Compartir
array:24 [
"pii" => "S0213911104718506"
"issn" => "02139111"
"doi" => "10.1016/S0213-9111(04)71850-6"
"estado" => "S300"
"fechaPublicacion" => "2004-09-01"
"aid" => "71850"
"copyright" => "Sociedad Española de Salud Pública y Administración Sanitaria"
"copyrightAnyo" => "2004"
"documento" => "article"
"crossmark" => 0
"licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
"subdocumento" => "rev"
"cita" => "Gac Sanit. 2004;18:391-7"
"abierto" => array:3 [
"ES" => true
"ES2" => true
"LATM" => true
]
"gratuito" => true
"lecturas" => array:2 [
"total" => 3952
"formatos" => array:3 [
"EPUB" => 160
"HTML" => 3174
"PDF" => 618
]
]
"itemSiguiente" => array:19 [
"pii" => "S0213911104718518"
"issn" => "02139111"
"doi" => "10.1016/S0213-9111(04)71851-8"
"estado" => "S300"
"fechaPublicacion" => "2004-09-01"
"aid" => "71851"
"copyright" => "Sociedad Española de Salud Pública y Administración Sanitaria"
"documento" => "article"
"crossmark" => 0
"licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
"subdocumento" => "sco"
"cita" => "Gac Sanit. 2004;18:398-405"
"abierto" => array:3 [
"ES" => true
"ES2" => true
"LATM" => true
]
"gratuito" => true
"lecturas" => array:2 [
"total" => 2803
"formatos" => array:3 [
"EPUB" => 131
"HTML" => 2206
"PDF" => 466
]
]
"es" => array:10 [
"idiomaDefecto" => true
"titulo" => "La introducción de tecnologías en los sistemas sanitarios: del dicho al hecho"
"tienePdf" => "es"
"tieneTextoCompleto" => 0
"tieneResumen" => array:2 [
0 => "es"
1 => "en"
]
"paginas" => array:1 [
0 => array:2 [
"paginaInicial" => "398"
"paginaFinal" => "405"
]
]
"titulosAlternativos" => array:1 [
"en" => array:1 [
"titulo" => "The introduction of technologies in health care systems: from saying to doing"
]
]
"contieneResumen" => array:2 [
"es" => true
"en" => true
]
"contienePdf" => array:1 [
"es" => true
]
"autores" => array:1 [
0 => array:2 [
"autoresLista" => "Anna García-Altés"
"autores" => array:1 [
0 => array:2 [
"nombre" => "Anna"
"apellidos" => "García-Altés"
]
]
]
]
]
"idiomaDefecto" => "es"
"EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911104718518?idApp=WGSE"
"url" => "/02139111/0000001800000005/v1_201310251504/S0213911104718518/v1_201310251504/es/main.assets"
]
"itemAnterior" => array:19 [
"pii" => "S021391110471849X"
"issn" => "02139111"
"doi" => "10.1016/S0213-9111(04)71849-X"
"estado" => "S300"
"fechaPublicacion" => "2004-09-01"
"aid" => "71849"
"copyright" => "Sociedad Española de Salud Pública y Administración Sanitaria"
"documento" => "article"
"crossmark" => 0
"licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
"subdocumento" => "fla"
"cita" => "Gac Sanit. 2004;18:387-90"
"abierto" => array:3 [
"ES" => true
"ES2" => true
"LATM" => true
]
"gratuito" => true
"lecturas" => array:2 [
"total" => 3286
"formatos" => array:3 [
"EPUB" => 138
"HTML" => 2616
"PDF" => 532
]
]
"es" => array:10 [
"idiomaDefecto" => true
"titulo" => "Características de los lesionados por accidente de tráfico con alcoholemia positiva"
"tienePdf" => "es"
"tieneTextoCompleto" => 0
"tieneResumen" => array:2 [
0 => "es"
1 => "en"
]
"paginas" => array:1 [
0 => array:2 [
"paginaInicial" => "387"
"paginaFinal" => "390"
]
]
"titulosAlternativos" => array:1 [
"en" => array:1 [
"titulo" => "Characteristics of road accident victims with positive blood alcohol levels"
]
]
"contieneResumen" => array:2 [
"es" => true
"en" => true
]
"contienePdf" => array:1 [
"es" => true
]
"autores" => array:1 [
0 => array:2 [
"autoresLista" => "Xavier Martínez, Antoni Plasència, Alicia Rodríguez-Martos, Elena Santamariña, Josep Martí, Lluís Torralba"
"autores" => array:6 [
0 => array:2 [
"nombre" => "Xavier"
"apellidos" => "Martínez"
]
1 => array:2 [
"nombre" => "Antoni"
"apellidos" => "Plasència"
]
2 => array:2 [
"nombre" => "Alicia"
"apellidos" => "Rodríguez-Martos"
]
3 => array:2 [
"nombre" => "Elena"
"apellidos" => "Santamariña"
]
4 => array:2 [
"nombre" => "Josep"
"apellidos" => "Martí"
]
5 => array:2 [
"nombre" => "Lluís"
"apellidos" => "Torralba"
]
]
]
]
]
"idiomaDefecto" => "es"
"EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021391110471849X?idApp=WGSE"
"url" => "/02139111/0000001800000005/v1_201310251504/S021391110471849X/v1_201310251504/es/main.assets"
]
"es" => array:14 [
"idiomaDefecto" => true
"titulo" => "Análisis de supervivencia en presencia de riesgos competitivos: estimadores de la probabilidad de suceso"
"tieneTextoCompleto" => 0
"paginas" => array:1 [
0 => array:2 [
