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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se analiza desde la perspectiva del pagador &#40;Sistema Nacional de Salud &#91;SNS&#93;&#41; la influencia que tienen los gen&#233;ricos en el gasto en medicamentos en la hipertensi&#243;n arterial&#44; examin&#225;ndose el subgrupo terap&#233;utico de mayor consumo y utilizaci&#243;n&#44; los inhibidores de la enzima de conversi&#243;n de la angiotensina &#40;IECA&#41; y antagonistas de los receptores de la angiotensina II &#40;ARA II&#41;&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Partiendo de los datos de facturaci&#243;n al SNS de todas las oficinas de farmacia del &#193;rea de Salud de M&#225;laga&#44; se explora el consumo &#40;envases y gasto&#41; de los f&#225;rmacos IECA&#44; IECA &#43; especialidades farmac&#233;uticas gen&#233;ricas &#40;EFG&#41; y ARA II&#44; desde 1999 hasta 2002&#44; as&#237; como el precio medio &#40;ponderando seg&#250;n ventas&#41; y el porcentaje de desviaci&#243;n de prescripci&#243;n de un grupo a otro&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El incremento en envases del subgrupo C09 fue del 20&#44;79&#37;&#44; muy superior para los ARA II &#40;136&#37;&#41; y los IECA &#43; EFG &#40;177&#37;&#41;&#46; El gasto total creci&#243; en m&#225;s del 42&#37;&#46; Se redujo el gusto en IECA en casi el 7&#37;&#44; a pesar del incremento en gasto de los IECA &#43; EFG&#44; mientras que los ARA II lo aumentaron en m&#225;s del 154&#37;&#46; El precio medio ponderado seg&#250;n las ventas de este subgrupo terap&#233;utico se increment&#243; en cerca del 18&#37;&#46; Se produjo un descenso en el precio medio ponderado de los principios activos donde hab&#237;a EFG &#40;captopril y enalapril&#41; adem&#225;s de otros &#40;trandolapril&#41;&#44; pero entre los ARA II destaca el aumento en el precio medio ponderado seg&#250;n las ventas de irbesart&#225;n &#40;9&#37;&#41; y valsart&#225;n &#40;16&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los gen&#233;ricos usados han originado una disminuci&#243;n en el gasto de IECA y del precio medio ponderado del subgrupo&#46; Pero a pesar del incesante aumento en el consumo de las especialidades farmac&#233;uticas gen&#233;ricas&#44; no se ha producido el efecto ahorrador pretendido con este tipo de medicamentos por el Ministerio de Sanidad y Consumo&#46; Se apunta como posible causa la desviaci&#243;n de las prescripciones hacia los medicamentos no afectados de sustituci&#243;n por parte de la oficina de farmacia&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetive</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">In this article we analyze the influence of generic drugs on pharmaceutical expenditure on hypertension from the payer&#8217;s perspective &#40;the public health service&#41;&#44; by examining the most widely used drugs&#58; angiotensin converting enzyme inhibitors &#40;ACEi&#41; and angiotensin II receptor blockers &#40;ARBs&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Based on billing data to the public health service from all the pharmacies in the Health Area of Malaga&#44; we studied the utilization &#40;containers and cost&#41; of ACEi &#40;generic drugs &#8211;ACEi&#43;G&#8211; and brand name&#41; and ARBs &#40;brand name only&#41; &#40;subgroup C09 &#8211; ATC index&#41; from 1999 to 2002&#46; The mean price &#40;weighted according to sales&#41; and the percentage of deviation of prescriptions from one group of drugs to another was also studied&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The increase in consumption of packages in subgroup C09 was 20&#46;79&#37;&#59; the increase was greater for ARBs &#40;136&#37;&#41; and for ACEi&#43;G &#40;177&#37;&#41;&#46; The total amount spent during the study period increased by more than 42&#37;&#46; Expenditure on ACEis decreased by almost 7&#37;&#44; despite the increase in expenditure on ACEi&#43;G&#44; whereas expenditure on ARBs increased by more than 154&#37;&#46; The mean price of this subgroup&#44; weighted according to sales&#44; increased by nearly 18&#37;&#46; The mean weighted price of the generic drugs&#44; captopril and enalapril&#44; and that of the brand name&#44; trandolapril&#44; decreased&#46; Notable among ARBs was the increase in mean price weighted according to sales of irbesartan &#40;9&#37;&#41; and valsartan &#40;16&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The use of generic drugs has reduced expenditure on ACEi and the mean weighted price of the subgroup&#46; However&#44; the increased use of generic drugs has not produced the expected savings for the Department of Health&#46; This could be due to deviation of prescription scores toward drugs not affected by substitution by the pharmacy&#46;</p>"
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                          "colaboracion" => "Grupos terap&#233;uticos y principios activos de mayor consumo en el Sistema"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Informaci&#243;n Terap&#233;utica del Sistema Nacional de Salud"
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                        "volumen" => "25"
                        "paginaInicial" => "78"
                        "paginaFinal" => "82"
                      ]
                    ]
                  ]
                ]
              ]
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            6 => array:3 [
              "identificador" => "bib0035"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sistema Nacional de Salud durante 2001"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Grupos terap&#233;uticos y principios activos de mayor consumo en el"
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                        "tituloSerie" => "Informaci&#243;n Terap&#233;utica del Sistema Nacional de Salud"
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                        "numero" => "3"
                        "paginaInicial" => "78"
