array:24 [
  "pii" => "S0213911102716725"
  "issn" => "02139111"
  "doi" => "10.1016/S0213-9111(02)71672-5"
  "estado" => "S300"
  "fechaPublicacion" => "2002-05-01"
  "aid" => "71672"
  "copyright" => "Sociedad Española de Salud Pública y Administración Sanitaria"
  "copyrightAnyo" => "2002"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "sco"
  "cita" => "Gac Sanit. 2002;16:267-73"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3293
    "formatos" => array:3 [
      "EPUB" => 116
      "HTML" => 2431
      "PDF" => 746
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0213911102716737"
    "issn" => "02139111"
    "doi" => "10.1016/S0213-9111(02)71673-7"
    "estado" => "S300"
    "fechaPublicacion" => "2002-05-01"
    "aid" => "71673"
    "copyright" => "Sociedad Española de Salud Pública y Administración Sanitaria"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "sco"
    "cita" => "Gac Sanit. 2002;16:273"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1812
      "formatos" => array:3 [
        "EPUB" => 97
        "HTML" => 1304
        "PDF" => 411
      ]
    ]
    "es" => array:7 [
      "idiomaDefecto" => true
      "titulo" => "Capancalá"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "273"
        ]
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:2 [
        0 => array:2 [
          "autoresLista" => "Antonio Burgos"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Antonio"
              "apellidos" => "Burgos"
            ]
          ]
        ]
        1 => array:2 [
          "autoresLista" => "C. Álvarez-Dardet"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "C."
              "apellidos" => "Álvarez-Dardet"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911102716737?idApp=WGSE"
    "url" => "/02139111/0000001600000003/v1_201310251746/S0213911102716737/v1_201310251746/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0213911102716713"
    "issn" => "02139111"
    "doi" => "10.1016/S0213-9111(02)71671-3"
    "estado" => "S300"
    "fechaPublicacion" => "2002-05-01"
    "aid" => "71671"
    "copyright" => "Sociedad Española de Salud Pública y Administración Sanitaria"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "sco"
    "cita" => "Gac Sanit. 2002;16:257-66"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5102
      "formatos" => array:3 [
        "EPUB" => 131
        "HTML" => 4454
        "PDF" => 517
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Concentraciones de compuestos tóxicos persistentes en la población española: el rompecabezas sin piezas y la protección de la salud pública"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "257"
          "paginaFinal" => "266"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Concentrations of persistent toxic compounds in the Spanish population: a puzzle without pieces and the protection of public health"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M. Porta, M. Kogevinas, E. Zumeta, J. Sunyer, N. Ribas-Fitó"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "M."
              "apellidos" => "Porta"
            ]
            1 => array:2 [
              "nombre" => "M."
              "apellidos" => "Kogevinas"
            ]
            2 => array:2 [
              "nombre" => "E."
              "apellidos" => "Zumeta"
            ]
            3 => array:2 [
              "nombre" => "J."
              "apellidos" => "Sunyer"
            ]
            4 => array:2 [
              "nombre" => "N."
              "apellidos" => "Ribas-Fitó"
            ]
            5 => array:1 [
              "colaborador" => "Grupo de Trabajo sobre Compuestos Tóxicos Persistentes y Salud del IMIM"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911102716713?idApp=WGSE"
    "url" => "/02139111/0000001600000003/v1_201310251746/S0213911102716713/v1_201310251746/es/main.assets"
  ]
  "es" => array:14 [
    "idiomaDefecto" => true
    "titulo" => "Algunos aspectos metodológicos sobre los modelos edad-período-cohorte. Aplicación a las tendencias de mortalidad por cáncer"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "267"
        "paginaFinal" => "273"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "J.R. González, F.J. Llorca, V. Moreno"
        "autores" => array:3 [
          0 => array:3 [
            "nombre" => "J.R."
            "apellidos" => "González"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "F&#46;J&#46;"
            "apellidos" => "Llorca"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:4 [
            "nombre" => "V&#46;"
            "apellidos" => "Moreno"
            "email" => array:1 [
              0 => "v&#46;moreno&#64;ico&#46;scs&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servicio de Prevenci&#243;n y Control del C&#225;ncer&#46; Institut Catal&#224; d&#39;Oncologia"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Departamento de Medicina Preventiva y Salud P&#250;blica&#46; Facultad de Medicina de la Universidad de Cantabria"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Epidemiolog&#237;a y Registro del C&#225;ncer&#46; Institut Catal&#224; d&#39;Oncologia"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#42;"
            "correspondencia" => "<span class="elsevierStyleItalic">Correspondencia&#58;</span> Dr&#46; V&#46; Moreno&#46; Servei d&#39;Epidemiologia i Registre del C&#224;ncer&#46; Institut Catal&#224; d&#39;Oncologia&#46; Avda&#46; Gran Via&#44; s&#47;n&#46; km 2&#44;7&#46; 08907 L&#39;Hospitalet de Llobregat&#46; Barcelona&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Some methodological aspects of age-period-cohort models&#46; Application to cancer mortality trends"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2001-12-28"
    "fechaAceptado" => "2002-02-20"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec268879"
          "palabras" => array:4 [
            0 => "Tendencias temporales"
            1 => "Modelos edad-per&#237;odo-cohorte"
            2 => "Epidemiolog&#237;a descriptiva"
            3 => "Mortalidad por c&#225;ncer"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec268878"
          "palabras" => array:4 [
            0 => "Time trends"
            1 => "Age-period-cohort models"
            2 => "Descriptive epidemiology"
