&#46; Direct costs were on average &#8364; 468 per patient more expensive with acarbose than with placebo&#46; The incremental cost-effectiveness ratios were &#8364; 2&#44;002 per life year gained and &#8364; 2&#44;199 per QALY gained&#46; An acceptability curve showed that with a willingness to pay &#8364; 20&#44;000&#44; which is generally accepted to represent very good value for money&#44; acarbose treatment was associated with a 93&#46;5&#37; probability of being cost-effective&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">This long-term economic study showed that the addition of acarbose to existing therapy for DM2 was associated with improvements in life expectancy and QALYs in these patients&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:33 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Global prevalence of diabetes&#58; estimates for the year 2000 and projections for 2030"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Wild"
                            1 => "G&#46; Roglic"
                            2 => "A&#46; Green"
                            3 => "R&#46; Sicree"
                            4 => "H&#46; King"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes Care"
                        "fecha" => "2004"
                        "volumen" => "27"
                        "paginaInicial" => "1047"
                        "paginaFinal" => "1053"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15111519"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Revealing the cost of type II diabetes in Europe"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "B&#46; J&#246;nsson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Diabetologia"
                        "fecha" => "2002"
                        "volumen" => "45"
                        "paginaInicial" => "5S"
                        "paginaFinal" => "12S"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "El coste de la diabetes en Espa&#241;a&#46; El estudio CODE-2"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Mata"
                            1 => "F&#46; Anto&#241;anzas"
                            2 => "M&#46; Tafalla"
                            3 => "P&#46; Sanz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gac Sanit"
                        "fecha" => "2002"
                        "volumen" => "16"
                        "paginaInicial" => "511"
                        "paginaFinal" => "520"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12459134"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A randomized double-blind trial of acarbose in type 2 diabetes shows improved glycemic control over 3 years &#40;UK Prospective Diabetes Study 44&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;R&#46; Holman"
                            1 => "C&#46;A&#46; Cull"
                            2 => "R&#46;C&#46; Turner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes Care"
                        "fecha" => "1999"
                        "volumen" => "22"
                        "paginaInicial" => "960"
                        "paginaFinal" => "964"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10372249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intensive bloodglucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes &#40;UKPDS 33&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "The UK Prospective Diabetes Study Group"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1998"
                        "volumen" => "352"
                        "paginaInicial" => "837"
                        "paginaFinal" => "853"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9742976"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hemoglobin A<span class="elsevierStyleInf">1c</span> measurements over nearly two decades&#58; substaining comparable values throughout the Diabetes Control and Complications trial and the Epidemiology of Diabetes Interventions and Complications Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Steffes"
                            1 => "P&#46; Cleary"
                            2 => "D&#46; Goldstein"
                            3 => "R&#46; Little"
                            4 => "H&#46;M&#46; Wiedmeyer"
                            5 => "C&#46; Rohlfing"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1373/clinchem.2004.042143"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Chem"
                        "fecha" => "2005"
                        "volumen" => "51"
                        "paginaInicial" => "753"
                        "paginaFinal" => "758"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15684277"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acarbose reduces the risk for myocardial infarction in type 2 diabetic patients&#58; meta-analysis of seven longterm studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Hanefeld"
                            1 => "M&#46; Cagatay"
                            2 => "T&#46; Petrowitsch"
                            3 => "D&#46; Neuser"
                            4 => "D&#46; Petzinna"
                            5 => "M&#46; Rupp"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "2004"
                        "volumen" => "25"
                        "paginaInicial" => "10"
                        "paginaFinal" => "16"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14683737"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The CORE Diabetes Model&#58; projecting longterm clinical outcomes&#44; costs and cost-effectiveness of interventions in diabetes mellitus &#40;types 1 and 2&#41; to support clinical and reimbursement decision-making"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;J&#46; Palmer"
                            1 => "S&#46; Roze"
                            2 => "W&#46;J&#46; Valentine"
                            3 => "M&#46;E&#46; Minshall"
                            4 => "V&#46; Foos"
                            5 => "F&#46;M&#46; Lurati"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Med Res Opin"
                        "fecha" => "2004"
                        "volumen" => "20"
                        "numero" => "Suppl 1"
                        "paginaInicial" => "5"
                        "paginaFinal" => "26"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validation of the CORE Diabetes Model against epidemiological and clinical studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;J&#46; Palmer"
                            1 => "S&#46; Roze"
                            2 => "W&#46;J&#46; Valentine"
                            3 => "M&#46;E&#46; Minshall"
                            4 => "V&#46; Foos"
                            5 => "F&#46;M&#46; Lurati"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Med Res Opin"
                        "fecha" => "2004"
                        "volumen" => "20"
                        "numero" => "Suppl 1"
                        "paginaInicial" => "27"
                        "paginaFinal" => "40"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The UKPDS risk engine&#58; a model for the risk of coronary heart disease in type II diabetes &#40;UKPDS 56&#41;"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "UKPDS study group"