                        "paginaFinal" => "83"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Clasificaci&#243;n Anat&#243;mica Terap&#233;utica&#46; ATC Index &#91;consultado 6&#47;05&#47;2003&#93;&#46; Disponible en&#58; <a class="elsevierStyleInterRef" href="http://www.whocc.no/atcddd/indexdatabase/9">http&#58;&#47;&#47;www&#46;whocc&#46;no&#47;atcddd&#47;indexdatabase&#47;9</a>&#46; Ley 13&#47;1996&#44; de Medidas Fiscales&#44; Administrativas y de Orden Social&#46; Cap&#237;tulo III&#46; Acci&#243;n administrativa en materia educativa y sanitaria&#46; Art&#237;culo 169&#46; Modificaci&#243;n de la Ley 25&#47;1990&#44; de 20 de diciembre&#44; del medicamento"
                ]
              ]
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            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A retrospective electronic chart review of blood pressure changes in elderly patients treated with amlodipine or angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Dollar"
                            1 => "C&#46; Brown"
                            2 => "D&#46; Putnam"
                            3 => "T&#46; McLaughlin"
                            4 => "L&#46; Okamoto"
                            5 => "R&#46; Arocho"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Ther"
                        "fecha" => "2002"
                        "volumen" => "24"
                        "paginaInicial" => "930"
                        "paginaFinal" => "941"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12117083"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Current recommendations for the treatment of hypertension&#58; are they still valid&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Moser"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hypertens"
                        "fecha" => "2002"
                        "volumen" => "20"
                        "paginaInicial" => "3"
                        "paginaFinal" => "10"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11791019"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "12&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Augmentation of myocardial blood flow in hypertensive heart disease by angiotensin antagonists&#58; a comparison of lisinopril and losartan"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "O&#46;O&#46; Akinboboye"
                            1 => "R&#46;L&#46; Chou"
                            2 => "S&#46;R&#46; Bergmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2002"
                        "volumen" => "40"
                        "paginaInicial" => "703"
                        "paginaFinal" => "709"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12204500"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Case 3&#58; a patient with systemic hypertension and left ventricular hypertrophy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;A&#46; Kloner"
                            1 => "V&#46;E&#46; Friedewald Jr&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2000"
                        "volumen" => "85"
                        "paginaInicial" => "522"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10728968"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "14&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Renoprotective effect of small doses of losartan and enalapril in patients with primary glomerulonephritis&#46; Short-term observation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46; Tylicki"
                            1 => "P&#46; Rutkowski"
                            2 => "M&#46; Renke"
                            3 => "B&#46; Rutkowski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "65227"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Nephrol"
                        "fecha" => "2002"
                        "volumen" => "22"
                        "paginaInicial" => "356"
                        "paginaFinal" => "362"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12169868"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            13 => array:3 [
              "identificador" => "bib0070"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of angiotensin-converting enzyme inhibitors in patients with heart failure and renal insufficiency&#58; how concerned should we be by the rise in serum creatinine&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Ahmed"
                          ]
                        ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Geriatr Soc"
                        "fecha" => "2002"
                        "volumen" => "50"
                        "paginaInicial" => "1297"
                        "paginaFinal" => "1300"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12133029"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
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                ]
              ]
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            14 => array:3 [
              "identificador" => "bib0075"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of enalapril and eprosartan on the renal vascular nitric oxide system in human essential hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46; Delles"
                            1 => "J&#46; Jacobi"
                            2 => "S&#46; John"
                            3 => "I&#46; Fleischmann"
                            4 => "R&#46;E&#46; Schmieder"
                          ]
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                      ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1523-1755.2002.00260.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2002"
                        "volumen" => "61"
                        "paginaInicial" => "1462"
                        "paginaFinal" => "1468"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11918753"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
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                ]
              ]
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            15 => array:3 [
              "identificador" => "bib0080"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparative effects on dynamic renal potassium excretion of ACE inhibition versus angiotensin receptor blockade in hypertensive patients with type II diabetes mellitus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;A&#46; Preston"