            3 => "Cancer mortality"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Los modelos edad-per&#237;odo-cohorte suelen utilizarse en estudios de epidemiolog&#237;a descriptiva para analizar las tendencias de la incidencia y de la mortalidad para valorar el efecto temporal de la ocurrencia de un evento&#46; La relaci&#243;n lineal exacta existente entre estos tres efectos hace que los par&#225;metros del modelo completo no puedan estimarse&#44; lo que se denomina <span class="elsevierStyleItalic">no identificabilidad</span>&#46; En estas notas se explicar&#225;n dos de los m&#233;todos m&#225;s usados para analizar modelos edad-per&#237;odo-cohorte&#58; uno se basa en funciones de penalizaci&#243;n y otro en funciones estimables &#40;tendencia lineal y curvaturas o desviaciones&#41;&#46; Ambos m&#233;todos se ilustrar&#225;n con dos ejemplos en el que se analizan la tendencia temporal de la mortalidad por c&#225;ncer de pulm&#243;n y mama en las mujeres de Catalu&#241;a&#46; Estos ejemplos ilustran que los m&#233;todos basados en funciones de penalizaci&#243;n tienden a atribuir la tendencia a un efecto cohorte exclusivo&#44; por lo que se aconseja utilizar los m&#233;todos basados en funciones estimables&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Age-period-cohort models are usually used in descriptive epidemiological studies to analyze time trends in incidence or mortality&#46; The exact linear relationship between the three effects of these models has the effect of making the parameters of the full model impossible to estimate&#44; which is called <span class="elsevierStyleItalic">non-identifiability</span>&#46; In these notes two of the most frequently used methods to analyze age-period-cohort models will be explained&#46; One is based on penalty functions and the other on estimable functions &#40;drift and curvatures or deviation from linearity&#41;&#46; Both methods will be illustrated with two examples in wich temporal trends of breast and lung cancer mortality in women from Catalonia in Spain will be studied&#46; These examples show how the methods based on penalty functions tend to attribute the trend exclusively to a cohort effect&#46; Consequently&#44; the use of methods based on estimate functions is recommended&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:21 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Time trend and age-period-cohort effects on incidence of thyroid cancer in Connecticut"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Zheng"
                            1 => "T&#46;R&#46; Holford"
                            2 => "Y&#46; Chen"
                            3 => "J&#46;Z&#46; Ma"
                            4 => "J&#46; Flannery"
                            5 => "W&#46; Liu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/(SICI)1097-0215(19960807)67:4<504::AID-IJC7>3.0.CO;2-W"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Cancer"
                        "fecha" => "1996"
                        "volumen" => "67"
                        "paginaInicial" => "504"
                        "paginaFinal" => "509"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8759608"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Age-period-cohort analysis of lung cancer mortality in Japan&#44; 1960-1995"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Takahashi"
                            1 => "M&#46; Okada"
                            2 => "K&#46; Kano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Epidemiol"
                        "fecha" => "2001"
                        "volumen" => "11"
                        "paginaInicial" => "151"
                        "paginaFinal" => "159"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11512571"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Age-period-cohort modeling of colorectal cancer incidence and mortality in Spain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; L&#243;pez-Abente"
                            1 => "M&#46; Poll&#225;n"
                            2 => "A&#46; Vergara"
                            3 => "C&#46; Moreno"
                            4 => "P&#46; Moreo"
                            5 => "E&#46; Ardanaz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Epidemiol&#44; Biomarkers Prev&#44;"
                        "fecha" => "1997"
                        "volumen" => "6"
                        "paginaInicial" => "999"
                        "paginaFinal" => "1005"
                        "itemHostRev" => array:3 [
                          "pii" => "S0091674902885633"
                          "estado" => "S300"
                          "issn" => "00916749"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Homicide mortality in the United States&#44; 1935-1994&#58; age&#44; period and cohort effects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Shahpar"
                            1 => "G&#46; Li"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Epidemiol"
                        "fecha" => "1999"
                        "volumen" => "150"
                        "paginaInicial" => "1213"
                        "paginaFinal" => "1222"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10588082"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The AIDS epidemicamong Spanish drug users&#58; a birth cohort-associated phenomenon"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Castilla"
                            1 => "M&#46; Poll&#225;n"
                            2 => "G&#46; L&#243;pez-Abente"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Public Health"
                        "fecha" => "1997"
                        "volumen" => "87"
                        "paginaInicial" => "770"
                        "paginaFinal" => "774"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9184504"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cohort analysis in sociological research"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "W&#46;M&#46; Mason"
                            1 => "S&#46;E&#46; Fienberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:1 [
                        "serieFecha" => "1985"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trends in incidence of testicular cancer and prostate cancer in Denmark"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46; Moller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Human Reprod&#44;"
                        "fecha" => "2001"
                        "volumen" => "16"
                        "paginaInicial" => "1007"
                        "paginaFinal" => "1011"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The estimation of age period and cohort effects for vital rates"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "T&#46;R&#46; Holford"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Biometrics"
                        "fecha" => "1983"
                        "volumen" => "39"
                        "paginaInicial" => "311"
                        "paginaFinal" => "324"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6626659"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Age-period-cohort analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "T&#46;R&#46; Holford"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Encyclopedia of epidemiologic methods"
                        "paginaInicial" => "17"
                        "paginaFinal" => "35"