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46;J&#46; Stevens"
                            1 => "V&#46; Kothari"
                            2 => "A&#46;I&#46; Adler"
                            3 => "I&#46;M&#46; Stratton"
                            4 => "R&#46;R&#46; Holman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Sci"
                        "fecha" => "2001"
                        "volumen" => "101"
                        "paginaInicial" => "671"
                        "paginaFinal" => "679"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11724655"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes &#40;UKPDS 35&#41;&#58; prospective observational study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46;M&#46; Stratton"
                            1 => "A&#46;I&#46; Adler"
                            2 => "H&#46;A&#46;W&#46; Neil"
                            3 => "D&#46;R&#46; Matthews"
                            4 => "S&#46;E&#46; Manley"
                            5 => "C&#46;A&#46; Cull"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "2000"
                        "volumen" => "321"
                        "paginaInicial" => "405"
                        "paginaFinal" => "412"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10938048"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acarbose treatment and risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance&#58; the STOP-NIDDM trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;L&#46; Chiasson"
                            1 => "R&#46;G&#46; Josse"
                            2 => "R&#46; Gomis"
                            3 => "M&#46; Hanefeld"
                            4 => "A&#46; Karasik"
                            5 => "M&#46; Laakso"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.290.4.486"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2003"
                        "volumen" => "290"
                        "paginaInicial" => "486"
                        "paginaFinal" => "494"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12876091"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Orden Ministerial de 23 de octubre de 2003&#44; por la que se determinan los nuevos conjuntos de presentaciones de especialidades farmac&#233;uticas y se aprueban los correspondientes precios de referencia&#46; BOE&#46; 2003&#59; 256&#58;38168-205&#46;"
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The economic burden of stroke in Spain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Bastida"
                            1 => "S&#46; Aguilar"
                            2 => "M&#46; &#193;lvarez"
                            3 => "D&#46; Gonz&#225;lez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Value in Health"
                        "fecha" => "2003"
                        "volumen" => "6"
                        "paginaInicial" => "614"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Economic evaluation of triflusal and aspirin in the treatment of acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Darb&#224;"
                            1 => "I&#46; Izquierdo"
                            2 => "C&#46; Pontes"
                            3 => "C&#46; Navas"
                            4 => "J&#46; Rovira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pharmacoeconomics"
                        "fecha" => "2002"
                        "volumen" => "20"
                        "paginaInicial" => "195"
                        "paginaFinal" => "201"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11929349"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Base de datos de costes sanitarios&#44; Versi&#243;n 1&#46;5&#46; Barcelona&#59; Soikos S&#46;L&#46;&#59; 2005&#46;"
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Ministerio de Sanidad y Consumo&#44; Instituto de Salud Carlos III&#46; An&#225;lisis coste-efectividad de diferentes estrategias para el cribado y tratamiento de la retinopat&#237;a diab&#233;tica en pacientes con diabetes mellitus&#46; Madrid&#58; Ministerio de Sanidad y Consumo&#59; 2004&#46;"
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The comparative medical costs of atherothrombotic disease in European countries"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Levy"
                            1 => "S&#46; Gabriel"
                            2 => "J&#46; Dinet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pharmacoeconomics"
                        "fecha" => "2003"
                        "volumen" => "21"
                        "paginaInicial" => "651"
                        "paginaFinal" => "659"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12807366"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Explotaci&#243;n de Bases del Conjunto M&#237;nimo B&#225;sico de Datos Hospitalarios &#40;CMBD&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Sistema Nacional de Salud&#44; a&#241;o 1997"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "1999"
                        "editorial" => "Ministerio de Sanidad"
                        "editorialLocalizacion" => "Madrid"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gu&#237;as de actuaci&#243;n cl&#237;nica de la Sociedad Espa&#241;ola de Cardiolog&#237;a en el infarto agudo de miocardio"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Ar&#243;s"
                            1 => "A&#46; Loma-Osorio"
                            2 => "A&#46; Alonso"
                            3 => "J&#46;J&#46; Alonso"
                            4 => "A&#46; Cabad&#233;s"
                            5 => "I&#46; Coma-Canella"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Esp Cardiol"
                        "fecha" => "1999"
                        "volumen" => "52"
                        "paginaInicial" => "919"
                        "paginaFinal" => "956"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10611807"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparisons of hypertension-related costs from multinational clinical studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;D&#46; Mullins"
                            1 => "M&#46; Sikirica"
                            2 => "V&#46; Seneviratne"
                            3 => "J&#46; Ahn"
                            4 => "K&#46;S&#46; Akhras"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pharmacoeconomics"
                        "fecha" => "2004"
                        "volumen" => "22"
                        "paginaInicial" => "1001"
                        "paginaFinal" => "1014"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15449964"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Real Decreto 1247&#47;2002 de 3 de diciembre&#44; por el que se regula la gesti&#243;n del fondo de cohesi&#243;n sanitaria&#46; BOE&#46; 2002&#59; 290&#58;42299-330&#46;"
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Costes de la di&#225;lisis cr&#243;nica en un hospital p&#250;blico&#58; mitos y realidades"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Lamas"
                            1 => "M&#46; Alonso"
                            2 => "J&#46; Saavedra"