                            1 => "N&#46;M&#46; Baltodano"
                            2 => "A&#46;B&#46; Alonso"
                            3 => "M&#46; Epstein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Pharmacol"
                        "fecha" => "2002"
                        "volumen" => "42"
                        "paginaInicial" => "754"
                        "paginaFinal" => "761"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12092742"
                            "web" => "Medline"
                          ]
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                      ]
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                  ]
                ]
              ]
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            16 => array:3 [
              "identificador" => "bib0085"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of angiotensin-converting enzyme inhibitor&#44; angiotensin II receptor antagonist and calcium antagonist on urinary podocytes in patients with IgA nephropathy"
                      "autores" => array:1 [
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Nakamura"
                            1 => "C&#46; Ushiyama"
                            2 => "S&#46; Suzuki"
                            3 => "M&#46; Hara"
                            4 => "N&#46; Shimada"
                            5 => "K&#46; Sekizuka"
                          ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "13619"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Nephrol"
                        "fecha" => "2000"
                        "volumen" => "20"
                        "paginaInicial" => "373"
                        "paginaFinal" => "379"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11092994"
                            "web" => "Medline"
                          ]
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                ]
              ]
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            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Synergistic efficacy of enalapril and losartan on exercise performance and oxygen consumption at peak exercise in congestive heart failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Guazzi"
                            1 => "P&#46; Palermo"
                            2 => "G&#46; Pontone"
                            3 => "F&#46; Susini"
                            4 => "P&#46; Agostoni"
                          ]
                        ]
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "1999"
                        "volumen" => "84"
                        "paginaInicial" => "1038"
                        "paginaFinal" => "1043"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10569660"
                            "web" => "Medline"
                          ]
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                  ]
                ]
              ]
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            18 => array:3 [
              "identificador" => "bib0095"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Are angiotensin II receptor blockers more efficacious than placebo in heart failure&#63; Implications of Elite-2"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:3 [
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                            1 => "J&#46; Norrie"
                            2 => "J&#46;V&#46; McMurray"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2001"
                        "volumen" => "87"
                        "paginaInicial" => "606"
                        "paginaFinal" => "607"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11230847"
                            "web" => "Medline"
                          ]
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              ]
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            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of angiotensin II receptor blockers in the treatment of heart failure patients"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Theal"
                            1 => "C&#46; Memers"
                            2 => "R&#46;S&#46; McKelvie"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cogest Heart Fail"
                        "fecha" => "2003"
                        "volumen" => "9"
                        "paginaInicial" => "29"
                        "paginaFinal" => "34"
                      ]
                    ]
                  ]
                ]
              ]
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            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical trials of angiotensin receptor blockers in heart failure&#58; what do we know and what will we learn&#63;"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:1 [
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Hypertens"
                        "fecha" => "2002"
                        "volumen" => "15"
                        "paginaInicial" => "22"
                        "paginaFinal" => "27"
                      ]
                    ]
                  ]
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            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "23&#46;"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "ACE inhibitors and ARBs in chronic heart failure&#58; the established&#44; the expected&#44; and the pragmatic"
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                          "etal" => false
                          "autores" => array:1 [
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Clin North Am"
                        "fecha" => "2003"
                        "volumen" => "87"
                        "paginaInicial" => "373"
                        "paginaFinal" => "389"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12693730"
                            "web" => "Medline"
                          ]