                        "serieFecha" => "2000"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Models for temporal variation in cancer rates I&#58; age-period and age-cohort models"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46; Clayton"
                            1 => "E&#46; Schifflers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Stat Med"
                        "fecha" => "1987"
                        "volumen" => "6"
                        "paginaInicial" => "449"
                        "paginaFinal" => "467"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3629047"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Age&#44; period and cohort models&#58; The use of individual records"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Robertson"
                            1 => "P&#46; Boyle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Stat Med"
                        "fecha" => "1986"
                        "volumen" => "5"
                        "paginaInicial" => "527"
                        "paginaFinal" => "538"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3675723"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Age&#44; period and cohort models applied to cancer mortality"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Osmond"
                            1 => "M&#46;J&#46; Gardner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Stat Med"
                        "fecha" => "1982"
                        "volumen" => "1"
                        "paginaInicial" => "245"
                        "paginaFinal" => "259"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7187097"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Age&#44; period and cohort models&#58; a review of knowledge and inplementation in GLIM"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Decarli"
                            1 => "C&#46; La Vecchia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Riv Stat Applicata"
                        "fecha" => "1987"
                        "volumen" => "20"
                        "paginaInicial" => "397"
                        "paginaFinal" => "410"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Autoregressive age period cohort models"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "W&#46;C&#46; Lee"
                            1 => "R&#46;C&#46; Lin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/(SICI)1097-0258(19960215)15:3<273::AID-SIM172>3.0.CO;2-R"
                      "Revista" => array:6 [
                        "tituloSerie" => "Stat Med"
                        "fecha" => "1996"
                        "volumen" => "15"
                        "paginaInicial" => "273"
                        "paginaFinal" => "281"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8643885"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Models for temporal variation in cancer rates II&#58; age-period-cohort models"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46; Clayton"
                            1 => "E&#46; Schifflers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Stat Med"
                        "fecha" => "1987"
                        "volumen" => "6"
                        "paginaInicial" => "468"
                        "paginaFinal" => "481"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Servei d&#39;informaci&#243; i Estudis&#44; Direcci&#243; General de Recursos Sanitaris"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Registre de Mortalitat de Catalunya"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:1 [
                        "serieFecha" => "1999"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "UK and USA breast cancer deaths down 25&#37; in year 2000 at ages 20&#8211;69 years"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Peto"
                            1 => "J&#46; Boreham"
                            2 => "M&#46; Clarke"
                            3 => "C&#46; Davies"
                            4 => "V&#46; Beral"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(05)73078-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2000"
                        "volumen" => "355"
                        "paginaInicial" => "1822"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10832854"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0091674901876181"
                          "estado" => "S300"
                          "issn" => "00916749"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Age-period-cohort models&#58; A comparative study of available methodologies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Robertson"
                            1 => "S&#46; Gandini"
                            2 => "P&#46; Boyle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Epidemiol"
                        "fecha" => "1999"
                        "volumen" => "52"
                        "paginaInicial" => "569"
                        "paginaFinal" => "583"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10408997"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Understanding the effects of age period&#44; and cohort on incidence and mortality rates"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "T&#46;R&#46; Holford"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Annu Rev publ Health"
                        "fecha" => "1991"
                        "volumen" => "12"
                        "paginaInicial" => "425"
                        "paginaFinal" => "457"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Statistical analysis of epidemiologic data"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Selvin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:3 [
                        "paginaInicial" => "103"
                        "paginaFinal" => "125"
                        "serieFecha" => "1996"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lee JAH&#46; Effect of age on incidence of breast cancer in females"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;H&#46; Moolgavkar"
                            1 => "R&#46;G&#46; Stevens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Natl Cancer Inst"
                        "fecha" => "1979"
                        "volumen" => "62"
                        "paginaInicial" => "493"
                        "paginaFinal" => "501"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/283278"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/02139111/0000001600000003/v1_201310251746/S0213911102716725/v1_201310251746/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "636"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Nota Metodol&#243;gica"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02139111/0000001600000003/v1_201310251746/S0213911102716725/v1_201310251746/es/main.pdf?idApp=WGSE&text.app=https://gacetasanitaria.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213911102716725?idApp=WGSE"
]
Compartir
Publique en esta revista
Información de la revista