                            3 => "G&#46; Garc&#237;a-Tr&#237;o"
                            4 => "M&#46; Rionda"
                            5 => "M&#46; Ameijeiras"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrolog&#237;a"
                        "fecha" => "2001"
                        "volumen" => "21"
                        "paginaInicial" => "283"
                        "paginaFinal" => "294"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11471309"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Coste-efectividad de irbesartan en pacientes hipertensos con nefropat&#237;a diab&#233;tica tipo II&#58; una perspectiva espa&#241;ola"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46;J&#46; Palmer"
                            1 => "L&#46; Annemans"
                            2 => "S&#46; Roze"
                            3 => "M&#46; Lamotte"
                            4 => "R&#46;A&#46; Rodby"
                            5 => "F&#46; De &#193;lvaro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrolog&#237;a"
                        "fecha" => "2004"
                        "volumen" => "24"
                        "paginaInicial" => "231"
                        "paginaFinal" => "238"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15283313"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Economic analysis of insulin glargine compared with NPH in the treatment of patients with type 1 diabetes in Spain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Rubio-Terr&#233;s"
                            1 => "J&#46; Rodr&#237;guez"
                            2 => "B&#46; Bolinder"
                            3 => "P&#46; De Pablos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Diabetolog&#237;a"
                        "fecha" => "2004"
                        "volumen" => "47"
                        "numero" => "Suppl 1"
                        "paginaInicial" => "345A"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Resoluci&#243;n de 26 de diciembre de 2001&#44; de la Direcci&#243;n General del Instituto Nacional de Salud&#44; sobre la revisi&#243;n de precios a aplicar por los centros sanitarios a las asistencias prestadas en los supuestos cuyo importe ha de reclamarse a los terceros obligados al pago o a los usuarios sin derecho a la asistencia de la Seguridad Social&#46; BOE&#46; 2002&#59; 5&#58;637-9&#46;"
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recent trends in hospitalization for diabetic ketoacidosis in Ontario children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;R&#46; Curtis"
                            1 => "T&#46; To"
                            2 => "S&#46; Muirhead"
                            3 => "E&#46; Cummings"
                            4 => "D&#46; Daneman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes Care"
                        "fecha" => "2002"
                        "volumen" => "25"
                        "paginaInicial" => "1591"
                        "paginaFinal" => "1596"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12196432"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Direct health care costs of diabetic patients in Spain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Oliva"
                            1 => "F&#46; Lobo"
                            2 => "B&#46; Molina"
                            3 => "S&#46; Monereo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes Care"
                        "fecha" => "2004"
                        "volumen" => "27"
                        "paginaInicial" => "2616"
                        "paginaFinal" => "2621"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15504995"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Outcomes and costs of outpatient and inpatient cataract surgery&#58; a randomised clinical trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "X&#46; Castells"
                            1 => "J&#46; Alonso"
                            2 => "M&#46; Castilla"
                            3 => "C&#46; Rib&#243;"
                            4 => "F&#46; Cots"
                            5 => "J&#46;M&#46; Ant&#243;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Epidemiol"
                        "fecha" => "2001"
                        "volumen" => "54"
                        "paginaInicial" => "23"
                        "paginaFinal" => "29"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11165465"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nontraumatic lower extremity amputations in diabetic and non-diabetic subjects in Madrid&#44; Spain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;L&#46; Calle-Pascual"
                            1 => "M&#46;J&#46; Redondo"
                            2 => "M&#46; Ballesteros"
                            3 => "M&#46;A&#46; Mart&#237;nez-Salinas"
                            4 => "J&#46;A&#46; D&#237;az"
                            5 => "P&#46; De Mat&#237;as"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes Metab"
                        "fecha" => "1997"
                        "volumen" => "23"
                        "paginaInicial" => "519"
                        "paginaFinal" => "523"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9496558"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Preventing chronic diseases&#58; a vital investment&#58; WHO global report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Worl Health Organization"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2005"
                        "editorial" => "Worl Health Organization"
                        "editorialLocalizacion" => "Ginebra"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Hutubessy R&#44; Chisholm D&#44; Tan-Torres Edejar T&#44; WHO-CHOICE&#46; Generalized cost-effectiveness analysis for national-level priority-setting in the health sector&#46; Cost effectiveness and resource allocation 2003&#44; 1&#58;8&#46; Disponible en&#58; <a class="elsevierStyleInterRef" href="http://www.resource-allocation.com/content/1/1/8">http&#58;&#47;&#47;www&#46;resource-allocation&#46;com&#47;content&#47;1&#47;1&#47;8</a>"
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An economic analysis of interventions for diabetes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;C&#46; Klonoff"
                            1 => "D&#46;M&#46; Schwartz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes Care"
                        "fecha" => "2000"
                        "volumen" => "23"
                        "paginaInicial" => "390"
                        "paginaFinal" => "404"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10868871"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/02139111/0000002100000002/v1_201301241548/S0213911107719842/v1_201301241548/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "764"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02139111/0000002100000002/v1_201301241548/S0213911107719842/v1_201301241548/es/main.pdf?idApp=WGSE&text.app=https://gacetasanitaria.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911107719842?idApp=WGSE"
]
Compartir
Métricas
Comité editorial
Publique en esta revista
Número actual
Información de la revista