"paginaInicial" => "391"
"paginaFinal" => "397"
]
]
"autores" => array:1 [
0 => array:4 [
"autoresLista" => "Javier Llorca, Miguel Delgado-Rodríguez"
"autores" => array:2 [
0 => array:4 [
"nombre" => "Javier"
"apellidos" => "Llorca"
"email" => array:1 [
0 => "llorcaj@unican.es"
]
"referencia" => array:2 [
0 => array:2 [
"etiqueta" => "<span class="elsevierStyleSup">a</span>"
"identificador" => "aff0005"
]
1 => array:2 [
"etiqueta" => "<span class="elsevierStyleSup">*</span>"
"identificador" => "cor0005"
]
]
]
1 => array:3 [
"nombre" => "Miguel"
"apellidos" => "Delgado-Rodríguez"
"referencia" => array:1 [
0 => array:2 [
"etiqueta" => "<span class="elsevierStyleSup">b</span>"
"identificador" => "aff0010"
]
]
]
]
"afiliaciones" => array:2 [
0 => array:3 [
"entidad" => "Medicina Preventiva y Salud Pública. Facultad de Medicina de la Universidad de Cantabria. Santander"
"etiqueta" => "a"
"identificador" => "aff0005"
]
1 => array:3 [
"entidad" => "Medicina Preventiva y Salud Pública. Universidad de Jaén. España"
"etiqueta" => "b"
"identificador" => "aff0010"
]
]
"correspondencia" => array:1 [
0 => array:3 [
"identificador" => "cor0005"
"etiqueta" => "*"
"correspondencia" => "Correspondencia: Medicina Preventiva y Salud Pública. Facultad de Medicina. Avda. Cardenal Herrera Oria, s/n. 39011 Santander. España."
]
]
]
]
"titulosAlternativos" => array:1 [
"en" => array:1 [
"titulo" => "Survival analysis with competing risks: estimating failure probability"
]
]
"pdfFichero" => "main.pdf"
"tienePdf" => true
"fechaRecibido" => "2003-10-31"
"fechaAceptado" => "2004-06-28"
"PalabrasClave" => array:2 [
"es" => array:1 [
0 => array:4 [
"clase" => "keyword"
"titulo" => "Palabras clave"
"identificador" => "xpalclavsec268593"
"palabras" => array:5 [
0 => "Análisis de supervivencia"
1 => "Kaplan-Meier"
2 => "Modelo de decrementos múltiples"
3 => "Riesgos competitivos"
4 => "Trasplante cardíaco"
]
]
]
"en" => array:1 [
0 => array:4 [
"clase" => "keyword"
"titulo" => "Key words"
"identificador" => "xpalclavsec268594"
"palabras" => array:5 [
0 => "Survival analysis"
1 => "Kaplan-Meier"
2 => "Multiple decrement model"
3 => "Competing risks"
4 => "Heart transplantation"
]
]
]
]
"tieneResumen" => true
"resumen" => array:2 [
"es" => array:2 [
"titulo" => "Resumen"
"resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Mostrar el efecto de los riesgos competitivos de muerte en el análisis de supervivencia.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se presenta un ejemplo sobre la supervivencia libre de rechazo tras un trasplante cardíaco, en el que la muerte antes de desarrollar el rechazo actúa como riesgo competitivo. Mediante una simulación se comparan el estimador de Kaplan-Meier y el modelo de decrementos múltiples.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El método de Kaplan-Meier sobrestima el riesgo de rechazo. A continuación, se expone la aplicación del modelo de decrementos múltiples para el análisis de acontecimientos secundarios (en el ejemplo, la muerte tras el rechazo). Finalmente, se discuten las asunciones propias del método de Kaplan-Meier y las razones por las que no puede ser aplicado en presencia de riesgos competitivos.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El análisis de supervivencia debe ajustarse por los riesgos competitivos de muerte para evitar la sobrestimación del riesgo de fallo que se produce con el método de Kaplan-Meier.</p>"
]
"en" => array:2 [
"titulo" => "Abstract"
"resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">To show the impact of competing risks of death on survival analysis.</p> <span class="elsevierStyleSectionTitle">Method</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">We provide an example of survival time without chronic rejection after heart transplantation, where death before rejection acts as a competing risk. Using a computer simulation, we compare the Kaplan-Meier estimator and the multiple decrement model.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The Kaplan-Meier method overestimated the probability of rejection. Next, we illustrate the use of the multiple decrement model to analyze secondary end points (in our example: death after rejection). Finally, we discuss Kaplan-Meier assumptions and why they fail in the presence of competing risks.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Survival analysis should be adjusted for competing risks of death to avoid overestimation of the risk of rejection produced with the Kaplan-Meier method.</p>"