Respuestas rápidas

Nueva respuesta rápida:

Requisitos y consideraciones

  • Las respuestas rápidas tienen como objetivo permitir el debate sobre observaciones científicas y de opinión sobre trabajos publicados el último año.
  • Deben ser enviadas desde la página web correspondiente al artículo en cuestión (no a través del sistema general de envío de artículos).
  • Son moderadas antes de su publicación a discreción del equipo editorial de la revista, no obstante no son peer-reviewed.
  • Deben ser originales y no infringir los derechos propiedad de terceros.
  • Los/las autores/as perderán el derecho a borrar o editar el texto, una vez sea publicado. Asimismo, la revista se reserva el derecho de borrar o editar el texto a discreción.
  • Algunas respuestas rápidas podrían ser seleccionadas adicionalmente para su publicación como cartas en la revista, en este caso seguirán el proceso editorial correspondiente.
  • Las respuestas rápidas serán publicadas en la web de la revista en 1 semana aproximadamente, después del envío del texto por parte de los/as autores/as.
  • La extensión máxima será de 500 palabras. Se admitirá una tabla o figura y hasta 5 referencias bibliográficas.
  • Se comunicará a los/las autores/ras del artículo comentado la existencia de la carta y la posibilidad de respuesta.
  • Al enviar esta respuesta rápida los autores/as aceptan los requisitos descritos.

Respuesta

Conflictos de interés

Los conflictos de interés pueden ser laborales, de investigación, económicos o morales. Los/las autores/as deben indicar si existe alguno de estos conflictos. Una descripción más detallada sobre los conflictos de intereses se encuentra disponible en las normas éticas de Gaceta Sanitaria.

El texto se adecua a las normas éticas de la revista
Idiomas
Gaceta Sanitaria
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?