Respuestas rápidas

Nueva respuesta rápida:

Requisitos y consideraciones

  • Las respuestas rápidas tienen como objetivo permitir el debate sobre observaciones científicas y de opinión sobre trabajos publicados el último año.
  • Deben ser enviadas desde la página web correspondiente al artículo en cuestión (no a través del sistema general de envío de artículos).
  • Son moderadas antes de su publicación a discreción del equipo editorial de la revista, no obstante no son peer-reviewed.
  • Deben ser originales y no infringir los derechos propiedad de terceros.
  • Los/las autores/as perderán el derecho a borrar o editar el texto, una vez sea publicado. Asimismo, la revista se reserva el derecho de borrar o editar el texto a discreción.
  • Algunas respuestas rápidas podrían ser seleccionadas adicionalmente para su publicación como cartas en la revista, en este caso seguirán el proceso editorial correspondiente.
  • Las respuestas rápidas serán publicadas en la web de la revista en 1 semana aproximadamente, después del envío del texto por parte de los/as autores/as.
  • La extensión máxima será de 500 palabras. Se admitirá una tabla o figura y hasta 5 referencias bibliográficas.
  • Se comunicará a los/las autores/ras del artículo comentado la existencia de la carta y la posibilidad de respuesta.
  • Al enviar esta respuesta rápida los autores/as aceptan los requisitos descritos.

Respuesta

Conflictos de interés

Los conflictos de interés pueden ser laborales, de investigación, económicos o morales. Los/las autores/as deben indicar si existe alguno de estos conflictos. Una descripción más detallada sobre los conflictos de intereses se encuentra disponible en las normas éticas de Gaceta Sanitaria.

El texto se adecua a las normas éticas de la revista

Suscríbase a la newsletter

Tabla de contenidos
Publique en
Gaceta Sanitaria
Podcast
El copago farmacéutico en España tras la reforma del año 2012 desde la perspectiva del usuario. ¿Evidencias de inequidad?
Vídeo selección del editor
María Victoria Zunzunegui conversando sobre mortalidad en la pandemia con Joan Carles March
Ver vídeo
María Victoria Zunzunegui conversando sobre mortalidad en la pandemia con Joan Carles March
Gaceta Sanitaria se adhiere a los principios y procedimientos dictados por el Committee on Publication Ethics (COPE)
www.publicationethics.org.

Gaceta Sanitaria sigue las recomendaciones para la preparación, presentación y publicación de trabajos académicos en revistas biomédicas

Idiomas
Gaceta Sanitaria
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?