]
]
"bibliografia" => array:2 [
"titulo" => "Bibliografía"
"seccion" => array:1 [
0 => array:2 [
"identificador" => "bibs0005"
"bibliografiaReferencia" => array:15 [
0 => array:3 [
"identificador" => "bib0005"
"etiqueta" => "1."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Regression models and life-tables"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:1 [
0 => "D.R. Cox"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:5 [
"tituloSerie" => "J Royal Stat Soc (B)"
"fecha" => "1972"
"volumen" => "34"
"paginaInicial" => "187"
"paginaFinal" => "220"
]
]
]
]
]
]
1 => array:3 [
"identificador" => "bib0010"
"etiqueta" => "2."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Estimation of failure probabilities in the presence of competing risks: new representations of old estimators"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:4 [
0 => "T.A. Gooley"
1 => "W. Leisenring"
2 => "J. Crowley"
3 => "B.E. Storer"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "Stat Med"
"fecha" => "1999"
"volumen" => "18"
"paginaInicial" => "695"
"paginaFinal" => "706"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/10204198"
"web" => "Medline"
]
]
]
]
]
]
]
]
2 => array:3 [
"identificador" => "bib0015"
"etiqueta" => "3."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Hazard plotting for incomplete failure data"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:1 [
0 => "W. Nelson"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:5 [
"tituloSerie" => "J Quality Technology"
"fecha" => "1969"
"volumen" => "1"
"paginaInicial" => "27"
"paginaFinal" => "52"
]
]
]
]
]
]
3 => array:3 [
"identificador" => "bib0020"
"etiqueta" => "4."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Nonparametric estimation of partial transition probabilities in multiple decrement models"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:1 [
0 => "O.O. Aalen"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:5 [
"tituloSerie" => "Annals Statistics"
"fecha" => "1978"
"volumen" => "6"
"paginaInicial" => "534"
"paginaFinal" => "545"
]
]
]
]
]
]
4 => array:3 [
"identificador" => "bib0025"
"etiqueta" => "5."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Using multiple decrement models to estimate risk and morbidity from specific AIDS illnesses"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:6 [
0 => "D.R. Hoover"
1 => "Y. Peng"
2 => "A.J. Saah"
3 => "R.R. Detels"
4 => "R.S. Day"
5 => "J.P. Phair"
]
]
]
]
]
"host" => array:1 [
0 => array:2 [
"doi" => "10.1002/(SICI)1097-0258(19961115)15:21<2307::AID-SIM450>3.0.CO;2-I"
"Revista" => array:6 [
"tituloSerie" => "Stat Med"
"fecha" => "1996"
"volumen" => "15"
"paginaInicial" => "2307"
"paginaFinal" => "2321"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/8931203"
"web" => "Medline"
]
]
]
]
]
]
]
]
5 => array:3 [
"identificador" => "bib0030"
"etiqueta" => "6."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Nonparametric estimation from incomplete observations"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:2 [
0 => "E.L. Kaplan"
1 => "P. Meier"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:5 [
"tituloSerie" => "J Am Stat Assoc"
"fecha" => "1958"
"volumen" => "53"
"paginaInicial" => "457"
"paginaFinal" => "481"
]
]
]
]
]
]
6 => array:3 [
"identificador" => "bib0035"
"etiqueta" => "7."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "The analysis of failure times in the presence of competing risks"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:6 [
0 => "R.L. Prentice"
1 => "J.D. Kalbfleisch"
2 => "A.V. Peterson"
3 => "N. Flournoy"
4 => "V.T. Farewell"
5 => "N.E. Breslow"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "Biometrics"
"fecha" => "1978"
"volumen" => "34"
"paginaInicial" => "541"
"paginaFinal" => "554"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/373811"
"web" => "Medline"
]
]
]
]
]
]
]
]
7 => array:3 [
"identificador" => "bib0040"
"etiqueta" => "8."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Competing risks in absence of independence. Impact of AIDS on liver function failure mortality, and lung cancer on ischemic heart disease mortality"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:2 [
0 => "J. Llorca"
1 => "M. Delgado-Rodríguez"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "J Clin Epidemiol"
"fecha" => "2000"
"volumen" => "53"
"paginaInicial" => "1145"