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            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ACE inhibitors vs ARBs&#58; is one class better for heart failure&#63;"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;E&#46; Dunlap"
                            1 => "R&#46;C&#46; Peterson"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cleve Clin J Med"
                        "fecha" => "2002"
                        "volumen" => "69"
                        "paginaInicial" => "433"
                        "paginaFinal" => "438"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12022388"
                            "web" => "Medline"
                          ]
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            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Are angiotensin II receptor blokers more efficacious than placebo in heart failure&#63; Implications of ELITE-2"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Berry"
                            1 => "J&#46; Norrie"
                            2 => "J&#46;V&#46; McMurray"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2001"
                        "volumen" => "87"
                        "paginaInicial" => "606"
                        "paginaFinal" => "607"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11230847"
                            "web" => "Medline"
                          ]
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                ]
              ]
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            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "Prescrire R&#232;daction&#46; Indications et choix des anthypertenseurs &#40;suite&#41;"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Rev Prescr"
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                        "volumen" => "20"
                        "paginaInicial" => "220"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Angiotensin II receptor blockers&#58; clinical relevance and therapeutics role"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;E&#46; Rodgers"
                            1 => "J&#46;H&#46; Patterson"
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Health Syst Pharm"
                        "fecha" => "2001"
                        "volumen" => "58"
                        "paginaInicial" => "671"
                        "paginaFinal" => "683"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11329759"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gen&#233;ricos&#58; &#191;buenos o malos&#63; Conocimientos y actitudes de los m&#233;dicos ante los medicamentos gen&#233;ricos"
                      "autores" => array:1 [
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                  "host" => array:1 [
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3148583"
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                ]
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                        "titulo" => "Encuesta Nacional sobre gen&#233;ricos&#46; Sigma Dos&#46; Presentada en la 5&#46;<span class="elsevierStyleSup">a</span> Jornada Nacional &#171;Los gen&#233;ricos hoy&#187;"
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                  "referenciaCompleta" => "Acuerdo sobre la prescripci&#243;n por principio activo &#91;consultado 26&#47;05&#47;2003&#93;&#46; Disponible en&#58; &#91;<a class="elsevierStyleInterRef" href="http://www.juntadeandalucia.es/servicioandaluzdesalud/publicaciones/sasinfo11/DATOS/SASINFO/otras_4.html">http&#58;&#47;&#47;www&#46;juntadeandalucia&#46;es&#47;servicioandaluzdesalud&#47;publicaciones&#47;sasinfo11&#47;DATOS&#47;SASINFO&#47;otras&#95;4&#46;html</a>"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Simulaci&#243;n econ&#243;mica sobre la aplicaci&#243;n desarrollo de la OM y RD de precios de referencia"
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                          "etal" => false
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                            2 => "E&#46; Blanco"
                            3 => "F&#46; S&#225;nchez de la Cuesta"
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                        ]
                      ]
                    ]
                  ]
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                      "Revista" => array:2 [
                        "tituloSerie" => "Libro de Ponencias de las XXII Jornadas de la Asociaci&#243;n de Econom&#237;a de la Salud"
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                      ]
                    ]
                  ]
                ]
              ]
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                    0 => array:1 [
                      "titulo" => "Los gen&#233;ricos en la OCDE"
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                      "Libro" => array:2 [
                        "titulo" => "Informe del National Economics Research Associates &#40;NERA&#41;"
                        "fecha" => "1998"
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                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "La cultura del gen&#233;rico no se debe implantar a golpe de Real Decreto &#91;entrevista&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                      "Revista" => array:5 [
                        "tituloSerie" => "OMC&#44; Revista del Consejo General de Colegios M&#233;dicos de Espa&#241;a"
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                        "volumen" => "63"
                        "paginaInicial" => "14"
                        "paginaFinal" => "16"
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                    ]
                  ]
                ]
              ]
            ]
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              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Declaraci&#243;n de la Comisi&#243;n Central de Deontolog&#237;a sobre la &#201;tica de la Prescripci&#243;n y Sustituci&#243;n de Medicamentos Gen&#233;ricos"
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