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"resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Conocer la evolución y la variabilidad en el consumo de los antiinflamarios no esteroideos clásicos (AINE) en las áreas de salud de Costa Rica durante el período 2000-2005.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudiaron los siguientes medicamentos: ibuprofeno, indometacina, penicilamina, sulindaco, tenoxican y diclofenaco sódico. Se utilizó como medida de consumo la dosis diaria definida por 1.000 habitantes y día (DHD), y en el análisis de variabilidad el coeficiente de variación ponderado por el tamaño de población (CVw), el rango extremo, el rango interpercentil, los gráficos de puntos y los mapas con categorías de consumo.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">En el período 2000-2005 el consumo de los AINE creció un 48% y el coste anual se incrementó un 184%. Los medicamentos de mayor consumo y participación en el gasto fueron sulindaco e indometacina. El consumo de los AINE varió entre 0,1 y 60,39 DHD según las áreas de salud, con un CVw del 66,38%. Los medicamento con mayor variabilidad fueron penicilamina (CVw del 449,89%) y tenoxican (CVw del 315,26%).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Hay un patrón geográfico diferenciado en el consumo de AINE en el país, y tasas muy diferentes dentro de una misma región. Dos posibles factores asociados a esta variabilidad, según los resultados obtenidos, son la oferta de servicios médicos y el porcentaje de población mayor de 65 años adscrita al área de salud.</p>"
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"titulo" => "Abstract"
"resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To determine changing patterns and variability in consumption of classic nonsteroidal anti-inflammatory drugs (NSAIDs) among the health areas in Costa Rica between 2000 and 2005.</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">The drugs studied were ibuprofen, indomethacin, penicillamine, sulindac, tenoxicam, and diclofenac sodium. To measure consumption, we used the defined daily dose per 1,000 inhabitants per day (DID). To analyze variability, the coefficient of variation weighed by the population size (CVw), extremal ratio, interquartile ratio, dot plot and map graphs were used.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">From 2000-2005, NSAID consumption increased by 48% and the annual cost rose by 184%. The drugs with greatest consumption and participation in cost were sulindac and indomethacin. NSAID consumption varied between 0.1 and 61.8 DID according to health areas, with a CVw of 66.8%. Variability was greatest with penicillamine (CVw<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>449.89%) and tenoxicam (CVw<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>315.26%).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Clearly differentiated geographical patterns in NSAID consumption were found in Costa Rica, with very different rates within the same region. According to the results obtained, two factors associated with this variability were the supply of health services and the percentage of the population aged 65 years or more within the catchment area.</p>"
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"etiqueta" => "1."
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"referenciaCompleta" => "Política Nacional de Salud 2002-2006. San José: Ministerio de Salud de Costa Rica; 2003."
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"referenciaCompleta" => "Caja Costarricense de Seguro Social. Lista Oficial de Medicamentos. San José: Comité Central de Farmacoterapia; 2004."
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"titulo" => "Association between nonsteroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation. An overview of epidemiologic studies published in the 1990s"
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"colaboracion" => "por el grupo VPMIRYSS"
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1 => "M. Martínez"
2 => "J. Librero"
3 => "R. Sotoca"
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