"paginaFinal" => "1149"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/11106888"
"web" => "Medline"
]
]
]
]
]
]
]
]
8 => array:3 [
"identificador" => "bib0045"
"etiqueta" => "9."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Censoring issues in survival analysis"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:3 [
0 => "K.M. Leung"
1 => "R.M. Elshoff"
2 => "A.A. Afifi"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:5 [
"tituloSerie" => "Annu Revue Public Health"
"fecha" => "1997"
"volumen" => "18"
"paginaInicial" => "83"
"paginaFinal" => "104"
]
]
]
]
]
]
9 => array:3 [
"identificador" => "bib0050"
"etiqueta" => "10."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Competing risk adjustment reduces overstimation of opportunistic infection rates in AIDS"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:3 [
0 => "Y. Yan"
1 => "R.D. Moore"
2 => "D.R. Hoover"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "J Clin Epidemiol"
"fecha" => "2000"
"volumen" => "53"
"paginaInicial" => "817"
"paginaFinal" => "822"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/10942864"
"web" => "Medline"
]
]
]
]
]
]
]
]
10 => array:3 [
"identificador" => "bib0055"
"etiqueta" => "11."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Survival analysis in Public Health research"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:2 [
0 => "E.T. Lee"
1 => "O.T. Go"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:5 [
"tituloSerie" => "Annu Revue Public Health"
"fecha" => "1997"
"volumen" => "18"
"paginaInicial" => "105"
"paginaFinal" => "134"
]
]
]
]
]
]
11 => array:3 [
"identificador" => "bib0060"
"etiqueta" => "12."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Multiariate estimation of cumulative incidence, prevalence, and morbidity time of a disease when death is likely"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:4 [
0 => "Y. Yan"
1 => "D.R. Hoever"
2 => "R.D. Moore"
3 => "X. Chengjie"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "J Clin Epidemiol"
"fecha" => "2003"
"volumen" => "56"
"paginaInicial" => "546"
"paginaFinal" => "552"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/12873649"
"web" => "Medline"
]
]
]
]
]
]
]
]
12 => array:3 [
"identificador" => "bib0065"
"etiqueta" => "13."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Non-parametric inference for cumulative incidence functions in competing risks studies"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:1 [
0 => "D.Y. Lin"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "Stat Med"
"fecha" => "1997"
"volumen" => "16"
"paginaInicial" => "901"
"paginaFinal" => "910"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/9160487"
"web" => "Medline"
]
]
]
]
]
]
]
]
13 => array:3 [
"identificador" => "bib0070"
"etiqueta" => "14."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Competing risks in mortality analysis"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:1 [
0 => "C.L. Chiang"
]
]
]
]
]
"host" => array:1 [
0 => array:2 [
"doi" => "10.1146/annurev.pu.12.050191.001433"
"Revista" => array:6 [
"tituloSerie" => "Annu Rev Public Health"
"fecha" => "1991"
"volumen" => "12"
"paginaInicial" => "281"
"paginaFinal" => "307"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/2049139"
"web" => "Medline"
]
]
]
]
]
]
]
]
14 => array:3 [
"identificador" => "bib0075"
"etiqueta" => "15."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Competing risks analysis using Markov chains: impact of cerebro-vascular and ischaemic heart disease in cancer mortality"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:2 [
0 => "J. Llorca"
1 => "M. Delgado-Rodríguez"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "Int J Epidemiol"
"fecha" => "2001"
"volumen" => "30"
"paginaInicial" => "99"
"paginaFinal" => "101"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/11171866"
"web" => "Medline"
]
]
]
]
]
]
]
]
]
]
]
]
]
"idiomaDefecto" => "es"
"url" => "/02139111/0000001800000005/v1_201310251504/S0213911104718506/v1_201310251504/es/main.assets"
"Apartado" => array:4 [
"identificador" => "688"
"tipo" => "SECCION"
"es" => array:2 [
"titulo" => "Revisión"
"idiomaDefecto" => true
]
"idiomaDefecto" => "es"
]
"PDF" => "https://static.elsevier.es/multimedia/02139111/0000001800000005/v1_201310251504/S0213911104718506/v1_201310251504/es/main.pdf?idApp=WGSE&text.app=https://gacetasanitaria.org/"
"EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911104718506?idApp=WGSE"
]